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Glyoxalase I Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
S-(p-Bromobenzyl)glutathioneIC501200.0 [1], 8200.0 [2], 23000.0 [3], 33200.0 [4]
S-(p-Bromobenzyl)glutathioneKi80.0 [1], 4300.0 [2], 9140.0 [3], 223872000000000.0 [4]
S-(N-4Chlorophenyl-N-hydroxycarbamoyl)glutathioneKi46.0 [1], 3600.0 [2], 16000.0 [3]
S-(N-4Bromophenyl-N-hydroxycarbamoyl)glutathioneKi14.0 [1], 1200.0 [2], 10000.0 [3]
IndomethacinKi18100.0 [1], 24000.0 [2], 24400.0 [3]
KetoprofenKi414000.0 [1], 843000.0 [2], 843100.0 [3]
TolmetinKi87800.0 [1], 1014000.0 [2]
FenoprofenKi383000.0 [1], 400000.0 [2]
ZomepiracKi107000.0 [1], 335000.0 [2], 335300.0 [3]
S-(N-Hydroxy-N-methylcarbamoyl)glutathioneKi1700.0 [1], 68000.0 [2], 86000.0 [3]
S-(N-Phenyl-N-hydroxycarbamoyl)glutathioneKi160.0 [1], 11000.0 [2], 28000.0 [3]
QuercetinIC503200.0 [1]
QuercetinKi66069300000000.0 [1]
SulindacKi77900.0 [1], 139000.0 [2]
MyricetinIC50560.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneKi10000.0 [1], 10300.0 [2]
BisdemethoxycurcuminKi18000.0 [1], 18200.0 [2]
AcemetacinKi12900.0 [1], 49000.0 [2]
2-Amino-5-[[1-(carboxymethylamino)-3-[(4-chlorophenyl)-hydroxycarbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi46.0 [1], 3600.0 [2]
S-Butyl 2-hydroxypropanethioateIC5016500000.0 [1]
S-Butyl 2-hydroxypropanethioateKi12900000.0 [1]
S-Benzyl 2-hydroxypropanethioateIC507100000.0 [1]
S-Benzyl 2-hydroxypropanethioateKi5500000.0 [1]
S-Benzyl 2-hydroxy-2-phenylethanethioateIC508100000.0 [1]
S-Benzyl 2-hydroxy-2-phenylethanethioateKi6300000.0 [1]
Methyl 2-(2-hydroxy-2-phenylacetyl)sulfanylacetateIC5010500000.0 [1]
Methyl 2-(2-hydroxy-2-phenylacetyl)sulfanylacetateKi8200000.0 [1]
Butyl 2-(2-hydroxy-2-phenylacetyl)sulfanylacetateIC5044500000.0 [1]
Butyl 2-(2-hydroxy-2-phenylacetyl)sulfanylacetateKi34700000.0 [1]
Methyl 3-(2-hydroxy-2-phenylacetyl)sulfanylpropanoateIC5049600000.0 [1]
Methyl 3-(2-hydroxy-2-phenylacetyl)sulfanylpropanoateKi38600000.0 [1]
S-Butyl 2-hydroxy-2-phenylethanethioateIC5037800000.0 [1]
S-Butyl 2-hydroxy-2-phenylethanethioateKi29600000.0 [1]
2-Amino-5-[[1-(carboxymethylamino)-3-[hydroxy(phenyl)carbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi160.0 [1], 11000.0 [2]
2-Amino-5-[[3-[(4-bromophenyl)-hydroxycarbamoyl]sulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi14.0 [1], 1200.0 [2]
2-Amino-5-[[1-(carboxymethylamino)-5-[hydroxy(methyl)amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acidIC503900.0 [1]
2-Amino-5-[[1-(carboxymethylamino)-5-[hydroxy(methyl)amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acidKi1900.0 [1]
2-Amino-5-[[1-(carboxymethylamino)-5-(hydroxyamino)-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acidIC50209600.0 [1]
2-Amino-5-[[1-(carboxymethylamino)-5-(hydroxyamino)-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acidKi92900.0 [1]
2-Amino-3-[[hydroxy(methyl)carbamoyl]sulfanylmethyl]butanedioic acidKi1700.0 [1], 68000.0 [2]
GlutathioneKi1047130000000.0 [1]
KaempferolIC5020600.0 [1]
LuteolinIC507700.0 [1]
NaringeninKi57544000000000.0 [1]
BaicaleinIC5011000.0 [1]
MorinKi33113100000000.0 [1]
ChrysinKi12022600000000.0 [1]
CyanidinIC5011700.0 [1]
FisetinKi75857800000000.0 [1]
3,3',4',5,5',7-HexahydroxyflavyliumIC501900.0 [1]
PiceatannolIC50760.0 [1]
PelargonidinIC5016400.0 [1]
MaltolKi4466840000000.0 [1]
LapacholKi26915300000000.0 [1]
Ethyl ferulateKi385000.0 [1]
S-MethylglutathioneKi239883000000.0 [1]
1,7-Bis(4-hydroxy-3-methoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)-1,6-heptadiene-3,5-dioneKi3600.0 [1]
6-(4-Hydroxy-3-methoxyphenyl)-4-hydroxy-3,5-hexadiene-2-oneKi90000.0 [1]
1,7-Bis(2-furanyl)-5-hydroxy-1,4,6-heptatriene-3-oneKi1500000.0 [1]
(1E,6E)-4-[(3,4-Dimethoxyphenyl)methylidene]-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dioneKi4600.0 [1]
2-Carbethoxy-5,7-dihydroxy-4'-methoxyisoflavoneKi89125100000000.0 [1]
3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acidIC502000.0 [1]
3-(3-Bromopropoxy)-4-chloro-7-(3-phenylureido)isocoumarinKi63095700000000.0 [1]
(1E,4Z,6E)-5-Hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(1H-pyrrol-2-yl)hepta-1,4,6-trien-3-oneKi18000.0 [1]
(1E,4Z,6E)-5-Hydroxy-1-[5-(hydroxymethyl)furan-2-yl]-7-(4-methoxyphenyl)hepta-1,4,6-trien-3-oneKi74000.0 [1]
(1E,6E)-4-[(4-Fluorophenyl)methylidene]-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dioneKi3200.0 [1]
(1E,6E)-4-(Hydroxymethylidene)-1,7-bis(4-methoxyphenyl)hepta-1,6-diene-3,5-dioneKi109000.0 [1]
(1E,6E)-4-[(3-Fluorophenyl)methylidene]-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dioneKi2600.0 [1]
2,4-Pentanedione, 3-(m-nitrobenzylidene)-Ki91000.0 [1]
S-(N-Hexyl-N-hydroxycarbamoyl)glutathioneKi16.0 [1]
2-Amino-3-[[3-[(4-bromophenyl)methylsulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]carbamoylamino]propanoic acidKi15500.0 [1]
S-(N-Heptyl-N-hydroxycarbamoyl)glutathioneKi18.0 [1]
S-(N-Pentyl-N-hydroxycarbamoyl)glutathioneKi170.0 [1]
S-(N-Butyl-N-hydroxycarbamoyl)glutathioneKi180.0 [1]
S-(N-Hydroxycarbamoyl)glutathioneKi183000.0 [1]
S-(N-Propyl-N-hydroxycarbamoyl)glutathioneKi800.0 [1]
S-(N-Ethyl-N-hydroxycarbamoyl)glutathioneKi1180.0 [1]
5-[[3-[(4-Bromophenyl)-hydroxycarbamoyl]sulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-[[3-[2-[2-[2-[2-[[8-[3-[2-[2-[3-[[8-[2-[2-[2-[2-[3-[[4-[[3-[(4-bromophenyl)-hydroxycarbamoyl]sulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-1-carboxy-4-oxobutyl]amino]propanoyloxy]ethoxy]ethoxy]ethoxy]ethylamino]-8-oxooctanoyl]amino]propoxy]ethoxy]ethoxy]propylamino]-8-oxooctanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3-oxopropyl]amino]-5-oxopentanoic acidKi1.0 [1]
5-[[3-[(4-Bromophenyl)-hydroxycarbamoyl]sulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-[[3-[2-[3-[[3-[2-[[3-[[3-[2-[3-[[4-[[3-[(4-bromophenyl)-hydroxycarbamoyl]sulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-1-carboxy-4-oxobutyl]amino]propanoyloxy]ethylamino]-3-oxopropyl]amino]-3-oxopropanoyl]amino]ethylamino]-3-oxopropanoyl]amino]propanoylamino]ethoxy]-3-oxopropyl]amino]-5-oxopentanoic acidKi0.3 [1]
2-(3-Aminopropanoylamino)-5-[[1-(carboxymethylamino)-3-[(4-chlorophenyl)-hydroxycarbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi330.0 [1]
5-[[1-(Carboxymethylamino)-3-[(4-chlorophenyl)-hydroxycarbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxo-2-(2-oxopropylamino)pentanoic acidKi130.0 [1]
5-[[1-(Carboxymethylamino)-3-[(4-chlorophenyl)-hydroxycarbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-2-[(3-ethoxy-3-oxopropyl)amino]-5-oxopentanoic acidKi46.0 [1]
(2S)-2-Amino-5-[[(2S)-1-(carboxymethylamino)-3-ethylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi2089300000000.0 [1]
Ethyl 2-(3-nitrobenzylidene)-3-oxobutanoateKi65000.0 [1]
2-(4-Methoxybenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acidIC5054600.0 [1]
3-(4-Methoxybenzylidene)-2,4-pentanedioneKi383000.0 [1]
2-Amino-5-[[1-[(2-ethoxy-2-oxoethyl)amino]-5-[hydroxy(methyl)amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acidIC50140500.0 [1]
2-Amino-5-[[1-[(2-ethoxy-2-oxoethyl)amino]-5-(hydroxyamino)-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acidIC501624600.0 [1]
(3-Nitrobenzylidene)propanedioic acidKi426000.0 [1]
2(1H)-Pyridinone, 1-hydroxy-4,6-diphenyl-IC501190.0 [1]
3-[(5-Nitrofuryl)methylene]-2,4-pentanedioneKi27000.0 [1]
(2S)-2-Amino-5-[[3-butylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi35481300000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-1-oxo-3-(5-phenylpentylsulfanyl)propan-2-yl]amino]-5-oxopentanoic acidKi131826000000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-1-oxo-3-phenacylsulfanylpropan-2-yl]amino]-5-oxopentanoic acidKi5128610000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-3-[(4-methoxyphenyl)methylsulfanyl]-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi20417400000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-3-[(4-methylphenyl)methylsulfanyl]-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi30903000000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-1-oxo-3-pentylsulfanylpropan-2-yl]amino]-5-oxopentanoic acidKi36307800000000.0 [1]
(2S)-2-Amino-5-[[3-benzylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi10715200000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-1-oxo-3-(4-phenylbutylsulfanyl)propan-2-yl]amino]-5-oxopentanoic acidKi25118900000000.0 [1]
(2S)-2-Amino-5-[[1-(carboxymethylamino)-1-oxo-3-(3-phenylpropylsulfanyl)propan-2-yl]amino]-5-oxopentanoic acidKi112202000000000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glyoxalase I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glyoxalase-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glyoxalase I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glyoxalase-i-inhibitors-ic50-ki.
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