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Glutamate NMDA receptor; GRIN1/GRIN2B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
IfenprodilIC50177.4 [1]
IfenprodilKi10.0 [1]
N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-yl]-methanesulfonamideIC501.4 [1], 1.9 [2], 50.29 [3]
N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-yl]-methanesulfonamideKi0.99 [1]
2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-olIC508.2 [1], 209.2 [2]
2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-olKi1.5 [1]
2-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olIC5012.0 [1], 47.27 [2]
2-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olKi1.1 [1]
MemantineIC501020.0 [1], 5200.0 [2], 5500.0 [3], 9520.0 [4]
RadiprodilIC504.0 [1], 6.0 [2], 69.91 [3]
3-(4-Phenylbutyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diolIC5018.5 [1]
3-(4-Phenylbutyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diolKi14.0 [1], 84.0 [2]
4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenolIC5057.0 [1]
4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenolKi10.0 [1]
4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenolIC5013.3 [1]
4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenolKi10.0 [1]
N-(2-Methoxybenzyl)cinnamamidineIC5026000.0 [1], 28600.0 [2]
N-(2-Methoxybenzyl)cinnamamidineKi0.7 [1]
7-Methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-olIC50360.0 [1]
7-Methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-olKi5.4 [1], 706.0 [2]
2-Phenyl-4-(piperidin-1-ylmethyl)-1H-benzimidazol-5-olIC50100.0 [1], 50118.72 [2]
3-(4-Phenylcyclohexyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diolIC5012100.0 [1]
3-(4-Phenylcyclohexyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diolKi3.3 [1], 9.0 [2]
TacrineIC5044000.0 [1]
TraxoprodilIC5030.0 [1]
TraxoprodilKi11.0 [1]
BesonprodilIC508.0 [1]
2-(4-Benzylpiperidinocarbonyl)-1H-indole-5-olIC5040.0 [1], 42.0 [2]
2-[[4-[(2-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olIC509.7 [1]
2-[[4-[(2-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olKi0.85 [1]
(E)-N-Benzyl-3-phenyl-acrylamidineIC5070.0 [1]
(E)-N-Benzyl-3-phenyl-acrylamidineKi9.0 [1]
2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-acetamideIC503.0 [1], 4.0 [2]
2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetamideIC502.0 [1], 5.0 [2]
2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetamideIC506.0 [1], 8.0 [2]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamideIC500.72 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamideKi0.68 [1]
2-[[4-[(3-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olIC5044.0 [1]
2-[[4-[(3-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olKi4.2 [1]
2-[[4-[(2,6-Difluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olIC5021.0 [1]
2-[[4-[(2,6-Difluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olKi0.82 [1]
2-[[4-[(4-Methylphenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olIC505.7 [1]
2-[[4-[(4-Methylphenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-olKi0.4 [1]
2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazole-5-carbonitrileIC50800.0 [1]
2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazole-5-carbonitrileKi790.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamideIC5014.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamideKi15.0 [1]
N-Methyl-N-[2-[(4-phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamideIC5025.0 [1]
N-Methyl-N-[2-[(4-phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamideKi470.0 [1]
N-[2-[(4-Benzylpiperidin-1-yl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamideIC50300.0 [1]
N-[2-[(4-Benzylpiperidin-1-yl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamideKi240.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]acetamideIC5042.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]acetamideKi93.0 [1]
1-(4-Hydroxyphenyl)-2-[4-[(4-isothiocyanatophenyl)methyl]piperidin-1-yl]ethanoneIC5016000.0 [1], 570000.0 [2]
N-[4-[2-(4-Benzylpiperidin-1-yl)propanoyl]phenyl]-2-chloroacetamideIC5014000.0 [1], 230000.0 [2]
2-Methyl-9-[9-(2-methylpyrido[3,4-b]indol-2-ium-9-yl)nonyl]pyrido[3,4-b]indol-2-iumIC502900.0 [1]
cis-7-(Benzyloxy)-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-olKi139.0 [1], 388.0 [2]
2-(4-Benzyl-piperidin-1-ylmethyl)-1H-benzimidazoleIC50710.0 [1]
2-(4-Benzyl-piperidin-1-ylmethyl)-1H-benzimidazoleKi420.0 [1]
2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazol-4-olIC50150.0 [1]
2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazol-4-olKi140.0 [1]
6-Methoxy-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazoleIC509200.0 [1]
6-Methoxy-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazoleKi8400.0 [1]
2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazoleIC50200.0 [1]
2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazoleKi260.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]benzenesulfonamideIC5049.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]benzenesulfonamideKi17.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-1-sulfonamideIC5019.0 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-1-sulfonamideKi21.0 [1]
2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-olIC509.2 [1]
2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-olKi3.2 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]ethanesulfonamideIC502.1 [1]
N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]ethanesulfonamideKi3.0 [1]
2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-amineIC5078.0 [1]
2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-amineKi180.0 [1]
6-Nitro-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazoleIC506600.0 [1]
6-Nitro-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazoleKi5400.0 [1]
2-[6-(9H-Pyrido[3,4-b]indol-2-ium-2-yl)hexyl]-9H-pyrido[3,4-b]indol-2-iumIC506500.0 [1]
2-[6-(9H-Pyrido[3,4-b]indol-2-ium-2-yl)hexyl]-9H-pyrido[3,4-b]indol-2-iumKi20000.0 [1]
KetamineIC503200.0 [1]
DizocilpineIC509.0 [1]
DextrorphanIC50246.0 [1]
EliprodilKi13.0 [1]
N-(4-(2-Benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamideIC50100.0 [1]
1-(2-(4-Hydroxyphenoxy)ethyl)-4-((4-methylphenyl)methyl)-4-piperidinolIC505.0 [1]
1-(4-Benzylpiperidin-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-oneIC50104.0 [1]
2-(4-Benzylpiperidinocarbonyl)-1H-indole-6-olIC5020.0 [1]
6-(3-(4-((4-Fluorophenyl)methyl)-1-piperidinyl)-1-oxopropyl)-2(3H)-benzoxazoloneIC5048.0 [1]
PeaqxIC5029600.0 [1]
3-(4-Phenylbutyl)-1,2,4,5-tetrahydro-3-benzazepin-5-olKi73.0 [1]
7-(3-Phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepteneKi16.0 [1]
N-BenzylbenzamidineKi10000.0 [1]
3-Methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amineKi10.0 [1]
2-[4-(Benzyloxy)piperidinocarbonyl]-1H-indole-6-olIC5046.0 [1]
2-[4-[(4-Methylphenyl)methyl]piperidin-1-yl]-2-oxo-N-(2-oxo-1,3-dihydroindol-5-yl)acetamideIC5015.0 [1]
2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-acetamideIC509.0 [1]
2-Methoxy-7-(3-phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-olKi16.0 [1]
2-(4-Phenylpiperidinocarbonyl)-1H-indole-6-olIC508000.0 [1]
2-(4-Phenethylpiperidinocarbonyl)-1H-indole-6-olIC5024.0 [1]
2-(4-Benzylpiperidinocarbonyl)-1H-indole-7-olIC5077.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glutamate NMDA receptor; GRIN1/GRIN2B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-nmda-receptor-grin1-grin2b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glutamate NMDA receptor; GRIN1/GRIN2B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-nmda-receptor-grin1-grin2b-inhibitors-ic50-ki.
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