Heat shock protein HSP 90-beta Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Luminespib	IC50	7.0 [1]
	Luminespib	Ki	0.06 [1], 0.07 [2], 2.0 [3], 8.2 [4]
	Tanespimycin	IC50	7.0 [1], 12.0 [2], 15.0 [3], 26500.0 [4]
	Tanespimycin	Ki	9.0 [1], 530.0 [2]
	6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine	IC50	7.0 [1], 17.0 [2], 30.0 [3], 38.0 [4], 140.0 [5]
	6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine	Ki	1.7 [1], 4.0 [2], 13.0 [3], 26.0 [4]
	Snx-2112	IC50	7.0 [1], 22.0 [2], 25.0 [3]
	Snx-2112	Ki	1.1 [1], 2.8 [2], 6.0 [3]
	Geldanamycin	IC50	10.0 [1], 20.0 [2], 22.0 [3], 348.0 [4]
	17-Aminogeldanamycin	IC50	7.0 [1], 12.0 [2]
	17-Aminogeldanamycin	Ki	3.0 [1], 21.0 [2]
	Alvespimycin	IC50	24.0 [1], 90.0 [2], 930.0 [3], 1410.0 [4]
	1-(2-Amino-4-methyl-quinazolin-7-yl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-indol-4-one	IC50	4.0 [1], 5.0 [2], 11.0 [3], 36.0 [4]
	PU-H71	IC50	42.0 [1], 50.0 [2]
	8-Cyclopentyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	6.0 [1], 24.0 [2]
	8-Cyclopentyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	5.0 [1]
	Radicicol	IC50	19.0 [1], 20.0 [2]
	Onalespib	IC50	30.0 [1], 350.0 [2]
	CID 67495834	IC50	30.0 [1]
	CID 67495834	Ki	4.0 [1]
	8-((6-Bromobenzo[d][1,3]dioxol-5-yl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	300.0 [1], 365.0 [2]
	2-Fluoro-8-[(6-Iodo-1,3-Benzodioxol-5-Yl)methyl]-9-[3-(Isopropylamino)propyl]-9h-Purin-6-Amine	IC50	80.0 [1], 90.0 [2]
	4-N-[5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-3-(ethylcarbamoyl)-1,2-oxazol-4-yl]cyclohexane-1,4-dicarboxamide	IC50	5.0 [1]
	5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[(4-hydroxycyclohexanecarbonyl)amino]-1,2-oxazole-3-carboxamide	IC50	5.0 [1]
	5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[[4-(hydroxymethyl)cyclohexanecarbonyl]amino]-1,2-oxazole-3-carboxamide	IC50	5.0 [1], 15.0 [2]
	6-Hydroxy-N-[[4-(methanesulfonamidomethyl)phenyl]methyl]-N-methyl-3-[(3-methylphenyl)methyl]-1H-indazole-5-carboxamide	IC50	150.0 [1], 1100.0 [2]
	3-[(3-Chlorophenyl)methyl]-6-hydroxy-N-[[4-(methanesulfonamidomethyl)phenyl]methyl]-N-methyl-1H-indazole-5-carboxamide	IC50	60.0 [1], 1000.0 [2]
	N,N-Dimethyl-4-[[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methyl]aniline	IC50	46130.0 [1], 100000.0 [2]
	6-[(4-Chlorophenyl)methyl]-2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine	IC50	47880.0 [1], 100000.0 [2]
	6-[(4-Fluorophenyl)methyl]-2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine	IC50	40240.0 [1], 100000.0 [2]
	2-[[2-Amino-5-(1,3-benzodioxol-5-ylmethyl)-[1,2,4]triazolo[1,5-c]quinazolin-10-yl]amino]ethanol	Ki	5000.0 [1], 13200.0 [2]
	5-(1,3-Benzodioxol-5-Ylmethyl)[1,2,4]triazolo[1,5-C]quinazolin-2-Amine	Ki	35.0 [1], 170.0 [2]
	8-(2-Methylpropyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	222.0 [1]
	8-(2-Methylpropyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	26.0 [1]
	(5-Chloro-2,4-dihydroxyphenyl)-(2-methyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)methanone	IC50	100.0 [1], 420.0 [2]
	8-Cyclohexyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	36.0 [1]
	8-Cyclohexyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	5.0 [1]
	8-(Oxan-4-yl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	19.0 [1]
	8-(Oxan-4-yl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	3.0 [1]
	8-Cyclobutyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	195.0 [1]
	8-Cyclobutyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	39.0 [1]
	8-Butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	1000.0 [1]
	8-Butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	56.0 [1]
	8-Tert-butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	1700.0 [1]
	8-Tert-butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	140.0 [1]
	8-Benzyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	480.0 [1]
	8-Benzyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	120.0 [1]
	8-Phenyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	230.0 [1]
	8-Phenyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	15.0 [1]
	8-(4-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	80.0 [1]
	8-(4-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10.0 [1]
	8-(3-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	81.0 [1]
	8-(3-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	20.0 [1]
	8-(4-Methoxyphenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	IC50	280.0 [1]
	8-(4-Methoxyphenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	40.0 [1]
	2-Fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	120.0 [1]
	2-Fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	31.0 [1]
	2-[[(3S)-Oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	120.0 [1]
	2-[[(3S)-Oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	35.0 [1]
	2-(Cyclopentylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	110.0 [1]
	2-(Cyclopentylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	12.0 [1]
	2-(Cyclopropylmethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	190.0 [1]
	2-(Cyclopropylmethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	19.0 [1]
	2-(2-Methoxyethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	720.0 [1]
	2-(2-Methoxyethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	60.0 [1]
	2-(Thian-4-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	90.0 [1]
	2-(Thian-4-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	25.0 [1]
	2-(Propylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	190.0 [1]
	2-(Propylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	21.0 [1]
	2-(Cyclopropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	420.0 [1]
	2-(Cyclopropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	48.0 [1]
	2-(2,2-Difluoroethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	220.0 [1]
	2-(2,2-Difluoroethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	29.0 [1]
	2-[(3-Methyloxetan-3-yl)methylamino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	450.0 [1]
	2-[(3-Methyloxetan-3-yl)methylamino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	22.0 [1]
	2-(Propan-2-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	140.0 [1]
	2-(Propan-2-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	25.0 [1]
	2-(2,2-Dimethylpropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	930.0 [1]
	2-(2,2-Dimethylpropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	22.0 [1]
	2,7,7-Trimethyl-9-[1-oxo-8-(propan-2-ylamino)-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	IC50	73.0 [1]
	2,7,7-Trimethyl-9-[1-oxo-8-(propan-2-ylamino)-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	30.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-2,3-dihydroisoindol-5-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	IC50	10000.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-2,3-dihydroisoindol-5-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	IC50	8500.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	590.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-2,3,4,5-tetrahydro-2-benzazepin-7-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	IC50	10000.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-2,3,4,5-tetrahydro-2-benzazepin-7-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	2-(2-Cyclopropylethyl)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	IC50	3600.0 [1]
	2-(2-Cyclopropylethyl)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	420.0 [1]
	2,7,7-Trimethyl-9-[8-(2-methylpropyl)-1-oxo-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	IC50	143.0 [1]
	2,7,7-Trimethyl-9-[8-(2-methylpropyl)-1-oxo-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	37.0 [1]
	4-(7,7-Dimethyl-5-oxo-1,2,3,4,6,8-hexahydrocarbazol-9-yl)-2-[[(3S)-oxolan-3-yl]amino]benzamide	IC50	530.0 [1]
	4-(7,7-Dimethyl-5-oxo-1,2,3,4,6,8-hexahydrocarbazol-9-yl)-2-[[(3S)-oxolan-3-yl]amino]benzamide	Ki	40.0 [1]
	(2,5-Dimethoxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanone	IC50	16440.0 [1], 40360.0 [2]
	(4-Fluorophenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanone	IC50	27210.0 [1], 100000.0 [2]
	(4-Chlorophenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanone	IC50	24480.0 [1], 100000.0 [2]
	(2,4-Dimethoxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanone	IC50	7880.0 [1], 30540.0 [2]
	(2,4-Dihydroxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanone	IC50	3230.0 [1], 10230.0 [2]
	(5-Chloro-2,4-dihydroxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanone	IC50	930.0 [1], 1670.0 [2]
	(2-Amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-(5-chloro-2,4-dihydroxyphenyl)methanone	IC50	310.0 [1], 510.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Heat shock protein HSP 90-beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/heat-shock-protein-hsp-90-beta-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Heat shock protein HSP 90-beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/heat-shock-protein-hsp-90-beta-inhibitors-ic50-ki.
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