![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_726285044070aa60717017603ebd38c3.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)-4-(trifluoromethyl)benzamide | IC50 | 1570.0 [1], 3650.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_5b91677bb9d8ae0fc14c2463a0cb52cc.svg) | 1-(4-Chlorophenyl)-N-(2-sulfanylideneimidazolidine-1-carbothioyl)-5-(trifluoromethyl)pyrazole-4-carboxamide | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_ed6c52e6828050a7b1e63e41429ab269.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)naphthalene-1-carboxamide | IC50 | 130.0 [1], 450.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_a868ec08875d00fd3b0c199b96fda21c.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)naphthalene-2-carboxamide | IC50 | 170.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_a9da412f432df04a8f0ef5cb02c6cc16.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)benzamide | IC50 | 170.0 [1], 440.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_0462aaf27cdb3931d9d6ad556e508d29.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)pyridine-3-carboxamide | IC50 | 133.0 [1], 670.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_5f45e4ca2e1ccc01d43d9ec31241ed40.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)pyridine-3-carboxamide | IC50 | 850.0 [1], 6560.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_73dd821ef26276e232302bd30d0fce49.svg) | 3-Methyl-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 3800.0 [1], 120000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_9623ed75b7a6f9dd701423c088164120.svg) | 3-Fluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 2620.0 [1], 3190.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_ff951f12738ab982b5db997fff742497.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-4-methoxybenzamide | IC50 | 210.0 [1], 830.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_cea0d0e3ef8dd230ea4e4c784357bc23.svg) | 3-Methoxy-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 51000.0 [1], 56000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_f0866b34a23e1a6a7ea5ded20aa3aa4f.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)-1-benzothiophene-2-carboxamide | IC50 | 260.0 [1], 4520.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_39fcc52995a97217ae9171f07924af20.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3-fluorobenzamide | IC50 | 220.0 [1], 240.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_fe04041fb998af4e8110f1c3e2e9a6c4.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-2-fluorobenzamide | IC50 | 100.0 [1], 350.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_2ca604ad8af26a483db17691d45cd807.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)thiophene-2-carboxamide | IC50 | 100.0 [1], 420.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8a93845bfc46fa87584c983e82044517.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-1,2-oxazole-5-carboxamide | IC50 | 100.0 [1], 330.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_686d0765c59bb2f267c49987c9974dd0.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)-1,2-oxazole-5-carboxamide | IC50 | 2430.0 [1], 5830.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_846a170481dcbb328e025cced4b39e5e.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)naphthalene-2-carboxamide | IC50 | 710.0 [1], 100000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_c37cc6112b329c558fd618a9edb82c32.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)furan-2-carboxamide | IC50 | 68290.0 [1], 160000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_9749b4eb8bf5c3bb3d4f5312d0b39aaa.svg) | 4-Chloro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 450.0 [1], 1970.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_dc3fb8b4b6153dd1ab7ac0cc7cc33b5a.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)furan-2-carboxamide | IC50 | 110.0 [1], 250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_9d9b621147da872e1c477268fa8e4a1b.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3,5-dimethyl-1,2-oxazole-4-carboxamide | IC50 | 350.0 [1], 460.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_d0e5d8f5a87b318793b0d15c63ffde38.svg) | 2-Fluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 43000.0 [1], 200000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8b2d9e7cabbc11f62784d21df6685dad.svg) | 2-Methylsulfanyl-N-(2-sulfanylideneimidazolidine-1-carbothioyl)pyridine-3-carboxamide | IC50 | 80000.0 [1], 200000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_352fb131807cae1e076b5fc25d9de822.svg) | 4-Tert-butyl-N-(5,6-dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)benzamide | IC50 | 370.0 [1], 650.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_975c0caca20dddfef9fd4f97ee1e3ba1.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3-methylbenzamide | IC50 | 140.0 [1], 790.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_d97fba28958fce2b62af5ab03ab55635.svg) | 4-Methoxy-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 55000.0 [1], 122000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_241ef200065851c1a6d1e1374f2db5d4.svg) | 4-Chloro-N-(5,6-dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)benzamide | IC50 | 270.0 [1], 640.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8207c2f96b260fe3590681d846843fe0.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)thiophene-2-carboxamide | IC50 | 1960.0 [1], 2790.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8e6887cd967b671a5dcc8a200ee73ef4.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-4-fluorobenzamide | IC50 | 200.0 [1], 370.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_c05246f1328201d8074166da56bbc849.svg) | 4-Fluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 480.0 [1], 1250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_4b351a214f4be8436863d5cfd2d974c7.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3-methoxybenzamide | IC50 | 310.0 [1], 400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_1b16aee13c130ebf64825f8cbcd09ba4.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-2,4-difluorobenzamide | IC50 | 190.0 [1], 410.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_d5288fd0a2fc412a0ecceee8b80614d1.svg) | 2,4-Difluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 110.0 [1], 170.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_dd5840bef27693affb6cfae49537c370.svg) | N-(2-Sulfanylideneimidazolidine-1-carbothioyl)naphthalene-1-carboxamide | IC50 | 100000.0 [1], 200000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_59d5656fb75d159dadffd8f4b7d69d6b.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-1-benzothiophene-2-carboxamide | IC50 | 130.0 [1], 190.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_c515880de9371b899be6d476ec901e72.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-4-(trifluoromethyl)benzamide | IC50 | 170.0 [1], 570.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_0046c4c116194919a2da8faf56566692.svg) | 1-(4-Chlorophenyl)-N-(5,6-dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-5-(trifluoromethyl)pyrazole-4-carboxamide | IC50 | 189.7 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_4ed0a71302206824d1a93cf5619c8a19.svg) | [3-[[6-Acetyl-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-yl]amino]cyclobutyl] acetate | IC50 | 0.11 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_4fbfab7b1f0fa76d899ce7e3af68a2a6.svg) | 1-[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.01 [1], 0.07 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_19b686bc2f2c45bcf79fb79b9733a627.svg) | 1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-[(3-hydroxycyclobutyl)amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.06 [1], 0.08 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_5bed82875a3171cdcecb1201d5debfdf.svg) | 1-(N-Benzoylthiocarbamoyl)-2-imidazolidinethione | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_846a776bc87eb4eb78673f04f926782d.svg) | 4-Tert-butyl-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamide | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_a881d2a29ecbf8ab68bffdf7df923640.svg) | N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide | IC50 | 2460.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_2de8ea4180d59ce0ee23eadd65dec9d9.svg) | 4-[[4-[6-Acetyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-yl]piperazin-1-yl]methyl]-3-fluorobenzonitrile | IC50 | 0.36 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_0b73f2a4b89a6ed3e0f5515b81f05d2b.svg) | 1-[3-(2,2-Difluoroethylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.18 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8639045c50f32429b27ed077c3b16254.svg) | 2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-N,N,5-trimethyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.09 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_78aaac24668ee20a1f86e8840099a142.svg) | 1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-one | IC50 | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8e41c8a924eef1f451869eb4d907d1e7.svg) | 2-[4-[(R)-(2,4-Difluorophenyl)-fluoromethyl]piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carbaldehyde | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_9b21e874a5398020f1e5d82258da3841.svg) | 1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_184b2841169ed0ca7e97c4b9042a8859.svg) | [2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-[(2S)-1-methylpyrrolidin-2-yl]methanone | IC50 | 0.08 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_cffd6e1398916695714292ebf743b6de.svg) | 6-(2,2-Difluoroethyl)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amine | IC50 | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_7a82d4caaf4a058f48251b9e7eaf2203.svg) | 1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[(3-fluorocyclobutyl)amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.19 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_231a0123b19cdbcb928134440702d4e4.svg) | 1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-one | IC50 | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_200aa870864f62c26fb2944821ac61cb.svg) | 2-[4-(2-Fluoro-4-methoxyphenoxy)piperidin-1-yl]-6-methyl-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amine | IC50 | 0.14 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_738d10284d2b629b64905eda747c0d39.svg) | 1-[3-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_ef82cf9d420c1942610232c797a2130b.svg) | 2-[4-[(2,4-Difluorophenyl)-fluoromethyl]piperidin-1-yl]-N,N-dimethyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_3314a9685564f8e043fe4286e26ea2ab.svg) | 1-[3-[4-(3-Methoxyphenyl)sulfonylpiperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.34 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8f042592d11fb13c8cc9497b553da1b3.svg) | Cyclopropyl-[2-(2,2-difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]methanone | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_0ff2594e26989b049f23a8b414aa3cb5.svg) | 1-[3-(Cyclobutylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.06 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_fa72b31144ccaf0667ea9a6395f2e5bc.svg) | 1-[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-5-methyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.09 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_611437697d830f3c1cf432854a247337.svg) | 1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-[[(3S)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.06 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_e85b9a8255f542162f787ad7b1692532.svg) | 1-[3-(Cyclobutylamino)-2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.04 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_56c6bd863aa5fe5569c21c60b1256858.svg) | 1-[3-[4-(2-Fluoro-4-methoxyphenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.06 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_380417de5a92d4bf24bd0dbb65ade5a2.svg) | 1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.08 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8f61460f1bc7ea55a1908cf9442fbf73.svg) | 3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-6-(2-fluoroethyl)-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amine | IC50 | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_e356d4ef02439e8063150c01e8c756a7.svg) | N-Cyclopropyl-3-[4-[(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amine | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_0b6d97730c1e0d9d8913a339e9e8074a.svg) | (2S)-1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxypropan-1-one | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_98eb577b9b57d2b496825f1cb15feda7.svg) | Methyl 2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxylate | IC50 | 0.13 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_5d5b66cec1eccd0ce8eb4470db008796.svg) | 2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-6-methylsulfonyl-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amine | IC50 | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_c5bde239a3a6faa85e241c823aa6ee17.svg) | 3-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-N,N-dimethyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_2f575397ee54dcc274d6a72e5ccbc58b.svg) | 1-[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-5-methyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxyethanone | IC50 | 0.09 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_6981c1e0576f80cd9091a5655e328b6e.svg) | (2R)-1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxypropan-1-one | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_9614a6503ad66329aec83e427e2344b5.svg) | 1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-[[(3S)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-one | IC50 | 0.04 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_d35686090e95afc0fab262f1c65a176c.svg) | [3-[[6-Acetyl-2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-yl]amino]cyclobutyl] acetate | IC50 | 0.22 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_e125d3df8866dc748e91ae95f58d5024.svg) | N-(2,2-Difluoroethyl)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amine | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_1cbf2f6804821fc0e4d643cf052794f5.svg) | 3-[4-(2-Fluoro-4-methoxyphenoxy)piperidin-1-yl]-N,N-dimethyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_b0f58a2bed223b169d56c567d62c0c21.svg) | 1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[[(3S)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.1 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_939ceb9674f38485564d6fb83fe0cb52.svg) | 1-[3-[[(2R)-Butan-2-yl]amino]-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.32 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_7fc27a6942705dee52f7404a2a48dce9.svg) | [3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-(oxolan-2-yl)methanone | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_7f706062172d8a6356e49c607906c061.svg) | N-Cyclobutyl-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-6-methylsulfonyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amine | IC50 | 0.05 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_c3365f726a19029795bf3c3bdf2a8348.svg) | 1-[3-[[(2S)-Butan-2-yl]amino]-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.06 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_41eef1f610ee8d3484be7df4a7852cd5.svg) | 2-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-N,N-dimethyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_4dcb2561bda469eb75828649cd836c8d.svg) | 1-[2-[4-[(2,4-Difluorophenyl)-fluoromethyl]piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_0090b34f2ef9046e6cc3718f45e10b2b.svg) | 1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.06 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_d455b85163acbba1ecfe311a3fc8c5d1.svg) | Methyl 3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxylate | IC50 | 0.13 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_32761de2d638e107f419abf0566be7a5.svg) | 3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-N-(2-methoxyethyl)-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_43bbb17faec45c07677e27519ca2fd33.svg) | 1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxyethanone | IC50 | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_6b7428b709bd249eca368663cbce664b.svg) | [2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-pyrrolidin-1-ylmethanone | IC50 | 0.39 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_7229e6c774c4b98cdbdf6c842d072cba.svg) | 1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methylpropan-1-one | IC50 | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_96c57cfa502310c28f68671198f27012.svg) | [2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-(oxolan-2-yl)methanone | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_259218da6f75f0cf3247922904dc480a.svg) | 1-[3-[4-(2-Fluoro-4-methoxyphenyl)sulfonylpiperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_8529602d1b914dcd3983eb8bbc609f77.svg) | (2S)-1-[3-(2,2-Difluoroethylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxypropan-1-one | IC50 | 0.11 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_e0de2403f6f2c5095c5b8f5e1c06d08f.svg) | 1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[(3-hydroxycyclobutyl)amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.12 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_a6d464a1fc9a685f881d659f5ab7c70e.svg) | 1-[2-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_61fd0d48182400f0f401f3cf6839137d.svg) | 1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2,2-difluoroethanone | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_456484c97007823464c26b726f3286cd.svg) | 4-[1-[6-Acetyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-yl]piperidin-4-yl]oxy-3-fluorobenzonitrile | IC50 | 0.09 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_bcc6bdaf97b2378a43b3210c3d62e05e.svg) | N-Cyclopropyl-3-[4-[(S)-(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amine | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_93089c8949c004df4b392e0e0ed6f8e8.svg) | 2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-N,N-dimethyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-6_f07657842942fa7e25ce6c70d4555b6e.svg) | N-Cyclopropyl-3-[4-[(R)-(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amine | IC50 | 0.03 [1] |