Glycogen synthase kinase-3 alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Pyrazolopyridazine 1a	IC50	250.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 13	IC50	0.8 [1]
	N-(5-Phenyl-2H-pyrazolo[3,4-b]pyridin-3-yl)butanamide	IC50	56.0 [1]
	Pyrazolopyridazine 5	IC50	4.0 [1]
	Chir-99021	IC50	7.8 [1], 10.0 [2]
	3-(3-Chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	IC50	78.0 [1], 104.0 [2]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	500.0 [1], 1500.0 [2]
	N-[5-Bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide	IC50	7.0 [1]
	2-Chloro-5-[4-(3-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-ylamino]-benzoic acid	IC50	76.0 [1], 76000.0 [2]
	N-[6-(3-Hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide	IC50	12.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 12	IC50	24.0 [1]
	Pyrazolo[3,4-b]pyridine analogue 9	IC50	4.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 5	IC50	8.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 14	IC50	1.0 [1]
	Pyrazolopyridine deriv. 13	IC50	5.0 [1]
	Pyrazolopyridine deriv. 18	IC50	18.0 [1]
	Pyrazolopyridine deriv. 20	IC50	7.0 [1]
	(5-Bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl) cyclopropane carboxamide	IC50	75.0 [1]
	CID 9957049	IC50	0.65 [1], 27.1 [2]
	2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-fluorobenzonitrile	IC50	2.0 [1], 230.0 [2]
	3-(2,4-Dichlorophenyl)-4-(1-(111C)methylindol-3-yl)pyrrole-2,5-dione	IC50	34.0 [1]
	3-(2,4-Dichlorophenyl)-4-(1-(111C)methylindol-3-yl)pyrrole-2,5-dione	Ki	9.0 [1]
	Staurosporine	IC50	28.0 [1]
	Harmine	IC50	10000.0 [1]
	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione	IC50	34.0 [1]
	6-Bromoindirubin-3'-oxime	IC50	5.0 [1]
	N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-YL)urea	IC50	70000.0 [1]
	Alsterpaullone	IC50	4.0 [1]
	Manzamine A	IC50	25000.0 [1]
	LY-2090314	IC50	1.5 [1]
	CID 53396311	IC50	7.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	10000.0 [1]
	Aminofurazanyl-azabenzimidazole 6n	IC50	1260.0 [1]
	Leucettine L41	IC50	210.0 [1]
	JNK Inhibitor VIII	Ki	8900.0 [1]
	Ilorasertib	IC50	10000.0 [1]
	GSK-3 Inhibitor II	IC50	390.0 [1]
	8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one	IC50	462.0 [1]
	Pyridine, 4-[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]-	IC50	2244.0 [1]
	Leucettamine B	IC50	7700.0 [1]
	CID 59604787	IC50	10000.0 [1]
	Palinurin	IC50	1600.0 [1]
	N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide	IC50	498.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 23	IC50	1.0 [1]
	2-(Phenylamino)-3-phenylmaleimide	IC50	529000.0 [1]
	3-[(3-Chloro-4-Hydroxyphenyl)amino]-4-(3-Chlorophenyl)-1h-Pyrrole-2,5-Dione	IC50	94000.0 [1]
	4-Arylmaleimide deriv. 6-l	IC50	20000.0 [1]
	Pyrazolopyridazine deriv. 13	IC50	9.0 [1]
	N-[6-(Furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide	IC50	141.0 [1]
	N-[6-(3-Sulfamoylphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide	IC50	481.0 [1]
	Indazole analogue 12	IC50	15.0 [1]
	4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]benzonitrile	IC50	7379.0 [1]
	5-Phenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine	IC50	530.0 [1]
	4-Arylmaleimide deriv. 6c	IC50	216000.0 [1]
	4-Arylmaleimide deriv. 6p	IC50	374000.0 [1]
	4-Arylmaleimide deriv. 6-g	IC50	93000.0 [1]
	4-Arylmaleimide deriv. 6cc	IC50	109000.0 [1]
	4-Arylmaleimide deriv. 8f	IC50	1412000.0 [1]
	4-Arylmaleimide deriv. 8g	IC50	694000.0 [1]
	N-[6-(4-Methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide	IC50	5000.0 [1]
	Indazole analogue 18	IC50	1000.0 [1]
	N-[6-(2,5-Difluorophenyl)-1H-indazol-3-yl]cyclopropanecarboxamide	IC50	1000.0 [1]
	Pyrazolo[3,4-b]pyridine analogue 37	IC50	18.0 [1]
	5-Phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine	IC50	430.0 [1]
	N-(5-Pyridin-3-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)butyramide	IC50	11.0 [1]
	N-[6-(4-Sulfamoylphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide	IC50	1000.0 [1]
	Indazole analogue 17	IC50	1000.0 [1]
	N-[6-(4-Fluorophenyl)-1H-indazol-3-yl]cyclopropanecarboxamide	IC50	1000.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	8900.0 [1]
	[(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone	IC50	691.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 7	IC50	8.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 10	IC50	36.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 15	IC50	6.0 [1]
	6-Aryl-pyrazolo[3,4-b]pyridine analogue 22	IC50	12.0 [1]
	Pyrazolo[3,4-b]pyridine analogue 6	IC50	5.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	8900.0 [1]
	[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanone	IC50	9100.0 [1]
	Cyclapolin 9	IC50	100000.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	911.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	N-(5-Phenyl-1H-pyrazolo[3,4-c]pyridin-3-yl)butanamide	IC50	7.0 [1]
	5-Phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine	IC50	1260.0 [1]
	Pyrazolopyridine deriv. 9	IC50	291.0 [1]
	Pyrazolopyridine deriv. 10	IC50	43.0 [1]
	Pyrazolopyridine deriv. 12	IC50	19.0 [1]
	1-Ethyl-3-(5-phenyl-2H-pyrazolo[3,4-b]pyridin-3-yl)urea	IC50	2810.0 [1]
	Pyrazolopyridine deriv. 15	IC50	3572.0 [1]
	Pyrazolopyridine deriv. 17	IC50	2345.0 [1]
	Pyrazolopyridine deriv. 19	IC50	20.0 [1]
	Pyrazolopyridine deriv. 21	IC50	27.0 [1]
	Pyrazolopyridine deriv. 23	IC50	443.0 [1]
	Pyrazolopyridine deriv. 24	IC50	851.0 [1]
	Pyrazolopyridine deriv. 25	IC50	169.0 [1]
	Pyrazolopyridine deriv. 26	IC50	241.0 [1]
	N-(5-Phenyl-1H-indazol-3-yl)butanamide	IC50	99.0 [1]
	Pyrazolopyrimidine deriv. 7	IC50	2697.0 [1]
	Pyrazolopyridazine deriv. 8	IC50	691.0 [1]
	Pyrazolopyridazine deriv. 9	IC50	22.0 [1]
	Pyrazolopyridazine deriv. 10	IC50	11.0 [1]
	Pyrazolopyridazine deriv. 11	IC50	7.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glycogen synthase kinase-3 alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glycogen-synthase-kinase-3-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glycogen synthase kinase-3 alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glycogen-synthase-kinase-3-alpha-inhibitors-ic50-ki.
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