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Glutamate [NMDA] receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenolIC506.0 [1]
4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenolKi5.6 [1], 6.0 [2]
(1R,Alphar)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolIC5037000.0 [1], 290000.0 [2]
(1R,Alphar)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolKi260.0 [1]
(1S,Alphar)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolIC5034000.0 [1], 95000.0 [2]
(1S,Alphar)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolKi2600.0 [1]
(1S)-1-(4-Chlorophenyl)-2-[(1S)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolIC5059.0 [1], 960.0 [2]
(1S)-1-(4-Chlorophenyl)-2-[(1S)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolKi500.0 [1]
(1S)-1-(4-Chlorophenyl)-2-[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolIC5024000.0 [1], 31000.0 [2]
(1S)-1-(4-Chlorophenyl)-2-[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolKi110.0 [1]
(1R)-1-(4-Chlorophenyl)-2-[(1S)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolIC5045000.0 [1], 52000.0 [2]
(1R)-1-(4-Chlorophenyl)-2-[(1S)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolKi2700.0 [1]
(1S,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-methoxyphenyl)-1-isoquinolineethanolIC5014000.0 [1], 29000.0 [2]
(1S,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-methoxyphenyl)-1-isoquinolineethanolKi2200.0 [1]
(1R,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolIC5040000.0 [1], 43000.0 [2]
(1R,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolKi6700.0 [1]
(1S)-2-[(1S)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]-1-(4-methoxyphenyl)ethanolIC50240.0 [1], 4600.0 [2]
(1S)-2-[(1S)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]-1-(4-methoxyphenyl)ethanolKi2700.0 [1]
(1R,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-methoxyphenyl)-1-isoquinolineethanolIC50140000.0 [1], 420000.0 [2]
(1R,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-methoxyphenyl)-1-isoquinolineethanolKi11000.0 [1]
(1S,Alphar)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-methoxyphenyl)-1-isoquinolineethanolIC50110000.0 [1], 243000.0 [2]
(1S,Alphar)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-methoxyphenyl)-1-isoquinolineethanolKi5800.0 [1]
(1S,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolIC501100.0 [1], 7400.0 [2]
(1S,Alphas)-1,2,3,4-Tetrahydro-6,7-dimethoxy-alpha-(4-chlorophenyl)-1-isoquinolineethanolKi920.0 [1]
(4S)-4-[(2-Aminoacetyl)amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-4-carboxy-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC5023.0 [1], 58.0 [2], 94.0 [3]
(4R,5S)-8-Amino-5-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-4-oxobutanoyl]amino]-4-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]-8-oxooctanoic acidIC5021.0 [1], 59.0 [2], 69.0 [3]
(4S)-4-[(2-Aminoacetyl)amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC509.0 [1], 18.0 [2], 20.0 [3]
(4S)-4-[(2-Aminoacetyl)amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC50766.0 [1], 1680.0 [2], 3360.0 [3]
(4S)-4-[(2-Aminoacetyl)amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC5047.0 [1], 56.0 [2], 99.0 [3]
(4S)-4-[(2-Aminoacetyl)amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC50475.0 [1], 546.0 [2], 570.0 [3]
(1R)-1-(4-Chlorophenyl)-2-[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolIC5056000.0 [1], 100000.0 [2]
(1R)-1-(4-Chlorophenyl)-2-[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]ethanolKi7.0 [1]
ChlorpromazineIC50600.0 [1], 1100.0 [2]
PhencyclidineKi15.3 [1], 23.0 [2]
5-Phosphono-D-norvalineIC50177.0 [1], 3700.0 [2]
MemantineKi540.0 [1], 1200.0 [2]
RacemethorphanIC50240.0 [1], 490.0 [2]
4-(3-Phosphonopropyl)piperazine-2-carboxylic acidIC50220.0 [1], 600.0 [2]
LevorphanolIC502500.0 [1], 2700.0 [2]
1,3-Di-o-tolylguanidineIC507800.0 [1], 10700.0 [2]
Heptanoic acid, 2-amino-7-phosphono-, (2R)-IC50461.0 [1], 11100.0 [2]
SelfotelIC5054.0 [1], 1600.0 [2]
2-Amino-4-methyl-5-phosphono-3-pentenoic acidIC5018.0 [1], 25.7 [2]
ArcaineIC509130.0 [1], 79980.0 [2]
TraxoprodilIC507.0 [1]
TraxoprodilKi11.0 [1]
Cyclohexanepropanoic acid, alpha-amino-2-(2-phosphonoethyl)-IC50976.0 [1], 1600.0 [2]
Cyclohexanepropanoic acid, alpha-amino-2-(2-phosphonoethyl)-, (1R-(1-alpha(S*),2-alpha))-IC50264.0 [1], 2589.0 [2]
(2R)-2-Amino-3-[(1R,2S)-2-(2-phosphonoethyl)cyclohexyl]propanoic acidIC50148.0 [1], 607.0 [2]
LicostinelIC505.9 [1], 5888436.55 [2]
BesonprodilIC504.0 [1]
N,N'-Bis(4-methylphenyl)guanidineIC5013300.0 [1], 31000.0 [2]
2,3-DihydroxyquinoxalineIC509800.0 [1], 102329299.2 [2]
6,7-Dichloroquinoxaline-2,3(1H,4H)-dioneIC50130.0 [1], 128824955.2 [2]
4-((2H-Tetrazol-5-yl)methyl)piperidine-2-carboxylic acidIC50107.0 [1], 4200.0 [2]
6-Chloroquinoxaline-2,3-diolIC501800.0 [1], 562341325.2 [2]
6,7-Dimethyl-5-nitro-1,4-dihydroquinoxaline-2,3-dioneIC5029.0 [1], 28840315.03 [2]
5,7-Dichloroquinoxaline-2,3-diolIC50280.0 [1], 281838293.1 [2]
5,7-Dimethyl-1,4-dihydroquinoxaline-2,3-dioneIC502100.0 [1], 478630092.3 [2]
[(1S)-1-{[(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acidIC5010000.0 [1]
6-Chloro-5,7-difluoro-1,4-dihydroquinoxaline-2,3-dioneIC50630.0 [1], 630957344.5 [2]
5,6,7-Trichloro-1,4-dihydroquinoxaline-2,3-dioneIC5030.0 [1], 29512092.27 [2]
5,6,7,8-Tetrafluoro-1,4-dihydro-2,3-quinoxalinedioneIC50730.0 [1], 724435960.1 [2]
6,7-Dimethylquinoxaline-2,3-diolIC503300.0 [1], 301995172.0 [2]
7-Chloro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dioneIC504.7 [1], 4677351.41 [2]
2-(4-Benzylpiperidinocarbonyl)-1H-indole-5-olIC5031.0 [1]
Benzo[g]quinoxaline-2,3(1H,4H)-dioneIC5016000.0 [1], 63095734.45 [2]
5,6,7-Trichloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC507.0 [1], 7079457.84 [2]
2,3,4(1H)-Quinolinetrione, 5,7-dimethyl-, 3-oximeIC5037.0 [1], 37153522.91 [2]
1,2,3,4-Tetrahydroquinoline-2,3,4-trione 3-oximeIC501400.0 [1], 707945784.4 [2]
6,7-Dichloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC5012.0 [1], 12022644.35 [2]
5,7-Dichloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC5033.0 [1], 33113112.15 [2]
5,6,7,8-Tetrafluoro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC503300.0 [1], 301995172.0 [2]
7-Chloro-6,8-difluoro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC50910.0 [1], 912010839.4 [2]
5-Chloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC504400.0 [1], 229086765.3 [2]
8-Chloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC50100000.0 [1], 10000000.0 [2]
7-Chloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC5053.0 [1], 52480746.02 [2]
6-Chloro-4-hydroxy-3-nitroso-1H-quinolin-2-oneIC503400.0 [1], 295120922.7 [2]
2,4-Dihydroxy-3-nitroquinolineIC5034000.0 [1], 29512092.27 [2]
(R)-4-(3-Phosphonopropyl)piperazine-2-carboxylic acidIC5086.0 [1], 321.0 [2]
7-Bromo-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dioneIC508.7 [1], 8709635.9 [2]
6-Chloro-7-methyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dioneIC5045.0 [1], 44668359.22 [2]
1,2-Bis(3-methylphenyl)guanidineIC50330.0 [1], 370.0 [2]
7-Fluoro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dioneIC5095.0 [1], 95499258.6 [2]
Guanidine, N,N'-bis(3-ethylphenyl)-IC5082.0 [1], 168.0 [2]
6-Chloro-7-methyl-1,4-dihydro-quinoxaline-2,3-dioneIC50780.0 [1], 776247116.6 [2]
6-Amino-7-fluoro-5-nitro-1,4-dihydroquinoxaline-2,3-dioneIC5011000.0 [1], 91201083.94 [2]
5-Amino-6-methyl-7-chloroquinoxaline-2,3(1H,4H)-dioneIC50150.0 [1], 151356124.8 [2]
7-Fluoro-5-nitro-6-(3-phenyl-propoxy)-1,4-dihydro-quinoxaline-2,3-dioneIC504000.0 [1], 251188643.2 [2]
8-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-6-carbonitrileIC502800.0 [1], 354813389.2 [2]
2,3-Quinoxalinedione, 6,7-diethyl-1,4-dihydro-5-nitro-IC50160.0 [1], 158489319.3 [2]
6,7-Diethyl-1,4-dihydroquinoxaline-2,3-dioneIC501800.0 [1], 549540873.9 [2]
7-Chloro-6-ethylsulfanyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dioneIC50640.0 [1], 645654229.0 [2]
5-Nitro-6-bromo-7-ethylquinoxaline-2,3(1H,4H)-dioneIC5082.0 [1], 81283051.62 [2]
7-Fluoro-6-methoxy-5-nitro-1,4-dihydroquinoxaline-2,3-dioneIC501900.0 [1], 524807460.3 [2]
6-Chloro-7-ethyl-5-nitro-1,4-dihydroquinoxaline-2,3-dioneIC5029.0 [1], 28840315.03 [2]
5-Nitro-4,6,7,8-tetrahydro-1H-cyclopenta[g]quinoxaline-2,3-dioneIC503100.0 [1], 323593656.9 [2]
5-Nitro-6-ethoxy-7-fluoroquinoxaline-2,3(1H,4H)-dioneIC503600.0 [1], 275422870.3 [2]
2,3-Quinoxalinedione, 7-chloro-6-ethyl-1,4-dihydro-5-nitro-IC50130.0 [1], 128824955.2 [2]
1H-Cyclopenta[g]quinoxaline-2,3-dione, 4,6,7,8-tetrahydro-IC5015000.0 [1], 67608297.54 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glutamate [NMDA] receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-nmda-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glutamate [NMDA] receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-nmda-receptor-inhibitors-ic50-ki.
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