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Glucagon receptor Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
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▼
Gra EX-25IC5047.0 [1], 55.0 [2], 140.0 [3], 144.0 [4]
Gra EX-25Ki63.0 [1]
CID 11570626IC506.6 [1], 15.7 [2], 20.0 [3], 80.0 [4]
CID 11570626Ki70.0 [1]
3-[[4-[1-[3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC5050.0 [1], 100.0 [2], 600.0 [3]
2-(4-Pyridinyl)-3-(4-fluorophenyl)-5-(4-chlorophenyl)-1H-pyrroleIC5080.0 [1], 800.0 [2], 1402.81 [3]
(+)-(1R)-1-[4-(4-Fluorophenyl)-2,6-diisopropyl-5-propylpyridin-3-yl]ethanolIC5065.0 [1], 110.0 [2]
4-[[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC503.2 [1], 46.0 [2]
3-[[4-[[3-(3,5-Dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acidIC5044.0 [1], 84.0 [2], 86.2 [3], 113.8 [4]
4-[[(4-Tert-butylcyclohexyl)-(1-methylbenzimidazol-2-yl)amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC504.0 [1], 55.0 [2], 170.0 [3], 430.0 [4]
1-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamideIC501.01 [1], 2.31 [2], 15.0 [3], 18.0 [4]
5-Fluoro-2-[3-(1-hydroxyethyl)-5-pentyl-2,6-di(propan-2-yl)pyridin-4-yl]phenolIC5012.0 [1], 30.0 [2], 2200.0 [3], 8000.0 [4]
5-Fluoro-2-[3-(1-hydroxyethyl)-2,6-di(propan-2-yl)-5-propylpyridin-4-yl]phenolIC5010.0 [1], 18.0 [2], 1000.0 [3], 8000.0 [4]
2-[3-(1-Hydroxy-ethyl)-2,6-diisopropyl-5-propyl-pyridin-4-yl]-phenolIC5025.0 [1], 40.0 [2], 190.0 [3], 1100.0 [4]
2-[3-Ethyl-5-(1-hydroxyethyl)-2,6-di(propan-2-yl)pyridin-4-yl]-5-fluorophenolIC5016.0 [1], 20.0 [2], 2000.0 [3], 5000.0 [4]
4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridineIC507.0 [1], 170.0 [2], 1442.12 [3]
3-Chloro-4-hydroxy-N-[(E)-(4-hydroxynaphthalen-1-yl)methylideneamino]benzamideIC50200.0 [1], 203.0 [2]
4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridineIC50117.22 [1], 490.0 [2]
4-[[9-Tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undecan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5032.0 [1], 34.0 [2], 92.0 [3]
2-[2,6-Diisopropyl-3-(hydroxymethyl)-5-pentyl-4-pyridyl]-5-fluorophenolIC50120.0 [1], 190.0 [2]
2,6-Diisopropyl-4-(4-fluorophenyl)-5-pentylpyridine-3-methanolIC50400.0 [1], 700.0 [2]
2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC5080.17 [1], 400.0 [2], 3200.0 [3]
[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-(2-methyl-propenyl)-pyridin-3-yl]-methanolIC502000.0 [1], 7000.0 [2]
4-[5-(4-Chloro-phenyl)-3-isopropyl-1H-pyrrol-2-yl]-pyridineIC5032.0 [1], 110.0 [2], 3032.0 [3]
2-(4-Chlorophenyl)-4-(2-phenoxyphenyl)-5-(4-pyridinyl)-1H-imidazoleIC506.5 [1], 150.31 [2], 290.0 [3]
2,4-Bis(4-chlorophenyl)-5-(4-pyridinyl)-1H-imidazoleIC5023.01 [1], 190.0 [2], 2200.0 [3]
3-[[1-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acidIC503.8 [1], 489.0 [2], 1085.0 [3]
2-(4-Pyridinyl)-3-(4-fluorophenyl)-5-(3-chlorophenyl)-1H-pyrroleIC5040.0 [1], 420.73 [2], 990.0 [3]
2-(4-Pyridinyl)-3-(4-fluorophenyl)-5-(2,4-dichlorophenyl)-1H-pyrroleIC5040.0 [1], 420.73 [2], 950.0 [3]
2-(4-Pyridinyl)-3-(3-bromophenyl)-5-(4-chlorophenyl)-1H-pyrroleIC5080.17 [1], 150.0 [2], 1700.0 [3]
2-(4-Pyridinyl)-3-[2-(allyloxy)phenyl]-5-(4-chlorophenyl)-1H-pyrroleIC5017.0 [1], 260.0 [2], 4742.42 [3]
2-(4-Chlorophenyl)-4-(4-biphenylyl)-5-(4-pyridinyl)-1H-imidazoleIC50140.0 [1], 3303.7 [2], 3800.0 [3]
2-(4-Chlorophenyl)-4-(4-iodophenyl)-5-(4-pyridinyl)-1H-imidazoleIC50130.0 [1], 140.28 [2], 750.0 [3]
2-(4-Chlorophenyl)-4-(4-phenoxyphenyl)-5-(4-pyridinyl)-1H-imidazoleIC5027.0 [1], 110.0 [2], 250.03 [3]
4-[2-(4-Chlorophenyl)-4-(3-phenoxyphenyl)-1H-imidazol-5-yl]pyridineIC5013.0 [1], 150.0 [2], 220.29 [3]
2-(4-Chlorophenyl)-4-(3-biphenylyl)-5-(4-pyridinyl)-1H-imidazoleIC5061.0 [1], 590.2 [2], 3000.0 [3]
4-[2-(4-Chloro-phenyl)-5-(2,4-dipropoxy-phenyl)-3H-imidazol-4-yl]-pyridineIC5013.0 [1], 120.0 [2], 2404.36 [3]
4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridineIC5090.0 [1], 180.3 [2], 490.0 [3]
4-[3-(4-Fluoro-phenyl)-1H-pyrrol-2-yl]-pyridineIC50160.32 [1], 3000.0 [2]
2-(4-Pyridinyl)-3,5-bis(4-fluorophenyl)-1H-pyrroleIC5090.0 [1], 340.41 [2], 350.0 [3]
2-(4-Pyridinyl)-3-(2-ethoxyphenyl)-5-(4-chlorophenyl)-1H-pyrroleIC5040.0 [1], 500.0 [2], 14223.29 [3]
2-(4-Pyridinyl)-3-(2-methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrroleIC5070.0 [1], 500.0 [2], 2654.61 [3]
2-(4-Pyridinyl)-3-(2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrroleIC508.0 [1], 140.0 [2], 2844.46 [3]
2-(4-Pyridinyl)-3-(2-bromophenyl)-5-(4-chlorophenyl)-1H-pyrroleIC5026.0 [1], 1000.0 [2], 2300.0 [3]
2-(4-Pyridinyl)-3-(4-bromophenyl)-5-(4-chlorophenyl)-1H-pyrroleIC50140.0 [1], 300.61 [2], 2300.0 [3]
2-(4-Pyridinyl)-3-(4-methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrroleIC50100.0 [1], 1150.8 [2], 1600.0 [3]
4-[3-(4-Fluoro-phenyl)-5-p-tolyl-1H-pyrrol-2-yl]-pyridineIC50250.0 [1], 1690.44 [2], 2200.0 [3]
2-(4-Pyridinyl)-3-phenyl-5-(4-chlorophenyl)-1H-pyrroleIC5060.0 [1], 210.38 [2], 380.0 [3]
2-(4-Pyridinyl)-3-(3-methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrroleIC5060.0 [1], 420.73 [2], 450.0 [3]
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-pyrrole-2-yl]benzonitrileIC5050.0 [1], 140.0 [2], 4900.0 [3]
2-(4-Pyridinyl)-3-(2-isobutoxyphenyl)-5-(4-chlorophenyl)-1H-pyrroleIC503.0 [1], 200.0 [2], 3767.04 [3]
3-[[5-[2-[[3-Chloro-4-[2-methyl-4-(trifluoromethyl)phenyl]anilino]methyl]-5-(trifluoromethyl)phenyl]pyridine-2-carbonyl]amino]propanoic acidIC5022.0 [1]
3-[[5-[2-[[3-Chloro-4-[2-methyl-4-(trifluoromethyl)phenyl]anilino]methyl]-5-(trifluoromethyl)phenyl]pyridine-2-carbonyl]amino]propanoic acidKi17.0 [1], 17.2 [2]
2-(4-Pyridinyl)-3,5-bis(4-chlorophenyl)-1H-pyrroleIC50160.32 [1], 190.0 [2], 810.0 [3]
SB-203580 analogue (4)IC50160.03 [1], 270.0 [2], 2900.0 [3]
Glucagon Receptor Antagonist IIC50129.0 [1], 181.0 [2]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC503.9 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidKi85.0 [1]
3-Chloro-4-hydroxy-N-[(E)-[1-[(4-propan-2-ylphenyl)methyl]indol-4-yl]methylideneamino]benzamideIC5023.0 [1], 84.0 [2]
3-Cyano-4-hydroxy-N-[(E)-[1-[(2,3,5,6-tetramethylphenyl)methyl]indol-4-yl]methylideneamino]benzamideIC502.3 [1]
3-Cyano-N-[(E)-[3,5-dimethoxy-4-[(4-propan-2-ylphenyl)methoxy]phenyl]methylideneamino]-4-hydroxybenzamideIC5020.0 [1]
3-(4-((1-(4-Cyclohexenylphenyl)-3-(3,5-dichlorophenyl)ureido)methyl)benzamido)propanoic acidIC5012.0 [1], 27.0 [2]
2,4-Bis(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50100.0 [1], 2000.0 [2]
3-Chloro-N-[(E)-[4-[2-(diethylamino)-2-oxoethoxy]naphthalen-1-yl]methylideneamino]-4-hydroxybenzamideIC5049.7 [1], 130.0 [2]
4-[[5,6-Dichloro-3-methyl-2-[4-(trifluoromethoxy)phenyl]iminobenzimidazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC504.0 [1], 23.0 [2]
3-[[4-[[[3,5-Bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]methyl]benzoyl]amino]propanoic acidIC5016.0 [1], 56.0 [2]
3-{4-[1-(4-Tert-butylphenyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acidIC5036.0 [1], 96.0 [2]
2,6-Diisopropyl-4-phenyl-5-pentylpyridine-3-methanolIC501400.0 [1]
3-Chloro-4-hydroxy-N-[(E)-[4-[(4-propan-2-ylphenyl)methoxy]naphthalen-1-yl]methylideneamino]benzamideIC504.3 [1], 53.0 [2]
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-pyrrole-2-yl]benzoic acidIC5090.16 [1], 3000.0 [2]
2-Phenyl-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50130.02 [1], 20000.0 [2]
4-[[8-Tert-butyl-3-(3,5-dichlorophenyl)-2-oxo-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5036.0 [1], 116.0 [2]
3-[[4-[[8-Tert-butyl-3-(3,5-dichlorophenyl)-2-oxo-1,3-diazaspiro[4.5]decan-1-yl]methyl]benzoyl]amino]propanoic acidIC5043.0 [1], 423.0 [2]
3-[[4-[[5-(3,5-Dichlorophenyl)-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acidIC5095.0 [1], 230.0 [2]
3-[[4-[(4-Chloro-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acidIC5053.0 [1], 76.0 [2]
3-[[4-[[8-Tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[4.5]decan-1-yl]methyl]benzoyl]amino]propanoic acidIC50336.0 [1], 459.0 [2]
4-[[8-Tert-butyl-3-(3-chlorophenyl)-2-oxo-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5094.0 [1], 353.0 [2]
4-[[5-(3,5-Dichlorophenyl)-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5035.0 [1], 36.0 [2]
3-[[4-[(4-Chloro-N-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acidIC5053.0 [1], 82.0 [2]
2-(4-Isopropylphenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50280.54 [1], 700.0 [2]
2-(4-((3,5-Bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamido)acetic acidIC50560.0 [1], 3000.0 [2]
4-[1-[3,5-Bis[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]ethyl]-N-(2H-tetrazol-5-yl)benzamideIC50130.0 [1], 1300.0 [2]
3-[[4-[[9-Tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undecan-1-yl]methyl]benzoyl]amino]propanoic acidIC50182.0 [1], 282.0 [2]
2-[4-(Methoxycarbonyl)phenyl]-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazoleIC50300.61 [1], 8700.0 [2]
2-(4-Methoxyphenyl)-5-(4-fluorophenyl)-4-(4-pyridyl)-1H-imidazoleIC50100.0 [1], 13000.0 [2]
4-[5-(4-Fluoro-phenyl)-2-p-tolyl-3H-imidazol-4-yl]-pyridineIC5090.16 [1], 1300.0 [2]
3-[[4-[[8-Tert-butyl-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-diazaspiro[4.5]decan-1-yl]methyl]benzoyl]amino]propanoic acidIC5060.0 [1], 515.0 [2]
3-[[4-[[[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-(5,6,7,8-tetrahydronaphthalen-2-yl)amino]methyl]benzoyl]amino]propanoic acidIC5054.0 [1], 79.0 [2]
2-(3-Bromophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50150.31 [1], 1400.0 [2]
4-[[5-Cyclohexyl-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50120.0 [1], 160.0 [2]
4-[[3,5-Bis[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5043.0 [1], 47.0 [2]
4-[[8-Tert-butyl-3-(4-chlorophenyl)-2-oxo-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50116.0 [1], 446.0 [2]
2-(4-Chlorophenyl)-4-(2-butoxyphenyl)-5-(4-pyridyl)-1H-imidazoleIC508.5 [1], 110.0 [2]
3-[[4-[[8-Tert-butyl-3-(3-chlorophenyl)-2-oxo-1,3-diazaspiro[4.5]decan-1-yl]methyl]benzoyl]amino]propanoic acidIC50351.0 [1], 601.0 [2]
4-[[8-Tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50105.0 [1], 193.0 [2]
N-[3-Cyano-4-methyl-5-[3-(2-methylpropyl)-1,2,4-oxadiazol-5-yl]thiophen-2-yl]-2-ethylbutanamideIC50185.0 [1], 368.0 [2]
3-[[4-[[4-(Trifluoromethoxy)-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino]methyl]benzoyl]amino]propanoic acidIC5051.0 [1], 92.0 [2]
N-[3-Cyano-6-[(2,4-dichlorophenyl)methyl-propan-2-ylamino]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamideIC5059.0 [1], 129.0 [2]
4-[[3-(3,5-Dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5039.0 [1], 330.0 [2]
4-[[3-[1-(4-Bromophenyl)ethyl]-8-tert-butyl-2-oxo-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5030.0 [1], 164.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glucagon receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/glucagon-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Glucagon receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glucagon-receptor-inhibitors-ic50-ki.
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