Glutamate receptor ionotropic, AMPA 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	IC50	2500.0 [1]
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	Ki	210.0 [1], 260.0 [2]
	Glutamic acid	Ki	940.0 [1]
	Kainic acid	Ki	12200.0 [1], 12221.0 [2]
	Tezampanel	Ki	2210.0 [1], 3000.0 [2], 3200.0 [3]
	(S)-Ampa	Ki	16.8 [1], 107.0 [2]
	4-(8-Methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)benzenamine	Ki	4000.0 [1], 5000.0 [2]
	6-(4-Amino-phenyl)-2,3,8,10-tetrahydro-1,4-dioxa-7,8-diaza-cyclohepta[b]naphthalen-9-one	Ki	21000.0 [1], 33000.0 [2]
	6-(4-Amino-3-methylphenyl)-2,3,8,10-tetrahydro-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Ki	4000.0 [1], 9000.0 [2]
	(3S,4As,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenoxy]-decahydro-isoquinoline-3-carboxylic acid	Ki	8260.0 [1], 16000.0 [2]
	(3S,4Ar,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenylamino]-decahydro-isoquinoline-3-carboxylic acid	Ki	5510.0 [1], 6000.0 [2]
	6-(4-Amino-3,5-dimethylphenyl)-2,3,8,10-tetrahydro-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Ki	94000.0 [1], 164000.0 [2]
	(3S,4Ar,6S,8aR)-6-[(4-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	553000.0 [1]
	(2s)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	273.0 [1], 323.0 [2]
	(2r)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	234.0 [1], 531.0 [2]
	6-(4-Amino-3-methylphenyl)-8-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methyl]-3,10-dihydro-2H-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Ki	50000.0 [1]
	6-(4-Aminophenyl)-8-(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)-3,10-dihydro-2H-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Ki	3000.0 [1], 14000.0 [2]
	alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	Ki	17.0 [1]
	Willardiine	Ki	898.0 [1]
	2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-YL)-propionic acid	Ki	25.1 [1]
	LY382884	Ki	100000.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione	IC50	300000.0 [1]
	Iodo-willardiine	Ki	176.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3(2-carboxythiophene-3-YL-methyl)-5-methylpyrimidine-2,4-dione	IC50	100000.0 [1]
	6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione	IC50	1000.0 [1]
	Bromo-willardiine	Ki	101.0 [1]
	2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid	Ki	250.0 [1]
	Cl-HIBO	Ki	370.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-naphthalen-2-ylprop-2-enyl]pentanedioic acid	Ki	10000.0 [1]
	3-(5-Chloro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-L-Alanine	Ki	53.1 [1]
	3-(5-Nitro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-L-Alanine	Ki	115.0 [1]
	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Ki	1610.0 [1]
	2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid	Ki	80.2 [1]
	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Ki	2930.0 [1]
	3-Hydroxy-4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridine-7-carboxylic acid	Ki	108.0 [1]
	3-[[3-[(2S)-2-Amino-2-carboxyethyl]-5-methyl-2,6-dioxopyrimidin-1-yl]methyl]-5-phenylthiophene-2-carboxylic acid	IC50	100000.0 [1]
	(S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-YL)isoxazol-4-YL]propionic acid	Ki	3.89 [1]
	2-Amino-3-[2-(2-carboxyethyl)-5-chloro-4-nitrophenyl]propanoic acid	Ki	3150.0 [1]
	4-Chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid	IC50	100000.0 [1]
	4,5,6,7-Tetrahydro-3-hydroxyisoxazolo[5,4-c]pyridine-5-carboxylic acid	Ki	494.0 [1]
	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione	IC50	100000.0 [1]
	2-(3-(3-Bromophenyl)ureido)-4-chlorobenzoic acid	IC50	100000.0 [1]
	(2S)-2-Amino-4-cyclopentylidenepentanedioic acid	Ki	3680.0 [1]
	3,4-Dichloro-5-(5-Hydroxypyridin-3-Yl)-L-Phenylalanine	Ki	2260.0 [1]
	(R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl)propanoic Acid	Ki	84000.0 [1]
	CID 10330442	Ki	3700.0 [1]
	(2S)-2-Amino-4-pentan-3-ylidenepentanedioic acid	Ki	280900.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-(2-methoxyphenyl)prop-2-enyl]pentanedioic acid	Ki	10000.0 [1]
	2-Methylpropyl (3S,4aS,6S,8aR)-6-[2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate	Ki	100000.0 [1]
	2-Ethylbutyl (3S,4aR,6S,8aR)-6-[2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate	Ki	100000.0 [1]
	(2S,4Z)-2-Amino-4-(2-methylpropylidene)pentanedioic Acid	Ki	44900.0 [1]
	[1,2,5]Oxadiazolo[3,4-G]quinoxaline-6,7(5H,8H)-dione 1-oxide	IC50	7600.0 [1]
	6-(4-Amino-3,5-dimethylphenyl)-8-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methyl]-3,10-dihydro-2H-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Ki	5000.0 [1]
	(S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid	Ki	16.7 [1]
	(2S)-2-Amino-3-(6-methyl-3,5-dioxo-1,2,4-triazin-2-yl)propanoic acid	Ki	372.0 [1]
	(S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid	Ki	461.0 [1]
	(2S)-2-Amino-3-(6-iodo-3,5-dioxo-1,2,4-triazin-2-yl)propanoic acid	Ki	101.0 [1]
	(3S,4Ar,6S,8aR)-6-[(4-carboxyimidazol-1-yl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;dihydrochloride	Ki	117000.0 [1]
	(3S,4Ar,6S,8aR)-6-[3-chloro-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	6400.0 [1]
	(3S,4Ar,6S,8aR)-6-[3-methyl-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	128000.0 [1]
	(3S,4Ar,6S,8aR)-6-(3-carboxyanilino)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	238000.0 [1]
	(3S,4Ar,6S,8aR)-6-[5-phenyl-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	3500.0 [1]
	(3S,4Ar,6S,8aR)-6-(2-carboxyanilino)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	77000.0 [1]
	(3S,4Ar,6S,8aR)-6-[5-methyl-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	6200.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-5-chlorophenyl)sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	22000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-4-chlorophenyl)sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	42000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-5-phenylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	8800.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-5-chlorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	151000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-4-chlorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	19000.0 [1]
	(1S,2S,6R,8S)-6-(Carboxymethyl)-3-oxo-7-oxa-4,12-diazatricyclo[6.4.0.02,6]dodec-9-ene-5-carboxylic acid	Ki	560000.0 [1]
	(3S,4As,6S,8aR)-6-[3-chloro-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	30000.0 [1]
	(3S,4As,6S,8aR)-6-[3-methoxy-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	252000.0 [1]
	(3S,4As,6S,8aR)-6-[4-fluoro-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	2700.0 [1]
	(3S,4As,6S,8aR)-6-[4-chloro-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	400.0 [1]
	(3S,4Ar,6S,8aR)-6-[4-fluoro-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	12000.0 [1]
	(3S,4As,6S,8aR)-6-[5-methyl-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	5200.0 [1]
	(3S,4As,6S,8aR)-6-[5-methoxy-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	2000.0 [1]
	(3S,4As,6S,8aR)-6-[2-(2H-tetrazol-5-yl)-5-thiophen-2-ylphenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	4400.0 [1]
	(3S,4As,6S,8aR)-6-[5-pyridin-3-yl-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	20000.0 [1]
	(3S,4As,6S,8aR)-6-[5-benzyl-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	9600.0 [1]
	(3S,4Ar,6S,8aR)-6-(4-carboxyanilino)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	1420000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxyphenyl)sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	15000.0 [1]
	(3S,4As,6S,8aR)-6-(3-carboxyphenyl)sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	9000.0 [1]
	(3S,4As,6S,8aR)-6-(4-carboxyphenyl)sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	418000.0 [1]
	(3S,4Ar,6S,8aR)-6-(2-carboxy-4-chloroanilino)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Ki	3300.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	70000.0 [1]
	(3S,4As,6S,8aR)-6-(3-carboxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	44000.0 [1]
	(3S,4As,6S,8aR)-6-(4-carboxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	913000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-3-fluorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	93000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-4-methylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	107000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-4-methoxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	87000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-4-phenylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	172000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-5-methylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	89000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-5-methoxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	111000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-6-chlorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	1470000.0 [1]
	(3S,4As,6S,8aR)-6-(2-carboxy-6-methylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	818000.0 [1]
	(3S,4Ar,6S,8aR)-6-[(2-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	29600000.0 [1]
	(3S,4Ar,6S,8aR)-6-[(3-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	149000.0 [1]
	(3S,4Ar,6S,8aR)-6-[[2-(2H-tetrazol-5-yl)phenyl]methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	13000.0 [1]
	(3S,4As,6S,8aR)-6-[2-(2H-tetrazol-5-yl)phenyl]sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Ki	22000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate receptor ionotropic, AMPA 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-ampa-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Glutamate receptor ionotropic, AMPA 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-ampa-2-inhibitors-ic50-ki.
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