G-protein coupled receptor 84 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Unii-K9WR6lra5D	IC50	0.01 [1]
	4-[2-[2-(1,4-Dioxan-2-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]ethynyl]-N-methylbenzamide	IC50	101.0 [1]
	GPR84 antagonist 8	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-[(2-methylpropan-2-yl)oxymethyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-[(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)methoxy]-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-[(5-propan-2-yl-1,2,4-oxadiazol-3-yl)methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(3-methylbut-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-[3-[Benzyl(methyl)amino]prop-1-ynyl]-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(3-hydroxypent-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(3-hydroxy-4-methylpent-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(3-hydroxyhex-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(3-Anilinoprop-1-ynyl)-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(Cyclopentyloxymethyl)-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(2-Cyclopropylethynyl)-2-[[(2R)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(3-methylbut-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2R)-1,4-Dioxan-2-yl]methoxy]-9-pentyl-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	9-(2,2-Dimethylbutylamino)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[2-(1,4-Dioxan-2-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]benzonitrile	IC50	100.0 [1], 101.0 [2]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(1,3-oxazol-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	101.0 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-[2-(3-methylimidazol-4-yl)ethynyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	101.0 [1]
	9-(2-Cyclopropylethynyl)-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(3,3-Dimethylbut-1-ynyl)-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(2-methoxypyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	101.0 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(6-propan-2-yloxypyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(6-morpholin-4-ylpyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(2,3-Dimethoxyphenyl)-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(2-ethoxypyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)-9-(2-morpholin-4-yl-2-oxoethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(2H-tetrazol-5-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 100.0 [2]
	2-(Oxolan-2-ylmethoxy)-9-(2-phenoxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(Oxolan-2-ylmethoxy)-9-[(6-pyrimidin-5-ylpyridin-2-yl)methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	100.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(oxetan-3-yloxymethyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-[(3-methyloxetan-3-yl)methoxymethyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)-2-(oxolan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)-9-(2H-tetrazol-5-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)-9-(2-oxo-2-pyrrolidin-1-ylethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 100.0 [2]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(pyridin-4-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(1,3-oxazol-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]oxy]acetonitrile	IC50	0.01 [1]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(4-hydroxy-4-methylpentyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	101.0 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(2-pyridin-2-ylethyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(Cyclopentyloxymethyl)-2-[[(2R)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-[3-(2-methoxyethoxy)prop-1-ynyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(oxan-4-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(oxan-4-ylmethoxymethyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	9-(2,2-Dimethylpropoxy)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(3-hydroxybutyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(6-piperidin-1-ylpyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(2-Cyclopropylethyl)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(4-hydroxypentyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(2-pyridin-3-ylethynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	9-(3-Anilinopropyl)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(2-pyridin-2-ylethynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(3-hydroxy-3-pyridin-3-ylpropyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(oxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-(Cyclopentylmethoxymethyl)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[2-(1,4-Dioxan-2-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]oxy]acetonitrile	IC50	101.0 [1]
	9-(2-Cyclopropylethyl)-2-[[(2R)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2R)-1,4-Dioxan-2-yl]methoxy]-9-(3-methoxypropyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-[[(2R)-1,4-Dioxan-2-yl]methoxy]-9-[2-(1-hydroxycyclopentyl)ethyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 101.0 [2]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(4-methoxybutyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(2-propan-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2S)-1,4-Dioxan-2-yl]methoxy]-9-(2-propoxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]benzonitrile	IC50	0.01 [1], 100.0 [2]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(2-pyridin-4-ylethynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(2-pyridin-3-ylethynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 100.0 [2]
	9-[3-(Benzylamino)prop-1-ynyl]-2-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(6-methoxypyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(3-hydroxybut-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(piperidin-1-ylmethyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(3-methoxyprop-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 100.0 [2]
	2-[[(2R)-2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-yl]methoxy]-9-(1,3-oxazol-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-[[(2S)-2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-yl]methoxy]-9-(1,3-oxazol-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1], 100.0 [2]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(3-hydroxy-3-methylbut-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(6-methylpyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(3-hydroxypent-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	9-[(3-Nitrophenyl)methoxy]-2-(oxolan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(1H-pyrazol-4-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-[(1,5-dimethylpyrazol-3-yl)methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(3-hydroxy-4-methylpent-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(3-hydroxyhex-1-ynyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-[2-(1-hydroxycyclopentyl)ethynyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(2-morpholin-4-ylethoxymethyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-[(1,5-dimethylpyrazol-3-yl)methoxy]-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(2-pyrimidin-4-ylethynyl)-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(4-hydroxybut-1-ynyl)-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	3-[2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-4-oxo-6,7-dihydrobenzo[a]quinolizin-9-yl]benzamide	IC50	10.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-pyridin-3-yl-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-pyrimidin-5-yl-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-(1H-indazol-5-yl)-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	2-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-ylmethoxy)-9-[(3-methyl-1,2,4-oxadiazol-5-yl)methoxy]-6,7-dihydrobenzo[a]quinolizin-4-one	IC50	10.0 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-[2-(3-methoxyphenyl)ethynyl]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	101.0 [1]
	N-(1-Butyltetrazol-5-yl)-2-[[2-(2,3-dihydro-1,4-benzodioxin-3-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]oxy]acetamide	IC50	0.01 [1]
	2-[[2-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)-4-oxo-6,7-dihydropyrimido[6,1-a]isoquinolin-9-yl]oxy]-N-(1-propyltetrazol-5-yl)acetamide	IC50	0.01 [1]
	9-Hydroxy-2-(oxolan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	1000.0 [1]
	9-(2,6-Dimethoxypyridin-3-yl)-2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-(6-pyrrolidin-1-ylpyridin-3-yl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-[(5-phenyl-1,3-oxazol-2-yl)methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]
	2-(1,4-Dioxan-2-ylmethoxy)-9-[(5-ethyl-1,2,4-oxadiazol-3-yl)methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	IC50	0.01 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ G-protein coupled receptor 84 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/g-protein-coupled-receptor-84-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ G-protein coupled receptor 84 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/g-protein-coupled-receptor-84-inhibitors-ic50-ki.
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