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G-protein coupled receptor kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3-[[2-Oxo-2-[(2E)-2-(pyridin-4-ylmethylidene)hydrazinyl]ethyl]amino]benzamideIC50150.0 [1], 4000.0 [2]
3-[[2-Oxo-2-[(2E)-2-(pyridin-4-ylmethylidene)hydrazinyl]ethyl]amino]benzamideKi10.0 [1]
CID 11677079IC5018.0 [1], 30.0 [2]
N-(2,6-Difluorobenzyl)-3-({[4-Propyl-5-(Pyrimidin-4-Yl)-4h-1,2,4-Triazol-3-Yl]methyl}amino)benzamideIC501.2 [1], 20.0 [2]
2-(4-Chloroanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideIC505600.0 [1]
2-(4-Chloroanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideKi1000.0 [1]
2-(2-Methoxyanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideIC5010000.0 [1]
2-(2-Methoxyanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideKi10000.0 [1]
2-Anilino-N-[(E)-pyridin-4-ylmethylideneamino]acetamideIC501800.0 [1]
2-Anilino-N-[(E)-pyridin-4-ylmethylideneamino]acetamideKi100.0 [1]
2-(3-Chloroanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideIC50700.0 [1]
2-(3-Chloroanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideKi100.0 [1]
2-(3-Methoxyanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideIC5049.0 [1]
2-(3-Methoxyanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideKi10.0 [1]
ParoxetineIC501380.0 [1]
SangivamycinKi67000.0 [1]
BalanolIC5042.0 [1]
Betaark1 InhibitorIC50126000.0 [1]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50770.0 [1]
2-(4-Methylanilino)-N-[(E)-pyridin-4-ylmethylideneamino]acetamideKi10000.0 [1]
4-{3-[(3-Chlorophenoxy)methyl]-1H-1,2,4-triazol-5-yl}pyridineIC504400.0 [1]
Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC50100000.0 [1]
4-[3-[(2,6-Dimethoxyphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50130.0 [1]
N-[2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-5-yl]acetamideIC503060.0 [1]
CID 44256277IC50460.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-N-(4-fluorophenyl)-1,3-benzoxazol-6-amineIC509300.0 [1]
1-[2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-6-yl]-3-phenylureaIC502630.0 [1]
1-[2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-6-yl]-3-(4-methylphenyl)sulfonylureaIC508300.0 [1]
Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC50100000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
N-Benzyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC506.1 [1]
N-Benzyl-3-[(4-methyl-3-pyridin-4-yl-1H-pyrazol-5-yl)methylamino]benzamideIC509.9 [1]
N-[(2,6-Difluorophenyl)methyl]-3-[(4-methyl-5-pyrimidin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC506.8 [1]
1-Benzyl-3-[3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]phenyl]ureaIC5019.0 [1]
N-[(3-Methoxyphenyl)methyl]-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5012.0 [1]
N-Benzyl-3-[(5-pyridin-4-yl-1,2-oxazol-3-yl)methylamino]benzamideIC5024.0 [1]
N-Benzyl-3-[(3-pyridin-4-yl-1H-pyrazol-5-yl)methylamino]benzamideIC5014.0 [1]
4-[4-Fluoro-3-[2-[2-(2-hydroxyethyl)morpholin-4-yl]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC501500.0 [1]
4-[4-Fluoro-3-[1-(2-methoxyphenyl)ethylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50400.0 [1]
4-[4-Fluoro-3-[2-[furan-2-ylmethyl(2-hydroxyethyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50460.0 [1]
4-[3-[2-[(1-Cyclopropylpiperidin-4-yl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50680.0 [1]
4-[4-Fluoro-3-[2-[2-methylpropyl(prop-2-ynyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC502400.0 [1]
4-[4-Fluoro-3-[2-[methyl-[(5-methyl-1H-imidazol-2-yl)methyl]amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC502000.0 [1]
4-[4-Fluoro-3-[3-[(5-methyl-1,3-oxazol-2-yl)methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC504000.0 [1]
4-[4-Fluoro-3-[2-[furan-2-ylmethyl(prop-2-ynyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50920.0 [1]
4-[4-Fluoro-3-[methyl(oxan-2-ylmethyl)carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5014000.0 [1]
4-[3-[2-(Azepan-1-yl)propylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC501200.0 [1]
Methyl 1-[[2-fluoro-5-[5-(1H-indazol-5-ylcarbamoyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]benzoyl]amino]cyclohexane-1-carboxylateIC50160.0 [1]
4-[4-Fluoro-3-[[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50250.0 [1]
4-[4-Fluoro-3-[methyl-[(5-methyl-1H-pyrazol-3-yl)methyl]carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC501100.0 [1]
4-[3-[Butan-2-yl(methyl)carbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5044000.0 [1]
4-[3-[(5-Ethyl-1,2,4-oxadiazol-3-yl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50160.0 [1]
4-[4-Fluoro-3-[3-oxo-3-(2-phenylethylamino)propyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC504700.0 [1]
4-[4-Fluoro-3-[(1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC504600.0 [1]
2-[2-Amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-7-(1H-indazol-6-yl)-1,3-benzoxazol-6-olIC506500.0 [1]
3-(2-Phenylethoxy)-N-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methyl]anilineIC50280.0 [1]
3-[[5-(2-Acetamidopyridin-4-yl)-4-methyl-1,2,4-triazol-3-yl]methylamino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamideIC50170.0 [1]
N-Benzyl-3-[(5-pyridin-4-yl-1H-imidazol-2-yl)methylamino]benzamideIC5021.0 [1]
N-[(2,6-Difluorophenyl)methyl]-3-[[4-methyl-5-[2-(methylamino)pyridin-4-yl]-1,2,4-triazol-3-yl]methylamino]benzamideIC5062.0 [1]
N-Benzyl-3-[[3-(3-methylpyridin-4-yl)-1H-1,2,4-triazol-5-yl]methylamino]benzamideIC5042.0 [1]
3-[(4-Methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]-N-[[4-(trifluoromethyl)phenyl]methyl]benzamideIC5045.0 [1]
N-Benzyl-N-methyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC50700.0 [1]
N-[(E)-7,8-Dihydro-6H-isoquinolin-5-ylideneamino]-2-(3-ethoxyanilino)acetamideIC50120.0 [1]
4-Chloro-N-[2-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)ethyl]anilineIC5010000.0 [1]
N-[(2-Chlorophenyl)methyl]-3-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC5012.0 [1]
N-Benzyl-3-[[4-(2-methoxyethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]methylamino]benzamideIC5016.0 [1]
3-Benzylsulfanyl-N-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methyl]anilineIC50290.0 [1]
N-[(2,6-Difluorophenyl)methyl]-3-[[4-methyl-5-[2-(2-phenylethylamino)pyridin-4-yl]-1,2,4-triazol-3-yl]methylamino]benzamideIC50250.0 [1]
N-[(4-Chlorophenyl)methyl]-5-pyridin-4-yl-1H-1,2,4-triazol-3-amineIC50980.0 [1]
N-Benzyl-3-[(4-propyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC5032.0 [1]
3-(9-Oxa-3,4,6,12-tetrazatricyclo[8.4.0.02,6]tetradeca-1(10),2,4,11,13-pentaen-5-ylmethylamino)-N-[[2-(trifluoromethyl)phenyl]methyl]benzamideIC501.8 [1]
3-[[4-(2-Hydroxyethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]methylamino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamideIC505.5 [1]
3-[(3-Pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzenesulfonamideIC5044.0 [1]
N-[2-Chloro-5-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]phenyl]acetamideIC50130.0 [1]
N-[(E)-7,8-Dihydro-6H-isoquinolin-5-ylideneamino]-2-(3-phenylmethoxyanilino)acetamideIC5053.0 [1]
N-Benzyl-3-[(2-pyridin-4-yl-1,3-thiazol-4-yl)methylamino]benzamideIC50470.0 [1]
N-[(2,6-Difluorophenyl)methyl]-3-(9-oxa-3,4,6,12-tetrazatricyclo[8.4.0.02,6]tetradeca-1(10),2,4,11,13-pentaen-5-ylmethylamino)benzamideIC501.7 [1]
4-Chloro-N-[[3-(2-methylpyridin-4-yl)-1H-1,2,4-triazol-5-yl]methyl]anilineIC5010000.0 [1]
N-Benzyl-3-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC5045.0 [1]
N-[(2,6-Difluorophenyl)methyl]-3-[[4-methyl-5-[2-(3-phenylpropylamino)pyridin-4-yl]-1,2,4-triazol-3-yl]methylamino]benzamideIC50110.0 [1]
[4-[5-[[3-(Benzylcarbamoyl)anilino]methyl]-1H-1,2,4-triazol-3-yl]pyridin-3-yl]methyl carbamateIC50560.0 [1]
3-[(4-Propyl-5-pyrimidin-4-yl-1,2,4-triazol-3-yl)methylamino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamideIC501.9 [1]
N-Benzyl-3-[(4-propan-2-yl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC50140.0 [1]
N-Benzyl-3-[(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)methylamino]benzamideIC50200.0 [1]
N-Benzyl-3-[[2-[(2E)-2-(7,8-dihydro-6H-isoquinolin-5-ylidene)hydrazinyl]-2-oxoethyl]amino]benzamideIC5020.0 [1]
N-Benzyl-3-[(2-pyridin-4-yl-1H-imidazol-5-yl)methylamino]benzamideIC50460.0 [1]
N-[3-[(3-Pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]phenyl]acetamideIC5065.0 [1]
2-[4-[5-[(4-Chloroanilino)methyl]-1H-1,2,4-triazol-3-yl]pyridin-3-yl]ethanolIC503800.0 [1]
N-[(E)-7,8-Dihydro-6H-isoquinolin-5-ylideneamino]-2-(3-methoxyanilino)acetamideIC5014.0 [1]
1-Phenyl-N-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methyl]methanamineIC5010000.0 [1]
N-Benzyl-3-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC507.5 [1]
N-[(4-Methoxyphenyl)methyl]-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5017.0 [1]
N-[(E)-7,8-Dihydro-6H-isoquinolin-5-ylideneamino]-2-(3-phenoxyanilino)acetamideIC5042.0 [1]
N-Benzyl-3-[(1-pyridin-4-ylpyrrol-3-yl)methylamino]benzamideIC501700.0 [1]
N-Phenyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5054.0 [1]
N-[(2-Methoxyphenyl)methyl]-3-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC5044.0 [1]
N-[(2-Chlorophenyl)methyl]-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC503.9 [1]
N-(3-Phenylpropyl)-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5023.0 [1]
3-Benzylsulfonyl-N-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methyl]anilineIC501800.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ G-protein coupled receptor kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/g-protein-coupled-receptor-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ G-protein coupled receptor kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/g-protein-coupled-receptor-kinase-2-inhibitors-ic50-ki.
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