GABA-A receptor; alpha-6/beta-3/gamma-2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Ethyl 8-ethynyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	28.8 [1]
	Ethyl (7S)-15-methoxy-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	83.0 [1], 83.2 [2]
	Tert-butyl 8-ethynyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	5.1 [1]
	Zolpidem	Ki	10000.0 [1]
	Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate	Ki	3.8 [1]
	Ethyl beta-carboline-3-carboxylate	Ki	1000.0 [1], 2700.0 [2]
	3-Methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine	Ki	10000.0 [1]
	Tert-Butyl beta-carboline-3-carboxylate	Ki	5000.0 [1]
	3-Propoxy-9H-pyrido[3,4-b]indole	Ki	1000.0 [1]
	3-Ethoxy-beta-carboline	Ki	1000.0 [1]
	CID 9971547	Ki	300.0 [1], 9000.0 [2]
	3-Butoxy-9H-beta-carboline	Ki	1000.0 [1]
	3-Isobutoxy-9H-beta-carboline	Ki	10000.0 [1]
	3-Benzyloxy-9H-beta-carboline	Ki	10000.0 [1]
	3-(Isopentyloxy)-9H-pyrido[3,4-b]indole	Ki	10000.0 [1]
	Tert-butyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	58.6 [1]
	Ethyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	113.7 [1], 114.0 [2]
	CID 5255267	Ki	2000.0 [1]
	Ethyl (7S)-15-ethynyl-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	125.0 [1], 126.0 [2]
	Ethyl (7S)-12-oxo-15-(2-trimethylsilylethynyl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	340.0 [1]
	Ethyl (7S)-15-bromo-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	46.0 [1]
	Flumazenil	Ki	148.0 [1]
	Flunitrazepam	Ki	2000.0 [1]
	Methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate	Ki	134.0 [1]
	Abecarnil	Ki	1000.0 [1], 10000.0 [2]
	Ethyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate	Ki	54.6 [1]
	6-Benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester	Ki	1000.0 [1]
	3-Isopropoxy-9H-beta-carboline	Ki	10000.0 [1]
	Tert-Butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate	Ki	4.0 [1]
	6-Methoxy-4-methoxymethyl-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	479.0 [1], 10000.0 [2]
	6-Propoxy-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester	Ki	1340.0 [1], 1343.0 [2]
	Cyclopropylmethyl 8-chloro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	168.0 [1]
	5-Methyl-8-chloro-3-acetyl-4H-imidazo[1,5-a][1,4]benzodiazepine-6(5H)-one	Ki	29500.0 [1]
	8-Chloro-2-(4-methoxy-phenyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Ki	1.9 [1]
	Tert-butyl 8-bromo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	9.4 [1]
	3-Ethyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	3648.0 [1], 3650.0 [2]
	3-Pentanoyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	2930.0 [1]
	Tert-butyl 5-methyl-8-nitro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	22.5 [1]
	Ethyl 8-ethyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	176.0 [1]
	Tert-butyl 8-iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	4.6 [1]
	3-Pentyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	960.0 [1]
	Tert-butyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	5.25 [1]
	5-Methyl-8-chloro-3-[(diethylamino)methyl]-4H-imidazo[1,5-a][1,4]benzodiazepine-6(5H)-one	Ki	30160.0 [1], 30200.0 [2]
	5-Methyl-8-chloro-3-[(diisopropylamino)methyl]-4H-imidazo[1,5-a][1,4]benzodiazepine-6(5H)-one	Ki	8600.0 [1]
	3-Chloromethyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	300.0 [1]
	Ethyl 8-ethoxy-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	51.5 [1]
	CID 10519948	Ki	44.3 [1]
	Tert-butyl 8-ethyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	22.9 [1]
	Ethyl 5-methyl-6-oxo-8-(3-trimethylsilylprop-1-ynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	300.0 [1]
	Ethyl (7S)-11-oxo-14-(2-trimethylsilylethynyl)-2,4,10-triazatetracyclo[10.4.0.02,6.07,10]hexadeca-1(16),3,5,12,14-pentaene-5-carboxylate	Ki	180.0 [1]
	Ethyl 5-methyl-6-oxo-8-prop-1-ynyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	100.0 [1]
	4-Methoxymethyl-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	1150.0 [1]
	4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	74.9 [1]
	6-Benzyloxy-4-ethyl-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	10000.0 [1]
	3-Hydroxymethyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	300.0 [1]
	3-Ethoxymethyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	300.0 [1]
	Tert-butyl 8-isothiocyanato-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	30.7 [1]
	(7S)-15-Ethynyl-5-(3-methyl-1,2,4-oxadiazol-5-yl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaen-12-one	Ki	301.0 [1]
	Ethyl (7S)-14-bromo-11-oxo-2,4,10-triazatetracyclo[10.4.0.02,6.07,10]hexadeca-1(16),3,5,12,14-pentaene-5-carboxylate	Ki	31.0 [1]
	Tert-butyl 5-methyl-6-oxo-8-pyrrolidin-1-yl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	325.0 [1]
	Ethyl (7R)-15-bromo-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	1000.0 [1]
	4-Methoxymethyl-6-propoxy-9H-beta-carbolin-3-ylamine	Ki	3000.0 [1]
	Tert-butyl 5-methyl-6-oxo-8-(3-trimethylsilylprop-1-ynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	301.0 [1]
	(7S)-14-Ethynyl-5-(3-methyl-1,2,4-oxadiazol-5-yl)-2,4,10-triazatetracyclo[10.4.0.02,6.07,10]hexadeca-1(16),3,5,12,14-pentaen-11-one	Ki	266.0 [1]
	Ethyl (7R)-15-ethynyl-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	61.0 [1]
	(7R)-15-Ethynyl-5-(3-methyl-1,2,4-oxadiazol-5-yl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaen-12-one	Ki	1000.0 [1]
	Ethyl 8-cyano-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	1000.0 [1]
	(7S)-5-(3-Ethyl-1,2,4-oxadiazol-5-yl)-14-ethynyl-2,4,10-triazatetracyclo[10.4.0.02,6.07,10]hexadeca-1(16),3,5,12,14-pentaen-11-one	Ki	361.0 [1]
	4-Methoxymethyl-6-octyloxy-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	3000.0 [1]
	4-Methoxymethyl-3,6-dipropoxy-9H-beta-carboline	Ki	1000.0 [1], 10000.0 [2]
	4-Ethyl-6-octyloxy-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	30000.0 [1]
	Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate	Ki	22.0 [1]
	4-Methoxymethyl-9-methyl-6-octyloxy-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	3000.0 [1]
	Ethyl (7R)-12-oxo-15-(2-trimethylsilylethynyl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	1000.0 [1]
	Tert-butyl 8-hydroxy-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	6.89 [1]
	Tert-butyl 8-methoxy-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	8.28 [1]
	Tert-butyl 8-(dimethylamino)-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	118.0 [1]
	(7S)-15-Ethynyl-5-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaen-12-one	Ki	333.0 [1]
	(7S)-5-(3-Ethyl-1,2,4-oxadiazol-5-yl)-15-ethynyl-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaen-12-one	Ki	150.0 [1]
	Tert-butyl 5-methyl-6-oxo-8-piperidin-1-yl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	247.0 [1]
	Ethyl (7S)-14-ethynyl-11-oxo-2,4,10-triazatetracyclo[10.4.0.02,6.07,10]hexadeca-1(16),3,5,12,14-pentaene-5-carboxylate	Ki	42.0 [1]
	(7S)-14-Ethynyl-5-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-2,4,10-triazatetracyclo[10.4.0.02,6.07,10]hexadeca-1(16),3,5,12,14-pentaen-11-one	Ki	267.0 [1]
	3-Ethoxy-4-ethyl-6,7-dimethoxy-9H-beta-carboline	Ki	300.0 [1]
	4-Ethyl-3,6,7-trimethoxy-9H-beta-carboline	Ki	300.0 [1]
	4-Ethyl-9-methyl-9H-beta-carboline-3-carboxylic acid ethyl ester	Ki	10000.0 [1]
	Diazepam	Ki	3000.0 [1]
	Lindane	IC50	4.9 [1]
	Triazolam	Ki	10000.0 [1]
	Fipronil	IC50	17.0 [1]
	Bretazenil	Ki	12.7 [1]
	2-Phenyl-3aH-pyrazolo[4,3-c]quinolin-3-one	Ki	17.0 [1]
	4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, ethyl ester	Ki	300.0 [1]
	3-[3-Tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole	Ki	4000.0 [1]
	1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one	Ki	3000.0 [1]
	7-Chloro-5-methyl-3-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one	Ki	227.0 [1]
	7,12-Dihydro-5,7,12-triaza-indeno[1,2-a]fluorene	Ki	1000.0 [1]
	1-Methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one	Ki	3000.0 [1]
	3-Chloro-9H-beta-carboline	Ki	10000.0 [1]
	1H-1,4-Benzodiazepine-7-carbonitrile, 2,3-dihydro-1-methyl-2-oxo-5-phenyl-	Ki	3000.0 [1]
	1-(9H-beta-Carbolin-3-yl)-butan-1-one	Ki	3000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ GABA-A receptor; alpha-6/beta-3/gamma-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/gaba-a-receptor-alpha-6-beta-3-gamma-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ GABA-A receptor; alpha-6/beta-3/gamma-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gaba-a-receptor-alpha-6-beta-3-gamma-2-inhibitors-ic50-ki.
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