Glutamate receptor ionotropic AMPA Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	IC50	52.0 [1], 200.0 [2]
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	Ki	70.0 [1]
	6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione	IC50	200.0 [1], 280.0 [2]
	6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione	Ki	360.0 [1]
	alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	IC50	19.0 [1], 23.0 [2], 364.0 [3]
	Tezampanel	IC50	1350.0 [1], 4800.0 [2]
	6-Imidazol-1-yl-7-nitro-1,4-dihydro-quinoxaline-2,3-dione	Ki	135.0 [1]
	alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid	IC50	88000.0 [1], 98000.0 [2]
	alpha-Amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)methyl-5-methyl-3-oxo-4-isoxazoline-4-propionic acid	IC50	12000.0 [1], 335000.0 [2]
	1-(Carboxymethyl)-6-nitro-7-(1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione	Ki	70.0 [1]
	(3S,4Ar,6R,8aR)-6-[2-(4H-triazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	IC50	1350.0 [1], 4810.0 [2]
	2-[2,3-Dioxo-7-[3-[(phenylcarbamoylamino)methyl]pyrrol-1-yl]-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	15.0 [1]
	1-Carboxymethyl-7-(1-pyrrolyl)-6-trifluoromethyl-2,3(1H,4H)-quinoxalinedione	Ki	180.0 [1]
	6-(1-Pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione	Ki	3000.0 [1]
	6-(1-Pyrrolyl)-7-nitro-2,3(1H,4H)-quinoxalinedione	Ki	400.0 [1]
	Glutamic acid	IC50	613.0 [1]
	7-Nitro-2,3-Dioxo-2,3-Dihydroquinoxaline-6-Carbonitrile	IC50	340.0 [1]
	Selfotel	IC50	967.0 [1]
	5,7-Dichlorokynurenic acid	IC50	100000.0 [1]
	6,7-Dichloroquinoxaline-2,3(1H,4H)-dione	IC50	27000.0 [1]
	6,7-Dichloro-3-hydroxy-2-quinoxalinecarboxylic acid	IC50	6700.0 [1]
	1,4-Dihydro-6-nitroquinoxaline-2,3-dione	IC50	2000.0 [1]
	[(1S)-1-{[(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid	IC50	3000.0 [1]
	2-Hydroxy-N,N,7-trimethyl-3-nitroso-6,8-dihydro-1H-pyrrolo[3,4-g]indole-5-sulfonamide	IC50	700.0 [1]
	9-Methyl-6-nitro-4,7,8,10-tetrahydro-1H-pyrido[3,4-f]quinoxaline-2,3-dione	IC50	80.0 [1]
	(3S,4Ar,6S,8aR)-6-(2H-tetrazol-5-yl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	IC50	100000.0 [1]
	2-Amino-3-[3-hydroxy-5-(1-methyl-1H-tetrazol-5-yl)-isoxazol-4-yl]-propionic acid	IC50	54000.0 [1]
	7,8-Dichloroimidazo[1,2-a]quinoxalin-4(5H)-one	IC50	7000.0 [1]
	(3S,4Ar,6S,8aR)-6-(2H-tetrazol-5-ylmethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	IC50	84500.0 [1]
	2-Amino-3-[3-oxo-5-(1,3-thiazol-2-yl)-1,2-oxazol-4-yl]propanoic acid	IC50	94.0 [1]
	2-[4-[4-(7-(111C)Methoxynaphthalen-1-yl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,5-dione	Ki	10000.0 [1]
	2-[4-[4-(3-Methoxyphenyl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,5-dione	Ki	10000.0 [1]
	2-Amino-3-[5-(2-methyltetrazol-5-yl)-3-oxo-1,2-oxazol-4-yl]propanoic acid	IC50	30.0 [1]
	N-(6,7-Dichloro-3-oxo-3,4-dihydro-quinoxaline-2-carbonyl)-benzenesulfonamide	IC50	4300.0 [1]
	1,1,1-Trifluoro-N-(7-nitro-2-oxo-1H-quinolin-3-yl)methanesulfonamide	Ki	600.0 [1]
	6-Nitro-9-propan-2-yl-4,7,8,10-tetrahydro-1H-pyrido[3,4-f]quinoxaline-2,3-dione	IC50	153.0 [1]
	Pyrido[3,2-f]quinoxaline-2,3-dione, 1,4,7,8,9,10-hexahydro-	IC50	24000.0 [1]
	[(1S)-1-[(7-Iodo-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methylamino]ethyl]phosphonic acid	IC50	340.0 [1]
	7,8-Dichloro-5H-[1,2,4]triazolo[4,3-a]quinoxalin-4-one	IC50	8000.0 [1]
	7,8-Dichlorotetrazolo[1,5-a]quinoxalin-4(5H)-one	IC50	100000.0 [1]
	(9S)-9-Ethyl-3-hydroxy-6-nitro-7,8,9,10-tetrahydropyrido[3,4-f]quinoxalin-9-ium-2-olate	IC50	166.0 [1]
	Methyl 8-methyl-2,3-dioxo-4,7,9,10-tetrahydro-1H-pyrido[4,3-f]quinoxaline-6-carboxylate	IC50	44000.0 [1]
	2-[7-[3-[[(4-Nitrophenyl)carbamoylamino]methyl]pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	5.0 [1]
	(3S,4Ar,6R,8aR)-6-(2H-tetrazol-5-yl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	IC50	100000.0 [1]
	2-Amino-3-[5-(1-methylimidazol-2-yl)-3-oxo-1,2-oxazol-4-yl]propanoic acid	IC50	100000.0 [1]
	(3S,4Ar,6S,8aR)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3,6-dicarboxylic acid	IC50	100000.0 [1]
	2-Amino-3-[5-(2-methyl-1,2,4-triazol-3-yl)-3-oxo-1,2-oxazol-4-yl]propanoic acid	IC50	5800.0 [1]
	2-Amino-3-[3-oxo-5-(1H-1,2,4-triazol-5-yl)-1,2-oxazol-4-yl]propanoic acid	IC50	1500.0 [1]
	2-Amino-3-[3-oxo-5-(2H-tetrazol-5-yl)-1,2-oxazol-4-yl]propanoic acid	IC50	72000.0 [1]
	2-Amino-3-[5-(1H-imidazol-2-yl)-3-oxo-1,2-oxazol-4-yl]propanoic acid	IC50	48000.0 [1]
	2-Amino-3-[5-(1-methyl-1,2,4-triazol-3-yl)-3-oxo-1,2-oxazol-4-yl]propanoic acid	IC50	700.0 [1]
	9-Cyclopentyl-2-pyridin-4-yl-1H-purin-6-one	IC50	2100.0 [1]
	6H-Purin-6-one, 1,9-dihydro-2-(4-pyridinyl)-	IC50	1900.0 [1]
	5-(Pyridin-4-yl)-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one	IC50	1800.0 [1]
	[7-(3-Aminomethyl-pyrrol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-2H-quinoxalin-1-yl]-acetic acid	Ki	840.0 [1]
	2,3-Dioxo-6-nitro-7-(3-carboxy-1H-pyrrole-1-yl)-1,2,3,4-tetrahydroquinoxaline-1-acetic acid	Ki	22.0 [1]
	(5R)-3-(3-Methyl-1-benzofuran-5-yl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one	IC50	10000.0 [1]
	8-Methyl-5-(4-nitrophenyl)-3-nitroso-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-2-ol	IC50	150.0 [1]
	3-Nitroso-6,7,8,9-tetrahydro-1H-benzo[g]indol-2-ol	IC50	7200.0 [1]
	1-[4-(2-Ethoxy-2-oxoethyl)-2,3-dioxo-7-(trifluoromethyl)-1H-quinoxalin-6-yl]pyrrole-3-carboxylic acid	Ki	1500.0 [1]
	Ethyl 4-[[1-[2,3-dioxo-7-(trifluoromethyl)-1,4-dihydroquinoxalin-6-yl]pyrrol-3-yl]methylcarbamoylamino]benzoate	Ki	450.0 [1]
	4-[[1-[2,3-Dioxo-7-(trifluoromethyl)-1,4-dihydroquinoxalin-6-yl]pyrrol-3-yl]methylcarbamoylamino]benzoic acid	Ki	54.0 [1]
	2-[7-[3-[[(4-Ethoxycarbonylphenyl)carbamoylamino]methyl]pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	4.0 [1]
	2-[7-[3-[[(3-Ethoxycarbonylphenyl)carbamoylamino]methyl]pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	4.0 [1]
	3-[[1-[4-(Carboxymethyl)-2,3-dioxo-7-(trifluoromethyl)-1H-quinoxalin-6-yl]pyrrol-3-yl]methylcarbamoylamino]benzoic acid	Ki	20.0 [1]
	2-[7-[3-(Aminomethyl)pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	10000.0 [1]
	6-[3-(Aminomethyl)pyrrol-1-yl]-7-(trifluoromethyl)-1,4-dihydroquinoxaline-2,3-dione	Ki	980.0 [1]
	2-[7-[3-(Benzamidomethyl)pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	78.0 [1]
	6-(2,5-Dimethyl-1-pyrrolyl)-7-nitro-2,3(1H,4H)-quinoxalinedione	Ki	20000.0 [1]
	2-[7-(2,5-Dimethylpyrrol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	2000.0 [1]
	6-(2,5-Dimethyl-1-pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione	Ki	25000.0 [1]
	2-[6-Nitro-2,3-dioxo-7-[3-[(E)-phenylmethoxyiminomethyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	210.0 [1]
	2-[7-[3-(Acetamidomethyl)pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	76.0 [1]
	1-[2,3-Dioxo-7-(trifluoromethyl)-1,4-dihydroquinoxalin-6-yl]pyrrole-2-carboxylic acid	Ki	25000.0 [1]
	2-[2,3-Dioxo-7-[3-[(E)-phenylmethoxyiminomethyl]pyrrol-1-yl]-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	250.0 [1]
	6-(2-Methoxycarbonyl-1-pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione	Ki	25000.0 [1]
	2-[6-Nitro-2,3-dioxo-7-[3-[(2-pyridin-4-ylethylcarbamoylamino)methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	95.0 [1]
	1-[[1-(7-Nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)pyrrol-3-yl]methyl]-3-pyridin-4-ylurea	Ki	110.0 [1]
	6-[3-(Aminomethyl)pyrrol-1-yl]-7-nitro-1,4-dihydroquinoxaline-2,3-dione	Ki	2000.0 [1]
	2-[7-[3-[(Benzylcarbamoylamino)methyl]pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	49.0 [1]
	2-[2,3-Dioxo-6-(trifluoromethyl)-7-[3-[[[4-(trifluoromethyl)phenyl]carbamoylamino]methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	5.0 [1]
	2-[6-Nitro-2,3-dioxo-7-[3-[(phenylcarbamoylamino)methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	71.0 [1]
	1-[[1-(7-Nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)pyrrol-3-yl]methyl]-3-phenylurea	Ki	250.0 [1]
	6-[3-[[Benzyl(methyl)amino]methyl]pyrrol-1-yl]-7-nitro-1,4-dihydroquinoxaline-2,3-dione	Ki	880.0 [1]
	2-[6-Nitro-2,3-dioxo-7-[3-[(pyridine-4-carbonylamino)methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	280.0 [1]
	2-[6-Nitro-2,3-dioxo-7-[3-[(3-phenylpropanoylamino)methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	500.0 [1]
	2-[6-Nitro-2,3-dioxo-7-[3-(2-oxo-2-piperidin-1-ylethyl)pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid	Ki	3000.0 [1]
	1-[2,3-Dioxo-7-(trifluoromethyl)-1,4-dihydroquinoxalin-6-yl]pyrrole-3-carbaldehyde	Ki	650.0 [1]
	2-[2,3-Dioxo-7-[3-[[(2-phenylacetyl)amino]methyl]pyrrol-1-yl]-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	140.0 [1]
	2-[7-[3-(Diethylaminomethyl)pyrrol-1-yl]-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]acetic acid	Ki	890.0 [1]
	N-Benzyl-1-[2,3-dioxo-7-(trifluoromethyl)-1,4-dihydroquinoxalin-6-yl]pyrrole-2-carboxamide	Ki	25000.0 [1]
	(4Ar,6R,8aR)-4a,8a-dimethyl-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline-3-carboxylic acid	IC50	1350.0 [1]
	(4Ar,6S,8aR)-4a,8a-dimethyl-6-(1H-1,2,4-triazol-5-ylsulfonylmethyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-3-carboxylic acid	IC50	630.0 [1]
	(4Ar,6S,8aR)-4a,8a-dimethyl-6-(2H-tetrazol-5-ylsulfanylmethyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-3-carboxylic acid	IC50	580.0 [1]
	1-(7-Nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)pyrrole-3-carboxylic acid	Ki	60.0 [1]
	6,7-Dichloro-1-ethyl-1,4-dihydro-quinoxaline-2,3-dione	IC50	21000.0 [1]
	6,7-Dichloro-1-methyl-1,4-dihydro-quinoxaline-2,3-dione	IC50	36000.0 [1]
	6,7-Dichloro-N-methylsulfonyl-3-oxo-4H-quinoxaline-2-carboxamide	IC50	14000.0 [1]
	1-[4-(Carboxymethyl)-2,3-dioxo-7-(trifluoromethyl)-1H-quinoxalin-6-yl]pyrrole-3-carboxylic acid	Ki	66.0 [1]
	1-[4-(2-Ethoxy-2-oxoethyl)-7-nitro-2,3-dioxo-1H-quinoxalin-6-yl]pyrrole-3-carboxylic acid	Ki	215.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate receptor ionotropic AMPA Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-ampa-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glutamate receptor ionotropic AMPA Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-ampa-inhibitors-ic50-ki.
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