Glutamate receptor ionotropic kainate 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	IC50	37000.0 [1], 50000.0 [2]
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	Ki	11730.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-naphthalen-2-ylprop-2-enyl]pentanedioic acid	Ki	14.0 [1], 14.8 [2], 15.0 [3], 10000.0 [4]
	4-Chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid	IC50	1200.0 [1], 30000.0 [2], 69000.0 [3]
	2-(3-(3-Bromophenyl)ureido)-4-chlorobenzoic acid	IC50	4800.0 [1], 30000.0 [2]
	Tezampanel	IC50	500.0 [1]
	Tezampanel	Ki	4160.0 [1], 4200.0 [2]
	Glutamic acid	Ki	701.0 [1]
	Kainic acid	Ki	177.0 [1]
	Apoptosis Inhibitor II, NS3694	IC50	5000.0 [1]
	(3S,4As,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenoxy]-decahydro-isoquinoline-3-carboxylic acid	Ki	1200.0 [1], 1690.0 [2]
	(3S,4Ar,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenylamino]-decahydro-isoquinoline-3-carboxylic acid	Ki	800.0 [1], 1550.0 [2]
	(3S,4Ar,6S,8aR)-6-[(4-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	3600.0 [1]
	1-(3-Bromophenyl)-3-[5-chloro-2-(2H-tetrazol-5-yl)phenyl]urea	IC50	2000.0 [1], 30000.0 [2]
	2-[3-(3-Bromophenyl)ureido]-4-chlorobenzenesulfonic acid	IC50	1500.0 [1], 30000.0 [2]
	1-(3-Bromophenyl)-3-[5-chloro-2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]urea	IC50	4600.0 [1], 30000.0 [2]
	(2S,4R)-2-Amino-4-[(E)-3-(4-chlorophenyl)prop-2-enyl]pentanedioic acid	Ki	8.0 [1]
	{2-[3-(3-Bromophenyl)ureido]-4-chlorophenyl}acetic acid	IC50	3600.0 [1], 30000.0 [2]
	alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	Ki	740.0 [1]
	(S)-Ampa	Ki	1150.0 [1]
	2S,4R-4-Methylglutamate	Ki	3.0 [1]
	Dysiherbaine	Ki	0.74 [1]
	LY382884	Ki	17130.0 [1]
	N-(3-(Trifluoromethyl)phenyl)-N'-(2-hydroxy-5-chlorophenyl)urea	IC50	30000.0 [1]
	Benzoic acid, 2-((((3-(trifluoromethyl)phenyl)amino)carbonyl)amino)-	IC50	72000.0 [1]
	2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid	Ki	4800.0 [1]
	4-Methylene-L-glutamic acid	Ki	270.0 [1]
	Cl-HIBO	Ki	6800.0 [1]
	5-Carboxy-2,4-dibenzamidobenzoic acid	IC50	1600.0 [1]
	(3S,4Ar,6S,8aR)-6-[[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	50.0 [1]
	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Ki	5450.0 [1]
	2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid	Ki	2920.0 [1]
	(2S,4R)-4-Propylglutamic acid	Ki	123.0 [1]
	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Ki	34200.0 [1]
	2-[(Anilinocarbonyl)amino]benzoic acid	IC50	100000.0 [1]
	(S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-YL)isoxazol-4-YL]propionic acid	Ki	81.0 [1]
	(2R,4S)-2-Allyl-4-aminopentanedioic acid	Ki	56.0 [1]
	(4R)-4-(3-Phenylpropyl)-L-glutamic acid	Ki	1190.0 [1]
	(2S,4R)-4-Pentylglutamic acid	Ki	267.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione	IC50	680.0 [1]
	(2S)-2-Amino-3-(2,4-dioxo-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl)propanoic acid	IC50	3.8 [1]
	(2S)-2-Amino-3-(2,4-dioxothieno[3,2-d]pyrimidin-1-yl)propanoic acid	IC50	1.9 [1]
	(2R,3S)-1-(9-Iodophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid	IC50	650.0 [1]
	4-Chloro-2-[(3-iodophenyl)carbamoylamino]benzoic Acid	IC50	2200.0 [1]
	2-(3-Benzo[1,3]dioxol-5-yl-ureido)-4-chloro-benzoic acid	IC50	3600.0 [1]
	4-Chloro-2-[3-(4-fluoro-phenyl)-ureido]-benzoic acid	IC50	14000.0 [1]
	4-Chloro-2-[3-(4-chloro-phenyl)-ureido]-benzoic acid	IC50	3100.0 [1]
	2-[3-(4-Bromo-phenyl)-ureido]-4-chloro-benzoic acid	IC50	2200.0 [1]
	2-Methyl-6-[3-(3-trifluoromethyl-phenyl)-ureido]-benzoic acid	IC50	100000.0 [1]
	3-[3-(3-Trifluoromethyl-phenyl)-ureido]-naphthalene-2-carboxylic acid	IC50	60000.0 [1]
	(2S)-2-Amino-4-cyclopentylidenepentanedioic acid	Ki	32.6 [1]
	4-Trifluoromethyl-2-[3-(3-trifluoromethyl-phenyl)-ureido]-benzoic acid	IC50	21000.0 [1]
	4-Chloro-2-[3-(2-hydroxy-phenyl)-ureido]-benzoic acid	IC50	21000.0 [1]
	5-Methyl-2-[3-(3-trifluoromethyl-phenyl)-ureido]-benzoic acid	IC50	100000.0 [1]
	3-Methyl-2-[3-(3-trifluoromethyl-phenyl)-ureido]-benzoic acid	IC50	100000.0 [1]
	4-Bromo-2-[3-(3-trifluoromethyl-phenyl)-ureido]-benzoic acid	IC50	6100.0 [1]
	4-Chloro-2-[3-(2-trifluoromethyl-phenyl)-ureido]-benzoic acid	IC50	4500.0 [1]
	4-Chloro-2-[3-(4-iodo-phenyl)-ureido]-benzoic acid	IC50	4700.0 [1]
	CID 10330442	Ki	54.4 [1]
	4-[(E)-2,2-Dimethylpropylidene]-L-glutamic acid	Ki	85.7 [1]
	4-Chloro-2-(3-phenyl-ureido)-benzoic acid	IC50	10000.0 [1]
	4-Chloro-2-(3-cyclohexyl-ureido)-benzoic acid	IC50	100000.0 [1]
	2-[3-(2-Bromo-phenyl)-ureido]-4-chloro-benzoic acid	IC50	4500.0 [1]
	(2s)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	18500.0 [1]
	4-Chloro-2-[3-(2-methoxy-phenyl)-ureido]-benzoic acid	IC50	12000.0 [1]
	4-Chloro-2-[3-(3-chloro-phenyl)-ureido]-benzoic acid	IC50	1300.0 [1]
	2-(3-Biphenyl-2-yl-ureido)-4-chloro-benzoic acid	IC50	10000.0 [1]
	4-Chloro-2-(3-thiophen-2-yl-ureido)-benzoic acid	IC50	18000.0 [1]
	(2S)-2-Amino-4-pentan-3-ylidenepentanedioic acid	Ki	241.0 [1]
	4-Chloro-2-(3-pyridin-2-yl-ureido)-benzoic acid	IC50	31000.0 [1]
	4-Chloro-2-(3-pyridin-4-yl-ureido)-benzoic acid	IC50	88000.0 [1]
	4-Chloro-2-[3-(2-iodo-phenyl)-ureido]-benzoic acid	IC50	5000.0 [1]
	(2r)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	10000.0 [1]
	2-(3-Biphenyl-4-yl-ureido)-4-chloro-benzoic acid	IC50	29000.0 [1]
	2-[7-[3-[[(4-Nitrophenyl)carbamoylamino]methyl]pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	100.0 [1]
	4-Chloro-2-[3-(4-methoxy-phenyl)-ureido]-benzoic acid	IC50	10000.0 [1]
	2-(3-Biphenyl-3-yl-ureido)-4-chloro-benzoic acid	IC50	12000.0 [1]
	E-2-Amino-4-[3-(2-chloro-phenyl)-allyl]-pentanedioic acid	Ki	254.0 [1]
	E-2-Amino-4-[3-(4-carboxy-phenyl)-allyl]-pentanedioic acid	Ki	3590.0 [1]
	E-2-Amino-4-[3-(4-isopropyl-phenyl)-allyl]-pentanedioic acid	Ki	58.0 [1]
	E-2-Amino-4-[3-(2,6-dichloro-phenyl)-allyl]-pentanedioic acid	Ki	131.0 [1]
	(2S,4R)-2-Amino-4-[(Z)-pent-2-enyl]pentanedioic acid	Ki	160.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-(2-methoxyphenyl)prop-2-enyl]pentanedioic acid	Ki	26.0 [1]
	2-Amino-4-but-2-enyl-pentanedioic acid	Ki	577.0 [1]
	2-Amino-4-hex-2-ynyl-pentanedioic acid	Ki	3606.0 [1]
	2-Amino-4-(2-methyl-3-phenyl-allyl)-pentanedioic acid	Ki	670.0 [1]
	E-2-Amino-4-[3-(4-fluoro-phenyl)-allyl]-pentanedioic acid	Ki	78.0 [1]
	E-2-Amino-4-[3-(4-methoxy-phenyl)-allyl]-pentanedioic acid	Ki	284.0 [1]
	E-2-Amino-4-[3-(4-trifluoromethyl-phenyl)-allyl]-pentanedioic acid	Ki	52.0 [1]
	2-Amino-4-pent-2-ynyl-pentanedioic acid	Ki	831.0 [1]
	2-Amino-4-pent-2-enyl-pentanedioic acid	Ki	161.0 [1]
	E-2-Amino-4-[3-(4-methylsulfanyl-phenyl)-allyl]-pentanedioic acid	Ki	32.0 [1]
	E-2-Amino-4-[3-(4-cyano-phenyl)-allyl]-pentanedioic acid	Ki	367.0 [1]
	E-2-Amino-4-[3-(3-chloro-phenyl)-allyl]-pentanedioic acid	Ki	60.0 [1]
	E-2-Amino-4-[3-(4-nitro-phenyl)-allyl]-pentanedioic acid	Ki	59.0 [1]
	2-Amino-4-hexyl-pentanedioic acid	Ki	2376.0 [1]
	E-2-Amino-4-[3-(3,4-dimethoxy-phenyl)-allyl]-pentanedioic acid	Ki	540.0 [1]
	(2S,4S)-2-Amino-4-prop-2-ynylpentanedioic acid	Ki	307.0 [1]
	(2S,4R)-2-Amino-4-[(E)-but-2-enyl]pentanedioic acid	Ki	21.0 [1]
	2-Amino-4-(3-chloro-allyl)-pentanedioic acid	Ki	41.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate receptor ionotropic kainate 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-kainate-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glutamate receptor ionotropic kainate 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-kainate-1-inhibitors-ic50-ki.
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