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G-protein coupled receptor 6 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-(2-Sulfanylideneimidazolidine-1-carbothioyl)-4-(trifluoromethyl)benzamideIC501570.0 [1], 3650.0 [2]
1-(4-Chlorophenyl)-N-(2-sulfanylideneimidazolidine-1-carbothioyl)-5-(trifluoromethyl)pyrazole-4-carboxamideIC50200000.0 [1]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)naphthalene-1-carboxamideIC50130.0 [1], 450.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)naphthalene-2-carboxamideIC50170.0 [1]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)benzamideIC50170.0 [1], 440.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)pyridine-3-carboxamideIC50133.0 [1], 670.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)pyridine-3-carboxamideIC50850.0 [1], 6560.0 [2]
3-Methyl-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC503800.0 [1], 120000.0 [2]
3-Fluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC502620.0 [1], 3190.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-4-methoxybenzamideIC50210.0 [1], 830.0 [2]
3-Methoxy-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC5051000.0 [1], 56000.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)-1-benzothiophene-2-carboxamideIC50260.0 [1], 4520.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3-fluorobenzamideIC50220.0 [1], 240.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-2-fluorobenzamideIC50100.0 [1], 350.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)thiophene-2-carboxamideIC50100.0 [1], 420.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-1,2-oxazole-5-carboxamideIC50100.0 [1], 330.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)-1,2-oxazole-5-carboxamideIC502430.0 [1], 5830.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)naphthalene-2-carboxamideIC50710.0 [1], 100000.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)furan-2-carboxamideIC5068290.0 [1], 160000.0 [2]
4-Chloro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC50450.0 [1], 1970.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)furan-2-carboxamideIC50110.0 [1], 250.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3,5-dimethyl-1,2-oxazole-4-carboxamideIC50350.0 [1], 460.0 [2]
2-Fluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC5043000.0 [1], 200000.0 [2]
2-Methylsulfanyl-N-(2-sulfanylideneimidazolidine-1-carbothioyl)pyridine-3-carboxamideIC5080000.0 [1], 200000.0 [2]
4-Tert-butyl-N-(5,6-dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)benzamideIC50370.0 [1], 650.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3-methylbenzamideIC50140.0 [1], 790.0 [2]
4-Methoxy-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC5055000.0 [1], 122000.0 [2]
4-Chloro-N-(5,6-dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)benzamideIC50270.0 [1], 640.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)thiophene-2-carboxamideIC501960.0 [1], 2790.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-4-fluorobenzamideIC50200.0 [1], 370.0 [2]
4-Fluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC50480.0 [1], 1250.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-3-methoxybenzamideIC50310.0 [1], 400.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-2,4-difluorobenzamideIC50190.0 [1], 410.0 [2]
2,4-Difluoro-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC50110.0 [1], 170.0 [2]
N-(2-Sulfanylideneimidazolidine-1-carbothioyl)naphthalene-1-carboxamideIC50100000.0 [1], 200000.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-1-benzothiophene-2-carboxamideIC50130.0 [1], 190.0 [2]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-4-(trifluoromethyl)benzamideIC50170.0 [1], 570.0 [2]
1-(4-Chlorophenyl)-N-(5,6-dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-5-(trifluoromethyl)pyrazole-4-carboxamideIC50189.7 [1]
[3-[[6-Acetyl-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-yl]amino]cyclobutyl] acetateIC500.11 [1], 0.6 [2]
1-[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.01 [1], 0.07 [2]
1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-[(3-hydroxycyclobutyl)amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.06 [1], 0.08 [2]
1-(N-Benzoylthiocarbamoyl)-2-imidazolidinethioneIC50100000.0 [1]
4-Tert-butyl-N-(2-sulfanylideneimidazolidine-1-carbothioyl)benzamideIC50200000.0 [1]
N-(5,6-Dihydroimidazo[2,1-c][1,2,4]dithiazol-3-ylidene)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamideIC502460.0 [1]
4-[[4-[6-Acetyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-yl]piperazin-1-yl]methyl]-3-fluorobenzonitrileIC500.36 [1]
1-[3-(2,2-Difluoroethylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.18 [1]
2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-N,N,5-trimethyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.09 [1]
1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-oneIC500.03 [1]
2-[4-[(R)-(2,4-Difluorophenyl)-fluoromethyl]piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carbaldehydeIC500.02 [1]
1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.02 [1]
[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-[(2S)-1-methylpyrrolidin-2-yl]methanoneIC500.08 [1]
6-(2,2-Difluoroethyl)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amineIC500.2 [1]
1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[(3-fluorocyclobutyl)amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.19 [1]
1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-oneIC500.03 [1]
2-[4-(2-Fluoro-4-methoxyphenoxy)piperidin-1-yl]-6-methyl-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amineIC500.14 [1]
1-[3-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.01 [1]
2-[4-[(2,4-Difluorophenyl)-fluoromethyl]piperidin-1-yl]-N,N-dimethyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.02 [1]
1-[3-[4-(3-Methoxyphenyl)sulfonylpiperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.34 [1]
Cyclopropyl-[2-(2,2-difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]methanoneIC500.02 [1]
1-[3-(Cyclobutylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.06 [1]
1-[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-5-methyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.09 [1]
1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-[[(3S)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.06 [1]
1-[3-(Cyclobutylamino)-2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.04 [1]
1-[3-[4-(2-Fluoro-4-methoxyphenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.06 [1]
1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.08 [1]
3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-6-(2-fluoroethyl)-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amineIC500.07 [1]
N-Cyclopropyl-3-[4-[(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amineIC500.01 [1]
(2S)-1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxypropan-1-oneIC500.01 [1]
Methyl 2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxylateIC500.13 [1]
2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-6-methylsulfonyl-N-propan-2-yl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amineIC500.03 [1]
3-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-N,N-dimethyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.02 [1]
1-[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-5-methyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxyethanoneIC500.09 [1]
(2R)-1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxypropan-1-oneIC500.01 [1]
1-[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-[[(3S)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-oneIC500.04 [1]
[3-[[6-Acetyl-2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-yl]amino]cyclobutyl] acetateIC500.22 [1]
N-(2,2-Difluoroethyl)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amineIC501.0 [1]
3-[4-(2-Fluoro-4-methoxyphenoxy)piperidin-1-yl]-N,N-dimethyl-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.02 [1]
1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[[(3S)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.1 [1]
1-[3-[[(2R)-Butan-2-yl]amino]-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.32 [1]
[3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-(oxolan-2-yl)methanoneIC500.02 [1]
N-Cyclobutyl-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-6-methylsulfonyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-3-amineIC500.05 [1]
1-[3-[[(2S)-Butan-2-yl]amino]-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.06 [1]
2-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-N,N-dimethyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.03 [1]
1-[2-[4-[(2,4-Difluorophenyl)-fluoromethyl]piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.01 [1]
1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.06 [1]
Methyl 3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxylateIC500.13 [1]
3-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-N-(2-methoxyethyl)-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.01 [1]
1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxyethanoneIC500.07 [1]
[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-pyrrolidin-1-ylmethanoneIC500.39 [1]
1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methylpropan-1-oneIC500.03 [1]
[2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-(oxolan-2-yl)methanoneIC500.02 [1]
1-[3-[4-(2-Fluoro-4-methoxyphenyl)sulfonylpiperidin-1-yl]-2-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.2 [1]
(2S)-1-[3-(2,2-Difluoroethylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2-methoxypropan-1-oneIC500.11 [1]
1-[2-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]-3-[(3-hydroxycyclobutyl)amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.12 [1]
1-[2-[4-(5-Chloro-2-fluorobenzoyl)piperidin-1-yl]-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanoneIC500.01 [1]
1-[2-(2,2-Difluoroethylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]-2,2-difluoroethanoneIC500.02 [1]
4-[1-[6-Acetyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-yl]piperidin-4-yl]oxy-3-fluorobenzonitrileIC500.09 [1]
N-Cyclopropyl-3-[4-[(S)-(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amineIC500.02 [1]
2-[4-(2,4-Difluorophenoxy)piperidin-1-yl]-N,N-dimethyl-3-(propan-2-ylamino)-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamideIC500.01 [1]
N-Cyclopropyl-3-[4-[(R)-(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-6-methyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-2-amineIC500.03 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ G-protein coupled receptor 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/g-protein-coupled-receptor-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ G-protein coupled receptor 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/g-protein-coupled-receptor-6-inhibitors-ic50-ki.
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