Glutamate receptor ionotropic, AMPA 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Perampanel	IC50	243.0 [1], 485.0 [2], 623.0 [3], 1180.0 [4], 6510.0 [5]
	4-[Methyl-(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]phenol	IC50	2970.0 [1], 83300.0 [2]
	Glutamic acid	Ki	1360.0 [1], 1362.0 [2]
	Kainic acid	Ki	7449.0 [1], 7450.0 [2], 7500.0 [3]
	Argiotoxin 636	IC50	350.0 [1], 3400.0 [2]
	6-((1S)-1-(1-(5-(2-Hydroxyethoxy)-2-pyridinyl)-1H-pyrazol-3-yl)ethyl)-2(3H)-benzothiazolone	IC50	65.3 [1], 68500.0 [2], 83300.0 [3]
	6-[(1S)-1-[1-[5-(3-Hydroxy-3-methylbutyl)pyridin-2-yl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	IC50	160.0 [1], 9260.0 [2]
	6-[(1S)-1-[1-[5-(2-Hydroxyethyl)pyridin-2-yl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	IC50	61.6 [1], 25700.0 [2], 83300.0 [3]
	6-[(1R)-1-(1-Pyridin-2-ylpyrazol-3-yl)ethyl]-3H-1,3-benzothiazol-2-one	IC50	615.0 [1], 9260.0 [2], 83300.0 [3]
	6-[(1S)-1-(1-Pyridin-2-ylpyrazol-3-yl)ethyl]-3H-1,3-benzothiazol-2-one	IC50	50.9 [1], 9260.0 [2], 83300.0 [3]
	N-(1H-Indazol-5-yl)-N-[(1-methylpyrazol-3-yl)methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine	IC50	53.9 [1], 83300.0 [2]
	6-[(1R)-1-[1-[5-(2-Hydroxyethyl)pyridin-2-yl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	IC50	2820.0 [1], 9260.0 [2]
	6-[Methyl-(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]-3H-1,3-benzothiazol-2-one	IC50	70.0 [1], 83300.0 [2]
	6-[(1S)-1-[1-(5-Fluoropyridin-2-yl)pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	IC50	53.6 [1], 83300.0 [2]
	N-(1H-Indazol-5-yl)-N-methyl-4-pyridin-2-yl-1,3-thiazol-2-amine	IC50	147.0 [1], 83300.0 [2]
	N-Methyl-N-(1-pyridin-2-ylpyrazol-3-yl)-1H-indazol-5-amine	IC50	353.0 [1], 83300.0 [2]
	6-[1-(1-Pyridin-2-ylpyrazol-3-yl)ethyl]-3H-1,3-benzothiazol-2-one	IC50	122.0 [1], 83300.0 [2]
	6-[(1R)-1-[1-[5-(2-Hydroxyethoxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	IC50	1790.0 [1], 9260.0 [2]
	(S)-Ampa	Ki	21.9 [1], 103.0 [2]
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	IC50	6000.0 [1]
	2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	Ki	1600.0 [1]
	Tezampanel	Ki	9200.0 [1]
	N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-butyramide	Ki	22000.0 [1], 170000.0 [2]
	N-[1-[8-(3-Amino-propylamino)-octylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-butyramide	Ki	65.0 [1], 8000.0 [2]
	6-(4-Amino-3,5-dimethylphenyl)-8-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methyl]-3,10-dihydro-2H-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Ki	6400.0 [1], 13200.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]cyclohexanecarboxamide	Ki	78.0 [1], 240.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]pyridine-4-carboxamide	Ki	64.0 [1], 330.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]pyridine-3-carboxamide	Ki	88.0 [1], 210.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]hexanamide	Ki	68.0 [1], 1000.0 [2]
	N-[8-(3-Aminopropylamino)octyl]-3-(4-hydroxyphenyl)-2-(propanoylamino)propanamide	Ki	100.0 [1], 280.0 [2]
	N-[1-[3-(8-Aminooctylamino)propylamino]-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]butanamide	Ki	350.0 [1], 8100.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-2,2-dimethylpropanamide	Ki	90.0 [1], 140.0 [2]
	N-[1-[4-(7-Aminoheptylamino)butylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	Ki	38.0 [1], 135.0 [2]
	N-[8-(3-Aminopropylamino)octyl]-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	Ki	110.0 [1], 250.0 [2]
	2-Acetamido-N-[8-(3-aminopropylamino)octyl]-3-(4-hydroxyphenyl)propanamide	Ki	220.0 [1], 300.0 [2]
	N-[8-(3-Aminopropylamino)octyl]-3-(4-hydroxyphenyl)-2-[[(E)-3-phenylprop-2-enoyl]amino]propanamide	Ki	110.0 [1], 170.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]pyridine-2-carboxamide	Ki	130.0 [1], 170.0 [2]
	N-[8-(3-Aminopropylamino)octyl]-3-(4-hydroxyphenyl)-2-(3-phenylpropanoylamino)propanamide	Ki	250.0 [1], 254.0 [2]
	N-[1-[5-(6-Aminohexylamino)pentylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	Ki	3.3 [1], 287.0 [2]
	N-[1-[8-(3-Aminopropylamino)octylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]benzamide	Ki	130.0 [1], 250.0 [2]
	N-[1-[7-(4-Amino-butylamino)-heptylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-butyramide	Ki	168.0 [1], 3000.0 [2]
	N-[1-[9-(2-Aminoethylamino)nonylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	Ki	410.0 [1], 6200.0 [2]
	N-[1-[6-(5-Aminopentylamino)hexylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	Ki	468.0 [1], 10000.0 [2]
	alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	Ki	22.0 [1]
	Joro spider toxin	IC50	40.0 [1]
	Willardiine	Ki	386.0 [1]
	2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-YL)-propionic acid	Ki	14.7 [1]
	Iodo-willardiine	Ki	163.0 [1]
	Bromo-willardiine	Ki	92.0 [1]
	2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid	Ki	170.0 [1]
	Cl-HIBO	Ki	130.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-naphthalen-2-ylprop-2-enyl]pentanedioic acid	Ki	10000.0 [1]
	3-(5-Chloro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-L-Alanine	Ki	65.0 [1]
	3-(5-Nitro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-L-Alanine	Ki	279.0 [1]
	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Ki	5150.0 [1]
	2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid	Ki	145.0 [1]
	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Ki	10000.0 [1]
	(S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-YL)isoxazol-4-YL]propionic acid	Ki	5.22 [1]
	Philanthotoxin-74	Ki	168.0 [1]
	4-Chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid	IC50	100000.0 [1]
	(2S)-2-Amino-3-(2,4-dioxothieno[3,2-d]pyrimidin-1-yl)propanoic acid	IC50	374.0 [1]
	2-(3-(3-Bromophenyl)ureido)-4-chlorobenzoic acid	IC50	100000.0 [1]
	(2S)-2-Amino-4-cyclopentylidenepentanedioic acid	Ki	1100.0 [1]
	CID 10330442	Ki	700.0 [1]
	(2s)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	185.0 [1]
	(2S)-2-Amino-4-pentan-3-ylidenepentanedioic acid	Ki	100000.0 [1]
	(2r)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Ki	150.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-(2-methoxyphenyl)prop-2-enyl]pentanedioic acid	Ki	10000.0 [1]
	(2S,4Z)-2-Amino-4-(2-methylpropylidene)pentanedioic Acid	Ki	113400.0 [1]
	6-[2-Ethoxyethyl-(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]-3H-1,3-benzothiazol-2-one	IC50	22.0 [1]
	(S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid	Ki	7.1 [1]
	(2S)-2-Amino-3-(6-methyl-3,5-dioxo-1,2,4-triazin-2-yl)propanoic acid	Ki	240.0 [1]
	(S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid	Ki	163.0 [1]
	(2S)-2-Amino-3-(6-iodo-3,5-dioxo-1,2,4-triazin-2-yl)propanoic acid	Ki	73.9 [1]
	(3S,4Ar,6S,8aR)-6-[(4-carboxyimidazol-1-yl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;dihydrochloride	Ki	134000.0 [1]
	(S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid	Ki	29.0 [1]
	(2S,4R)-2-Amino-4-[(E)-3-(4-chlorophenyl)prop-2-enyl]pentanedioic acid	Ki	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 77 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate receptor ionotropic, AMPA 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-ampa-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Glutamate receptor ionotropic, AMPA 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-receptor-ionotropic-ampa-1-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan