GABA A receptor alpha-2/beta-2/gamma-2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Flumazenil	Ki	5.7 [1]
	Zolpidem	Ki	408.0 [1]
	Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate	Ki	2.6 [1]
	Eszopiclone	Ki	114.0 [1]
	Ethyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate	Ki	16.3 [1]
	Ethyl 8-ethynyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	21.4 [1]
	Tert-butyl 8-ethynyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	26.3 [1]
	Tert-butyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	142.6 [1]
	Ethyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	141.9 [1]
	Tert-butyl 8-bromo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	10.7 [1]
	Ethyl 8-ethyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	27.0 [1]
	CID 10519948	Ki	7.2 [1]
	Tert-butyl 8-ethyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	56.0 [1]
	Ethyl 5-methyl-6-oxo-8-(3-trimethylsilylprop-1-ynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	300.0 [1]
	Ethyl 5-methyl-6-oxo-8-prop-1-ynyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	22.2 [1]
	Unii-82MI0GT75Z	Ki	10000.0 [1]
	1-(2,6-Dichloro-4-ethynylphenyl)-4-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-4-pentyl-1H-1,2,3-triazole	Ki	1390.0 [1]
	1-[4-(Trifluoromethyl)phenyl]-5-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-4-propyl-1H-1,2,3-triazole	Ki	470.0 [1]
	1-(2,4,6-Trichlorophenyl)-4-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-tert-butyl-1H-1,2,3-triazole	Ki	390.0 [1]
	1-(4-Bromophenyl)-4-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-5-hexyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-4-hexyl-1H-1,2,3-triazole	Ki	1980.0 [1]
	4-Butyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-1,2,3-triazole	Ki	1010.0 [1]
	1-(4-Bromophenyl)-5-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichlorophenyl)-4-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-bromophenyl)-4-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-5-pentyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-4-phenyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-5-phenyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-5-propyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichlorophenyl)-5-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,4,6-Trichlorophenyl)-5-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(4-Ethynylphenyl)-5-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-(2,6-Dichloro-4-bromophenyl)-5-butyl-1H-1,2,3-triazole	Ki	9150.0 [1]
	1-[(Z)-[2-[[(2R,3S)-2-[[(5R)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]methyl]-4-oxo-1-sulfoazetidin-3-yl]amino]-1-(2-amino-1,3-thiazol-4-yl)-2-oxoethylidene]amino]oxycyclopropane-1-carboxylic acid	IC50	1340000.0 [1]
	1-[(Z)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2R,3S)-2-[[4-[(diaminomethylideneamino)methyl]triazol-1-yl]methyl]-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxycyclopropane-1-carboxylic acid	IC50	890000.0 [1]
	Unii-29H7N9XI1B	IC50	2400000.0 [1]
	1-[(Z)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2R,3S)-2-[[4-[(diaminomethylideneamino)methyl]triazol-2-yl]methyl]-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxycyclopropane-1-carboxylic acid	IC50	190000.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-ethyl-5-methyltriazole	Ki	1060.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-ethyl-4-methyltriazole	Ki	9150.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4,5-diethyltriazole	Ki	959.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-methyl-4-propyltriazole	Ki	322.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-methyl-5-propyltriazole	Ki	9150.0 [1]
	1-[2,6-Dibromo-4-(trifluoromethyl)phenyl]-5-methyl-4-propyltriazole	Ki	9150.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-ethyl-4-propyltriazole	Ki	9150.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-ethyl-5-propyltriazole	Ki	9150.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4,5-dipropyltriazole	Ki	9150.0 [1]
	[3-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-propyltriazol-4-yl]methanol	Ki	387.0 [1]
	[1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-propyltriazol-4-yl]methanol	Ki	9150.0 [1]
	5-(Chloromethyl)-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-propyltriazole	Ki	266.0 [1]
	4-(Chloromethyl)-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-propyltriazole	Ki	9150.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-cyclohexyl-1H-1,2,3-triazole	Ki	1500.0 [1]
	1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(3-chloropropyl)-1H-1,2,3-triazole	Ki	616.0 [1]
	3-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-5-phenyl-3H-1,2,3-triazol-4-amine	Ki	1160.0 [1]
	15-Methoxy-12-oxa-9-aza-3-azoniatetracyclo[9.7.0.03,8.013,18]octadeca-1(11),3,5,7,13(18),14,16-heptaen-10-one;chloride	Ki	8081.0 [1]
	Ethyl 6-(4-methylphenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	105.0 [1]
	Ethyl 8-fluoro-6-(4-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	60.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ GABA A receptor alpha-2/beta-2/gamma-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/gaba-a-receptor-alpha-2-beta-2-gamma-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ GABA A receptor alpha-2/beta-2/gamma-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gaba-a-receptor-alpha-2-beta-2-gamma-2-inhibitors-ic50-ki.
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