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Geranylgeranyl transferase type I Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
TipifarnibIC501000.0 [1], 10000.0 [2], 50000.0 [3]
4-[(5-{[4-(3-Chlorophenyl)-3-oxopiperazin-1-YL]methyl}-1H-imidazol-1-YL)methyl]benzonitrileIC5098.0 [1], 99.0 [2], 98000.0 [3]
(S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2-carbonyl]-amino}-4-methyl-pentanoic acidIC505.0 [1], 240.0 [2]
4'-[[(R)-2-Amino-3-mercaptopropyl]amino]biphenyl-3-carboxylic acidIC5090000.0 [1], 100000.0 [2]
[3-Hydroxy-1,4-bis(sulfanyl)butan-2-yl] 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylateIC5017.0 [1], 40000.0 [2]
Bms-214662IC501300.0 [1], 2300.0 [2]
Methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylpentanoateIC507.3 [1], 2000.0 [2]
1-[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-2-pyridin-4-ylethanoneIC50114000.0 [1]
2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acidIC5050.0 [1], 55.0 [2]
2'-Methoxy-4'-[[(R)-2-amino-3-mercaptopropyl]amino]biphenyl-3-carboxylic acidIC5035000.0 [1], 43600.0 [2]
2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrileIC507.1 [1], 7.2 [2]
[2-Oxo-2-[[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy]amino]ethyl]phosphonic acidIC5066.0 [1], 20500.0 [2]
1-[(2R)-2-[(4-Cyanophenyl)methyl-methylamino]-3-(3-methylimidazol-4-yl)propanoyl]-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-4-carbonitrileIC501600.0 [1]
(R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiolIC50100000.0 [1]
(R)-2-Amino-3-[(3'-methyl-1,1'-biphenyl-4-yl)amino]-1-propanethiolIC50100000.0 [1]
4'-[[(R)-2-Amino-3-mercaptopropyl]amino]biphenyl-3-carboxylic acid methyl esterIC50100000.0 [1]
4-[(1S)-1-Amino-1-(3-methylimidazol-4-yl)ethyl]-2-[3-[(3S)-3-ethyl-1-methyl-2-oxoazepan-3-yl]phenoxy]benzonitrileIC503.6 [1]
(4-Chlorophenyl)-[5-(3-chlorophenyl)tetrazolo[1,5-a]quinolin-7-yl]-(3-methylimidazol-4-yl)methanamineIC5055.0 [1], 176.0 [2]
[(2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraenyl] N-sulfamoylcarbamateIC5010800.0 [1], 28200.0 [2]
4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl esterIC5060.6 [1], 61.0 [2]
[2-(Trifluoromethoxy)phenyl]methyl 4-[[3-[(4-cyanophenyl)methyl]-2-methylimidazol-4-yl]methyl]piperazine-1-carboxylateIC5053.0 [1], 660.0 [2]
GliotoxinIC5017000.0 [1]
LonafarnibIC5050000.0 [1]
(S)-Methyl 2-(4-((R)-2-amino-3-mercaptopropylamino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoateIC5054.0 [1]
CID 395754IC5050.0 [1]
Chaetomellic acid AIC5092000.0 [1]
GGTI-2133 free baseIC5038.0 [1]
Itaconic anhydrideIC501000000.0 [1]
3-Oxo-18-oxa-2,5,9,11-tetrazahexacyclo[17.6.2.22,5.113,17.07,11.022,26]triaconta-1(25),7,9,13(28),14,16,19(27),20,22(26),23-decaene-16-carbonitrileIC50301.0 [1]
4-[[3-[(4-Cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]-3-[3-(trifluoromethoxy)phenyl]benzonitrileIC50990.0 [1]
(3R)-3-Benzyl-4-(4-methoxyphenyl)sulfonyl-1-[(3-methylimidazol-4-yl)methyl]-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrileIC5099500.0 [1]
4-[[3-[(4-Cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]-3-[4-(trifluoromethoxy)phenyl]benzonitrileIC501300.0 [1]
4-[alpha-(1-Methyl-1H-imidazole-5-yl)-3-(1-naphthyl)-4-cyanobenzyloxymethyl]benzonitrileIC5018.0 [1]
3-(3-Chlorophenyl)-4-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]benzonitrileIC506800.0 [1]
4-[[3-[(4-Cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]-3-(4-ethoxyphenyl)benzonitrileIC502300.0 [1]
3-(4-Tert-butylphenyl)-4-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]benzonitrileIC50870.0 [1]
Lauric anhydrideIC50229000.0 [1]
H-Cys-4-Abz-Met-OHIC50100000.0 [1]
[(2Z,6E)-7,11-Dimethyl-3-prop-2-enyldodeca-2,6,10-trienyl] phosphono hydrogen phosphateIC50100000.0 [1]
(2S)-2-[[(3S)-2-[(2S)-2-[2-(1H-Imidazol-5-yl)ethylamino]-3-methylbutanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-4-methylsulfanylbutanoic acidIC50234.0 [1]
[(2Z,6E)-3-Ethenyl-7,11-dimethyldodeca-2,6,10-trienyl] phosphono hydrogen phosphateIC50100000.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(2-methylphenyl)methyl]imidazole-4-sulfonamideIC50780.0 [1]
N-Benzyl-N-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methylimidazole-4-sulfonamideIC502700.0 [1]
6-[alpha-(1-Methyl-5-imidazolyl)-4-cyanobenzyloxymethyl]biphenyl-3-carbonitrileIC503500.0 [1]
(1R,5R)-30-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.6.2.12,5.114,18.08,12.023,27]triaconta-8,10,14(29),15,17,20(28),21,23(27)-octaene-17-carbonitrileIC50390.0 [1]
Tert-butyl 4-[[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl-(1-methylimidazol-4-yl)sulfonylamino]methyl]piperidine-1-carboxylateIC5010000.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(1-pyrimidin-2-ylpiperidin-4-yl)methyl]imidazole-4-sulfonamideIC5010000.0 [1]
[1-[[3-(1,3-Benzodioxol-5-ylmethyl)imidazol-4-yl]methyl]-4-naphthalen-1-ylpyrrol-3-yl]-(4-methylpiperazin-1-yl)methanoneIC5016000.0 [1]
4-[3-(4-Cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]-3-(3-ethoxyphenyl)benzonitrileIC502400.0 [1]
(2S,3R)-2-[[(2S,3R)-2-[[(2R)-2-Amino-3-sulfanylpropyl]amino]-3-methylpentyl]amino]-3-methyl-N-[(3S)-2-oxooxolan-3-yl]pentanamideIC5010000.0 [1]
6-[[(4-Cyano-3-naphthalen-1-ylphenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-3-carbonitrileIC5024.0 [1]
(1R,5R)-29-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.5.2.12,5.114,18.08,12.023,26]nonacosa-8,10,14(28),15,17,20(27),21,23(26)-octaene-17-carbonitrileIC5018000.0 [1]
(5S)-30-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.6.2.12,5.114,18.08,12.023,27]triaconta-1(26),8,10,14(29),15,17,20(28),21,23(27),24-decaene-17-carbonitrileIC50650.0 [1]
[(2Z,6E)-3-Tert-butyl-7,11-dimethyldodeca-2,6,10-trienyl] phosphono hydrogen phosphateIC5050000.0 [1]
1-[[(2R,3R)-3-[(2,4-Dichlorophenyl)methoxy]-5-fluoro-2,3-dihydro-1-benzothiophen-2-yl]methyl]imidazoleIC5018300.0 [1]
2-Methyl-3-(acetylthio)-9-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1,4-dioneIC5090300.0 [1]
[(2Z,6E,10E)-3-Ethenyl-7,11,15-trimethylhexadeca-2,6,10,14-tetraenyl] phosphono hydrogen phosphateIC503050.0 [1]
(5R)-6-Methyl-31-oxo-20-oxa-2,6,11,13-tetrazahexacyclo[19.6.2.12,5.115,19.09,13.024,28]hentriaconta-1(27),9,11,15(30),16,18,21(29),22,24(28),25-decaene-18-carbonitrileIC5039.0 [1]
(1R,5S)-29-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.5.2.12,5.114,18.08,12.023,26]nonacosa-8,10,14(28),15,17,20(27),21,23(26)-octaene-17-carbonitrileIC5020000.0 [1]
(5R)-7,31-Dioxo-20-oxa-2,6,11,13-tetrazahexacyclo[19.6.2.12,5.115,19.09,13.024,28]hentriaconta-1(27),9,11,15(30),16,18,21(29),22,24(28),25-decaene-18-carbonitrileIC50150.0 [1]
(1S,5S)-29-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.5.2.12,5.114,18.08,12.023,26]nonacosa-8,10,14(28),15,17,20(27),21,23(26)-octaene-17-carbonitrileIC504000.0 [1]
(1S,5R)-29-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.5.2.12,5.114,18.08,12.023,26]nonacosa-8,10,14(28),15,17,20(27),21,23(26)-octaene-17-carbonitrileIC5020000.0 [1]
(5S)-6-Methyl-31-oxo-20-oxa-2,6,11,13-tetrazahexacyclo[19.6.2.12,5.115,19.09,13.024,28]hentriaconta-1(27),9,11,15(30),16,18,21(29),22,24(28),25-decaene-18-carbonitrileIC5032.0 [1]
(1R,5S)-30-Oxo-19,24-dioxa-2,6,10,12-tetrazahexacyclo[18.6.2.12,5.114,18.08,12.023,27]triaconta-8,10,14(29),15,17,20(28),21,23(27)-octaene-17-carbonitrileIC5015000.0 [1]
4-[(1R)-1-Amino-1-(3-methylimidazol-4-yl)ethyl]-2-[3-[(3R)-3-ethyl-1-methyl-2-oxoazepan-3-yl]phenoxy]benzonitrileIC5054.0 [1]
4-((1H-Imidazol-1-yl)methyl)-2-(3-(2-oxoazepan-3-yl)phenoxy)benzonitrileIC501200.0 [1]
4-[(1R)-1-Amino-1-(3-methylimidazol-4-yl)ethyl]-2-[3-[(3S)-3-ethyl-1-methyl-2-oxoazepan-3-yl]phenoxy]benzonitrileIC5013.0 [1]
(1R,5S)-30-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.6.2.12,5.114,18.08,12.023,27]triaconta-8,10,14(29),15,17,20(28),21,23(27)-octaene-17-carbonitrileIC502200.0 [1]
(5S)-7,31-Dioxo-20-oxa-2,6,11,13-tetrazahexacyclo[19.6.2.12,5.115,19.09,13.024,28]hentriaconta-1(27),9,11,15(30),16,18,21(29),22,24(28),25-decaene-18-carbonitrileIC5094.0 [1]
N-Benzyl-N-[2-[N-(1H-imidazol-5-ylmethyl)anilino]ethyl]-1-methylimidazole-4-sulfonamideIC5010000.0 [1]
N-Tert-butyl-2-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl-(1-methylimidazol-4-yl)sulfonylamino]acetamideIC5010000.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-N-(cyclohexylmethyl)-1-methylimidazole-4-sulfonamideIC50530.0 [1]
N-Benzyl-N-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]benzenesulfonamideIC50310.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(4-phenylphenyl)methyl]imidazole-4-sulfonamideIC507300.0 [1]
N-Benzyl-N-[2-[4-bromo-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methylimidazole-4-sulfonamideIC50530.0 [1]
Ggti-2418IC509.5 [1]
(6S)-27-Oxo-20-oxa-3,7,11,13-tetrazapentacyclo[19.3.1.13,6.115,19.09,13]heptacosa-1(25),9,11,15(26),16,18,21,23-octaene-18-carbonitrileIC5020000.0 [1]
N-Benzyl-N-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-5-(dimethylamino)naphthalene-1-sulfonamideIC5010000.0 [1]
Phosphono [(2Z,6E,10E)-7,11,15-trimethyl-3-prop-2-enylhexadeca-2,6,10,14-tetraenyl] hydrogen phosphateIC503380.0 [1]
1-[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-2-pyridin-3-ylethanoneIC5046000.0 [1]
N-Benzyl-N-[2-[4-bromo-N-(1H-imidazol-5-ylmethyl)anilino]ethyl]-1-methylimidazole-4-sulfonamideIC504400.0 [1]
N-Benzyl-N-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]pyridine-2-sulfonamideIC50820.0 [1]
N-(2-Bromoprop-2-enyl)-N-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methylimidazole-4-sulfonamideIC505500.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(4-methylphenyl)methyl]imidazole-4-sulfonamideIC50580.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(4-pyrrol-1-ylphenyl)methyl]imidazole-4-sulfonamideIC505800.0 [1]
N-Benzyl-N-[2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]thiophene-2-sulfonamideIC5010000.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-prop-2-enylimidazole-4-sulfonamideIC5010000.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-(2-methylprop-2-enyl)imidazole-4-sulfonamideIC50600.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-(2-pyrrol-1-ylethyl)imidazole-4-sulfonamideIC50510.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(3-methylphenyl)methyl]imidazole-4-sulfonamideIC50630.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-(pyridin-4-ylmethyl)imidazole-4-sulfonamideIC5010000.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-N-[(4-cyanophenyl)methyl]-1-methylimidazole-4-sulfonamideIC506500.0 [1]
N-[2-[4-Cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-1-methyl-N-[(3-phenylphenyl)methyl]imidazole-4-sulfonamideIC50550.0 [1]
4-[[[3-[(4-Cyanophenyl)methyl]imidazol-4-yl]methylamino]methyl]-3-(3-ethoxyphenyl)benzonitrileIC502600.0 [1]
(5R)-30-Oxo-19-oxa-2,6,10,12-tetrazahexacyclo[18.6.2.12,5.114,18.08,12.023,27]triaconta-1(26),8,10,14(29),15,17,20(28),21,23(27),24-decaene-17-carbonitrileIC503900.0 [1]
N-Benzyl-N-[3-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]propyl]-1-methylimidazole-4-sulfonamideIC504600.0 [1]
N-Benzyl-N-[(1R,2S)-2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]cyclopentyl]-1-methylimidazole-4-sulfonamideIC5010000.0 [1]
N-Benzyl-N-[(1S,2S)-2-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]cyclopentyl]-1-methylimidazole-4-sulfonamideIC509150.0 [1]
N-Benzyl-N-[(1S,3R)-3-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]cyclopentyl]-1-methylimidazole-4-sulfonamideIC5010000.0 [1]
N-Benzyl-N-[(1R,3R)-3-[4-cyano-N-[(3-methylimidazol-4-yl)methyl]anilino]cyclopentyl]-1-methylimidazole-4-sulfonamideIC507050.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Geranylgeranyl transferase type I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/geranylgeranyl-transferase-type-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Geranylgeranyl transferase type I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/geranylgeranyl-transferase-type-i-inhibitors-ic50-ki.
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