GABA receptor alpha-1 subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Zolpidem	IC50	14.0 [1], 130.0 [2]
	Zolpidem	Ki	61.9 [1]
	Pentobarbital	IC50	1000000.0 [1]
	Flumazenil	Ki	3.3 [1]
	Alisertib	IC50	490.0 [1]
	Eszopiclone	Ki	50.1 [1]
	Ethyl (7S)-15-methoxy-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	49.0 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	330.0 [1]
	2-(4-Chlorophenyl)-3aH-pyrazolo[4,3-c]quinolin-3-one	IC50	1.0 [1]
	3-[3-Tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole	Ki	0.8 [1]
	1-Methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one	IC50	10000.0 [1]
	N-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-acetamide	IC50	10000.0 [1]
	13-(4-Methyl-1,3-thiazol-2-yl)-15-pyridin-4-yl-4,11-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2(7),3,5,13-pentaen-12-one	Ki	1.3 [1]
	4-Bromo-3,5-dimethyl-1-((4-(3-nitrophenyl)thiazol-2-yl)methyl)-1H-pyrazole	IC50	10000.0 [1]
	4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	150.0 [1]
	8-Methyl-5-[4-(trifluoromethyl)-1-benzothiophen-2-yl]-1,9-dihydro-[1,3]oxazolo[4,5-h][2,3]benzodiazepin-2-one	IC50	479.0 [1]
	3-(2-Chlorobenzyloxy)-2-(4-chlorophenyl)-6,7,8,9-tetrahydro-2H-pyrazolo[4,3-c]quinoline	IC50	46.0 [1]
	2-(4-Chlorophenyl)-3-[(4-fluorophenyl)methoxy]-6,7,8,9-tetrahydropyrazolo[4,3-c]quinoline	IC50	50.0 [1]
	2-(1,3-Benzodioxol-5-yl)-3-[(2-chlorophenyl)methoxy]pyrazolo[4,3-c]quinoline	IC50	50.0 [1]
	N-(4-Chlorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)thiophene-2-sulfonamide	IC50	470.0 [1]
	1-(4-Chlorobenzoyl)-6,6-dimethyl-3-methylsulfanyl-1,3,3a,5,7,7a-hexahydro-2-benzothiophen-4-one	IC50	580.0 [1]
	1-(4-Chlorobenzoyl)-3-(methylthio)-hexahydrobenzo[c]thiophen-4(1H)-one	IC50	580.0 [1]
	6,6-Dimethyl-3-methylsulfanyl-1-(3-nitrobenzoyl)-1,3,3a,5,7,7a-hexahydro-2-benzothiophen-4-one	IC50	10000.0 [1]
	(3-Aminobenzo[b]thiophen-2-yl)(4-chlorophenyl)methanone	IC50	1000.0 [1]
	2-(4-Chlorophenyl)-3-(cyclopropylmethoxy)-8-imidazol-1-ylpyrazolo[4,3-c]quinoline	IC50	134.0 [1]
	3-(2-Chlorobenzyloxy)-2-(4-chlorophenyl)-2H-pyrazolo[4,3-c]quinoline	IC50	64.0 [1]
	2-(4-Chlorophenyl)-3-(cyclopropylmethoxy)-2H-pyrazolo[4,3-c]quinoline	IC50	74.0 [1]
	4-(4-Chlorophenyl)-5-[(2-chlorophenyl)methoxy]-3,4,8-triazatricyclo[7.5.0.02,6]tetradeca-1(9),2,5,7-tetraene	IC50	242.0 [1]
	2-(4-Chlorophenyl)-3-[(2-chlorophenyl)methoxy]-8,8-dimethyl-7,9-dihydro-6H-pyrazolo[4,3-c]quinoline	IC50	67.0 [1]
	2-(4-Chlorophenyl)-3-[(4-chlorophenyl)methoxy]-6,7,8,9-tetrahydropyrazolo[4,3-c]quinoline	IC50	157.0 [1]
	3-(2-Chlorophenoxy)-2-(4-chlorophenyl)-6,7,8,9-tetrahydropyrazolo[4,3-c]quinoline	IC50	3000.0 [1]
	3-(2-Chlorobenzyloxy)-2-(2-fluorophenyl)-2H-pyrazolo[4,3-c]quinoline	IC50	1.0 [1]
	2-(4-Chlorophenyl)-3-(cyclopropylmethoxy)-6,7,8,9-tetrahydropyrazolo[4,3-c]quinoline	IC50	94.0 [1]
	2-(4-Chlorophenyl)-3-[(2-fluorophenyl)methoxy]-6,7,8,9-tetrahydropyrazolo[4,3-c]quinoline	IC50	64.0 [1]
	(5S)-1-Methyl-5-prop-2-enyl-5-[3-[3-(trifluoromethyl)diazirin-3-yl]phenyl]-1,3-diazinane-2,4,6-trione	IC50	120000.0 [1]
	(5R)-1-Methyl-5-prop-2-enyl-5-[3-[3-(trifluoromethyl)diazirin-3-yl]phenyl]-1,3-diazinane-2,4,6-trione	IC50	3800.0 [1]
	2-[1-[2-(2-Methoxypyridin-3-yl)pyridin-4-yl]benzimidazol-5-yl]propan-2-ol	IC50	1.2 [1]
	4-[4-[5-(2-Hydroxypropan-2-yl)benzimidazol-1-yl]pyridin-2-yl]pyridine-3-carbonitrile	IC50	26.0 [1]
	2-[1-[2-(2-Chloropyridin-3-yl)pyridin-4-yl]benzimidazol-5-yl]propan-2-ol	IC50	38.0 [1]
	2-[1-[2-(3-Fluoropyridin-4-yl)pyridin-4-yl]benzimidazol-5-yl]propan-2-ol	IC50	7.5 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 40 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ GABA receptor alpha-1 subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/gaba-receptor-alpha-1-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ GABA receptor alpha-1 subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gaba-receptor-alpha-1-subunit-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan