Glutaminyl-peptide cyclotransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	1-(3,4-Dimethoxyphenyl)-3-[3-(1h-Imidazol-1-Yl)propyl]thiourea	IC50	5300.0 [1]
	1-(3,4-Dimethoxyphenyl)-3-[3-(1h-Imidazol-1-Yl)propyl]thiourea	Ki	60.0 [1]
	1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thiourea	IC50	29.2 [1], 119.0 [2]
	1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thiourea	Ki	6.3 [1]
	Thioamide deriv. 81	Ki	90.0 [1]
	5-(5-(Benzylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazole	IC50	4240.0 [1]
	2-(1H-Benzo[d]imidazol-5-yl)-5-(methylthio)-1,3,4-oxadiazole	IC50	24800.0 [1]
	5-(5-(Phenethylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazole	IC50	7260.0 [1]
	5-(5-(3-Phenylpropylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazole	IC50	7560.0 [1]
	5-(5-((Naphthalen-2-yl)methylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazole	IC50	8670.0 [1]
	5-(5-(Allylthio)-1,3,4-oxadiazol-2-yl)benzimidazole	IC50	7230.0 [1]
	5-(5-(Ethylthio)-1,3,4-oxadiazol-2-yl)benzimidazole	IC50	14700.0 [1]
	5-(3H-Benzimidazol-5-yl)-N-benzyl-1,3,4-oxadiazol-2-amine	IC50	28130.0 [1]
	Benzimidazole	Ki	150000.0 [1]
	7,4'-Dihydroxyflavone	IC50	45200.0 [1]
	N-(4-Ethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]thiourea	Ki	890.0 [1]
	3-(3-(1H-Imidazol-1-yl)propyl)-2-thioxoimidazolidin-4-one	Ki	700.0 [1]
	1-Cyclohexyl-3-[3-(1H-imidazol-1-yl)propyl]thiourea	Ki	4700.0 [1]
	3-[3-(1H-Imidazol-1-yl)propyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one	Ki	300.0 [1]
	1-[3-(1H-Imidazol-1-yl)propyl]-3-(4-methoxyphenyl)thiourea	Ki	700.0 [1]
	1-(3-(1H-Imidazol-1-yl)propyl)-3-(4-acetylphenyl)thiourea	Ki	1790.0 [1]
	1-[3-(4-Methylphenoxy)propyl]-1H-imidazole	Ki	7700.0 [1]
	5,7-Dihydroxy-2-(2-fluorophenyl)-4H-1-benzopyran-4-one	IC50	34600.0 [1]
	[(3-Imidazolylpropyl)amino](phenylamino)methane-1-thione	Ki	4480.0 [1]
	Rac-PQ-912	IC50	482.0 [1]
	Glutaminyl Cyclase Inhibitor 2	IC50	1230.0 [1]
	1-Alkylimidazole thiourea deriv. 52	Ki	340.0 [1]
	2-[4-(Dimethylamino)phenyl]-7-hydroxy-4H-1-benzopyran-4-one	IC50	16800.0 [1]
	(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-methylguanidine	Ki	1530.0 [1]
	(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-phenylguanidine	Ki	1020.0 [1]
	(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-(3,4-dimethoxyphenyl)guanidine	Ki	1360.0 [1]
	(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-(4-methoxyphenyl)guanidine	Ki	700.0 [1]
	5,7-Dihydroxy-2-thiophen-2-ylchromen-4-one	IC50	15300.0 [1]
	5,7-Dihydroxy-2-(5-methylthiophen-2-yl)chromen-4-one	IC50	15000.0 [1]
	5,7-Dihydroxy-2-(3-methylphenyl)chromen-4-one	IC50	16100.0 [1]
	2-(4-Ethylphenyl)-5,7-dihydroxychromen-4-one	IC50	37200.0 [1]
	2-(4-Ethoxyphenyl)-5,7-dihydroxychromen-4-one	IC50	14200.0 [1]
	5,7-Dihydroxy-2-(3-methylthiophen-2-yl)chromen-4-one	IC50	19300.0 [1]
	Glutaminyl Cyclase Inhibitor 1	IC50	500.0 [1]
	1-[3-Methoxy-4-(4-pyridin-3-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	19.8 [1]
	1-[3-Methoxy-4-(2-piperidin-1-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	24.7 [1]
	1-[4-[3-(2,6-Diaminopyridin-4-yl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	16.6 [1]
	3-Fluoro-2-(4-fluorophenyl)-N-(3-imidazol-1-ylpropyl)aniline	IC50	1560.0 [1]
	1-[4-[2-(Dimethylamino)ethoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	38.6 [1]
	2-(3,4-Dimethoxyphenyl)-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	890.0 [1]
	2-(3,4-Dimethoxyphenyl)-6-fluoro-N-(3-imidazol-1-ylpropyl)aniline	IC50	1380.0 [1]
	1-[4-[3-(2-Aminopyrimidin-5-yl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	20.5 [1]
	1-[4-[3-(4-Aminophenyl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	9.0 [1]
	1-[3-Methoxy-4-(3-pyridin-4-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	14.4 [1]
	1-[3-Methoxy-4-(3-piperidin-1-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	13.4 [1]
	1-[3-Methoxy-4-[3-(pyrimidin-2-ylamino)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	17.5 [1]
	1-[3-Methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	12.5 [1]
	2-(3-Fluorophenyl)-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	15500.0 [1]
	1-[3-Methoxy-4-[2-(methylamino)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	38.7 [1]
	2-(3,4-Dimethoxyphenyl)-3-methyl-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	700.0 [1]
	1-[3-Methoxy-4-[4-(4-methylpiperazin-1-yl)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	8.2 [1]
	2-(4-Fluorophenyl)-5-methyl-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	1620.0 [1]
	1-[4-[4-(Dimethylamino)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	3.7 [1]
	1-[3-Methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	7.3 [1]
	N-[3-[2-Methoxy-4-[3-(5-methylimidazol-1-yl)propylcarbamothioylamino]phenoxy]propyl]acetamide	IC50	40.8 [1]
	N-[4-[4-[2-Methoxy-4-[3-(5-methylimidazol-1-yl)propylcarbamothioylamino]phenoxy]butyl]pyridin-2-yl]acetamide	IC50	19.0 [1]
	1-[3-Methoxy-4-(3-piperidin-4-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	7.2 [1]
	1-[4-[3-(2-Aminopyridin-4-yl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	10.7 [1]
	2-(4-Fluorophenyl)-N-(3-imidazol-1-ylpropyl)aniline	IC50	3020.0 [1]
	1-[3-Methoxy-4-[4-(methylamino)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	16.2 [1]
	1-[3-Methoxy-4-(2-piperidin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	13.8 [1]
	1-[4-[3-[(5-Fluoropyrimidin-2-yl)amino]propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	18.5 [1]
	1-[3-Methoxy-4-[3-(methylamino)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	6.9 [1]
	1-[3-Methoxy-4-(4-piperidin-1-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	12.5 [1]
	2-(3,4-Dimethoxyphenyl)-N-(3-imidazol-1-ylpropyl)aniline	IC50	2080.0 [1]
	3-Fluoro-2-(4-fluorophenyl)-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	880.0 [1]
	1-[3-Methoxy-4-(4-piperidin-4-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	7.8 [1]
	1-[3-Methoxy-4-(3-morpholin-4-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	14.1 [1]
	1-[3-Methoxy-4-[2-(pyrimidin-2-ylamino)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	39.4 [1]
	2-(3,4-Dimethoxyphenyl)-N-(3-imidazol-1-ylpropyl)-3-methylaniline	IC50	640.0 [1]
	1-[4-(3-Aminopropoxy)-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	5.3 [1]
	1-[4-[4-(4-Aminophenyl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	8.3 [1]
	1-[3-Methoxy-4-(3-piperazin-1-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	11.4 [1]
	1-[3-Methoxy-4-(2-pyridin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	23.5 [1]
	2-(3,4-Dimethoxyphenyl)-5-methyl-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	2570.0 [1]
	1-[4-[4-[(5-Fluoropyrimidin-2-yl)amino]butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	17.5 [1]
	1-[3-Methoxy-4-(2-piperazin-1-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	0.7 [1]
	1-[4-[2-(2-Aminopyridin-4-yl)ethoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	5.5 [1]
	2-(4-Fluorophenyl)-N-(3-imidazol-1-ylpropyl)-3-methylaniline	IC50	830.0 [1]
	1-[3-Methoxy-4-[4-(pyrimidin-2-ylamino)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	5.7 [1]
	1-[4-[4-(6-Aminopyridin-2-yl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	19.3 [1]
	1-[3-Methoxy-4-(4-pyrimidin-5-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	21.3 [1]
	1-[3-Methoxy-4-[3-(1-methylpiperidin-4-yl)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	20.2 [1]
	1-[3-Methoxy-4-[2-(1-methylpiperidin-4-yl)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	4.6 [1]
	1-[4-[4-(2,6-Diaminopyridin-4-yl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	15.3 [1]
	1-[4-[4-(2-Aminopyrimidin-5-yl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	18.4 [1]
	1-[3-Methoxy-4-(4-pyridin-4-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	9.1 [1]
	1-[4-(2-Aminoethoxy)-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	30.2 [1]
	1-[4-[3-(Diaminomethylideneamino)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	41.2 [1]
	1-[4-[2-(4-Aminophenyl)ethoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	7.7 [1]
	1-[4-(4-Aminobutoxy)-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	13.8 [1]
	1-[3-Methoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	11.7 [1]
	2-(3,4-Dimethoxyphenyl)-4-methyl-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	940.0 [1]
	2-(4-Fluorophenyl)-3-methyl-N-[3-(4-methylimidazol-1-yl)propyl]aniline	IC50	790.0 [1]
	1-[3-Methoxy-4-[4-(1-methylpiperidin-4-yl)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thiourea	IC50	12.3 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutaminyl-peptide cyclotransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/glutaminyl-peptide-cyclotransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Glutaminyl-peptide cyclotransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutaminyl-peptide-cyclotransferase-inhibitors-ic50-ki.
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