Glycine receptor (alpha-1/beta) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Strychnine	IC50	58.0 [1], 180.0 [2]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-propoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	116.0 [1], 354.81 [2]
	(4Ar,5aS,8aS,13aS,15aS,15bR)-6-propyl-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-6-ium-14-one;bromide	IC50	6530.0 [1], 13489.63 [2]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-prop-2-enoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	46.0 [1], 158.49 [2]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-methoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	56.0 [1], 213.8 [2]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-prop-2-ynoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	43.0 [1], 239.88 [2]
	Strychnine, 2-propionamido-	IC50	311.0 [1], 940.0 [2]
	2-Aminostrychnine	IC50	97.0 [1], 270.0 [2]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-hydroxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	80.0 [1], 210.0 [2]
	Gelsemine	IC50	30000.0 [1]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-(2-phenylethoxyimino)-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	776.25 [1]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-(2-methylpropoxyimino)-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	1122.02 [1]
	Methyl 5-[(E)-[(4aR,5aS,8aR,13aS,15aR,15bR)-14-oxo-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-15-ylidene]amino]oxypentanoate	IC50	1479.11 [1]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-phenylmethoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	309.03 [1]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-pentoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	707.95 [1]
	Methyl 2-[(E)-[(4aR,5aS,8aR,13aS,15aR,15bR)-14-oxo-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-15-ylidene]amino]oxyacetate	IC50	660.69 [1]
	(4Ar,5aS,8aR,13aS,15E,15aR,15bR)-15-butoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one	IC50	870.96 [1]
	(4Ar,5aS,8aR,13aS,15aS,15bR)-2,4a,5,5a,8,13a,15,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-7,14-dione	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glycine receptor (alpha-1/beta) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Feb. 2025, https://www.aatbio.com/data-sets/glycine-receptor-alpha-1-beta-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 19). Quest Database™ Glycine receptor (alpha-1/beta) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glycine-receptor-alpha-1-beta-inhibitors-ic50-ki.
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