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Glucagon Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
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▼
4-[[(4-Tert-butylcyclohexyl)-(5-cyclopentyloxy-1-methylbenzimidazol-2-yl)amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC505000.0 [1]
4-[[(4-Tert-butylcyclohexyl)-(1-methyl-6-propoxybenzimidazol-2-yl)amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC505000.0 [1]
4-[[(4-Tert-butylcyclohexyl)-[1-methyl-5-(trifluoromethyl)benzimidazol-2-yl]amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC506800.0 [1]
4-[[(4-Tert-butylcyclohexyl)-(5-methoxy-1-methylbenzimidazol-2-yl)amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC505900.0 [1]
4-[[(4-Tert-butylcyclohexyl)-(5-ethoxy-1-methylbenzimidazol-2-yl)amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC507600.0 [1]
4-[[(4-Tert-butylcyclohexyl)-(5,6-dichloro-1-methylbenzimidazol-2-yl)amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC503700.0 [1]
3-[[4-[1-[3-Methyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acidKi203.0 [1]
3-(4-(1-(2-(4-(Trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-5-ylamino)butyl)benzamido)propanoic acidKi38.2 [1]
3-[[4-[1-[4-(4-Fluoropyrazol-1-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi1659.0 [1]
3-[[4-[(3,3-Dimethylcyclobutyl)-[[2-[4-(trifluoromethyl)pyrazol-1-yl]pyrimidin-5-yl]amino]methyl]benzoyl]amino]propanoic acidKi5.55 [1]
3-[[4-[1-(4-Indazol-2-ylphenoxy)butyl]benzoyl]amino]propanoic acidKi109.0 [1]
3-[[4-[1-[6-[4-(Trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acidKi233.0 [1]
CID 68178630Ki110.0 [1]
3-[[4-[1-[2-[4-(Trifluoromethyl)pyrazol-1-yl]pyrimidin-5-yl]oxybutyl]benzoyl]amino]propanoic acidKi1050.0 [1]
3-[[4-[5-Chloro-2-[[4-(2,4-dichlorophenyl)anilino]methyl]phenyl]benzoyl]amino]propanoic acidKi33.0 [1]
3-[[4-[(3,3-Dimethylcyclobutyl)-[(6-fluoro-3-methylquinolin-2-yl)amino]methyl]benzoyl]amino]propanoic acidKi14.0 [1]
3-{4-[(3,3-Dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acidKi53.0 [1]
3-[[4-[1-[4-(3,4-Dimethylphenyl)phenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acidKi265.0 [1]
3-[[4-[1-[6-[4-(2-Methylpropyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acidKi254.0 [1]
3-[[4-[(3,3-Dimethylcyclobutyl)-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi15.8 [1]
3-[[4-[1-[4-(3-Butylpyrazol-1-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi1331.0 [1]
3-[[4-[1-[4-[2-Methyl-5-(trifluoromethyl)pyrazol-3-yl]phenoxy]butyl]benzoyl]amino]propanoic acidKi556.0 [1]
3-[[4-[1-[[6-(4-Phenylpyrazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi25.7 [1]
3-[[4-[Cyclohexyl-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi17.0 [1]
3-[[4-[3-Methyl-1-[[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi69.8 [1]
3-[[4-[Cyclobutyl-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi91.9 [1]
3-[[4-[2-Cyclopropyl-1-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]ethyl]benzoyl]amino]propanoic acidKi71.6 [1]
3-[[3-Fluoro-4-[1-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi57.2 [1]
3-[[4-[Cyclopentyl-[[2-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-5-yl]amino]methyl]benzoyl]amino]propanoic acidKi44.7 [1]
3-[[4-[1-[4-(7-Methylindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi98.2 [1]
3-[[4-[1-[4-(6-Methylindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi161.0 [1]
3-[[4-[1-[4-(4-Methylindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi316.0 [1]
3-[[4-[Cyclopentyl-[[6-[4-(trifluoromethyl)imidazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi1100.0 [1]
3-[[4-[1-[4-(5-Methylindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi208.0 [1]
3-[[4-[1-[[6-(4-Phenylimidazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi47.3 [1]
3-[[4-[1-[4-(4-Chloropyrazol-1-yl)-3,5-dimethylphenoxy]butyl]benzoyl]amino]propanoic acidKi93.2 [1]
3-[[4-[(3,3-Dimethylcyclobutyl)-[[6-[4-(trifluoromethyl)imidazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi42.2 [1]
3-[[4-[2,2-Dimethyl-1-[[6-[4-(trifluoromethyl)imidazol-1-yl]pyridin-3-yl]amino]propyl]benzoyl]amino]propanoic acidKi87.2 [1]
3-[[4-[1-[3,5-Difluoro-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acidKi240.0 [1]
3-[[4-[1-[4-(4-Chloro-3-methylpyrazol-1-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi665.0 [1]
3-(4-(1-(4-(2H-Indazol-2-yl)-3-methylphenoxy)butyl)benzamido)propanoic acidKi464.0 [1]
Ethyl 3-[[4-[(3,3-dimethylcyclobutyl)-[[2-[4-(trifluoromethyl)pyrazol-1-yl]pyrimidin-5-yl]amino]methyl]benzoyl]amino]propanoateKi41.0 [1]
Ethyl 3-[[4-[(3,3-dimethylcyclobutyl)-[2-[4-(trifluoromethyl)pyrazol-1-yl]pyrimidin-5-yl]oxymethyl]benzoyl]amino]propanoateKi251.0 [1]
3-[Methyl-[4-[1-[[6-(4-phenylpyrazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi142.0 [1]
3-[[4-[(1S)-1-(4-Indazol-2-yl-3,5-dimethylphenoxy)butyl]benzoyl]amino]propanoic acidKi47.8 [1]
3-[[4-[1-(4-Indazol-2-yl-3,5-dimethylphenoxy)butyl]benzoyl]amino]propanoic acidKi109.0 [1]
3-[[6-[[(1R)-1-[3,5-Dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenyl]-3-methylbutyl]amino]pyridine-3-carbonyl]amino]propanoic acidKi27.4 [1]
3-[[4-[[[6-(4-Chloro-3-methylpyrazol-1-yl)pyridin-3-yl]amino]-cyclopentylmethyl]benzoyl]amino]propanoic acidKi65.9 [1]
3-[[6-[[(1S)-1-[3,5-Dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenyl]-3-methylbutyl]amino]pyridine-3-carbonyl]amino]propanoic acidKi193.0 [1]
3-[[4-[1-[[6-(4-Cyclopropylpyrazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi101.0 [1]
3-[[6-[[Cyclohexyl-[2-methyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenyl]methyl]amino]pyridine-3-carbonyl]amino]propanoic acidKi297.0 [1]
3-(4-(1-(2-Methyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)-propanoic acidKi315.0 [1]
3-[[6-[[Cyclopentyl-[3,5-dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenyl]methyl]amino]pyridine-3-carbonyl]amino]propanoic acidKi28.0 [1]
3-[[4-[Cyclobutyl-[3,5-dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]methyl]benzoyl]amino]propanoic acidKi20.2 [1]
3-[[4-[Cyclopentyl-[[6-(4-propan-2-ylimidazol-1-yl)pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi88.4 [1]
3-[[4-[[[6-(4-Chloroimidazol-1-yl)pyridin-3-yl]amino]-cyclopentylmethyl]benzoyl]amino]propanoic acidKi225.0 [1]
3-[[4-[(3,3-Dimethylcyclobutyl)-[2-[4-(trifluoromethyl)pyrazol-1-yl]pyrimidin-5-yl]oxymethyl]benzoyl]amino]propanoic acidKi94.9 [1]
3-[[4-[[[6-(4-Tert-butylimidazol-1-yl)pyridin-3-yl]amino]-cyclopentylmethyl]benzoyl]amino]propanoic acidKi45.7 [1]
3-[[3-Methyl-4-[1-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi143.0 [1]
3-[[4-[(3,3-Difluorocyclobutyl)-[[6-[4-(trifluoromethyl)imidazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi235.0 [1]
3-[[4-[Oxan-4-yl-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi432.0 [1]
3-[[4-[Cyclopentyl-(4-indazol-2-ylphenoxy)methyl]benzoyl]amino]propanoic acidKi103.0 [1]
3-[[4-[Cyclopentyl-[3,5-dimethyl-4-[4-(trifluoromethyl)imidazol-1-yl]phenoxy]methyl]benzoyl]amino]propanoic acidKi51.0 [1]
3-[[6-[1-[[6-(4-Phenylpyrazol-1-yl)pyridin-3-yl]amino]butyl]pyridine-3-carbonyl]amino]propanoic acidKi132.0 [1]
3-[[4-[1-[6-(4-Phenylpyrazol-1-yl)pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acidKi58.0 [1]
3-[[4-[(S)-(3,3-Dimethylcyclobutyl)-[[6-[4-(trifluoromethyl)imidazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi35.0 [1]
3-[[4-[(1R)-1-[[6-(4-Tert-butylpyrazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi30.2 [1]
3-[[4-[(1S)-1-[[6-(4-Tert-butylpyrazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi20.2 [1]
3-[[4-[1-[4-(7-Chloroindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi354.0 [1]
3-[[4-[1-[4-(5-Chloroindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi62.8 [1]
3-[[4-[1-[3,5-Dimethyl-4-[4-(trifluoromethyl)imidazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acidKi89.5 [1]
3-[[4-[1-[4-(4-Cyclopropylpyrazol-1-yl)-3,5-dimethylphenoxy]butyl]benzoyl]amino]propanoic acidKi62.6 [1]
3-[[4-[(R)-Cyclohexyl-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi26.7 [1]
3-[[4-[(S)-Cyclohexyl-[[6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]amino]methyl]benzoyl]amino]propanoic acidKi9.05 [1]
3-[[4-[1-[3,5-Dimethyl-4-[4-(trifluoromethyl)triazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acidKi125.0 [1]
3-[[4-[1-[[6-(4-Pyridin-2-ylpyrazol-1-yl)pyridin-3-yl]amino]butyl]benzoyl]amino]propanoic acidKi192.0 [1]
3-[[4-[1-[4-(5-Fluoroindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi137.0 [1]
3-[[4-[1-[4-(6-Fluoroindazol-2-yl)phenoxy]butyl]benzoyl]amino]propanoic acidKi175.0 [1]
3-[[6-[1-[6-[4-(Trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]butylamino]pyridine-3-carbonyl]amino]propanoic acidKi399.0 [1]
3-[[4-[(3,3-Dimethylcyclobutyl)-[3,5-dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]methyl]benzoyl]amino]propanoic acidKi35.2 [1]
3-[[4-[1-[5-Methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acidKi446.0 [1]
3-[[4-[1-[3-Methoxy-5-methyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acidKi32.3 [1]
3-[[4-[2-[[4-(4-Chlorophenyl)anilino]methyl]phenyl]-3-methylbenzoyl]amino]propanoic acidKi45.0 [1]
3-[[4-[5-Chloro-2-[[4-(2,4-dichlorophenyl)anilino]methyl]phenyl]-2-fluorobenzoyl]amino]propanoic acidKi240.0 [1]
3-[[4-[5-Chloro-2-[1-[4-(4-chlorophenyl)anilino]ethyl]phenyl]benzoyl]amino]propanoic acidKi270.0 [1]
3-[[4-[5-Chloro-2-[[4-(4-fluorophenyl)anilino]methyl]phenyl]-2-fluorobenzoyl]amino]propanoic acidKi240.0 [1]
3-[[4-[5-Chloro-2-[[4-(4-chlorophenyl)anilino]methyl]phenyl]-2-fluorobenzoyl]amino]propanoic acidKi120.0 [1]
3-[[4-[2-[[4-(4-Chlorophenyl)anilino]methyl]phenyl]benzoyl]amino]propanoic acidKi60.0 [1]
3-[[4-[2-[[4-(4-Fluoro-3-nitrophenyl)anilino]methyl]phenyl]benzoyl]amino]propanoic acidKi38.0 [1]
3-[[4-[5-Chloro-2-[1-[4-(4-fluorophenyl)anilino]ethyl]phenyl]benzoyl]amino]propanoic acidKi770.0 [1]
3-[[4-[3-Methyl-1-[(6-methylquinolin-3-yl)amino]butyl]benzoyl]amino]propanoic acidKi160.0 [1]
3-[[4-[3-Methyl-1-[(4-methylquinolin-3-yl)amino]butyl]benzoyl]amino]propanoic acidKi109.0 [1]
3-[[4-[3-Methyl-1-[(2-methylquinolin-3-yl)amino]butyl]benzoyl]amino]propanoic acidKi360.0 [1]
3-[[4-[1-[(7-Fluoro-4-methylquinolin-2-yl)amino]-3-methylbutyl]benzoyl]amino]propanoic acidKi242.0 [1]
3-[[4-[3-Methyl-1-[(3-methylquinolin-2-yl)amino]butyl]benzoyl]amino]propanoic acidKi1237.0 [1]
3-(4-((3,3-Dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoic acidKi50.0 [1]
3-[[4-[3-Methyl-1-[[6-(trifluoromethyl)quinolin-2-yl]amino]butyl]benzoyl]amino]propanoic acidKi91.0 [1]
3-[[4-[3-Methyl-1-[[7-(trifluoromethyl)quinolin-2-yl]amino]butyl]benzoyl]amino]propanoic acidKi479.0 [1]
3-[[4-[1-[(8-Chloroquinolin-2-yl)amino]-3-methylbutyl]benzoyl]amino]propanoic acidKi199.0 [1]
3-[[4-[1-[(8-Methoxyquinolin-2-yl)amino]-3-methylbutyl]benzoyl]amino]propanoic acidKi1855.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Glucagon Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/glucagon-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Glucagon Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glucagon-inhibitors-ic50-ki.
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