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Glycine transporter 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2,4-Dichloro-N-[[1-(cyclopropylmethyl)-4-(1-methyltriazol-4-yl)sulfonylcyclohexyl]methyl]benzamideIC501.89 [1], 1.9 [2], 5.4 [3], 5.44 [4]
(R)-NfpsIC500.39 [1], 3.0 [2], 26.0 [3]
N-Methyl-SSR504734IC502.5 [1], 3.0 [2], 7.51 [3]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]propane-1-sulfonamideIC50100.0 [1]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]propane-1-sulfonamideKi3.0 [1], 100.0 [2]
2-Chloro-N-[(S)-phenyl-[(2S)-piperidin-2-yl]methyl]-3-(trifluoromethyl)benzamideIC5080.1 [1], 314.0 [2]
4-Benzyloxy-3,5-Dimethoxy-N-[(1-Dimethylaminocyclopentyl)Methyl]BenzamideIC50100.0 [1], 100000.0 [2]
2,4-Dichloro-N-[[4-(cyclopropylmethyl)-1-ethylsulfonylpiperidin-4-yl]methyl]benzamideIC5026.0 [1]
2,4-Dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamideIC504.4 [1]
[1-[4-[6-[[5-(4-Chlorophenyl)-1,2,4-oxadiazol-3-yl]methoxy]-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]cyclopentyl]methanolIC5026.8 [1]
[1-[4-[6-[[5-(4-Chlorophenyl)-1,2,4-oxadiazol-3-yl]methoxy]-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]cyclopentyl]methanolKi26.8 [1]
2,4-Dichloro-N-[[1-(cyclopropylmethyl)-4-propylsulfonylcyclohexyl]methyl]benzamideIC5036.9 [1], 1627.0 [2]
2,4-Dichloro-N-[[1-(cyclopropylmethyl)-4-ethylsulfonylcyclohexyl]methyl]benzamideIC50132.4 [1], 1323.0 [2]
N-[(3Ar,6aS)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-5-yl]-N-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]-1-methylimidazole-4-carboxamideKi1.71 [1], 26.9 [2]
2,4-Dichloro-N-[[1-(cyclopropylmethyl)-4-(2H-triazol-4-ylsulfonyl)cyclohexyl]methyl]benzamideIC503000.0 [1]
2,4-Dichloro-N-[[1-(cyclopropylmethyl)-4-[(5-methyl-1,2-oxazol-3-yl)sulfonyl]cyclohexyl]methyl]benzamideIC507.3 [1], 8.6 [2]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]methanesulfonamideIC50100.0 [1]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]methanesulfonamideKi100.0 [1]
2,4-Dichloro-N-[2-[[1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]benzamideIC5010000.0 [1]
2,4-Dichloro-N-[2-[[1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]benzamideKi10000.0 [1]
N-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl]pyridine-3-sulfonamideIC5010000.0 [1]
N-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl]pyridine-3-sulfonamideKi1000.0 [1]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]-3-(ethylamino)propane-1-sulfonamideIC5010000.0 [1]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]-3-(ethylamino)propane-1-sulfonamideKi10000.0 [1]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]-3-(diethylamino)propane-1-sulfonamideIC5010000.0 [1]
N-[2-[[1-[1-(4-Chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]ethyl]-3-(diethylamino)propane-1-sulfonamideKi10000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideIC5010.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideKi10.0 [1]
Tert-butyl N-[2-[[8-[(3,4-dichlorophenyl)methyl]-7-(ethoxycarbonylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]carbamateIC501000000.0 [1]
Tert-butyl N-[2-[[8-[(3,4-dichlorophenyl)methyl]-7-(ethoxycarbonylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]carbamateKi10000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-[(1-methylimidazol-4-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-[(1-methylimidazol-4-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi100.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylpyrazole-4-sulfonamideIC5010.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylpyrazole-4-sulfonamideKi10.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]pyridine-3-sulfonamideIC501000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]pyridine-3-sulfonamideKi1000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-[(1-methylpyrazol-4-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-[(1-methylpyrazol-4-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi1000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-(thiophen-2-ylsulfonylamino)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-(thiophen-2-ylsulfonylamino)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi100000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]pyrrolidine-3-sulfonamideIC50100000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]pyrrolidine-3-sulfonamideKi10000.0 [1]
[8-[(3,4-Dichlorophenyl)methyl]-7-(ethoxycarbonylamino)-5,6,7,8-tetrahydronaphthalen-2-yl] trifluoromethanesulfonateIC50100000.0 [1]
[8-[(3,4-Dichlorophenyl)methyl]-7-(ethoxycarbonylamino)-5,6,7,8-tetrahydronaphthalen-2-yl] trifluoromethanesulfonateKi10000.0 [1]
1-[(3-Chlorophenyl)methyl]-7-[2-(1,1-dioxo-1,2-thiazolidin-2-yl)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-amineIC501000.0 [1]
1-[(3-Chlorophenyl)methyl]-7-[2-(1,1-dioxo-1,2-thiazolidin-2-yl)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-amineKi1000.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]cyclobutanesulfonamideIC501000.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]cyclobutanesulfonamideKi100.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-1-cyclopropylmethanesulfonamideIC50100.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-1-cyclopropylmethanesulfonamideKi100.0 [1]
Ethyl N-[1-[(4-chlorophenyl)methyl]-7-[2-[methyl(propylsulfonyl)amino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000000.0 [1]
Ethyl N-[1-[(4-chlorophenyl)methyl]-7-[2-[methyl(propylsulfonyl)amino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi100000.0 [1]
1-[(3-Chlorophenyl)methyl]-7-(1-propylsulfonylazetidin-3-yl)oxy-1,2,3,4-tetrahydronaphthalen-2-amineIC5010000.0 [1]
1-[(3-Chlorophenyl)methyl]-7-(1-propylsulfonylazetidin-3-yl)oxy-1,2,3,4-tetrahydronaphthalen-2-amineKi1000.0 [1]
Tert-Butyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000000.0 [1]
Tert-Butyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi10000.0 [1]
Tert-Butyl[1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC5010000.0 [1]
Tert-Butyl[1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi100000.0 [1]
N-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]methyl]propane-1-sulfonamideIC50100000.0 [1]
N-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]methyl]propane-1-sulfonamideKi10000.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-N-methylpropane-1-sulfonamideIC50100.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-N-methylpropane-1-sulfonamideKi100.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-N-methylpropane-1-sulfonamideIC501000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-N-methylpropane-1-sulfonamideKi100.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]methanesulfonamideIC501000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]methanesulfonamideKi1000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]benzenesulfonamideIC5010000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]benzenesulfonamideKi10000.0 [1]
Ethyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC50100000.0 [1]
Ethyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi10000.0 [1]
7-Amino-8-[(4-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalene-2-carbonitrileIC50100000.0 [1]
7-Amino-8-[(4-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalene-2-carbonitrileKi100000.0 [1]
7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-olIC50100000.0 [1]
7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-olKi100000.0 [1]
Tert-butyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[(propylsulfonylamino)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000000.0 [1]
Tert-butyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[(propylsulfonylamino)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi10000.0 [1]
N-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]methyl]-3-fluoropropane-1-sulfonamideIC50100000.0 [1]
N-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]methyl]-3-fluoropropane-1-sulfonamideKi10000.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]propane-1-sulfonamideIC50100.0 [1]
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]propane-1-sulfonamideKi10000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-(methanesulfonamido)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC50100000.0 [1]
Ethyl N-[1-[(3,4-dichlorophenyl)methyl]-7-[2-(methanesulfonamido)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi10000.0 [1]
Ethyl N-[7-[2-(benzenesulfonamido)ethoxy]-1-[(3,4-dichlorophenyl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC501000000.0 [1]
Ethyl N-[7-[2-(benzenesulfonamido)ethoxy]-1-[(3,4-dichlorophenyl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi100000.0 [1]
Ethyl N-[1-[(3-chlorophenyl)methyl]-7-[2-(ethylsulfonylamino)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateIC50100000.0 [1]
Ethyl N-[1-[(3-chlorophenyl)methyl]-7-[2-(ethylsulfonylamino)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamateKi10000.0 [1]
N-[1-[(3,4-Dichlorophenyl)methyl]-7-[2-[(1-methylimidazol-4-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]formamideIC50100.0 [1]
N-[1-[(3,4-Dichlorophenyl)methyl]-7-[2-[(1-methylimidazol-4-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]formamideKi10.0 [1]
N-[2-[[8-[(3,4-Dichlorophenyl)methyl]-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideIC50100000.0 [1]
N-[2-[[8-[(3,4-Dichlorophenyl)methyl]-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideKi10000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-4-methylthiophene-2-sulfonamideIC5010000.0 [1]
N-[2-[[7-Amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-4-methylthiophene-2-sulfonamideKi100.0 [1]
N-[2-[[7-Amino-8-[(4-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideIC5010.0 [1]
N-[2-[[7-Amino-8-[(4-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideKi10.0 [1]
N-[2-[[7-Amino-8-[(4-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylpyrazole-4-sulfonamideIC5010.0 [1]
N-[2-[[7-Amino-8-[(4-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylpyrazole-4-sulfonamideKi10.0 [1]
N-[2-[[7-Amino-8-[(3-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylpyrazole-4-sulfonamideIC5010.0 [1]
N-[2-[[7-Amino-8-[(3-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylpyrazole-4-sulfonamideKi10.0 [1]
N-[2-[[7-Amino-8-[(3-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideIC5010.0 [1]
N-[2-[[7-Amino-8-[(3-chlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]ethyl]-1-methylimidazole-4-sulfonamideKi10.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glycine transporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/glycine-transporter-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Glycine transporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glycine-transporter-1-inhibitors-ic50-ki.
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