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G-protein coupled receptor ChemR23 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[4-Chloro-2-hydroxy-3-[(3S)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC5010000.0 [1]
(3R,4S)-N-[3-Cyano-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-3-[[(2R)-2-methylmorpholin-4-yl]methyl]-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-3-[[methyl(2-methylpropyl)amino]methyl]-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-N-[3-Cyano-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-3-[[methyl(2,2,2-trifluoroethyl)amino]methyl]-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(5S)-N-[3,5-Bis(trifluoromethyl)phenyl]-2-(2,6-dimethylphenyl)-5-fluoro-3-oxo-3a,4,5,6-tetrahydro-1H-cyclopenta[c]pyrrole-6a-carboxamideIC5030.0 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC50300.0 [1]
1-(2-Methylphenyl)-5-oxo-N-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-5-oxo-1-phenylpyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-(1,2,3,6-tetrahydropyridin-4-yl)pyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3,4-bis(prop-2-enyl)pyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-ethyl-3-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-ethyl-3-methyl-5-oxopyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-(3,6-dihydro-2H-thiopyran-4-yl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1-methylpiperidin-4-yl)-5-oxopyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
Tert-butyl 4-[3-[[3,5-bis(trifluoromethyl)phenyl]carbamoyl]-1-(2,6-dimethylphenyl)-5-oxopyrrolidin-3-yl]piperidine-1-carboxylateIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(3,5-dimethylpyrazol-1-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4R)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-(thian-4-yl)pyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1-hydroxyethyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S)-N-[3-Chloro-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-(1-pyrrolidin-1-ylethyl)pyrrolidine-3-carboxamideIC50300.0 [1]
(3R,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
1-(2,6-Dimethylphenyl)-3-ethyl-5-oxo-N-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC50300.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3-Chloro-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methoxy-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-cyclopentyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-propylpyrrolidine-3-carboxamideIC5030.0 [1]
(3R)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-3-(oxan-4-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-cyclobutyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4R)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-3-(oxan-4-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-[3-pyrrolidin-1-yl-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3-Cyclopropyl-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(2-methylbutan-2-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
3-[(1-Benzylpyrrolidin-3-yl)methyl]-N-[3,5-bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-cyclohexyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(3-methylbutyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3,4-diethyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-N-[3-ethoxy-5-(trifluoromethyl)phenyl]-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-butyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3-Cyclopentyloxy-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R)-1-(2,6-Dimethylphenyl)-5-oxo-3-propan-2-yl-N-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC5030.0 [1]
1-(2-Chlorophenyl)-N-[3-cyclopropyl-5-(trifluoromethyl)phenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-cyclopropylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3-Cyclopropyl-5-(trifluoromethyl)phenyl]-1-(2-methoxyphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC50300.0 [1]
(3S,4S)-N-[3-(Dimethylamino)-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3-Cyclopropyl-5-(trifluoromethyl)phenyl]-1-(2-methylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-N-[3-fluoro-5-(trifluoromethyl)phenyl]-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R)-N-[3-Cyclopropyl-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3R)-N-[3-Cyano-5-(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-[(dimethylamino)methyl]-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-ethenylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-[3-(trifluoromethyl)-5-[[2-(trifluoromethyl)pyrrolidin-1-yl]methyl]phenyl]pyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-(morpholin-4-ylmethyl)phenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(2-methylprop-2-enyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-3-[(dimethylamino)methyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(oxan-4-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-2-(2,6-dimethylphenyl)-1-oxo-4,6,7,7a-tetrahydro-3H-pyrano[3,4-c]pyrrole-3a-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1H-imidazol-2-ylmethyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-(phenylmethoxymethyl)pyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-methyl-6-(morpholin-4-ylmethyl)phenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3R)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-(methoxymethyl)-6-methylphenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-bromo-6-methylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-fluoro-6-methylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3R)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-4-methyl-3-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3S,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-N-[3,5-Bis(trifluoromethyl)phenyl]-3-[[cyclobutyl(methyl)amino]methyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
(3R,4S)-3-[(4,4-Difluoropiperidin-1-yl)methyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-N-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-5-oxo-3-propan-2-yl-1-(2-prop-2-enylphenyl)pyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-(hydroxymethyl)-6-methylphenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-methyl-6-(2-morpholin-4-ylethyl)phenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-methyl-6-prop-2-enylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-methoxy-6-methylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-methyl-1-(2-methylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-hydroxy-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-methylphenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3,4-dimethyl-1-(2-methylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-methyl-6-(2-pyrrolidin-1-ylethyl)phenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC50300.0 [1]
(3S,4S)-1-(2,6-Dimethylphenyl)-3-ethyl-4-methyl-N-[3-(morpholin-4-ylmethyl)-5-(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-[2-(2-hydroxyethyl)-6-methylphenyl]-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamideIC50300.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-2-(2,6-dimethylphenyl)-1-oxo-3,4,5,6,7,7a-hexahydroisoindole-3a-carboxamideIC5030.0 [1]
(3R,4S)-3-[[Cyclobutyl(methyl)amino]methyl]-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-N-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(methoxymethyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-3-(3,6-dihydro-2H-pyran-4-yl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-5-oxo-3-propylpyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(2-hydroxypropan-2-yl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(hydroxymethyl)-5-oxopyrrolidine-3-carboxamideIC5030.0 [1]
Tert-butyl 4-[3-[[3,5-bis(trifluoromethyl)phenyl]carbamoyl]-1-(2,6-dimethylphenyl)-5-oxopyrrolidin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxylateIC5030.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ G-protein coupled receptor ChemR23 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/g-protein-coupled-receptor-chemr23-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ G-protein coupled receptor ChemR23 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/g-protein-coupled-receptor-chemr23-inhibitors-ic50-ki.
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