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G protein-coupled receptor kinase 5 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[2-(Dimethylamino)ethyl]-3-[6-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]benzamideIC505000.0 [1], 20000.0 [2]
4-[6-[(4-Fluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]benzamideIC505000.0 [1], 20000.0 [2]
4-(6-Benzylimidazo[1,2-b]pyridazin-3-yl)benzamideIC5020000.0 [1], 80000.0 [2]
6-(1-Methylpyrazol-4-yl)-3-thiophen-2-ylimidazo[1,2-b]pyridazineIC5020000.0 [1], 80000.0 [2]
ParoxetineIC50100000.0 [1]
DoramapimodIC5030000.0 [1]
BalanolIC50160.0 [1]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
CID 11677079IC502300.0 [1]
CID 59604787IC5010000.0 [1]
N-(2,6-Difluorobenzyl)-3-({[4-Propyl-5-(Pyrimidin-4-Yl)-4h-1,2,4-Triazol-3-Yl]methyl}amino)benzamideIC502200.0 [1]
CID 118888941IC50380.0 [1]
4-[3-[(2,6-Dimethoxyphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC504950.0 [1]
N-[2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-5-yl]acetamideIC503220.0 [1]
CID 44256277IC5059.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-N-(4-fluorophenyl)-1,3-benzoxazol-6-amineIC503700.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
1-[2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-6-yl]-3-phenylureaIC501660.0 [1]
1-[2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-6-yl]-3-(4-methylphenyl)sulfonylureaIC50880.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-Benzyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC505700.0 [1]
N-Benzyl-3-[(4-methyl-3-pyridin-4-yl-1H-pyrazol-5-yl)methylamino]benzamideIC5030000.0 [1]
2-Fluoro-5-[5-(1H-indazol-5-ylcarbamoyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]benzoic acidIC50100000.0 [1]
4-[4-Fluoro-3-(methylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[[3,5-Bis(trifluoromethyl)phenyl]methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[2-(2-hydroxyethyl)morpholin-4-yl]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5012000.0 [1]
4-[3-[(2,6-Dichlorophenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(2,6-Dimethylphenyl)ethylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5058000.0 [1]
4-[4-Fluoro-3-[(2-methoxyphenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC502300.0 [1]
4-[3-[2-[(2,6-Dimethylphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5088000.0 [1]
4-[4-Fluoro-3-[1-(2-methoxyphenyl)ethylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC502800.0 [1]
4-[3-[2-[[2,6-Bis(trifluoromethyl)phenyl]methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[(2,6-Dimethoxyphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-(Benzylcarbamoyl)-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC504700.0 [1]
4-[4-Fluoro-3-[(3-methylpyridin-2-yl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5068000.0 [1]
4-[4-Fluoro-3-[2-[furan-2-ylmethyl(2-hydroxyethyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC501700.0 [1]
4-[4-Fluoro-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC501800.0 [1]
4-[3-[2-[(1-Cyclopropylpiperidin-4-yl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5019000.0 [1]
4-[4-Fluoro-3-(2-pyridin-4-ylethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5040000.0 [1]
4-[4-Fluoro-3-[2-[2-methylpropyl(prop-2-ynyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5013000.0 [1]
4-[4-Fluoro-3-[2-[methyl-[(5-methyl-1H-imidazol-2-yl)methyl]amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5019000.0 [1]
4-[4-Fluoro-3-[3-[(5-methyl-1,3-oxazol-2-yl)methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5066000.0 [1]
4-[4-Fluoro-3-[2-[furan-2-ylmethyl(prop-2-ynyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC503500.0 [1]
4-[4-Fluoro-3-[(3-methoxyphenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC503800.0 [1]
4-[4-Fluoro-3-[methyl(oxan-2-ylmethyl)carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(Azepan-1-yl)propylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5071000.0 [1]
Methyl 1-[[2-fluoro-5-[5-(1H-indazol-5-ylcarbamoyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]benzoyl]amino]cyclohexane-1-carboxylateIC5019000.0 [1]
4-[3-[[2,6-Bis(trifluoromethyl)phenyl]methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50260.0 [1]
4-[4-Fluoro-3-[methyl-[(5-methyl-1H-pyrazol-3-yl)methyl]carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5044000.0 [1]
4-[3-[Butan-2-yl(methyl)carbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[(5-Ethyl-1,2,4-oxadiazol-3-yl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50380.0 [1]
4-[4-Fluoro-3-[3-oxo-3-(2-phenylethylamino)propyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-(2-pyridin-2-ylethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC506200.0 [1]
4-[4-Fluoro-3-[(3-fluorophenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50800.0 [1]
4-[3-[(2,6-Difluorophenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC505000.0 [1]
4-[4-Fluoro-3-[(4-methoxyphenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC508100.0 [1]
4-[3-[(2,6-Dimethylphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-N,6-dimethyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
N-(1,3-Benzodioxol-5-yl)-4-[4-fluoro-3-(pyridin-2-ylmethylcarbamoyl)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[(1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
(2S)-6-Amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acidIC5061300.0 [1]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]pentanedioic acidIC503900.0 [1]
(2S)-6-Amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acidIC507400.0 [1]
(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-Amino-1-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoic acidIC502100.0 [1]
(2S)-6-Amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-aminopropanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acidIC509400.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-7-(1H-indazol-6-yl)-1,3-benzoxazol-6-olIC50530.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
3-(9-Oxa-3,4,6,12-tetrazatricyclo[8.4.0.02,6]tetradeca-1(10),2,4,11,13-pentaen-5-ylmethylamino)-N-[[2-(trifluoromethyl)phenyl]methyl]benzamideIC501500.0 [1]
N-Benzyl-3-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC5021000.0 [1]
N-Methyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5030000.0 [1]
4-[3-[2-[Butan-2-yl(hydroxymethyl)amino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5038000.0 [1]
4-[4-Fluoro-3-[2-[(1-methyl-5-oxopyrrolidin-3-yl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5027000.0 [1]
4-[4-Fluoro-3-[2-oxo-2-(3-propoxypyrrolidin-1-yl)ethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5025000.0 [1]
4-[4-Fluoro-3-(octan-2-ylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5077000.0 [1]
4-[3-[2-[(6-Cyanopyridin-3-yl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5027000.0 [1]
4-[4-Fluoro-3-[3-[[1-(hydroxymethyl)cyclopropyl]methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(3,5-Dimethyl-1,2-oxazol-4-yl)ethylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5018000.0 [1]
4-[4-Fluoro-3-[3-[2-methylpropyl(propan-2-yl)amino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[2-hydroxyethyl(3-methylbutyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5016000.0 [1]
4-[4-Fluoro-3-(imidazo[1,2-a]pyridin-2-ylmethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC501900.0 [1]
4-[3-[2-[(2,5-Dimethylphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-(1-Azabicyclo[2.2.2]octan-3-ylcarbamoyl)-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5021000.0 [1]
4-[4-Fluoro-3-[2-(3-methoxypropyl)piperidine-1-carbonyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[3-[(1-methylcyclohexyl)methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[Bis(3-hydroxypropyl)amino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5021000.0 [1]
4-[3-[2-(4-Tert-butylazepan-1-yl)-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[Butyl(but-2-ynyl)amino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC502400.0 [1]
4-[4-Fluoro-3-[2-(5-methyl-1,3-dihydroisoindol-2-yl)-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC506300.0 [1]
4-[3-(6,7-Dihydro-5H-cyclopenta[b]pyridin-3-ylmethylcarbamoyl)-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC509500.0 [1]
4-[4-Fluoro-3-[2-[2-hydroxyethyl(2-methylbutyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC509300.0 [1]
4-[3-[3-(3-Ethyl-3-hydroxypiperidin-1-yl)-3-oxopropyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-(9-methyl-3,9-diazabicyclo[4.2.1]nonan-3-yl)-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC506100.0 [1]
4-[4-Fluoro-3-(6-methylheptan-2-ylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-aminopropanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]pentanedioic acidIC501600.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-N-propyl-1,3-benzoxazol-5-amineIC50700.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-N-methyl-1,3-benzoxazol-5-amineIC50660.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-N-butyl-1,3-benzoxazol-5-amineIC50500.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-N,N-dimethyl-1,3-benzoxazol-5-amineIC501760.0 [1]
5-(1-Piperidin-4-ylpyrazol-4-yl)-3-(5-pyrrolidin-1-yl-1,3-benzoxazol-2-yl)pyridin-2-amineIC50120.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ G protein-coupled receptor kinase 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/g-protein-coupled-receptor-kinase-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ G protein-coupled receptor kinase 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/g-protein-coupled-receptor-kinase-5-inhibitors-ic50-ki.
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