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Glycine transporter 2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
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▼
4-Benzyloxy-3,5-Dimethoxy-N-[(1-Dimethylaminocyclopentyl)Methyl]BenzamideIC5016.0 [1]
N-(1-Methylpiperidin-4-yl)-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50105.0 [1]
2,4-Dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
N-ArachidonoylglycineIC503000.0 [1]
(R)-NfpsIC5030000.0 [1]
(2S)-2-Amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acidIC50100.0 [1]
PF-03463275IC5010000.0 [1]
N-((1-(Propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
[3H](R)-NptsIC5010000.0 [1]
N-((4-(Morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
N-{[1-(Dimethylamino)cyclohexyl]methyl}-3,4,5-trimethoxybenzamideIC5010000.0 [1]
2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-phenyl-butyl)-benzamideIC50170.0 [1]
2-[(7-Hydroxy-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-N-[(E)-4-phenylbut-3-enyl]benzamideIC5030.0 [1]
2-[(5-Hydroxy-1,3-dihydroisoindol-2-yl)methyl]-N-[(E)-4-phenylbut-3-enyl]benzamideIC5033.0 [1]
4-Butoxy-N-(2-dimethylamino-2-methyl-propyl)-3,5-dimethoxy-benzamideIC50696.0 [1]
4-Butoxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5-dimethoxy-benzamideIC5077.0 [1]
N-(1-Dimethylamino-cyclohexylmethyl)-3,5-dimethoxy-4-propoxy-benzamideIC502313.0 [1]
4-Butoxy-N-(1-dimethylamino-cyclohexylmethyl)-3-methoxy-benzamideIC502563.0 [1]
4-Butoxy-N-(2-dimethylamino-2-phenyl-ethyl)-3,5-dimethoxy-benzamideIC50566.0 [1]
4-Butoxy-N-[1-(ethyl-methyl-amino)-cyclohexylmethyl]-3,5-dimethoxy-benzamideIC501321.0 [1]
4-Benzyloxy-N-(1-dimethylamino-cyclohexylmethyl)-3,5-dimethoxy-benzamideIC5084.0 [1]
3,6-Dichloro-2-fluoro-N-((1-(propylsulfonyl)-4-(pyridine-2-yL)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
{Methyl-[2-(3-thiophen-2-yl-biphenyl-4-yloxy)-ethyl]-amino}-acetic acidIC5030000.0 [1]
2,4-Dichloro-N-((4-(6-methylpyridin-2-yl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2-Chloro-N-((4-(6-methylpyridin-2-yl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,6-Dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
(S)-2,4-Dichloro-N-(1-(1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)ethyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-((4-(cyclopropylmethyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2-Chloro-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-((1-(ethylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-((1-(methylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-((1-(cyclopropylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2-Amino-6-chloro-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-((4-(4-methylpyridin-2-yl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-[[4-(cyclopropylmethyl)-1-(1-methylpyrazol-4-yl)sulfonylpiperidin-4-yl]methyl]benzamideIC5010000.0 [1]
2-Chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
2,4-Dichloro-N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamideIC5030000.0 [1]
4-Butoxy-3,5-dimethoxy-N-(1-piperidin-1-yl-cyclohexylmethyl)-benzamideIC501563.0 [1]
[5-Ethylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[2-(2-fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[2-(4,4-Difluoropiperidin-1-yl)-5-methylsulfonylphenyl]-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[2-(2-Fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanoneIC5010000.0 [1]
3-[2-(5-Fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-propan-2-yloxybenzonitrileIC5010000.0 [1]
[2-(5-Fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanoneIC5010000.0 [1]
[5-Methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-(2-phenyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)methanoneIC5010000.0 [1]
[2-(2-Fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-(5-methylsulfonyl-2-propan-2-yloxyphenyl)methanoneIC5010000.0 [1]
[2-(4,4-Difluoropiperidin-1-yl)-5-methylsulfonylphenyl]-[2-(5-fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[2-(3-Fluorophenyl)-5-methylsulfonylphenyl]-[2-(5-fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[2-(3-Methylphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanoneIC5010000.0 [1]
(2-Phenyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-[5-propan-2-ylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanoneIC5010000.0 [1]
[5-Ethylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
3-(2-Phenyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl)-4-propan-2-yloxybenzonitrileIC5010000.0 [1]
4-(3-Fluorophenyl)-3-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrileIC5010000.0 [1]
4-(Cyclopropylmethoxy)-3-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrileIC5010000.0 [1]
[2-(3-Fluorophenyl)-5-methylsulfonylphenyl]-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[5-Ethylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[2-(5-fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[2-(Cyclopropylmethoxy)-5-methylsulfonylphenyl]-[2-(2-fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
[2-(4,4-Difluoropiperidin-1-yl)-5-methylsulfonylphenyl]-[2-(2-fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]methanoneIC5010000.0 [1]
GlyT1 Inhibitor 1IC5010000.0 [1]
3-[2-(2-Methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzonitrileIC5010000.0 [1]
3-[2-(5-Fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzonitrileIC5010000.0 [1]
3-[2-(2-Fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzonitrileIC5010000.0 [1]
(2-Cyclopentyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanoneIC5010000.0 [1]
[2-(2-Methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanoneIC5010000.0 [1]
3-(2-Cyclopentyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzonitrileIC5010000.0 [1]
4-(4,4-Difluoropiperidin-1-yl)-3-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrileIC5010000.0 [1]
[2-(2-Fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-[2-(3-fluorophenyl)-5-methylsulfonylphenyl]methanoneIC5010000.0 [1]
4-[(4-Tert-butylphenoxy)methyl]-N-[1-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]pyrrolidin-3-yl]benzamideIC504040.0 [1]
N-[1-(1-Benzylpiperidin-4-yl)pyrrolidin-3-yl]-4-[(4-tert-butylphenoxy)methyl]benzamideIC50516.0 [1]
4-[(4-Tert-butylphenoxy)methyl]-N-[1-(1-methylpiperidin-4-yl)pyrrolidin-3-yl]benzamideIC50250.0 [1]
4-[(4-Tert-butylphenoxy)methyl]-N-(1-cyclohexylpyrrolidin-3-yl)benzamideIC502200.0 [1]
4-[(4-Tert-butylphenoxy)methyl]-N-(1-propan-2-ylpyrrolidin-3-yl)benzamideIC502800.0 [1]
N-[1-(1-Methylpiperidin-4-yl)pyrrolidin-3-yl]-4-(phenoxymethyl)benzamideIC50879.0 [1]
4-[(4-Fluorophenoxy)methyl]-N-[1-(1-methylpiperidin-4-yl)pyrrolidin-3-yl]benzamideIC502320.0 [1]
4-[(4-Chlorophenoxy)methyl]-N-[1-(1-methylpiperidin-4-yl)pyrrolidin-3-yl]benzamideIC50440.0 [1]
N-[1-(1-Methylpiperidin-4-yl)pyrrolidin-3-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50112.0 [1]
4-[(2,4-Dichlorophenoxy)methyl]-N-[1-(1-methylpiperidin-4-yl)pyrrolidin-3-yl]benzamideIC50431.0 [1]
4-[(3-Chlorophenoxy)methyl]-N-[1-(1-methylpiperidin-4-yl)pyrrolidin-3-yl]benzamideIC50869.0 [1]
4-[(3,4-Dichlorophenoxy)methyl]-N-[1-(1-methylpiperidin-4-yl)pyrrolidin-3-yl]benzamideIC50361.0 [1]
N-[(3S)-1-(1-Methylpiperidin-4-yl)pyrrolidin-3-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50115.0 [1]
N-[(3R)-1-(1-Methylpiperidin-4-yl)pyrrolidin-3-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50363.0 [1]
N-[1-[2-(Dimethylamino)ethyl]piperidin-4-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC5071.4 [1]
N-(1-Butylpiperidin-4-yl)-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50330.0 [1]
N-(1-Ethylpiperidin-4-yl)-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50107.0 [1]
N-[1-(2-Fluoroethyl)piperidin-4-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC5099.1 [1]
N-[1-(2-Hydroxyethyl)piperidin-4-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC5065.8 [1]
N-[1-(3-Hydroxypropyl)piperidin-4-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC50181.0 [1]
N-[1-(Pyridin-3-ylmethyl)piperidin-4-yl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamideIC5051.9 [1]
4-(3-Fluorophenyl)-3-[2-(5-fluoropyridin-3-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrileIC5010000.0 [1]
[2-(2-Fluorophenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-[2-[(2-methylpropan-2-yl)oxy]-5-methylsulfonylphenyl]methanoneIC5010000.0 [1]
[1-[3-[7-[[5-(4-Chlorophenyl)-1,2,4-oxadiazol-3-yl]methoxy]-1,2,3,4-tetrahydronaphthalen-1-yl]propyl]piperidin-3-yl]methanolIC50319.0 [1]
2-[(7-Hydroxy-1,3,4,5-tetrahydro-2-benzazepin-2-yl)methyl]-N-[(E)-4-phenylbut-3-enyl]benzamideIC50320.0 [1]
2-[[(2-Hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)amino]methyl]-N-[(E)-4-phenylbut-3-enyl]benzamideIC50130.0 [1]
2-{[2-(2-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-phenyl-butyl)-benzamideIC501200.0 [1]
2-{[2-(3-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-phenyl-butyl)-benzamideIC50330.0 [1]
2-{[2-(4-Amino-phenyl)-ethylamino]-methyl}-N-(4-phenyl-butyl)-benzamideIC504000.0 [1]
2-{[2-(4-Fluoro-phenyl)-ethylamino]-methyl}-N-(4-phenyl-butyl)-benzamideIC503400.0 [1]
2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-(3-phenoxy-propyl)-benzamideIC501600.0 [1]
2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-[4-(4-methoxy-phenyl)-butyl]-benzamideIC50130.0 [1]
2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-[4-(4-trifluoromethoxy-phenyl)-butyl]-benzamideIC50370.0 [1]
2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-[4-(4-trifluoromethyl-phenyl)-butyl]-benzamideIC50140.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glycine transporter 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glycine-transporter-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glycine transporter 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glycine-transporter-2-inhibitors-ic50-ki.
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