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GABA transporter 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
TiagabineIC5070.0 [1], 280.0 [2], 380.19 [3]
TiagabineKi16.98 [1], 47.86 [2]
(S)-Snap 5114IC50100000.0 [1], 170000.0 [2], 388000.0 [3], 389045.14 [4]
(R)-Piperidine-3-carboxylic acidIC505900.0 [1], 81500.0 [2]
1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-ethyl}-piperidine-3-carboxylic acidIC50132000.0 [1], 133000.0 [2]
gamma-Aminobutyric acidIC503000.0 [1], 5000.0 [2]
Nipecotic acidIC5010.1 [1], 8000.0 [2]
N-(4,4-Diphenyl-3-butenyl)nipecotic acidIC50130.0 [1], 200.0 [2]
(S)-Piperidine-3-carboxylic acidIC50116000.0 [1]
1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acidIC50130.0 [1]
1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acidKi72.44 [1]
(2R)-2-[(2R)-1-(4,4-Diphenylbut-3-enyl)pyrrolidin-2-yl]-2-hydroxyacetic acidIC5013803.84 [1]
(2R)-2-[(2R)-1-(4,4-Diphenylbut-3-enyl)pyrrolidin-2-yl]-2-hydroxyacetic acidKi3981.07 [1]
(2S)-2-[(2R)-1-(4,4-Diphenylbut-3-enyl)pyrrolidin-2-yl]-2-hydroxyacetic acidIC501905.46 [1]
(2S)-2-[(2R)-1-(4,4-Diphenylbut-3-enyl)pyrrolidin-2-yl]-2-hydroxyacetic acidKi213.8 [1]
(2R)-2-[(2R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]pyrrolidin-2-yl]-2-hydroxyacetic acidIC504168.69 [1]
(2R)-2-[(2R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]pyrrolidin-2-yl]-2-hydroxyacetic acidKi1096.48 [1]
(2S)-2-[(2R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]pyrrolidin-2-yl]-2-hydroxyacetic acidIC50724.44 [1]
(2S)-2-[(2R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]pyrrolidin-2-yl]-2-hydroxyacetic acidKi66.07 [1]
(1R,5S)-3-[4,4-Bis(5-methylthiophen-2-yl)but-3-enyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acidKi10000.0 [1]
Tiagabine hydrochlorideIC5049.0 [1]
HinokininIC5020600.0 [1]
GuvacineIC5014000.0 [1]
1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acidIC50233000.0 [1]
3-Pyridinecarboxylic acid, 1-(4,4-diphenyl-3-butenyl)-1,2,5,6-tetrahydro-IC50200.0 [1]
CI-966 Free baseIC50260.0 [1]
1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)piperidin-4-olIC5011400.0 [1]
N-(1-Benzylpiperidin-4-yl)-2,4-dichlorobenzamideKi100000.0 [1]
N-(1-Benzylpiperidin-4-yl)benzamideIC501000000.0 [1]
1-(3-(9H-Carbazol-9-yl)propyl)-4-(4-methoxyphenyl)piperidin-4-olKi27000.0 [1]
2-Ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamideIC50500000.0 [1]
N-(1-Benzylpiperidin-4-yl)-2,3-dimethoxybenzamideIC50500000.0 [1]
N-(1-Benzylpiperidine-4-yl)-2-naphthamideKi100000.0 [1]
1-(2-Trityloxy-ethyl)-piperidine-3-carboxylic acidIC501400.0 [1]
N-(1-Benzylpiperidin-4-yl)-4-fluorobenzamideIC50300000.0 [1]
(3R)-1-[2-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethoxy]ethyl]piperidine-3-carboxylic acidIC5039810.72 [1]
1-[2-[[4-Methoxy-3-(trifluoromethyl)phenyl]-phenyl-[3-(trifluoromethyl)phenyl]methoxy]ethyl]piperidine-3-carboxylic acidIC5073000.0 [1]
1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acidIC5058000.0 [1]
1-{3-[Tris-(4-methoxy-phenyl)-methoxy]-propyl}-piperidine-3-carboxylic acidIC50121000.0 [1]
1-[2-[Bis(4-fluorophenyl)-(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acidIC5019000.0 [1]
1-[2-[Tris(4-methoxyphenyl)methylsulfanyl]ethyl]piperidine-3-carboxylic acidIC5078000.0 [1]
1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-piperidine-3-carboxylic acidIC5043000.0 [1]
1-[2-(9-Phenyl-9H-xanthen-9-yloxy)-ethyl]-piperidine-3-carboxylic acidIC505000.0 [1]
1-{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-piperidine-3-carboxylic acidIC506900.0 [1]
1-[2-(9-Phenyl-9H-fluoren-9-yloxy)-ethyl]-piperidine-3-carboxylic acidIC503000.0 [1]
1-[2-[(4-Methoxyphenyl)-bis(4-methylphenyl)methoxy]ethyl]piperidine-3-carboxylic acidIC50142000.0 [1]
1-[2-[Bis(4-chlorophenyl)-(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acidIC50122000.0 [1]
(3R)-1-[2-[2-(10H-Phenothiazine-10-yl)ethoxy]ethyl]piperidine-3-carboxylic acidIC50309.03 [1]
(3R)-1-[2-(2-Benzo[b][1]benzazepin-11-ylethoxy)ethyl]piperidine-3-carboxylic acidIC50645.65 [1]
1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic acidIC5043000.0 [1]
CID 118711599IC50100000.0 [1]
N-(1-Benzylpiperidin-4-yl)-2,6-dichloropyridine-3-carboxamideIC501000000.0 [1]
2,4-Dichloro-N-[1-(pyridin-3-ylmethyl)piperidin-4-yl]benzamideIC501000000.0 [1]
2,4-Dichloro-N-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]benzamideIC50100000.0 [1]
2,4-Dichloro-N-(1-phenacylpiperidin-4-yl)benzamideIC50100000.0 [1]
2,4-Dichloro-N-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]benzamideIC50100000.0 [1]
2,4-Dichloro-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]benzamideIC5050000.0 [1]
2,4-Dichloro-N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]benzamideIC50100000.0 [1]
2,4-Dichloro-N-[1-(3-diethoxyphosphorylpropyl)piperidin-4-yl]benzamideIC501000000.0 [1]
Methyl 4-[[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]methyl]benzoateIC50100000.0 [1]
2,4-Dichloro-N-[1-(pyridin-4-ylmethyl)piperidin-4-yl]benzamideIC501000000.0 [1]
(1-Benzylpiperidin-4-yl) 2,4-dichlorobenzoateIC501000000.0 [1]
2,4-Dichloro-N-[1-(3-cyanopropyl)piperidin-4-yl]benzamideIC501000000.0 [1]
Tert-butyl 2-[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]acetateIC501000000.0 [1]
2,4-Dichloro-N-(1-prop-2-ynylpiperidin-4-yl)benzamideIC501000000.0 [1]
2-[4-[(2,4-Dichlorobenzoyl)amino]piperidin-1-yl]acetic acidIC501000000.0 [1]
2,4-Dichloro-N-[1-[(2-cyanophenyl)methyl]piperidin-4-yl]benzamideIC5050000.0 [1]
2,4-Dichloro-N-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]benzamideIC50100000.0 [1]
2,4-Dichloro-N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]benzamideIC5050000.0 [1]
2,4-Dichloro-N-[1-(quinolin-2-ylmethyl)piperidin-4-yl]benzamideIC5050000.0 [1]
1-Benzyl-piperidin-4-yl benzoateIC501000000.0 [1]
N-(1-Benzylpiperidin-4-yl)-2-methylpropanamideIC501000000.0 [1]
(3R)-1-[4,4-Bis(2-methylphenyl)-3-butenyl]-3-piperidinecarboxylic acidKi41.69 [1]
1-Benzyl-N-[(2,4-dichlorophenyl)methyl]piperidin-4-amineIC50400000.0 [1]
2,4-Dichloro-N-(1-propylpiperidin-4-yl)benzamideIC501000000.0 [1]
2,4-Dichloro-N-(1-ethylpiperidin-4-yl)benzamideIC501000000.0 [1]
N-(1-Benzylpiperidin-4-yl)-3-(trifluoromethyl)benzamideIC50500000.0 [1]
CID 43345728IC501000000.0 [1]
(3R)-1-[4,4-Bis[3-(cyclohexyloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-3-carboxylic acid;hydrochlorideIC50680.0 [1]
1-[4,4-Bis[3-(cyclohexyloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC50940.0 [1]
1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC50100000.0 [1]
1-[4,4-Bis[3-(cyclohexyloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC501240.0 [1]
1-[4,4-Bis[3-(methoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC50100000.0 [1]
1-[4,4-Bis[3-(naphthalen-1-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC50100000.0 [1]
1-[4,4-Bis[3-(naphthalen-1-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC50100000.0 [1]
1-[4,4-Bis[3-(propan-2-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC50100000.0 [1]
1-[4,4-Bis[3-(phenoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC501500.0 [1]
(3R)-1-[4,4-Bis[3-(methoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-3-carboxylic acid;hydrochlorideIC502800.0 [1]
1-[4,4-Bis[3-(methoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC5012300.0 [1]
(3R)-1-[4,4-Bis[3-(naphthalen-1-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-3-carboxylic acid;hydrochlorideIC5066300.0 [1]
1-[4,4-Bis[3-(phenylmethoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC5027600.0 [1]
1-[4,4-Bis[3-(phenylmethoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC504340.0 [1]
1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC501360.0 [1]
1-[4,4-Bis[3-(phenoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochlorideIC50650.0 [1]
(3R)-1-[4,4-Bis[3-(phenoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-3-carboxylic acid;hydrochlorideIC50340.0 [1]
1-[4,4-Bis[3-(propan-2-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochlorideIC50100000.0 [1]
(3R)-1-[4,4-Bis[3-(propan-2-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-3-carboxylic acid;hydrochlorideIC507100.0 [1]
2,4-Dichloro-N-[1-(pyridin-2-ylmethyl)piperidin-4-yl]benzamideIC501000000.0 [1]
(3R)-1-[(E)-4-(2-Fluorophenyl)-4-(2-methylphenyl)but-3-enyl]piperidine-3-carboxylic acidKi14.79 [1]
1-[4,4-Bis(5-methylthiophen-2-yl)but-3-enyl]-3-fluoropiperidine-3-carboxylic acidKi138.04 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ GABA transporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/gaba-transporter-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ GABA transporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gaba-transporter-1-inhibitors-ic50-ki.
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