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Hematopoietic prostaglandin D synthase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
▲
▼
2-Phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazoleIC5021.0 [1], 23.0 [2], 700.0 [3], 97700.0 [4]
4-(Benzhydryloxy)-1-[3-(1H-tetraazol-5-YL)propyl]piperidineIC501800.0 [1], 3800.0 [2], 73900.0 [3]
2-BenzoylthiopheneIC509200.0 [1], 12800.0 [2], 83500.0 [3]
4-{[4-(4-Fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acidIC50138.0 [1], 1400.0 [2], 94600.0 [3]
N-Cyclopentyl-3-(5-cyclopropyl-1H-pyrazol-4-yl)-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamideIC5010.0 [1], 40.0 [2], 317.0 [3]
3-(5-Cyclopropyl-1H-pyrazol-4-yl)-N-ethyl-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamideIC5040.0 [1], 501.0 [2], 4000.0 [3]
CID 46899922IC50700.0 [1], 79200.0 [2]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-6-thiophen-2-ylpyridine-3-carboxamideIC501200.0 [1], 97000.0 [2]
3-(Dimethylamino)-N-[5-(1H-indol-4-yl)pyridin-3-yl]propanamideIC50300.0 [1], 460.0 [2]
3-(1H-Indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamideIC50170.0 [1], 2900.0 [2]
CID 46899923IC501900.0 [1], 76400.0 [2]
N-Benzhydryl-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamideIC5010800.0 [1], 71200.0 [2]
CID 46900088IC508000.0 [1], 73900.0 [2]
N-(1-Amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamideIC507100.0 [1], 66900.0 [2]
N-[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(3-hydroxyphenyl)thiophene-2-carboxamideIC502100.0 [1], 72500.0 [2]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-(3-hydroxyphenyl)benzamideIC504600.0 [1], 88500.0 [2]
N-[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-(3-hydroxyphenyl)benzamideIC501000.0 [1], 91000.0 [2]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-hydroxy-4-(3-hydroxyphenyl)benzamideIC5024800.0 [1], 61300.0 [2]
N-[(1-Amino-1-oxo-3-phenylpropan-2-yl)carbamoyl]-5-(3-hydroxyphenyl)thiophene-2-carboxamideIC503700.0 [1], 89500.0 [2]
N-[[1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]-5-(3-hydroxyphenyl)thiophene-2-carboxamideIC501300.0 [1], 91300.0 [2]
6-(3-Methoxyphenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC5060.0 [1], 210.0 [2]
4-(Dimethylamino)-N-[5-(1h-Indol-4-Yl)pyridin-3-Yl]butanamideIC50180.0 [1], 820.0 [2]
N-(6-Bromo-1,3-benzothiazol-2-yl)-4-(3-fluorobenzoyl)piperazine-1-carboxamideIC50106.0 [1]
2-Phenyl-5-(2-phenyl-1H-imidazol-5-yl)pyrimidineIC5012.0 [1], 250.0 [2]
2-Phenyl-5-(2-phenyl-1H-imidazol-5-yl)pyridineIC5097.0 [1], 480.0 [2]
5-(3-Methyl-2-phenylimidazol-4-yl)-2-phenylpyrimidineIC50250.0 [1], 625.0 [2]
5-(5-Methyl-2-phenyl-1H-imidazol-4-yl)-2-phenylpyrimidineIC5082.0 [1], 450.0 [2]
2-Phenyl-5-(2-pyridin-3-yl-1H-imidazol-5-yl)pyrimidineIC5021.0 [1], 79.0 [2]
2-Phenyl-5-(2-(pyridin-4-yl)-1H-imidazol-5-yl)pyrimidineIC5075.0 [1], 125.0 [2]
5-[2-(1-Benzylpiperidin-4-yl)-1H-imidazol-5-yl]-2-phenylpyrimidineIC506.0 [1], 80.0 [2]
4-(3-Fluorobenzoyl)-N-(6-methyl-1,3-benzothiazol-2-yl)piperazine-1-carboxamideIC50260.0 [1]
5-(2-Benzyl-1H-imidazol-5-yl)-2-phenylpyrimidineIC5059.0 [1], 625.0 [2]
2-Phenyl-5-(5-phenyl-4H-1,2,4-triazol-3-yl)pyrimidineIC5084.0 [1], 1000.0 [2]
2-Phenoxy-5-(2-pyridin-3-yl-1H-imidazol-5-yl)pyrimidineIC50370.0 [1], 625.0 [2]
2-Phenyl-5-(2-(pyridin-2-yl)-1H-imidazol-5-yl)pyrimidineIC5053.0 [1], 125.0 [2]
2-(3,4-Dimethoxyphenyl)-5-(2-phenyl-1H-imidazol-5-yl)pyrimidineIC503500.0 [1], 8000.0 [2]
5-[2-(3-Fluorophenyl)-1H-imidazol-5-yl]-2-phenylpyrimidineIC504.0 [1], 188.0 [2]
(E)-2-Phenyl-5-(2-(2-(pyridin-3-yl)vinyl)-1H-imidazol-5-yl)pyrimidineIC5023.0 [1], 150.0 [2]
Ethyl 5-(2-phenoxypyrimidin-5-yl)-1H-pyrazole-3-carboxylateIC50130.0 [1], 1300.0 [2]
(4-Methylpiperazin-1-yl)(5-(2-phenoxypyrimidin-5-yl)-1H-pyrazol-3-yl)methanoneIC50420.0 [1], 650.0 [2]
4-(2-Phenylpyrimidin-5-yl)-2-pyridin-3-yl-1,3-thiazoleIC50150.0 [1], 1000.0 [2]
2-(3-Fluorophenyl)-5-(2-phenyl-1H-imidazol-5-yl)pyrimidineIC5047.0 [1], 280.0 [2]
2-(3-Fluorophenyl)-5-(2-(pyridin-3-yl)-1H-imidazol-5-yl)pyrimidineIC5041.0 [1], 156.0 [2]
N-(5,6-Dimethyl-1,3-benzothiazol-2-yl)-4-(3-fluorobenzoyl)piperazine-1-carboxamideIC50222.0 [1]
4-(3-Fluorobenzoyl)-N-(6-methoxy-1,3-benzothiazol-2-yl)piperazine-1-carboxamideIC50318.0 [1]
N-(6-Chloro-1,3-benzothiazol-2-yl)-4-(3-fluorobenzoyl)piperazine-1-carboxamideIC50204.0 [1]
4,5,6,7-Tetrabromo-3',3''-disulfophenolphthaleinIC5027000.0 [1]
Ethacrynic acidIC50122300.0 [1]
Cibacron BlueIC50200.0 [1]
TranilastIC5011600.0 [1]
OxfendazoleIC50300000.0 [1]
3-(4-Methylphenyl)-5H-indeno[1,2-c]pyridazin-5-oneIC503800.0 [1]
3-(4-Hydroxyphenyl)-5H-indeno[1,2-c]pyridazin-5-oneIC503800.0 [1]
4-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-5-amineIC5033000.0 [1]
4-Methyl-2-phenyl-N-(4-sulfamoylphenyl)-1,3-thiazole-5-carboxamideIC501.0 [1]
1-Phenyl-1H-pyrazole-4-carboxylic acidIC50890000.0 [1]
6-(3-Fluorophenyl)-N-[1-(2,2,2-Trifluoroethyl)piperidin-4-Yl]pyridine-3-CarboxamideIC50200.0 [1]
Ethyl 5-hydroxy-6-phenyl-3-pyridazinecarboxylateIC5045000.0 [1]
3-(3,5-Dimethyl-1H-pyrrol-2-yl)-1H-pyrazoleIC5026400.0 [1]
1-(5-Chloro-1,3-benzoxazol-2-yl)-N-[(1S,2S)-2-phenylmethoxycyclopentyl]piperidine-4-carboxamideIC5010000.0 [1]
2-(4-Methoxybenzoyl)thiopheneIC50105000.0 [1]
N-[[4-[5-(2-Hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-2-pyridin-2-ylpyrimidine-5-carboxamideIC5070.0 [1]
N-[5-(1H-Indol-4-yl)pyridin-3-yl]-3-pyridin-3-ylpropanamideIC5026.0 [1]
N-[5-(1H-Indol-4-yl)pyridin-3-yl]propanamideIC5032.0 [1]
(2S)-N-[5-(1H-Indol-4-yl)pyridin-3-yl]-5-oxopyrrolidine-2-carboxamideIC5035.0 [1]
N-[5-(1H-Indol-4-yl)pyridin-3-yl]-2-(tetrazol-1-yl)acetamideIC5043.0 [1]
N-[5-(1H-Indol-4-yl)pyridin-3-yl]-3-piperidin-1-ylpropanamideIC50130.0 [1]
N-[5-(1H-Indol-4-yl)pyridin-3-yl]-2-(3-methylimidazol-4-yl)acetamideIC501200.0 [1]
6-Phenoxy-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC5031.0 [1]
6-Piperidin-1-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC5048.0 [1]
6-Pyrrolidin-1-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC50230.0 [1]
6-Morpholin-4-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC50320.0 [1]
6-(3-Oxopiperazin-1-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC50590.0 [1]
6-(2-Oxo-1H-pyridin-4-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC5070.0 [1]
6-(6-Oxo-1H-pyridin-2-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamideIC5071.0 [1]
4-Methyl-2-pyrimidin-2-yl-N-[4-(trifluoromethyl)indol-1-yl]pyrimidine-5-carboxamideIC508.0 [1]
4-Methyl-2-pyridin-2-yl-N-[4-(trifluoromethyl)indol-1-yl]pyrimidine-5-carboxamideIC5010.0 [1]
2-(3-Fluorophenyl)-N-[[3-[(1-hydroxy-2-methylpropan-2-yl)sulfamoyl]phenyl]methyl]pyrimidine-5-carboxamideIC5023.0 [1]
2-(3-Fluorophenyl)-4-methyl-N-[[3-(methylsulfamoyl)phenyl]methyl]pyrimidine-5-carboxamideIC509.5 [1]
2-Bromo-1-(4-methoxynaphthalen-1-yl)ethanoneIC5012400.0 [1]
3-Phenyl-5-(1H-pyrazol-3-YL)isoxazoleIC50920.0 [1]
4-{[4-(2-Methoxyphenyl)-1,3-thiazol-2-yl]amino}benzoic acidIC50994.0 [1]
N-[4-Methyl-3-[[3-[(4-methylpiperazin-1-yl)methyl]benzoyl]amino]phenyl]-3-phenyl-1,2-thiazole-5-carboxamideIC5075.0 [1]
Methyl 6-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)pyridine-3-carboxylateIC501500.0 [1]
N-(5-Fluoro-3-methyl-1H-indol-1-yl)-4-methyl-2-(pyridin-2-yl)pyrimidine-5-carboxamideIC507.0 [1]
2-Methyl-5-(1H-pyrazol-5-yl)pyridineIC5034700.0 [1]
2,4-Dichloro-6-(1H-pyrazol-5-yl)phenolIC5017400.0 [1]
N-Benzhydryl-5-phenylthiophene-2-carboxamideIC5019900.0 [1]
N-Benzhydryl-2-phenyl-1,3-thiazole-4-carboxamideIC5010800.0 [1]
N-Benzhydryl-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamideIC5043800.0 [1]
N-Benzhydryl-5-(3-cyanophenyl)thiophene-2-carboxamideIC501800.0 [1]
N-Benzhydryl-5-(1H-indol-4-yl)thiophene-2-carboxamideIC5057900.0 [1]
N-(1-Amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamideIC505070.0 [1]
N-(1-Amino-4-methyl-1-oxopentan-2-yl)-4-(3-hydroxyphenyl)benzamideIC5057600.0 [1]
N-(1-Amino-3-methyl-1-oxobutan-2-yl)-4-(3-hydroxyphenyl)benzamideIC5053300.0 [1]
N-(1,6-Diamino-1-oxohexan-2-yl)-4-(3-hydroxyphenyl)benzamideIC5024600.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamideIC5014700.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-3-hydroxy-4-(3-hydroxyphenyl)benzamideIC5020500.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-3-(3-hydroxyphenyl)benzamideIC5038000.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-thiophen-2-ylbenzamideIC5054000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hematopoietic prostaglandin D synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/hematopoietic-prostaglandin-d-synthase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Hematopoietic prostaglandin D synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hematopoietic-prostaglandin-d-synthase-inhibitors-ic50-ki.
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