Glutamate carboxypeptidase II Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(Phosphonomethyl)pentanedioic acid	IC50	0.3 [1], 1.1 [2]
	2-(Phosphonomethyl)pentanedioic acid	Ki	0.2 [1], 0.28 [2], 0.3 [3], 31.2 [4]
	N-{[(1s)-1-Carboxy-5-{[(4-Iodophenyl)carbonyl]amino}pentyl]carbamoyl}-L-Glutamic Acid	IC50	0.02 [1]
	N-{[(1s)-1-Carboxy-5-{[(4-Iodophenyl)carbonyl]amino}pentyl]carbamoyl}-L-Glutamic Acid	Ki	0.0 [1], 0.01 [2]
	2-(3-Mercaptopropyl)pentanedioic acid	IC50	90.0 [1]
	CID 11722553	Ki	0.58 [1], 0.75 [2], 1.08 [3]
	(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid	IC50	47.0 [1]
	(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid	Ki	8.0 [1]
	3-(2-Carboxy-5-mercaptopentyl)benzoic acid	IC50	15.0 [1]
	N~2~-{[(1s)-1-Carboxy-3-(Methylsulfanyl)propyl]carbamoyl}-N~6~-(4-Iodobenzoyl)-L-Lysine	Ki	23.0 [1]
	5-Sulfanylpentanoic Acid	IC50	1400.0 [1]
	N~2~-{[(1s)-1-Carboxybut-3-Yn-1-Yl]carbamoyl}-N~6~-(4-Iodobenzoyl)-L-Lysine	Ki	5.3 [1]
	N~2~-{[(1s)-1-Carboxy-2-(Furan-2-Yl)ethyl]carbamoyl}-N~6~-(4-Iodobenzoyl)-L-Lysine	Ki	5.3 [1]
	3-(2-Mercaptoethyl)-[1,1'-biphenyl]-2,3'-dicarboxylic acid	IC50	2.0 [1]
	3-(2-Mercaptoethyl)-[1,1'-biphenyl]-2,3'-dicarboxylic acid	Ki	1.0 [1]
	1-(3-Carboxyphenyl)-3-(2-mercapto-ethyl)-1H-indole-2-carboxylic acid	IC50	22.0 [1]
	2-(2-Hydroxycarbamoyl-ethyl)-pentanedioic acid	IC50	1200.0 [1]
	(S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)pentanedioic Acid	IC50	498.0 [1]
	(S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)pentanedioic Acid	Ki	44.3 [1]
	Tripotassium;(2S)-2-[[oxido(4-phenylbutoxy)phosphoryl]amino]pentanedioate	IC50	180.0 [1]
	N~2~-{[(1s)-1-Carboxybut-3-En-1-Yl]carbamoyl}-N~6~-[(4-Iodophenyl)carbonyl]-L-Lysine	Ki	11.0 [1]
	(S)-2-(3-(Carboxymethyl)ureido)-6-(4-iodobenzamido)hexanoic acid	Ki	1320.0 [1], 4390.0 [2]
	(S)-2-(3-((S)-1-Carboxybutyl)ureido)-6-(4-iodobenzamido)hexanoic acid	Ki	52.3 [1], 145.0 [2]
	(2S)-2-[[(1S)-1-Carboxy-2-thiophen-2-ylethyl]carbamoylamino]-6-[(4-iodobenzoyl)amino]hexanoic acid	Ki	16.2 [1]
	(2S)-2-[[(1S)-1-Carboxy-2-(1,3-thiazol-4-yl)ethyl]carbamoylamino]-6-[(4-iodobenzoyl)amino]hexanoic acid	Ki	16.1 [1]
	N-({(1s)-5-[Acetyl(4-Bromobenzyl)amino]-1-Carboxypentyl}carbamoyl)-L-Glutamic Acid	Ki	0.04 [1]
	(2S)-2-[[(1S)-5-Acetamido-1-carboxypentyl]carbamoylamino]pentanedioic acid	Ki	0.17 [1]
	4-[2-Carboxy-5-(hydroxyamino)-5-oxopentyl]benzoic acid	IC50	40.0 [1], 63.0 [2]
	Benzyl (2S,3S)-3-[(4-hydroxyphenyl)methyl]-4-oxo-1-[2-(3-phenylmethoxycarbonylphenyl)acetyl]azetidine-2-carboxylate	IC50	226.0 [1], 348.0 [2]
	4-[[(2S,3S)-3-[(4-Hydroxyphenyl)methyl]-4-oxo-1-[2-(3-phenylmethoxycarbonylphenyl)acetyl]azetidine-2-carbonyl]oxymethyl]benzoic acid	IC50	3500.0 [1]
	4-[[(2S,3S)-3-Benzyl-4-oxo-1-[2-(3-phenylmethoxycarbonylphenyl)acetyl]azetidine-2-carbonyl]oxymethyl]benzoic acid	IC50	8980.0 [1]
	3-Benzyl-1-[2-(3-carboxy-phenyl)-acetyl]-4-oxo-azetidine-2-carboxylic acid 4-carboxy-benzyl ester	IC50	30000.0 [1]
	4-[[(2S,3S)-3-Benzyl-1-[2-[3-[(4-carboxyphenyl)methoxycarbonyl]phenyl]acetyl]-4-oxoazetidine-2-carbonyl]oxymethyl]benzoic acid	IC50	5840.0 [1]
	3-Benzyl-1-[2-(3-benzyloxycarbonyl-phenyl)-acetyl]-4-oxo-azetidine-2-carboxylic acid benzyl ester	IC50	1430.0 [1]
	(S)-2-(3-((S)-1-Carboxy-5-(4-fluorobenzamido)pentyl)ureido)pentanedioic acid	Ki	0.19 [1], 0.26 [2]
	(2S)-2-[[(1S)-1-Carboxy-5-[(5-iodopyridine-3-carbonyl)amino]pentyl]carbamoylamino]pentanedioic acid	Ki	0.35 [1], 0.56 [2]
	Glutamic acid	IC50	428000.0 [1]
	Phosphoserine	IC50	523000.0 [1]
	Quisqualic acid	IC50	9500.0 [1]
	Willardiine	IC50	67000.0 [1]
	L-Serine O-sulfate	IC50	438000.0 [1]
	Glutamine hydroxamate	IC50	100000.0 [1]
	(2S)-2-(Phosphonoamino)pentanedioic Acid	IC50	2.3 [1]
	2-Benzyl-3-mercaptopropanoic acid	Ki	11.0 [1]
	L-Glutamic acid, N-((((1S)-1-carboxy-5-((((4-iodophenyl)amino)carbonyl)amino)pentyl)amino)carbonyl)-	IC50	10.0 [1]
	1,2,4-Butanetricarboxylic acid	IC50	20000.0 [1]
	4-(Hydroxyamino)-4-oxobutanoic acid	IC50	43000.0 [1]
	2-({Hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]phosphoryl}methyl)pentanedioic acid	IC50	82.0 [1]
	Iofolastat	IC50	22.0 [1]
	Pentanedioic acid, 2-mercapto-	IC50	2600.0 [1]
	2-(Phosphonomethyl)Succinic Acid	Ki	700.0 [1]
	(R)-2-(Phosphonomethyl)Pentanedioic Acid	Ki	30.0 [1]
	n-Hydroxy-d-asparagine	IC50	100000.0 [1]
	2-[3-(1-Carboxy-2-mercapto-ethyl)-ureido]-pentanedioic acid	Ki	376.0 [1]
	N-Hydroxy-L-asparagine	IC50	100000.0 [1]
	2-Hydroxycarbamoylmethyl-pentanedioic acid	IC50	220.0 [1]
	2-Phosphonomethyl-hexanedioic acid	IC50	185.0 [1]
	(2s)-2-(Phosphonomethyl)pentanedioic Acid	Ki	0.1 [1]
	3-(Mercaptomethyl)benzoic acid	IC50	1300.0 [1]
	(2S,4S)-2-[[(1S,3S)-1,3-Dicarboxybutyl]carbamoylamino]-4-methylpentanedioic acid	Ki	1109.0 [1]
	(2S,4R)-2-[[(1S,3R)-1,3-Dicarboxybutyl]carbamoylamino]-4-methylpentanedioic acid	Ki	1285.0 [1]
	Benzoic acid, 3-[(1-carboxy-4-mercaptobutyl)thio]-	IC50	32.0 [1]
	2-Mercaptomethylglutaric acid	IC50	6000.0 [1]
	N~2~-[(1-Carboxycyclopropyl)carbamoyl]-N~6~-(4-Iodobenzoyl)-L-Lysine	Ki	318.0 [1]
	N~2~-{[(S)-Carboxy(4-Hydroxyphenyl)methyl]carbamoyl}-N~6~-(4-Iodobenzoyl)-L-Lysine	Ki	85.1 [1]
	N~2~-{[(1s)-1-Carboxy-2-(Pyridin-4-Yl)ethyl]carbamoyl}-N~6~-(4-Iodobenzoyl)-L-Lysine	Ki	105.0 [1]
	2-[(3-Carboxyphenyl)methoxy]-5-(sulfanylmethyl)benzoic acid	IC50	2.0 [1]
	2-(2-Mercaptoethyl)Benzoic Acid	IC50	930.0 [1]
	Benzoic acid, 3-(1-carboxy-4-mercaptobutoxy)-	IC50	14.0 [1]
	3-(1-Oxo-3,4-dihydroisothiochromen-8-yl)benzoic acid	IC50	20000.0 [1]
	1-[(4-Bromo-3-carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1h-indole-2-carboxylic acid	IC50	140.0 [1]
	2-(4-Mercapto-butyl)-pentanedioic acid	IC50	1100.0 [1]
	2-[(3-Carboxyphenyl)methoxy]-6-(2-sulfanylethyl)benzoic acid	IC50	69.0 [1]
	3-(2-Mercaptoethyl)-1H-indole-2-carboxylic acid	IC50	1200.0 [1]
	3-(2-Mercaptoethyl)-1-(phenylmethyl)-1h-indole-2-carboxylic acid	IC50	12000.0 [1]
	1-[[3-Carboxy-5-(1,1-dimethylethyl)phenyl]methyl]-3-(2-mercaptoethyl)-1h-indole-2-carboxylic acid	IC50	34.0 [1]
	1-[(2-Carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1h-indole-2-carboxylic acid	IC50	22.0 [1]
	3-(2-Mercaptoethyl)-1-phenyl-1H-indole-2-carboxylic acid	IC50	6100.0 [1]
	1-[(4-Carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1h-indole-2-carboxylic acid	IC50	94.0 [1]
	1-[(3-Carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1h-indole-2-carboxylic acid	IC50	22.0 [1]
	3-{2-Carboxy-2-[(hydroxycarbamoyl)methyl]ethyl}benzoic acid	IC50	15000.0 [1]
	2-[[Hydroxy(phenylmethoxy)phosphoryl]methyl]pentanedioic acid	IC50	12.5 [1]
	3-[2-(2-Benzoyloxymethyl-3-benzyl-4-oxo-azetidin-1-yl)-2-oxo-ethyl]-benzoic acid benzyl ester	IC50	100000.0 [1]
	Benzoic acid 3-benzyl-1-ethanesulfonyl-4-oxo-azetidin-2-ylmethyl ester	IC50	2190.0 [1]
	Benzoic acid 1-benzenesulfonyl-3-benzyl-4-oxo-azetidin-2-ylmethyl ester	IC50	3080.0 [1]
	1-Benzoyl-3-(4-hydroxy-benzyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester	IC50	9140.0 [1]
	Benzoic acid 3-benzyl-1-(4-nitro-benzenesulfonyl)-4-oxo-azetidin-2-ylmethyl ester	IC50	11500.0 [1]
	Benzoic acid 3-benzyl-4-oxo-1-(toluene-4-sulfonyl)-azetidin-2-ylmethyl ester	IC50	4790.0 [1]
	3-Benzyl-4-oxo-1-(toluene-4-sulfonyl)-azetidine-2-carboxylic acid benzyl ester	IC50	30000.0 [1]
	Benzoic acid 1-benzoyl-3-benzyl-4-oxo-azetidin-2-ylmethyl ester	IC50	1590.0 [1]
	4-[[(2S,3S)-1-Benzoyl-3-benzyl-4-oxoazetidin-2-yl]methoxycarbonyl]benzoic acid	IC50	100000.0 [1]
	1-Benzoyl-3-benzyl-4-oxo-azetidine-2-carboxylic acid 4-carboxy-benzyl ester	IC50	24300.0 [1]
	2-(2-Phosphonooxy-ethyl)-pentanedioic acid	IC50	1200.0 [1]
	2-(5-Mercapto-pentyl)-pentanedioic acid	IC50	2600.0 [1]
	2-Phosphonopentanedioic Acid	IC50	1400.0 [1]
	2-[3-(4,6-Dicarboxy-hexyldisulfanyl)-propyl]-pentanedioic acid	IC50	3100.0 [1]
	2-(3-Tritylsulfanyl-propyl)-pentanedioic acid	IC50	10000.0 [1]
	Tetralithium;(2S)-2-(phosphonatoamino)pentanedioate	IC50	0.86 [1]
	(2R,4S)-2-Benzyl-4-[[(1S,3R)-1,3-dicarboxy-4-phenylbutyl]carbamoylamino]pentanedioic acid	Ki	392.0 [1]
	3-[2-Carboxy-2-(phosphonomethyl)ethyl]benzoic acid	IC50	120.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate carboxypeptidase II Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glutamate-carboxypeptidase-ii-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glutamate carboxypeptidase II Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-carboxypeptidase-ii-inhibitors-ic50-ki.
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