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Heparanase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
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▼
2-[3-[5-(4-Chlorophenyl)-1,3-benzoxazol-2-yl]-4-(propylamino)phenyl]-1,3-dioxoisoindole-5-carboxylic acidIC50199.53 [1], 200.0 [2]
1,3-Bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)phenyl]ureaIC5075.0 [1], 560.0 [2]
2-(2-Methoxy-5-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-(3-Benzooxazol-2-yl-phenyl)-1,3-dioxo-2,3-dihydro-1h-isoindole-5-carboxylic acidIC507943.28 [1], 8000.0 [2]
2-(2-(4-(3-(4-Bromophenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC50420.0 [1], 600.0 [2], 602.56 [3]
2-(4-(5-(2-Chloro-4-(4-chlorobenzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC502500.0 [1], 2511.89 [2]
2-(4-(5-(4-(3-(4-Bromophenyl)acrylamido)-2-chlorophenyl)furan-2-yl)thiazol-2-yl)acetic acidIC50398.11 [1], 400.0 [2]
1,3-Bis[4-(1H-benzimidazol-2-yl)phenyl]ureaIC50270.0 [1]
(E)-2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50398.11 [1], 400.0 [2]
N-(4-{[4-(1H-Benzoimidazol-2-yl)phenylamino]methyl}phenyl)-3-bromo-4-methoxy-benzamideIC50230.0 [1]
N-(4-{[5-(1H-Benzoimidazol-2-yl)-pyridin-2-ylamino]methyl}-phenyl)-3-bromo-4-methoxy-benzamideIC50290.0 [1]
2-(4-(5-(2-Chloro-4-(3,4-dichlorobenzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC501000.0 [1]
2-(4-(5-(2-Chloro-4-(4-(trifluoromethoxy)benzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC501500.0 [1], 1513.56 [2]
2-[3-[5-(4-Fluorophenyl)-1,3-benzoxazol-2-yl]-4-(propylamino)phenyl]-1,3-dioxoisoindole-5-carboxylic acidIC50500.0 [1], 501.19 [2]
2-(4-(5-(2-Chloro-4-(3-(2,4-dichlorophenyl)acrylamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC50300.0 [1], 302.0 [2]
{4-[5-(2,4-Dichloro-phenyl)-furan-2-yl]-thiazol-2-yl}-acetic acidIC5025000.0 [1]
2-(4-(5-(2-Chloro-4-cinnamamidophenyl)furan-2-yl)thiazol-2-yl)acetic acidIC50446.68 [1], 450.0 [2]
2-(4-(5-(2-Chloro-4-(2,4-dichlorobenzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC503467.37 [1], 3500.0 [2]
(2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acidIC50199.53 [1], 200.0 [2]
2-(5-(5-(4-Chlorophenyl)benzo[d]oxazol-2-yl)-2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC504466.84 [1], 4500.0 [2]
1,3-Dioxo-2-(3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)isoindoline-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-(5-(5-Chlorobenzo[d]oxazol-2-yl)-2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-{5-[5-(3,4-Difluoro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC50600.0 [1], 602.56 [2]
2-{3-[5-(3,5-Difluoro-phenyl)-benzooxazol-2-yl]-4-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC50891.25 [1], 900.0 [2]
2-(4-(Butylamino)-3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC50398.11 [1], 400.0 [2]
2-(2-Ethoxy-5-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-{5-[5-(3,5-Difluoro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC50398.11 [1], 400.0 [2]
2-[4-(2-Methoxy-ethylamino)-3-(5-phenyl-benzooxazol-2-yl)-phenyl]-1,3-dioxo-indan-5-carboxylic acidIC501995.26 [1], 2000.0 [2]
2-(4-Isopropoxy-3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-(3-(5-(4-Chlorophenyl)benzo[d]oxazol-2-yl)-4-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC502500.0 [1], 2511.89 [2]
2-(3-(5-Chlorobenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC501500.0 [1], 1513.56 [2]
2-(2-(2-Methoxyethoxy)-5-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC503981.07 [1], 4000.0 [2]
2-(4-(Ethylamino)-3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC501000.0 [1]
2-(4-Ethoxy-3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC501288.25 [1], 1300.0 [2]
1,3-Dioxo-2-(3-(5-phenylbenzo[d]oxazol-2-yl)-4-(propylamino)phenyl)isoindoline-5-carboxylic acidIC50250.0 [1], 251.19 [2]
2-(4-(2-Methoxyethoxy)-3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC505000.0 [1], 5011.87 [2]
2-{5-[5-(2,4-Difluoro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC50794.33 [1], 800.0 [2]
2-(5-(5-(3-Cyanophenyl)benzo[d]oxazol-2-yl)-2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-[3-(5-Benzo[1,3]dioxol-5-yl-benzooxazol-2-yl)-4-methoxy-phenyl]-1,3-dioxo-indan-5-carboxylic acidIC50199.53 [1], 200.0 [2]
2-[2-Methoxy-5-[5-[4-(trifluoromethoxy)phenyl]-1,3-benzoxazol-2-yl]phenyl]-1,3-dioxoisoindole-5-carboxylic acidIC50398.11 [1], 400.0 [2]
2-[5-(5-Benzo[1,3]dioxol-5-yl-benzooxazol-2-yl)-2-methoxy-phenyl]-1,3-dioxo-indan-5-carboxylic acidIC50741.31 [1], 750.0 [2]
2-[5-[5-(3-Acetamidophenyl)-1,3-benzoxazol-2-yl]-2-methoxyphenyl]-1,3-dioxoisoindole-5-carboxylic acidIC508912.51 [1], 9000.0 [2]
2-(5-(5-(3-Chlorophenyl)benzo[d]oxazol-2-yl)-2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC50600.0 [1], 602.56 [2]
2-(3-(5-Methylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC502500.0 [1], 2511.89 [2]
2-(5-(5-(4-Fluorophenyl)benzo[d]oxazol-2-yl)-2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC50398.11 [1], 400.0 [2]
2-(5-(5-(3-Fluorophenyl)benzo[d]oxazol-2-yl)-2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acidIC501000.0 [1]
2-[4-[Methyl(propyl)amino]-3-(5-phenyl-1,3-benzoxazol-2-yl)phenyl]-1,3-dioxoisoindole-5-carboxylic acidIC50602.56 [1], 6000.0 [2]
2-{2-Methoxy-5-[5-(2-methoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC508912.51 [1], 9000.0 [2]
2-{2-Methoxy-5-[5-(4-methoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC50446.68 [1], 450.0 [2]
2-{2-Methoxy-5-[5-(3-methoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acidIC503000.0 [1], 3019.95 [2]
2-[4-[5-[2-Chloro-4-[[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]amino]phenyl]furan-2-yl]-1,3-thiazol-2-yl]acetic acidIC50600.0 [1], 602.56 [2]
2-(2-(4-(3-(2-Chlorophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC502500.0 [1], 2511.89 [2]
2-(4-(5-(2-Chloro-4-(3-(4-methoxyphenyl)acrylamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC50398.11 [1], 400.0 [2]
(2-{4-[2-(4-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acidIC50398.11 [1], 400.0 [2]
2-(2-(4-(3-(3-Methoxyphenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC502500.0 [1], 2511.89 [2]
2-(2-(3-Fluoro-4-(3-(4-(trifluoromethyl)phenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC501995.26 [1], 2000.0 [2]
2-(2-(4-(3-(3-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50794.33 [1], 800.0 [2]
2-(2-(4-(3-(4-Bromophenyl)acrylamido)-2-chlorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50398.11 [1], 400.0 [2]
2-(2-(4-Cinnamamidophenyl)benzo[d]oxazol-5-yl)acetic acidIC503000.0 [1], 3019.95 [2]
(2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC50398.11 [1], 400.0 [2]
2-(2-(4-(3-(3-Chlorophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50691.83 [1], 700.0 [2]
(2-{4-[2-(2-Chloro-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC503000.0 [1], 3019.95 [2]
(2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC50500.0 [1], 501.19 [2]
(2-{4-[2-(2,4-Difluoro-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acidIC50741.31 [1], 750.0 [2]
2-(2-(4-(3-(4-Fluorophenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC502500.0 [1], 2511.89 [2]
2-(2-(3-Fluoro-4-(3-(4-fluorophenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC503000.0 [1], 3019.95 [2]
2-(2-(4-(3-(3-Chloro-4-fluorophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50741.31 [1], 750.0 [2]
2-(4-(5-(2-Chloro-4-(4-(trifluoromethyl)benzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC503467.37 [1], 3500.0 [2]
(2-{4-[2-(4-Methoxy-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC503000.0 [1], 3019.95 [2]
(2-{4-[2-(4-Cyano-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acidIC50300.0 [1], 302.0 [2]
2-(2-(4-(3-(4-Methoxyphenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC503000.0 [1], 3019.95 [2]
2-(2-(3-Fluoro-4-(3-(4-methoxyphenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC503000.0 [1], 3019.95 [2]
(2-{4-[2-(4-Difluoromethoxy-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC501500.0 [1], 1513.56 [2]
2-(2-(4-(3-(3-Bromophenyl)acrylamido)-2-chlorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50741.31 [1], 750.0 [2]
2-(4-(5-(2-Chloro-4-(3-cyanobenzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acidIC503981.07 [1], 4000.0 [2]
2-(2-(4-(3-(4-Cyanophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50794.33 [1], 800.0 [2]
(2-{4-[2-(4-Fluoro-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC502500.0 [1], 2511.89 [2]
2-(2-(2-Chloro-4-(3-(3-methoxyphenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC502500.0 [1], 2511.89 [2]
2-(2-(4-(3-(3-Chloro-2-fluorophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC50300.0 [1], 302.0 [2]
(2-{4-[2-(3-Fluoro-4-methoxy-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC50300.0 [1], 302.0 [2]
2-(2-(4-Cinnamamido-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC505495.41 [1], 5500.0 [2]
(2-{4-[2-(4-Bromo-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC50691.83 [1], 700.0 [2]
(2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acidIC50199.53 [1], 200.0 [2]
2-(2-(4-(3-(3-Bromophenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acidIC50741.31 [1], 750.0 [2]
2-(2-(4-(3-(4-Chlorophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acidIC502500.0 [1], 2511.89 [2]
(2-{4-[2-(3-Methoxy-phenylcarbamoyl)-vinyl]-phenyl}-benzooxazol-5-yl)-acetic acidIC503000.0 [1], 3019.95 [2]
(2-{4-[2-(3,4-Dichloro-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acidIC50199.53 [1], 200.0 [2]
[(2R,3R,4R,5S)-4,6-Disulfooxy-2-(sulfooxymethyl)-5-[(2R,3S,4S,5R,6R)-3,4,5-trisulfooxy-6-(sulfooxymethyl)oxan-2-yl]oxyoxan-3-yl] hydrogen sulfateKi2230.0 [1], 68300.0 [2]
Octadecasodium;[(2R,3R,4S,5S,6R)-6-[(2R,3S,4S,5R,6R)-2-[(2R,3S,4S,5R,6R)-2-[(2R,3R,4S,5S,6R)-3,5-disulfonatooxy-2-(sulfonatooxymethyl)-6-[(2R,3S,4R,5R,6R)-2,4,5-trisulfonatooxy-6-(sulfonatooxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl]oxy-3,4,5-trisulfonatooxyoxan-2-yl]methyl phosphateKi7.9 [1]
8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acidIC5026600.0 [1]
(5R)-3-Hexadecanoyl-4-hydroxy-5-(hydroxymethyl)furan-2(5H)-oneIC5017000.0 [1]
PixatimodKi6.1 [1]
5-Bromo-2-hydroxy-N-[2-hydroxy-1-[2-(4-methylanilino)-2-oxoethyl]indol-3-yl]iminobenzamideIC5010000.0 [1]
3-Hexadecanoyl-5-hydroxymethyl-4-methoxy-5H-furan-2-oneIC50100000.0 [1]
2-(3-Nitro-4-phenoxybenzoyl)benzoic acidIC501000.0 [1]
4,5-Dihydroxy-6-(trifluoroacetylamino)piperidine-3-carboxylic acidIC501000.0 [1]
Tetrasodium;2-[[4-[[4-[[5-[[5-[(1,5-disulfonatonaphthalen-2-yl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]carbamoylamino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]naphthalene-1,5-disulfonateIC502000.0 [1]
2-[3-[4-[3-(4-Chloro-2-cyclohexylphenoxy)-5-nitrophenoxy]phenyl]propanoylamino]ethanesulfonic acidIC505000.0 [1]
N-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-bromo-4-ethoxy-benzamideIC501200.0 [1]
1-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-3-(3-bromo-4-methoxyphenyl)ureaIC50930.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Heparanase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/heparanase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Heparanase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/heparanase-inhibitors-ic50-ki.
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