Glycogen synthase kinase-3 beta Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	33.0 [1]
	Staurosporine	Ki	22.0 [1]
	N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-YL)urea	IC50	104.0 [1]
	N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-YL)urea	Ki	38.0 [1], 770.0 [2]
	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione	IC50	33.88 [1]
	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	IC50	1500.0 [1]
	Alsterpaullone	IC50	4.0 [1]
	Kenpaullone	IC50	23.0 [1]
	Hymenialdisine	IC50	10.0 [1]
	3-(3-Chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	IC50	77.0 [1], 78.0 [2], 90.0 [3], 104.0 [4], 380.0 [5]
	3-(3-Chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	Ki	24.0 [1]
	Manzamine A	IC50	10200.0 [1]
	Chir-99021	IC50	4.9 [1], 7.0 [2], 30.0 [3]
	Indirubin-3'-monoxime	IC50	22.0 [1], 200.0 [2]
	Tideglusib	IC50	60.0 [1], 78.0 [2], 1000.0 [3], 2000.0 [4]
	LY-2090314	IC50	0.7 [1], 0.9 [2], 1.1 [3]
	Paullone	IC50	4.0 [1], 100.0 [2], 619.44 [3], 620.0 [4]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	650.0 [1], 1500.0 [2]
	GSK-3 Inhibitor II	IC50	390.0 [1], 790.0 [2]
	3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(morpholine-4-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dione	IC50	1.3 [1], 2.6 [2]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	71.0 [1], 1000.0 [2], 1100.0 [3]
	5-Iodo-Indirubin-3'-monoxime	IC50	9.0 [1]
	3-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-N,N-dimethyl-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxamide	IC50	1.6 [1], 12.0 [2]
	Bisindolylmaleimide IX	IC50	2.8 [1], 3.0 [2], 38.0 [3]
	2,4'-Dibromoacetophenone	IC50	500.0 [1]
	Indirubin	IC50	4.0 [1], 5.0 [2], 600.0 [3]
	2-Chloroacetophenone	IC50	50000.0 [1]
	2-Bromoacetophenone	IC50	5000.0 [1]
	2-Bromo-4'-chloroacetophenone	IC50	1000.0 [1]
	4-(1H-Indol-3-yl)pyrimidin-2-amine	IC50	14810.0 [1], 350000.0 [2]
	2-Bromo-4'-nitroacetophenone	IC50	2000.0 [1]
	2,4'-Dichloroacetophenone	IC50	2500.0 [1]
	2-Bromo-4'-methoxyacetophenone	IC50	1000.0 [1]
	9-Cyanopaullone	IC50	10.0 [1]
	2-Chloro-5-[4-(3-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-ylamino]-benzoic acid	IC50	76.0 [1], 160.0 [2]
	Palinurin	IC50	2600.0 [1], 4500.0 [2]
	Pyrazolo[1,5-b]pyridazine deriv. 16	IC50	32.0 [1]
	Pyrazolo[1,5-b]pyridazine deriv. 16	Ki	10.0 [1], 19.0 [2]
	2-Chloro-1-(4,5-dibromo-2-thiophenyl)ethanone	IC50	1000.0 [1]
	CID 9957049	IC50	0.56 [1], 0.58 [2], 0.6 [3]
	4-[5-(Piperidin-1-ylmethyl)-4-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)triazol-1-yl]-1,2,5-oxadiazol-3-amine	IC50	280.0 [1]
	2-Chloro-1-(3,4-dibromo-2-thienyl)-1-ethanone	IC50	500.0 [1]
	Paullone Analog 46	IC50	10000.0 [1]
	N'-Dodecanoyl-1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide	IC50	2800.0 [1], 3010.0 [2]
	4-Acylamino-6-arylfuro[2,3-d]pyrimidine 24	IC50	5.0 [1]
	20-Ethyl-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dione	IC50	18.0 [1], 25.0 [2]
	3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dione	IC50	1.6 [1], 2.0 [2]
	N-[3-[2-Methyl-4-(3-methylphenyl)piperazin-1-yl]propyl]-3-pyridin-3-yl-1,2,4-oxadiazole-5-carboxamide	IC50	200.0 [1], 690.0 [2], 17000.0 [3]
	5-(4-Methoxyphenyl)-N-(Pyridin-4-Ylmethyl)-1,3-Oxazole-4-Carboxamide	IC50	79.43 [1], 398.11 [2], 1995.26 [3]
	7-(4-Morpholin-4-ylphenyl)-2-pyridin-4-yl-5H-thieno[3,2-c]pyridin-4-one	IC50	63.1 [1], 501.19 [2], 1258.93 [3]
	N-[[1-[(2,4-Dichlorophenyl)methyl]piperidin-4-yl]methyl]-5-methoxy-1H-indazole-3-carboxamide	IC50	310.0 [1], 1390.0 [2]
	5-(2,3-Difluorophenyl)-N-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1H-indazole-3-carboxamide	IC50	18.0 [1], 240.0 [2]
	5-(2,3-Difluorophenyl)-N-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1H-indazole-3-carboxamide	Ki	15.0 [1]
	Methyl 2-[[4-[[(5-methoxy-1H-indazole-3-carbonyl)amino]methyl]piperidin-1-yl]methyl]-1,3-oxazole-4-carboxylate	IC50	210.0 [1], 5170.0 [2]
	5-[[4-[[[5-(6-Methoxypyridin-3-yl)-1H-indazole-3-carbonyl]amino]methyl]piperidin-1-yl]methyl]furan-2-carboxylic acid	IC50	20.0 [1], 21.0 [2], 70800.0 [3]
	Methyl 2-[[4-[[(5-methoxy-1H-indazole-3-carbonyl)amino]methyl]piperidin-1-yl]methyl]-1,3-thiazole-4-carboxylate	IC50	130.0 [1], 2130.0 [2]
	Methyl 2-[[4-[[(5-methoxy-1H-indazole-3-carbonyl)amino]methyl]piperidin-1-yl]methyl]furan-3-carboxylate	IC50	230.0 [1], 820.0 [2]
	2-[[4-[[[5-(2,3-Difluorophenyl)-1H-indazole-3-carbonyl]amino]methyl]piperidin-1-yl]methyl]-1,3-oxazole-4-carboxylic acid	IC50	6.0 [1], 10.0 [2], 100000.0 [3]
	Lithium	IC50	6530.0 [1], 2000000.0 [2]
	Bisindolylmaleimide i	IC50	190.0 [1], 190.55 [2]
	6-Bromoindirubin-3'-oxime	IC50	174.0 [1], 1500.0 [2]
	1-Azakenpaullone	IC50	18.0 [1]
	4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine	IC50	660.0 [1], 3000.0 [2]
	3-(2-Aminopyrimidin-4-yl)-1H-indol-4-ol	IC50	1300.0 [1]
	N-(5-Methyl-1H-pyrazol-3-yl)-2-phenylquinazolin-4-amine	Ki	22.0 [1]
	4-(5-Bromo-1H-indol-3-yl)pyrimidin-2-amine	IC50	2000.0 [1]
	Cdk1/2 Inhibitor III	IC50	140.0 [1], 210.0 [2]
	Pyridine, 4-[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]-	IC50	1318.0 [1], 6700.0 [2]
	N-[5-Bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide	IC50	7.0 [1]
	GSK-3beta Inhibitor xi	IC50	5.0 [1], 25.0 [2]
	2-Bromo-4'-phenylacetophenone	IC50	2500.0 [1]
	2-(Phenylamino)-3-phenylmaleimide	IC50	520.0 [1], 590.0 [2]
	4-Arylmaleimide deriv. 6-l	IC50	20.0 [1]
	4-(4-Hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1H)-one	IC50	17.2 [1], 5280.0 [2]
	(Z)-5-((1H-Indol-3-yl)methylene)thiazolidine-2,4-dione	IC50	4930.0 [1], 21000.0 [2]
	Indazole analogue 12	IC50	15.0 [1], 100.0 [2]
	3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione	IC50	7.0 [1], 21.1 [2]
	7,12-Dihydro-9-(trifluoromethyl)indolo[3,2-d][1]benzazepine-6(5H)-one	IC50	29.99 [1], 30.0 [2]
	Pyrazolopyridazine 1	Ki	10.0 [1]
	Pyrazolo[1,5-b]pyridazine deriv. 22	IC50	16.0 [1]
	Pyrazolo[1,5-b]pyridazine deriv. 22	Ki	30.0 [1]
	N-[6-(3-Hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide	IC50	8.0 [1], 12.0 [2]
	9-Methyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	130.0 [1], 130.02 [2]
	[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine	Ki	20.0 [1]
	Thieno analogue of kenpaullone	IC50	119.95 [1], 120.0 [2]
	4-Benzyl-2-ethyl-1,2,4-thiadiazolidine-3,5-dione	IC50	7000.0 [1], 7149.0 [2]
	1-(3-Methoxyphenyl)-N-[(E)-pyridin-4-ylmethylideneamino]pyrazolo[3,4-d]pyrimidin-4-amine	IC50	6.31 [1], 16.0 [2]
	Indolylylmaleimide 1	IC50	16.98 [1], 17.0 [2]
	9-Chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	23.99 [1], 24.0 [2]
	11-Chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	199.99 [1], 200.0 [2]
	9-Fluoro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	79.98 [1], 80.0 [2]
	9-Bromo-4-hydroxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	4295.36 [1], 4300.0 [2]
	2,3-Dimethoxy-7,12-dihydro-9-bromoindolo[3,2-d][1]benzazepine-6(5H)-one	IC50	100.0 [1]
	4-Methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	139958.73 [1], 140000.0 [2]
	9-Bromo-4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	15995.58 [1], 16000.0 [2]
	2,3-Dimethoxy-7,12-dihydro-9-(trifluoromethyl)indolo[3,2-d][1]benzazepine-6(5H)-one	IC50	74.99 [1], 75.0 [2]
	8,10-Dichloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	5000.0 [1], 5000.35 [2]
	3-(1-Methylindol-3-yl)-4-[1-(3-morpholin-4-ylpropyl)pyrazolo[3,4-b]pyridin-3-yl]pyrrole-2,5-dione	IC50	340.0 [1], 750.0 [2]
	Paullone Analog 22	IC50	399.94 [1], 400.0 [2]
	Paullone Analog 39	IC50	2098.94 [1], 2100.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glycogen synthase kinase-3 beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/glycogen-synthase-kinase-3-beta-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Glycogen synthase kinase-3 beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glycogen-synthase-kinase-3-beta-inhibitors-ic50-ki.
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