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Geranylgeranyl pyrophosphate synthetase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Digeranyl bisphosphonateIC50200.0 [1]
Zoledronic acidIC5097000.0 [1], 100000.0 [2]
Zoledronic acidKi2700.0 [1]
Minodronic acidIC50670.0 [1], 65000.0 [2], 100000.0 [3]
Minodronic acidKi1800.0 [1]
3-(Decyloxy)-1-(2,2-Diphosphonoethyl)pyridiniumIC50251.19 [1], 280.0 [2], 250000.0 [3]
Risedronic acidIC50100000.0 [1], 350000.0 [2], 300000000.0 [3]
(1-Hydroxy-1-Phosphono-2-[1,1';3',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic AcidIC501995.26 [1], 2100.0 [2]
(1-Hydroxy-1-Phosphono-2-[1,1';3',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic AcidKi60.0 [1]
[2-(3-Dibenzofuran-4-yl-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acidIC503981.07 [1], 4000.0 [2]
[2-(3-Dibenzofuran-4-yl-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acidKi110.0 [1]
(1-Hydroxy-1-phosphono-2-[1,1';4',1'']terphenyl-3-yl-ethyl)-phosphonic acidIC50720.0 [1], 794.33 [2]
(1-Hydroxy-1-phosphono-2-[1,1';4',1'']terphenyl-3-yl-ethyl)-phosphonic acidKi20.0 [1]
CID 16122555IC502511.89 [1], 2600.0 [2]
CID 16122555Ki70.0 [1]
[1-Hydroxy-2-(1,1':3',1''-Terphenyl-3-Yloxy)Ethane-1,1-Diyl]Bis(Phosphonic Acid)IC503981.07 [1], 4100.0 [2]
[1-Hydroxy-2-(1,1':3',1''-Terphenyl-3-Yloxy)Ethane-1,1-Diyl]Bis(Phosphonic Acid)Ki110.0 [1]
3-Biphenyl-3-Yl-1-(2-Hydroxy-2,2-Diphosphonoethyl)pyridiniumIC508200.0 [1], 10000.0 [2]
3-Biphenyl-3-Yl-1-(2-Hydroxy-2,2-Diphosphonoethyl)pyridiniumKi230.0 [1]
[2-[1-[(3E)-4,8-Dimethylnona-3,7-dienyl]triazol-4-yl]-1-phosphonoethyl]phosphonic acidIC5045.0 [1], 170.0 [2]
Alendronic acidIC50398107.17 [1], 440000.0 [2]
Pamidronic acidIC50180000.0 [1], 199526.23 [2]
Ibandronic AcidIC5079432.82 [1], 83000.0 [2]
(1-Hydroxy-1-phosphonodecyl)phosphonic acidIC50630.96 [1], 720.0 [2]
(1-Hydroxyheptane-1,1-Diyl)bis(Phosphonic Acid)IC5010000.0 [1], 11000.0 [2]
Lauryl alcohol diphosphonic acidIC50920.0 [1], 2511.89 [2]
(2E, 6E)-FarnesylbisphosphonateIC50100.0 [1]
[(7Z)-2,8,12-Trimethyl-5-phosphonotrideca-2,7,11-trien-5-yl]phosphonic acidIC503000.0 [1], 60000.0 [2]
(2,8-Dimethyl-5-phosphononona-2,7-dien-5-yl)phosphonic acidIC50100000.0 [1]
[2-[1-[(2E)-3,7-Dimethylocta-2,6-dienyl]triazol-4-yl]-1-phosphonoethyl]phosphonic acidIC5017000.0 [1]
Neridronic acidIC50690000.0 [1]
N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamineIC504500.0 [1]
(1-Hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acidIC50220000.0 [1]
[1-Hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid)IC50410000.0 [1]
{[(3-Methylpyridin-2-Yl)amino]methanediyl}bis(Phosphonic Acid)IC50220000.0 [1]
1-Hydroxy-2-(4-aminophenyl)ethane-1,1-diphosphonic acidIC50180000.0 [1]
1,1-Diphosphono-2-(1H-imidazole-4-yl)ethanolIC50220000.0 [1]
Phosphonic acid, (1-hydroxybutylidene)di-IC50620000.0 [1]
1-Hydroxypentane-1,1-bisphosphonateIC50200000.0 [1]
2-[(Bis-phosphono-methyl)-amino]-4-methyl-pyridiniumIC50260000.0 [1]
(1-Hydroxyoctane-1,1-diyl)diphosphonic acidIC504300.0 [1]
(3-Amino-1-hydroxy-1-phosphono-butyl)-phosphonic acidIC50330000.0 [1]
(1-Hydroxy-1-phosphono-hexyl)-phosphonic acidIC5053000.0 [1]
Deoxy Risedronic AcidIC50316227.77 [1]
4-(2-Hydroxy-2,2-bis-phosphono-ethylsulfanyl)-pyridiniumIC50550000.0 [1]
1,1-Diphosphono-1-undecanolIC501400.0 [1]
{1-Hydroxy-3-[methyl(4-phenylbutyl)amino]propane-1,1-diyl}bis(phosphonic acid)IC503981.07 [1]
2-Hydroxy-2-phosphono-3-(imidazo[1,2-a]pyridine-3-yl)propanoic acidIC501000000.0 [1]
[(Octylamino)-phosphonomethyl]phosphonic acidIC502200.0 [1]
3-Azageranylgeranyl diphosphateIC50140.0 [1]
[(Hexylamino)-phosphonomethyl]phosphonic acidIC5019000.0 [1]
Geranyl biphosphonateIC5010000.0 [1]
Hydroxy-(1-hydroxy-1-phosphono-2-pyridin-1-ium-1-ylethyl)phosphinateIC50125892.54 [1]
1-(2-Hydroxy-2,2-Diphosphonoethyl)-3-PhenylpyridiniumIC5012589.25 [1]
Hydroxy-(1-phosphono-2-pyridin-1-ium-1-ylethyl)phosphinateIC50158489.32 [1]
Hydroxy-[2-(3-methylpyridin-1-ium-1-yl)-1-phosphonoethyl]phosphinateIC5050118.72 [1]
[2-(3-Bromopyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinateIC50100000.0 [1]
Hydroxy-[2-(3-phenylpyridin-1-ium-1-yl)-1-phosphonoethyl]phosphinateIC5010000.0 [1]
(2-Dimethylsulfonio-1-hydroxy-1-phosphonoethyl)-hydroxyphosphinateIC5063095.73 [1]
Bisphosphonate, 9IC50100.0 [1]
{2-[Dodecyl(methyl)amino]-1-phosphonoethyl}phosphonic acidIC50316.23 [1]
{2-[3-(Decyloxy)phenyl]-1-hydroxy-1-phosphonoethyl}phosphonic acidIC50630.96 [1]
{2-[5-(Decyloxy)pyridin-3-Yl]ethane-1,1-Diyl}bis(Phosphonic Acid)IC505011.87 [1]
[1,3-Bis(2,4-dichlorophenyl)-2-phosphonopropan-2-yl]phosphonic acidIC5025118.86 [1]
(2-Carbamimidamido-1-hydroxy-1-phosphonoethyl)phosphonic acidIC5079432.82 [1]
[({4-[4-(Propan-2-Yloxy)phenyl]pyridin-2-Yl}amino)methanediyl]bis(Phosphonic Acid)IC50100000.0 [1]
3-[[(3E)-4,8-Dimethylnona-3,7-dienyl]-methylamino]propyl phosphono hydrogen phosphateIC50310.0 [1]
[(2E,6E,10E)-14-(Dimethylamino)-3,7,11-trimethyltetradeca-2,6,10-trienyl] phosphono hydrogen phosphateIC50100000.0 [1]
Tetrasodium;[2-[1-[(4Z)-5,9-dimethyldeca-4,8-dienyl]triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphaneIC501300.0 [1]
Tetrasodium;[1-[1-(3,7-dimethylocta-2,6-dienyl)triazol-4-yl]-2-phosphonatobutan-2-yl]-dioxido-oxo-lambda5-phosphaneIC505850.0 [1]
(9-Phosphonoheptadecan-9-yl)phosphonic acidIC502511.89 [1]
[2-[3-Decoxy-5-(3,5-difluorophenyl)pyridin-1-ium-1-yl]-1-phosphonoethyl]-hydroxyphosphinateIC50794.33 [1]
Hydroxy-[2-(3-oct-1-ynylpyridin-1-ium-1-yl)-1-phosphonoethyl]phosphinateIC501584.89 [1]
(6e,11e)-Heptadeca-6,11-Diene-9,9-Diylbis(Phosphonic Acid)IC501995.26 [1]
{1-[3-(Decyloxy)phenyl]-2-phosphonodecan-2-yl}phosphonic acidIC502511.89 [1]
[2-[3-(3-Butoxyphenyl)pyridin-1-ium-1-yl]-1-phosphonoethyl]-hydroxyphosphinateIC502511.89 [1]
{2-[5-(Dodecyloxy)pyridin-3-yl]-1-phosphonoethyl}phosphonic acidIC505011.87 [1]
[2-(3-Hexylpyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinateIC506309.57 [1]
2-[[(2E,6E)-2,6-Dimethyl-9,9-diphosphononona-2,6-dienyl]amino]benzoic acidIC50100000.0 [1]
[(3Z)-4,8-Dimethyl-1-phosphononona-3,7-dienyl]phosphonic acidIC50100000.0 [1]
[(3Z,7E)-4,8,12-Trimethyl-1-phosphonotrideca-3,7,11-trienyl]phosphonic acidIC5040000.0 [1]
[(3Z,7Z)-4,8,12-Trimethyl-1-phosphonotrideca-3,7,11-trienyl]phosphonic acidIC5070000.0 [1]
[(3E,7Z)-4,8,12-Trimethyl-1-phosphonotrideca-3,7,11-trienyl]phosphonic acidIC50600.0 [1]
[(6Z,11E)-2,6,12,16-Tetramethyl-9-phosphonoheptadeca-2,6,11,15-tetraen-9-yl]phosphonic acidIC507000.0 [1]
[(6Z,11Z)-2,6,12,16-Tetramethyl-9-phosphonoheptadeca-2,6,11,15-tetraen-9-yl]phosphonic acidIC506000.0 [1]
[(7E)-2,8,12-Trimethyl-5-phosphonotrideca-2,7,11-trien-5-yl]phosphonic acidIC503000.0 [1]
[(6E,11Z,15E)-2,6,12,16,20-Pentamethyl-9-phosphonohenicosa-2,6,11,15,19-pentaen-9-yl]phosphonic acidIC50300.0 [1]
Tetrasodium;[(3Z)-4,8-dimethyl-1-phosphonatonona-3,7-dienyl]-dioxido-oxo-lambda5-phosphaneIC50100000.0 [1]
Tetrasodium;dioxido-oxo-[(3Z,7Z)-4,8,12-trimethyl-1-phosphonatotrideca-3,7,11-trienyl]-lambda5-phosphaneIC5070000.0 [1]
Tetrasodium;dioxido-oxo-[(3E,7Z)-4,8,12-trimethyl-1-phosphonatotrideca-3,7,11-trienyl]-lambda5-phosphaneIC5040000.0 [1]
Tetrasodium;[(3E)-4,8-dimethyl-1-phosphonatonona-3,7-dienyl]-dioxido-oxo-lambda5-phosphaneIC5010000.0 [1]
2-[[(2E,7E)-9-(2-Carboxyanilino)-2,8-dimethyl-5,5-diphosphononona-2,7-dienyl]amino]benzoic acidIC50100000.0 [1]
Tetrasodium;dioxido-oxo-[(6Z,11E)-2,6,12,16-tetramethyl-9-phosphonatoheptadeca-2,6,11,15-tetraen-9-yl]-lambda5-phosphaneIC507000.0 [1]
Tetrasodium;dioxido-oxo-[(7Z)-2,8,12-trimethyl-5-phosphonatotrideca-2,7,11-trien-5-yl]-lambda5-phosphaneIC5060000.0 [1]
[(7Z,11E)-2,8,12,16-Tetramethyl-5-phosphonoheptadeca-2,7,11,15-tetraen-5-yl]phosphonic acidIC501000.0 [1]
2-[[(2Z,7E)-2,8,12-Trimethyl-5,5-diphosphonotrideca-2,7,11-trienyl]amino]benzoic acidIC50900.0 [1]
2-[[(2E,6Z,11E)-2,6,12,16-Tetramethyl-9,9-diphosphonoheptadeca-2,6,11,15-tetraenyl]amino]benzoic acidIC50900.0 [1]
2-[Methyl-(4-methyl-pent-3-enyl)-amino]-ethyl-diphosphateIC50240000.0 [1]
[2-[Decyl(methyl)amino]-1-phosphonoethyl]phosphonic acidIC50120000.0 [1]
[2-[Methyl(octyl)amino]-1-phosphonoethyl]phosphonic acidIC50440000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Geranylgeranyl pyrophosphate synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/geranylgeranyl-pyrophosphate-synthetase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Geranylgeranyl pyrophosphate synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/geranylgeranyl-pyrophosphate-synthetase-inhibitors-ic50-ki.
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