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Glucokinase regulatory protein Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC504.0 [1]
(2R)-1,1,1-Trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC5021.0 [1]
1,1,1,3,3,3-Hexafluoro-2-{4-[4-(Thiophen-2-Ylsulfonyl)piperazin-1-Yl]phenyl}propan-2-OlIC501420.0 [1]
(2R)-2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC509.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamideIC502500.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]-1,3-benzodioxole-5-sulfonamideIC506500.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]-4-methoxybenzenesulfonamideIC507300.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]benzenesulfonamideIC5033000.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]cyclopropanesulfonamideIC5033000.0 [1]
N-[(R)-(2-Chlorophenyl)-[7-[3-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC504400.0 [1]
N-[(R)-(2-Chlorophenyl)-[7-[3-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC502700.0 [1]
N-[(R)-(2-Amino-5-chloropyridin-4-yl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC5025.0 [1]
N-[1-Benzofuran-2-yl(phenyl)methyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamideIC501200.0 [1]
N-[(R)-1-Benzofuran-2-Yl(Phenyl)methyl]-3,4-Dihydro-2h-1,5-Benzodioxepine-7-SulfonamideIC50870.0 [1]
2-[4-[(2S)-2-Benzyl-4-(2-thienylsulfonyl)piperazino]phenyl]-1,1,1,3,3,3-hexafluoro-2-propanolIC50701.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC509.7 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[2-[(4-methylphenyl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC504310.0 [1]
N-[(R)-1-Benzofuran-2-yl-(2-chlorophenyl)methyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamideIC5052.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]-3,3-difluoro-2,4-dihydro-1,5-benzodioxepine-7-sulfonamideIC50810.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]-3-fluoro-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamideIC5074.0 [1]
(2S)-1,1,1-Trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC5012.0 [1]
(2S)-1,1,1-Trifluoro-2-[4-[(2S)-2-(oxan-4-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC50100.0 [1]
(2R)-1,1,1-Trifluoro-2-[4-[(2S)-2-(oxan-4-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC5095.0 [1]
N-[(R)-1-Benzothiophen-2-Yl(2-Chlorophenyl)methyl]-3,4-Dihydro-2h-1,5-Benzodioxepine-7-SulfonamideIC5017.0 [1]
N-[(R)-1-Benzothiophen-2-yl-(2-chlorophenyl)methyl]-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamideIC50100.0 [1]
N-[(R)-(2-Chlorophenyl)-([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamideIC50160.0 [1]
2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5010.0 [1]
2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-3,3,3-trifluoropropane-1,2-diolIC5024.0 [1]
N-[(R)-(2-Chlorophenyl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC50110.0 [1]
N-[(R)-(6-Amino-3-chloropyridin-2-yl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC506.0 [1]
N-[(R)-(2-Chlorophenyl)-[7-[4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC50300.0 [1]
N-[(R)-(2-Chlorophenyl)-[7-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC50190.0 [1]
2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoropent-4-yn-2-olIC506.0 [1]
2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-olIC5018.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]benzenesulfonamideIC5061.0 [1]
5-[(3S)-4-[4-[N-Methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl]-3-prop-1-ynylpiperazin-1-yl]sulfonylpyridin-2-amineIC50266.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-cyclopropylbenzenesulfonamideIC50101.0 [1]
5-[(3S)-4-[4-(Methylsulfonimidoyl)phenyl]-3-prop-1-ynylpiperazin-1-yl]sulfonylpyridin-2-amineIC50310.0 [1]
5-[(3S)-4-[4-(Cyclopropylsulfonimidoyl)phenyl]-3-prop-1-ynylpiperazin-1-yl]sulfonylpyridin-2-amineIC50256.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-(cyclopropylmethyl)benzenesulfonamideIC50320.0 [1]
1-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]ethanoneIC501090.0 [1]
5-[(3S)-3-Prop-1-ynyl-4-[4-(trifluoromethylsulfonimidoyl)phenyl]piperazin-1-yl]sulfonylpyridin-2-amineIC5045.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-methylbenzenesulfonamideIC5035.0 [1]
6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-methylpyridine-3-sulfonamideIC5068.0 [1]
2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluorohex-4-yn-2-olIC505.0 [1]
2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoro-3-methoxypropan-2-olIC5016.0 [1]
3-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-4,4,4-trifluoro-3-hydroxybutanenitrileIC5028.0 [1]
5-[(3S)-3-Prop-1-ynyl-4-[4-(1,1,1-trifluoropropan-2-yl)phenyl]piperazin-1-yl]sulfonylpyridin-2-amineIC501050.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2S)-2-(morpholin-4-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC5036.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(3S)-3-methyl-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC503170.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2S)-2-propan-2-yl-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC505340.0 [1]
2-[[1-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-thiophen-2-ylsulfonylpiperazin-2-yl]methyl]phenolIC50215.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[2-[(2-methylphenyl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC501230.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[2-[(3-methylphenyl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC501010.0 [1]
2-(4-((2S)-2-Ethyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanolIC501440.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2S)-2-phenyl-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC502060.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[2-(pyridin-4-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC501560.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2S)-2-methyl-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC50300.0 [1]
3-[[1-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-thiophen-2-ylsulfonylpiperazin-2-yl]methyl]phenolIC501930.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2S)-2-(oxan-4-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC5058.0 [1]
4-[[1-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-thiophen-2-ylsulfonylpiperazin-2-yl]methyl]phenolIC50850.0 [1]
1,1,1,3,3,3-Hexafluoro-2-[4-[(2R)-2-methyl-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC509150.0 [1]
2-[4-[(2S)-2-(Cyclohexylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501500.0 [1]
2-[4-[(3R)-3-Methyl-4-(2-thienylsulfonyl)piperazino]phenyl]-1,1,1,3,3,3-hexafluoro-2-propanolIC504180.0 [1]
(2S)-2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-3,3,3-trifluoropropane-1,2-diolIC5028.0 [1]
N-[(R)-(2-Amino-5-chloropyrimidin-4-yl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC5018.0 [1]
2-[2-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyrimidin-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5010.0 [1]
(2R)-2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-olIC5013.0 [1]
(2R)-2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-3,3,3-trifluoropropane-1,2-diolIC506.0 [1]
(2S)-2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-olIC5013.0 [1]
(2S)-2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-3,3,3-trifluoropropane-1,2-diolIC5013.0 [1]
(2R)-2-[6-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-3-yl]-3,3,3-trifluoropropane-1,2-diolIC5070.0 [1]
N-[(R)-(2-Chloro-6-fluorophenyl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC5056.0 [1]
N-[(R)-(2-Amino-5-chloro-3-fluoropyridin-4-yl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC503.8 [1]
N-[(R)-(6-Amino-3-chloro-5-fluoropyridin-2-yl)-[7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl]methyl]cyclopropanesulfonamideIC5011.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-propan-2-ylbenzenesulfonamideIC50235.0 [1]
(2R)-3-Amino-2-[4-[(2S)-4-(6-aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC5047.0 [1]
(2S)-3-Amino-2-[4-[(2S)-4-(6-aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC50374.0 [1]
5-[(3S)-3-Prop-1-ynyl-4-[4-(trifluoromethylsulfonimidoyl)phenyl]piperazin-1-yl]sulfonylpyridin-2-amineIC50182.0 [1]
5-[(3S)-3-Prop-1-ynyl-4-[4-(trifluoromethylsulfonimidoyl)phenyl]piperazin-1-yl]sulfonylpyridin-2-amineIC5017.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-methylbenzamideIC503070.0 [1]
5-[(3S)-4-Phenyl-3-prop-1-ynylpiperazin-1-yl]sulfonylpyridin-2-amineIC5025000.0 [1]
5-[(3S)-4-(4-Methylsulfinylphenyl)-3-prop-1-ynylpiperazin-1-yl]sulfonylpyridin-2-amineIC503360.0 [1]
4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-N-phenylbenzenesulfonamideIC501600.0 [1]
5-[(3S)-4-(4-Methylsulfonylphenyl)-3-prop-1-ynylpiperazin-1-yl]sulfonylpyridin-2-amineIC50401.0 [1]
2-[5-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]pyridin-2-yl]-1,1,1-trifluoropropan-2-olIC5069.0 [1]
2-[2-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5081.0 [1]
2-[2-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1-trifluoropropan-2-olIC5049.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glucokinase regulatory protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glucokinase-regulatory-protein-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glucokinase regulatory protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glucokinase-regulatory-protein-inhibitors-ic50-ki.
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