Glutamate receptor ionotropic kainate 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	IC50	29000.0 [1]
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	Ki	13200.0 [1], 100000.0 [2]
	Tezampanel	Ki	100000.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-naphthalen-2-ylprop-2-enyl]pentanedioic acid	Ki	10000.0 [1], 13723.0 [2], 15406.0 [3], 15410.0 [4]
	Kainic acid	Ki	32.0 [1], 32.4 [2], 53.0 [3]
	Glutamic acid	Ki	1106.0 [1]
	4-Chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid	IC50	62000.0 [1]
	2-(3-(3-Bromophenyl)ureido)-4-chlorobenzoic acid	IC50	28000.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-(2-methoxyphenyl)prop-2-enyl]pentanedioic acid	Ki	48.0 [1]
	(3S,4Ar,6S,8aR)-6-[(4-carboxyimidazol-1-yl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;dihydrochloride	Ki	236000.0 [1], 1000000.0 [2]
	(2S,4R)-2-Amino-4-[(E)-3-(4-chlorophenyl)prop-2-enyl]pentanedioic acid	Ki	3859.0 [1], 4649.0 [2]
	alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	Ki	100000.0 [1]
	(S)-Ampa	Ki	1000000.0 [1]
	2S,4R-4-Methylglutamate	Ki	10.0 [1]
	Dysiherbaine	Ki	1.2 [1]
	LY382884	Ki	100000.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione	IC50	300000.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3(2-carboxythiophene-3-YL-methyl)-5-methylpyrimidine-2,4-dione	IC50	100000.0 [1]
	2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid	Ki	100000.0 [1]
	4-Methylene-L-glutamic acid	Ki	450.0 [1]
	Cl-HIBO	Ki	100000.0 [1]
	(3S,4Ar,6S,8aR)-6-[[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	50.0 [1]
	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Ki	100000.0 [1]
	2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid	Ki	100000.0 [1]
	(2S,4R)-4-Propylglutamic acid	Ki	2450.0 [1]
	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Ki	100000.0 [1]
	3-[[3-[(2S)-2-Amino-2-carboxyethyl]-5-methyl-2,6-dioxopyrimidin-1-yl]methyl]-5-phenylthiophene-2-carboxylic acid	IC50	100000.0 [1]
	(S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-YL)isoxazol-4-YL]propionic acid	Ki	18800.0 [1]
	(2R,4S)-2-Allyl-4-aminopentanedioic acid	Ki	1840.0 [1]
	(4R)-4-(3-Phenylpropyl)-L-glutamic acid	Ki	10000.0 [1]
	(2S,4R)-4-Pentylglutamic acid	Ki	41152.0 [1]
	(3S,4As,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenoxy]-decahydro-isoquinoline-3-carboxylic acid	Ki	100000.0 [1]
	(3S,4Ar,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenylamino]-decahydro-isoquinoline-3-carboxylic acid	Ki	100000.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione	IC50	100000.0 [1]
	(3R,4E,6E)-7-[4,5-Bis(1-hydroxyethenyl)pyrrolidin-3-yl]-3-methylocta-1,4,6-trien-2-ol	Ki	18.3 [1]
	(2R,3S)-1-(9-Iodophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid	IC50	100000.0 [1]
	1-(3-Bromophenyl)-3-[5-chloro-2-(2H-tetrazol-5-yl)phenyl]urea	IC50	10000.0 [1]
	(2S)-2-Amino-4-cyclopentylidenepentanedioic acid	Ki	100000.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-(3,4-dimethylphenyl)ethenyl]pyrrolidine-3-acetic acid	Ki	107.8 [1]
	CID 10330442	Ki	82500.0 [1]
	4-[(E)-2,2-Dimethylpropylidene]-L-glutamic acid	Ki	100000.0 [1]
	(2s)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	100000.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-(4-methylphenyl)ethenyl]pyrrolidine-3-acetic acid	Ki	41.1 [1]
	(2S)-2-Amino-4-pentan-3-ylidenepentanedioic acid	Ki	207000.0 [1]
	(2r)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	1000000.0 [1]
	2-[7-[3-[[(4-Nitrophenyl)carbamoylamino]methyl]pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	610.0 [1]
	E-2-Amino-4-[3-(2-chloro-phenyl)-allyl]-pentanedioic acid	Ki	1404.0 [1]
	E-2-Amino-4-[3-(4-carboxy-phenyl)-allyl]-pentanedioic acid	Ki	27280.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-(3-butoxyphenyl)ethenyl]pyrrolidine-3-acetic acid	Ki	275.3 [1]
	(2S,3S,4S)-4-(1-Biphenyl-3-yl-vinyl)-3-carboxymethyl-pyrrolidine-2-carboxylic acid	Ki	90.6 [1]
	E-2-Amino-4-[3-(4-isopropyl-phenyl)-allyl]-pentanedioic acid	Ki	27532.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-[4-(1-ethylethenyl)phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	288.0 [1]
	E-2-Amino-4-[3-(2,6-dichloro-phenyl)-allyl]-pentanedioic acid	Ki	1568.0 [1]
	(2S,3S,4R)-3-(Carboxymethyl)-4-[1-(3-phenylphenyl)ethyl]pyrrolidine-2-carboxylic acid	Ki	10000.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-[4-(phenethyloxy)phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	126.2 [1]
	(2S,4R)-2-Amino-4-[(Z)-pent-2-enyl]pentanedioic acid	Ki	22529.0 [1]
	(2S,3S,4R)-3-(Carboxymethyl)-4-[1-(4-prop-1-en-2-ylphenyl)ethenyl]pyrrolidine-2-carboxylic acid	Ki	2303.3 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-(4-propylphenyl)ethenyl]pyrrolidine-2-carboxylic acid	Ki	146.8 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-(4-butoxyphenyl)ethenyl]pyrrolidine-3-acetic acid	Ki	146.6 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-(4-phenoxyphenyl)ethenyl]pyrrolidine-2-carboxylic acid	Ki	209.6 [1]
	2-Amino-4-but-2-enyl-pentanedioic acid	Ki	5373.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-(3-methyl-4-fluorophenyl)ethenyl]pyrrolidine-3-acetic acid	Ki	54.3 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-(4-chlorophenyl)ethenyl]pyrrolidine-2-carboxylic acid	Ki	31.7 [1]
	2-Amino-4-hex-2-ynyl-pentanedioic acid	Ki	68547.0 [1]
	2-Amino-4-(2-methyl-3-phenyl-allyl)-pentanedioic acid	Ki	500.0 [1]
	E-2-Amino-4-[3-(4-fluoro-phenyl)-allyl]-pentanedioic acid	Ki	559.0 [1]
	E-2-Amino-4-[3-(4-methoxy-phenyl)-allyl]-pentanedioic acid	Ki	22340.0 [1]
	E-2-Amino-4-[3-(4-trifluoromethyl-phenyl)-allyl]-pentanedioic acid	Ki	43929.0 [1]
	(2S,3S,4S)-4-[1-(4-Butylphenyl)ethenyl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid	Ki	145.6 [1]
	(2S,3S,4S)-4-[1-(4-Tert-butylphenyl)ethenyl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid	Ki	262.7 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-[3-(2-phenylethoxy)phenyl]ethenyl]pyrrolidine-2-carboxylic acid	Ki	667.0 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-[3-methyl-4-(2-phenylethoxy)phenyl]ethenyl]pyrrolidine-2-carboxylic acid	Ki	129.3 [1]
	2-Amino-4-pent-2-ynyl-pentanedioic acid	Ki	10247.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-(3-methoxyphenyl)ethenyl]pyrrolidine-3-acetic acid	Ki	93.5 [1]
	2-Amino-4-pent-2-enyl-pentanedioic acid	Ki	2984.0 [1]
	E-2-Amino-4-[3-(4-methylsulfanyl-phenyl)-allyl]-pentanedioic acid	Ki	6024.0 [1]
	(2S,3S,4R)-2-Carboxy-4-(1-phenylethenyl)pyrrolidine-3-acetic acid	Ki	6969.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-[4-(1-methylethenyl)phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	131.5 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-[3-(3,3-diphenylpropoxy)phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	2423.3 [1]
	(2S,3S,4R)-3-(Carboxymethyl)-4-(1-phenylethyl)pyrrolidine-2-carboxylic acid	Ki	10000.0 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-(4-ethylphenyl)ethenyl]pyrrolidine-2-carboxylic acid	Ki	82.2 [1]
	(2S,3S,4S)-4-(1-Biphenyl-4-yl-vinyl)-3-carboxymethyl-pyrrolidine-2-carboxylic acid	Ki	130.6 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-[4-[(5-phenylpentyl)oxy]phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	1295.7 [1]
	(2S,3S,4S)-3-(Carboxymethyl)-4-[1-(4-fluorophenyl)ethenyl]pyrrolidine-2-carboxylic acid	Ki	38.4 [1]
	E-2-Amino-4-[3-(4-cyano-phenyl)-allyl]-pentanedioic acid	Ki	4491.0 [1]
	E-2-Amino-4-[3-(3-chloro-phenyl)-allyl]-pentanedioic acid	Ki	1132.0 [1]
	E-2-Amino-4-[3-(4-nitro-phenyl)-allyl]-pentanedioic acid	Ki	3845.0 [1]
	(2S,3S,4S)-2-Carboxy-4-[1-[3-methoxy-4-(phenethyloxy)phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	1284.0 [1]
	2-Amino-4-hexyl-pentanedioic acid	Ki	7207.0 [1]
	(2S,3S,4S)-2-Carboxy-4-(1-phenylethenyl)pyrrolidine-3-acetic acid	Ki	29.8 [1]
	E-2-Amino-4-[3-(3,4-dimethoxy-phenyl)-allyl]-pentanedioic acid	Ki	13949.0 [1]
	(2S,3S,4R)-4-(1-Biphenyl-3-yl-vinyl)-3-carboxymethyl-pyrrolidine-2-carboxylic acid	Ki	3109.2 [1]
	(2S,3S,4R)-2-Carboxy-4-[1-[3-(3,3-diphenylpropoxy)phenyl]ethenyl]pyrrolidine-3-acetic acid	Ki	10000.0 [1]
	(2S,4S)-2-Amino-4-prop-2-ynylpentanedioic acid	Ki	823.0 [1]
	(2S,4R)-2-Amino-4-[(E)-but-2-enyl]pentanedioic acid	Ki	3258.0 [1]
	2-Amino-4-(3-chloro-allyl)-pentanedioic acid	Ki	2893.0 [1]
	2-Amino-4-(3-phenyl-prop-2-ynyl)-pentanedioic acid	Ki	1000.0 [1]
	Z-2-Amino-4-(3-phenyl-allyl)-pentanedioic acid	Ki	339.0 [1]
	E-2-Amino-4-(3-p-tolyl-allyl)-pentanedioic acid	Ki	4375.0 [1]
	E-2-Amino-4-[3-(3-methoxy-phenyl)-allyl]-pentanedioic acid	Ki	6349.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate receptor ionotropic kainate 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-kainate-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glutamate receptor ionotropic kainate 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-kainate-2-inhibitors-ic50-ki.
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