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Glutaminyl-peptide cyclotransferase Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
1-(3,4-Dimethoxyphenyl)-3-[3-(1h-Imidazol-1-Yl)propyl]thioureaIC505300.0 [1]
1-(3,4-Dimethoxyphenyl)-3-[3-(1h-Imidazol-1-Yl)propyl]thioureaKi60.0 [1]
1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thioureaIC5029.2 [1], 119.0 [2]
1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thioureaKi6.3 [1]
Thioamide deriv. 81Ki90.0 [1]
5-(5-(Benzylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazoleIC504240.0 [1]
2-(1H-Benzo[d]imidazol-5-yl)-5-(methylthio)-1,3,4-oxadiazoleIC5024800.0 [1]
5-(5-(Phenethylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazoleIC507260.0 [1]
5-(5-(3-Phenylpropylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazoleIC507560.0 [1]
5-(5-((Naphthalen-2-yl)methylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazoleIC508670.0 [1]
5-(5-(Allylthio)-1,3,4-oxadiazol-2-yl)benzimidazoleIC507230.0 [1]
5-(5-(Ethylthio)-1,3,4-oxadiazol-2-yl)benzimidazoleIC5014700.0 [1]
5-(3H-Benzimidazol-5-yl)-N-benzyl-1,3,4-oxadiazol-2-amineIC5028130.0 [1]
BenzimidazoleKi150000.0 [1]
7,4'-DihydroxyflavoneIC5045200.0 [1]
N-(4-Ethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]thioureaKi890.0 [1]
3-(3-(1H-Imidazol-1-yl)propyl)-2-thioxoimidazolidin-4-oneKi700.0 [1]
1-Cyclohexyl-3-[3-(1H-imidazol-1-yl)propyl]thioureaKi4700.0 [1]
3-[3-(1H-Imidazol-1-yl)propyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-oneKi300.0 [1]
1-[3-(1H-Imidazol-1-yl)propyl]-3-(4-methoxyphenyl)thioureaKi700.0 [1]
1-(3-(1H-Imidazol-1-yl)propyl)-3-(4-acetylphenyl)thioureaKi1790.0 [1]
1-[3-(4-Methylphenoxy)propyl]-1H-imidazoleKi7700.0 [1]
5,7-Dihydroxy-2-(2-fluorophenyl)-4H-1-benzopyran-4-oneIC5034600.0 [1]
[(3-Imidazolylpropyl)amino](phenylamino)methane-1-thioneKi4480.0 [1]
Rac-PQ-912IC50482.0 [1]
Glutaminyl Cyclase Inhibitor 2IC501230.0 [1]
1-Alkylimidazole thiourea deriv. 52Ki340.0 [1]
2-[4-(Dimethylamino)phenyl]-7-hydroxy-4H-1-benzopyran-4-oneIC5016800.0 [1]
(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-methylguanidineKi1530.0 [1]
(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-phenylguanidineKi1020.0 [1]
(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-(3,4-dimethoxyphenyl)guanidineKi1360.0 [1]
(3-(1H-Imidazol-1-yl)propyl)-2-cyano-3-(4-methoxyphenyl)guanidineKi700.0 [1]
5,7-Dihydroxy-2-thiophen-2-ylchromen-4-oneIC5015300.0 [1]
5,7-Dihydroxy-2-(5-methylthiophen-2-yl)chromen-4-oneIC5015000.0 [1]
5,7-Dihydroxy-2-(3-methylphenyl)chromen-4-oneIC5016100.0 [1]
2-(4-Ethylphenyl)-5,7-dihydroxychromen-4-oneIC5037200.0 [1]
2-(4-Ethoxyphenyl)-5,7-dihydroxychromen-4-oneIC5014200.0 [1]
5,7-Dihydroxy-2-(3-methylthiophen-2-yl)chromen-4-oneIC5019300.0 [1]
Glutaminyl Cyclase Inhibitor 1IC50500.0 [1]
1-[3-Methoxy-4-(4-pyridin-3-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5019.8 [1]
1-[3-Methoxy-4-(2-piperidin-1-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5024.7 [1]
1-[4-[3-(2,6-Diaminopyridin-4-yl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5016.6 [1]
3-Fluoro-2-(4-fluorophenyl)-N-(3-imidazol-1-ylpropyl)anilineIC501560.0 [1]
1-[4-[2-(Dimethylamino)ethoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5038.6 [1]
2-(3,4-Dimethoxyphenyl)-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC50890.0 [1]
2-(3,4-Dimethoxyphenyl)-6-fluoro-N-(3-imidazol-1-ylpropyl)anilineIC501380.0 [1]
1-[4-[3-(2-Aminopyrimidin-5-yl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5020.5 [1]
1-[4-[3-(4-Aminophenyl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC509.0 [1]
1-[3-Methoxy-4-(3-pyridin-4-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5014.4 [1]
1-[3-Methoxy-4-(3-piperidin-1-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5013.4 [1]
1-[3-Methoxy-4-[3-(pyrimidin-2-ylamino)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5017.5 [1]
1-[3-Methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5012.5 [1]
2-(3-Fluorophenyl)-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC5015500.0 [1]
1-[3-Methoxy-4-[2-(methylamino)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5038.7 [1]
2-(3,4-Dimethoxyphenyl)-3-methyl-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC50700.0 [1]
1-[3-Methoxy-4-[4-(4-methylpiperazin-1-yl)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC508.2 [1]
2-(4-Fluorophenyl)-5-methyl-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC501620.0 [1]
1-[4-[4-(Dimethylamino)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC503.7 [1]
1-[3-Methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC507.3 [1]
N-[3-[2-Methoxy-4-[3-(5-methylimidazol-1-yl)propylcarbamothioylamino]phenoxy]propyl]acetamideIC5040.8 [1]
N-[4-[4-[2-Methoxy-4-[3-(5-methylimidazol-1-yl)propylcarbamothioylamino]phenoxy]butyl]pyridin-2-yl]acetamideIC5019.0 [1]
1-[3-Methoxy-4-(3-piperidin-4-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC507.2 [1]
1-[4-[3-(2-Aminopyridin-4-yl)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5010.7 [1]
2-(4-Fluorophenyl)-N-(3-imidazol-1-ylpropyl)anilineIC503020.0 [1]
1-[3-Methoxy-4-[4-(methylamino)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5016.2 [1]
1-[3-Methoxy-4-(2-piperidin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5013.8 [1]
1-[4-[3-[(5-Fluoropyrimidin-2-yl)amino]propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5018.5 [1]
1-[3-Methoxy-4-[3-(methylamino)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC506.9 [1]
1-[3-Methoxy-4-(4-piperidin-1-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5012.5 [1]
2-(3,4-Dimethoxyphenyl)-N-(3-imidazol-1-ylpropyl)anilineIC502080.0 [1]
3-Fluoro-2-(4-fluorophenyl)-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC50880.0 [1]
1-[3-Methoxy-4-(4-piperidin-4-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC507.8 [1]
1-[3-Methoxy-4-(3-morpholin-4-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5014.1 [1]
1-[3-Methoxy-4-[2-(pyrimidin-2-ylamino)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5039.4 [1]
2-(3,4-Dimethoxyphenyl)-N-(3-imidazol-1-ylpropyl)-3-methylanilineIC50640.0 [1]
1-[4-(3-Aminopropoxy)-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC505.3 [1]
1-[4-[4-(4-Aminophenyl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC508.3 [1]
1-[3-Methoxy-4-(3-piperazin-1-ylpropoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5011.4 [1]
1-[3-Methoxy-4-(2-pyridin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5023.5 [1]
2-(3,4-Dimethoxyphenyl)-5-methyl-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC502570.0 [1]
1-[4-[4-[(5-Fluoropyrimidin-2-yl)amino]butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5017.5 [1]
1-[3-Methoxy-4-(2-piperazin-1-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC500.7 [1]
1-[4-[2-(2-Aminopyridin-4-yl)ethoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC505.5 [1]
2-(4-Fluorophenyl)-N-(3-imidazol-1-ylpropyl)-3-methylanilineIC50830.0 [1]
1-[3-Methoxy-4-[4-(pyrimidin-2-ylamino)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC505.7 [1]
1-[4-[4-(6-Aminopyridin-2-yl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5019.3 [1]
1-[3-Methoxy-4-(4-pyrimidin-5-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5021.3 [1]
1-[3-Methoxy-4-[3-(1-methylpiperidin-4-yl)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5020.2 [1]
1-[3-Methoxy-4-[2-(1-methylpiperidin-4-yl)ethoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC504.6 [1]
1-[4-[4-(2,6-Diaminopyridin-4-yl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5015.3 [1]
1-[4-[4-(2-Aminopyrimidin-5-yl)butoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5018.4 [1]
1-[3-Methoxy-4-(4-pyridin-4-ylbutoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC509.1 [1]
1-[4-(2-Aminoethoxy)-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5030.2 [1]
1-[4-[3-(Diaminomethylideneamino)propoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5041.2 [1]
1-[4-[2-(4-Aminophenyl)ethoxy]-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC507.7 [1]
1-[4-(4-Aminobutoxy)-3-methoxyphenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5013.8 [1]
1-[3-Methoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5011.7 [1]
2-(3,4-Dimethoxyphenyl)-4-methyl-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC50940.0 [1]
2-(4-Fluorophenyl)-3-methyl-N-[3-(4-methylimidazol-1-yl)propyl]anilineIC50790.0 [1]
1-[3-Methoxy-4-[4-(1-methylpiperidin-4-yl)butoxy]phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]thioureaIC5012.3 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Glutaminyl-peptide cyclotransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc.21 Dec2024https://www.aatbio.com/data-sets/glutaminyl-peptide-cyclotransferase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 21). Quest Database™ Glutaminyl-peptide cyclotransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutaminyl-peptide-cyclotransferase-inhibitors-ic50-ki.
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