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Gastric inhibitory polypeptide receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Gra EX-25IC5028.3 [1], 1300.0 [2]
3-[[4-[[3-(3,5-Dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acidIC506277.0 [1], 7500.0 [2]
3-[[4-[(4-Chloro-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acidIC50410.0 [1], 649.0 [2]
3-[[4-[(4-Chloro-N-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acidIC50460.0 [1], 869.0 [2]
3-[[4-[[[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-(5,6,7,8-tetrahydronaphthalen-2-yl)amino]methyl]benzoyl]amino]propanoic acidIC50390.0 [1], 830.0 [2]
3-[[4-[[4-(Trifluoromethoxy)-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino]methyl]benzoyl]amino]propanoic acidIC50480.0 [1], 833.0 [2]
1-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamideIC50296.0 [1], 435.0 [2]
3-[[1-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acidIC50132.0 [1], 603.0 [2]
3-[[4-[2-(4-Chlorophenyl)-2-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]ethyl]benzoyl]amino]propanoic acidIC50211.0 [1], 381.0 [2]
3-[[4-[[2,3-Dihydro-1H-inden-5-yl-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]amino]methyl]benzoyl]amino]propanoic acidIC50770.0 [1], 950.0 [2]
3-[[4-[[9H-Fluoren-2-yl-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]amino]methyl]benzoyl]amino]propanoic acidIC50290.0 [1], 488.0 [2]
3-[[4-[[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-(9H-fluoren-2-ylmethyl)amino]benzoyl]amino]propanoic acidIC50320.0 [1], 555.0 [2]
3-[[4-[[2,3-Dihydro-1H-inden-5-yl-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]methyl]benzoyl]amino]propanoic acidIC50510.0 [1], 1095.0 [2]
3-[[4-[[5,6,7,8-Tetrahydronaphthalen-2-yl-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]methyl]benzoyl]amino]propanoic acidIC50390.0 [1], 564.0 [2]
3-[[4-[(3-Methyl-4-propan-2-yl-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acidIC50293.0 [1], 633.0 [2]
3-[[4-[[N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-(trifluoromethyl)anilino]methyl]benzoyl]amino]propanoic acidIC50990.0 [1], 1100.0 [2]
CID 11570626IC501019.0 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50359.0 [1]
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamideIC5050118.72 [1]
4-[[9-Tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undecan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50430.0 [1]
3-[[4-[[4-(Cyclohexen-1-yl)-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50701.0 [1]
3-(4-((1-(4-Cyclohexenylphenyl)-3-(3,5-dichlorophenyl)ureido)methyl)benzamido)propanoic acidIC5064.0 [1]
3-[[4-[[[3,5-Bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]methyl]benzoyl]amino]propanoic acidIC5093.0 [1]
3-{4-[1-(4-Tert-butylphenyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acidIC5038.0 [1]
4-[[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5045.0 [1]
4-[[5-(3,5-Dichlorophenyl)-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC503000.0 [1]
4-[1-[3,5-Bis[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]ethyl]-N-(2H-tetrazol-5-yl)benzamideIC506000.0 [1]
4-[[3-Cyclohexyl-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50910.0 [1]
(2R)-3-[[4-[[4-Cyclohexyl-N-[(3-methylsulfanylphenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50411.0 [1]
(2R)-3-[[4-[[N-[(3-Tert-butylphenyl)carbamoyl]-4-cyclohexylanilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC5074.0 [1]
(2S)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50445.0 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-methoxypropanoic acidIC503020.0 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[[3-methoxy-5-(trifluoromethyl)phenyl]carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50279.0 [1]
(2R)-3-[[4-[[4-Cyclohexyl-N-[[4-(trifluoromethylsulfanyl)phenyl]carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC5012.0 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[(2,2,4,4-tetrafluoro-1,3-benzodioxin-6-yl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC5083.0 [1]
3-[[4-[[4-Tert-butyl-N-[[4-(trifluoromethoxy)phenyl]carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50315.0 [1]
(2R)-3-[[4-[[N-[[3-Bromo-5-(trifluoromethyl)phenyl]carbamoyl]-4-(cyclohexen-1-yl)anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50380.0 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[[3-methylsulfonyl-4-(trifluoromethoxy)phenyl]carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50497.0 [1]
(2R)-3-[[4-[[4-Cyclohexyl-N-[(3,5-dichlorophenyl)carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC5093.0 [1]
4-[[5-Cyclohexyl-1-[4-(trifluoromethoxy)phenyl]pyrazol-4-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC5020000.0 [1]
(2R)-3-[[4-[[N-[(3-Chlorophenyl)carbamoyl]-4-(cyclohexen-1-yl)anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50406.0 [1]
(R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acidIC50216.0 [1]
(2R)-3-[[4-[[4-(Cyclohexen-1-yl)-N-[[3-fluoro-5-(trifluoromethyl)phenyl]carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50277.0 [1]
(2R)-3-[[4-[[N-[[4-Cyano-3-(trifluoromethyl)phenyl]carbamoyl]-4-cyclohexylanilino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50198.0 [1]
4-[[5-Cyclohexyl-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC502100.0 [1]
3-(4-((5-Cyclohexyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-4-yl)methyl)benzamido)propanoic acidIC5025000.0 [1]
(2R)-3-[[4-[[(4-Tert-butylcyclohexyl)-[(3,5-dimethylphenyl)carbamoyl]amino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50220.0 [1]
4-[[3-(3,5-Dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC507100.0 [1]
3-(4-((5-Cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamido)propanoic acidIC502800.0 [1]
4-[[3-(3,5-Dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-ylmethyl)benzamideIC5010000.0 [1]
(2R)-3-[[4-[[(4-Tert-butylcyclohexyl)-[[3-methyl-5-(trifluoromethyl)phenyl]carbamoyl]amino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC5098.0 [1]
4-[[3-Methyl-4-propoxy-2-[4-(trifluoromethoxy)phenyl]imino-6-(trifluoromethyl)benzimidazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50370.0 [1]
4-[[2-(4-Tert-butylphenyl)imino-3-methyl-4-propoxy-6-(trifluoromethyl)benzimidazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50290.0 [1]
4-[[6-Chloro-3-methyl-4-propoxy-2-[4-(trifluoromethoxy)phenyl]iminobenzimidazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC50510.0 [1]
3-[[4-[(1S)-1-[5-(6-Chloronaphthalen-2-yl)-3-(3,5-dichlorophenyl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC50795.0 [1]
3-[[4-[(1S)-1-[3-(3,5-Dichlorophenyl)-5-[6-(trifluoromethyl)naphthalen-2-yl]pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC50378.0 [1]
3-[[4-[(1R)-1-[3-(3,5-Dichlorophenyl)-5-[6-(trifluoromethoxy)naphthalen-2-yl]pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC501134.0 [1]
3-[[4-[(1S)-1-[3-(3,5-Dichlorophenyl)-5-(6-ethoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC50885.0 [1]
3-[[4-[(1S)-1-[3-[2-Fluoro-5-(trifluoromethyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC50933.0 [1]
3-[[4-[[3-(3,5-Dichlorophenyl)-5-[6-(trifluoromethoxy)naphthalen-2-yl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acidIC50711.0 [1]
3-[[4-[[3-(3,5-Dichlorophenyl)-5-[5-(trifluoromethoxy)naphthalen-2-yl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acidIC501984.0 [1]
3-[[4-[[3-(3,5-Dichlorophenyl)-5-naphthalen-2-ylpyrazol-1-yl]methyl]benzoyl]amino]propanoic acidIC504337.0 [1]
3-(4-((3-Cyclohexyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-4-yl)methyl)benzamido)propanoic acidIC507400.0 [1]
4-[[5-(4-Tert-butylcyclohexyl)-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamideIC505700.0 [1]
(2S)-3-[[4-[[[3,5-Bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC50373.0 [1]
(2R)-3-[[4-[[[3,5-Bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC5087.0 [1]
3-[[1-[[3,5-Bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acidIC502023.0 [1]
1-[[3,5-Bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamideIC504256.0 [1]
3-[[1-[(4-Tert-butylcyclohexyl)-[2-[4-(trifluoromethoxy)phenyl]acetyl]amino]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acidIC50286.0 [1]
5-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-N-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamideIC50178.0 [1]
3-[[5-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonyl]amino]propanoic acidIC50171.0 [1]
3-[[4-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-3,4-dihydro-2H-chromene-7-carbonyl]amino]propanoic acidIC50217.0 [1]
4-[(4-Tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-N-(2H-tetrazol-5-yl)-3,4-dihydro-2H-chromene-7-carboxamideIC50117.0 [1]
1-[(4-Tert-butylcyclohexyl)-[4-(trifluoromethoxy)benzoyl]amino]-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamideIC50610.0 [1]
1-[(4-Tert-butylcyclohexyl)-[2-[4-(trifluoromethoxy)phenyl]acetyl]amino]-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamideIC50118.0 [1]
1-[(4-Tert-butylcyclohexyl)-[(3,5-dichlorophenyl)carbamoyl]amino]-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamideIC503525.0 [1]
3-[[4-[1-[3-[2-Methoxy-5-(trifluoromethyl)phenyl]-6-[4-(trifluoromethoxy)phenyl]indazol-1-yl]butyl]benzoyl]amino]propanoic acidIC501400.0 [1]
3-[[4-[1-[6-(4-Methoxyphenyl)-3-[2-methoxy-5-(trifluoromethyl)phenyl]indazol-1-yl]pentyl]benzoyl]amino]propanoic acidIC501100.0 [1]
3-[[4-[1-[3-[2-Methoxy-5-(trifluoromethyl)phenyl]-6-(4-methylphenyl)indazol-1-yl]pentyl]benzoyl]amino]propanoic acidIC501000.0 [1]
3-[[4-[1-[3-[2-Methoxy-5-(trifluoromethyl)phenyl]-6-[4-(trifluoromethoxy)phenyl]indazol-1-yl]pentyl]benzoyl]amino]propanoic acidIC50750.0 [1]
3-[[4-[1-[3-[2-Methoxy-5-(trifluoromethyl)phenyl]-6-(4-methylphenyl)indazol-1-yl]ethyl]benzoyl]amino]propanoic acidIC501300.0 [1]
(2R)-3-[[4-[[2,3-Dihydro-1H-inden-5-yl-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]amino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC501000.0 [1]
(2R)-3-[[4-[[2,3-Dihydro-1H-inden-5-yl-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]methyl]benzoyl]amino]-2-hydroxypropanoic acidIC501000.0 [1]
3-[[4-[[[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-(2,3-dihydro-1H-inden-5-yl)amino]methyl]benzoyl]amino]propanoic acidIC50638.0 [1]
3-[[4-[9H-Fluoren-2-ylmethyl-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]amino]benzoyl]amino]propanoic acidIC50732.0 [1]
3-[[4-[9H-Fluoren-2-ylmethyl-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]benzoyl]amino]propanoic acidIC50645.0 [1]
3-[[4-[2-(4-Chlorophenyl)-2-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]ethyl]benzoyl]amino]propanoic acidIC50429.0 [1]
3-[[4-[[4-(Cyclohexen-1-yl)-N-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]anilino]methyl]benzoyl]amino]propanoic acidIC50207.0 [1]
3-[[4-[[4-(Cyclohexen-1-yl)-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino]methyl]benzoyl]amino]propanoic acidIC50368.0 [1]
3-[[4-[[[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-(1,2,3,4-tetrahydronaphthalen-1-yl)amino]methyl]benzoyl]amino]propanoic acidIC501113.0 [1]
3-[[4-[(4-Tert-butyl-N-[4-(4-tert-butylphenyl)-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acidIC50729.0 [1]
3-[[4-[[N-[4-(4-Tert-butylphenyl)-1,3-thiazol-2-yl]-4-(cyclohexen-1-yl)anilino]methyl]benzoyl]amino]propanoic acidIC50721.0 [1]
3-[[4-[[N-[4-(4-Chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-4-(cyclohexen-1-yl)anilino]methyl]benzoyl]amino]propanoic acidIC501002.0 [1]
3-[[4-[[N-[4-(2-Methoxyphenyl)-1,3-thiazol-2-yl]-4-(trifluoromethylsulfanyl)anilino]methyl]benzoyl]amino]propanoic acidIC501000.0 [1]
3-[[4-[2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-2-[4-(trifluoromethoxy)phenyl]ethyl]benzoyl]amino]propanoic acidIC50316.0 [1]
3-[[4-[[N-[4-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(trifluoromethylsulfanyl)anilino]methyl]benzoyl]amino]propanoic acidIC50777.0 [1]
3-[[4-[(N-[4-[3,5-Bis(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-3-methyl-4-propan-2-ylanilino)methyl]benzoyl]amino]propanoic acidIC50584.0 [1]
(2R)-2-Hydroxy-3-[[4-[2-[4-(trifluoromethoxy)phenyl]-2-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]ethyl]benzoyl]amino]propanoic acidIC50565.0 [1]
3-[[1-[(4-Tert-butylcyclohexyl)-[(3,5-dichlorophenyl)carbamoyl]amino]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acidIC501279.0 [1]
(4S)-4-[[2-[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoyl]amino]-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-[4-(2-methylphenyl)phenyl]-1-oxopropan-2-yl]amino]-3-[4-(2-ethyl-4-methoxyphenyl)phenyl]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(2-fluorophenyl)-2-methyl-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acidIC5010000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Gastric inhibitory polypeptide receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/gastric-inhibitory-polypeptide-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Gastric inhibitory polypeptide receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gastric-inhibitory-polypeptide-receptor-inhibitors-ic50-ki.
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