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G protein-coupled receptor 44 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
RamatrobanIC5028.0 [1], 29.0 [2], 169.0 [3], 461.0 [4]
RamatrobanKi4.3 [1], 290.0 [2], 340.0 [3]
Nvp-qav680IC5025.0 [1]
Nvp-qav680Ki29.0 [1], 36.0 [2]
MK-7246IC502.2 [1], 3.0 [2]
MK-7246Ki2.5 [1]
2-[3-[[2-(Benzenesulfonyl)phenyl]methyl]-2-methyl-4-oxo-6,7-dihydro-5H-pyrrolo[3,2-c]pyridin-1-yl]acetic acidIC508.0 [1]
2-(1-(3,4-Difluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidIC509.0 [1], 60.0 [2], 150.0 [3]
2-(1-(3,4-Difluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidKi31.0 [1], 33.0 [2]
2-(2-Benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acidIC50110.0 [1], 170.0 [2], 190.0 [3]
FevipiprantIC501.4 [1]
FevipiprantKi4.0 [1]
2-(5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acidIC5019.0 [1], 28.0 [2], 35.0 [3], 100.0 [4], 130.0 [5]
2-(5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acidKi13.0 [1]
Amg-009Ki1.0 [1]
[5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-acetic acidIC5067.0 [1], 74.0 [2], 106.0 [3], 158.0 [4]
[5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-acetic acidKi68.0 [1]
2-[2-Benzoyl-8-(trifluoromethyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC5050.0 [1], 130.0 [2], 160.0 [3]
2-(1-(3-Cyano-4-fluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidIC508.0 [1], 40.0 [2], 101.0 [3], 168.0 [4]
2-(1-(3-Cyano-4-fluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidKi36.0 [1], 37.0 [2]
[1-(4-Fluoro-3-methoxy-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidIC5018.0 [1], 91.0 [2], 156.0 [3]
[1-(4-Fluoro-3-methoxy-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidKi56.0 [1]
2-(1-(4-Chloro-3-cyanophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidIC506.0 [1], 41.0 [2], 56.0 [3]
2-(1-(4-Chloro-3-cyanophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidKi35.0 [1]
{4-Chloro-2-[(3-chlorophenyl)ethynyl]phenoxy}acetic acidIC5029.0 [1], 104.0 [2], 114.0 [3], 1200.0 [4], 6900.0 [5]
{4-Chloro-2-[(3-chlorophenyl)ethynyl]phenoxy}acetic acidKi29.0 [1]
SetipiprantIC506.0 [1], 30.0 [2], 80.0 [3], 235.0 [4], 340.0 [5]
AM-156 free acidIC506.5 [1], 13.0 [2], 14.0 [3], 16.0 [4]
AM-156 free acidKi13.5 [1]
2-(4-Chloro-2-cycloheptylphenoxy)acetic acidIC50148.0 [1], 248.0 [2], 10000.0 [3]
2-(4-Chloro-2-cycloheptylphenoxy)acetic acidKi59.0 [1]
2-(1-(4-Chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidIC50108.0 [1], 565.0 [2]
2-(1-(4-Chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidKi103.0 [1]
2-[1-[4-[(3,4-Dichlorobenzoyl)amino]benzoyl]isoquinolin-4-yl]acetic acidIC5013.0 [1], 19.0 [2], 23.0 [3]
2-[4-[[2-(Benzenesulfonyl)phenyl]methyl]-5-methyl-3-phenylpyrazol-1-yl]acetic acidIC5040.0 [1], 50.0 [2], 85.0 [3], 240.0 [4], 520.0 [5]
2-[2-(3-Chlorobenzoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC509.0 [1], 40.0 [2], 60.0 [3], 95.0 [4]
2-[2-[4-(4-Ethylphenyl)benzoyl]-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC504.0 [1], 7.0 [2], 190.0 [3], 240.0 [4], 320.0 [5]
[1-(4-Methanesulfonyl-3-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidIC504.0 [1], 11.0 [2], 40.0 [3]
[1-(4-Methanesulfonyl-3-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidKi22.0 [1], 31.0 [2]
2-[2-(3-Chlorobenzoyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC5010.0 [1], 30.0 [2], 40.0 [3], 50.0 [4], 70.0 [5]
[1-(2-Chloro-4-methanesulfonyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidIC501.7 [1], 14.0 [2], 47.0 [3]
[1-(2-Chloro-4-methanesulfonyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidKi3.0 [1], 4.0 [2]
2-[8-Fluoro-2-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC504.0 [1], 12.0 [2], 34.0 [3], 40.0 [4], 70.0 [5]
[2-(Naphthalene-1-carbonyl)-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl]-acetic acidIC509.0 [1], 30.0 [2], 140.0 [3], 420.0 [4], 1120.0 [5]
[1-(4-Ethanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidIC500.8 [1], 4.0 [2], 22.0 [3]
[1-(4-Ethanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidKi7.0 [1], 8.0 [2]
[1-(2-Chloro-4-ethanesulfonyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidIC501.3 [1], 7.0 [2], 16.0 [3]
[1-(2-Chloro-4-ethanesulfonyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidKi6.0 [1], 7.0 [2]
2-(1-(4-Cyano-3-ethoxyphenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidIC505.0 [1], 31.0 [2]
2-(1-(4-Cyano-3-ethoxyphenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidKi43.0 [1]
[2-Methyl-1-(4-nitro-benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidIC5024.0 [1], 143.0 [2], 144.0 [3]
[2-Methyl-1-(4-nitro-benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidKi147.0 [1]
2-[2-Methyl-1-[(2-methyl-4-methylsulfonylphenyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]acetic acidIC504.0 [1], 26.0 [2], 32.0 [3]
2-[2-Methyl-1-[(2-methyl-4-methylsulfonylphenyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]acetic acidKi31.0 [1]
2-[8-Fluoro-2-(2-naphthalen-1-ylacetyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC504.0 [1], 70.0 [2], 160.0 [3], 180.0 [4], 275.0 [5]
2-[8-Chloro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC504.0 [1], 30.0 [2], 65.0 [3], 100.0 [4], 110.0 [5]
2-[2-(Naphthalene-1-carbonyl)-8-(trifluoromethyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC5011.0 [1], 20.0 [2], 70.0 [3], 180.0 [4], 380.0 [5]
2-[8-Fluoro-2-[2-(1H-indol-3-yl)acetyl]-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC505.0 [1], 15.0 [2], 35.0 [3], 40.0 [4], 50.0 [5]
2-[8-Fluoro-2-(3-naphthalen-1-ylpropanoyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acidIC5010.0 [1], 30.0 [2], 65.0 [3], 160.0 [4], 210.0 [5]
2-[1-[[2,4-Bis(trifluoromethyl)phenyl]methyl]-2-methylpyrrolo[2,3-b]pyridin-3-yl]acetic acidIC5014.0 [1], 64.0 [2], 214.0 [3]
2-[1-[[2,4-Bis(trifluoromethyl)phenyl]methyl]-2-methylpyrrolo[2,3-b]pyridin-3-yl]acetic acidKi29.0 [1]
FentiazacIC50550.0 [1], 960.0 [2]
5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-(phenylamino)-IC50100.0 [1], 1300.0 [2]
[3-(2-Benzenesulfonylbenzyl)-5-fluoro-2-methylindol-1-yl]acetic acidIC505.0 [1], 14.0 [2], 16.0 [3]
2-[5-Chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl)methyl]-2,2'-dioxospiro[indole-3,4'-pyrrolidine]-1-yl]acetic acidIC500.23 [1], 19.0 [2]
2-[5-Chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl)methyl]-2,2'-dioxospiro[indole-3,4'-pyrrolidine]-1-yl]acetic acidKi3.8 [1]
2-[(3S)-5-Chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2'-dioxospiro[indole-3,4'-pyrrolidine]-1-yl]acetic acidIC5062.0 [1], 1800.0 [2]
2-[(3S)-5-Chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2'-dioxospiro[indole-3,4'-pyrrolidine]-1-yl]acetic acidKi13.0 [1], 683.0 [2]
2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acidIC501.2 [1], 3.0 [2]
2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acidKi0.6 [1], 1.5 [2]
2-(2-(Biphenyl-2-ylmethyl)-4-(4-chlorophenyl)thiazol-5-yl)acetic acidIC5041.0 [1], 510.0 [2]
2-(2-Benzyl-4-(4-chlorophenyl)thiazol-5-yl)acetic acidIC50180.0 [1], 4100.0 [2]
2-(4-(4-Chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5-yl)acetic acidIC5093.0 [1], 1300.0 [2]
2-[4-Chloro-2-[2-(2-methyl-5-propylsulfonylphenyl)ethynyl]phenoxy]acetic acidIC507.0 [1], 32.0 [2], 81.0 [3]
2-[4-Chloro-2-[2-(2-methyl-5-propylsulfonylphenyl)ethynyl]phenoxy]acetic acidKi2.0 [1]
4-(N-[(2S,4R)-1-Benzoyl-2-methyl-3,4-dihydro-2H-quinolin-4-yl]anilino)-4-oxobutanoic acidIC500.77 [1], 3.0 [2], 130.0 [3]
2-[3-[[1-[(2,4-Difluorophenyl)methyl]-6-oxopyridazin-3-yl]methyl]-5-fluoro-2-methylindol-1-yl]acetic acidIC500.8 [1], 1.2 [2], 2.0 [3], 3.0 [4]
2-[4-Chloro-2-[2-(2-fluoro-5-propylsulfonylphenyl)ethynyl]phenoxy]acetic acidIC508.0 [1], 23.0 [2], 28.0 [3]
2-[4-Chloro-2-[2-(2-fluoro-5-propylsulfonylphenyl)ethynyl]phenoxy]acetic acidKi3.4 [1]
2-[1-[4-[(3,4-Dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acidIC5038.0 [1], 180.0 [2]
2-[1-[4-[[(E)-3-(3,4-Dichlorophenyl)prop-2-enoyl]amino]benzoyl]isoquinolin-4-yl]acetic acidIC504.0 [1], 17.0 [2]
2-[1-(4-Benzamidobenzoyl)isoquinolin-4-yl]acetic acidIC507.9 [1], 42.0 [2]
2-[1-[4-[[4-(Trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acidIC504.9 [1], 15.0 [2]
2-[1-[4-(Pyrimidine-2-carbonylamino)benzoyl]isoquinolin-4-yl]acetic acidIC50290.0 [1], 550.0 [2]
2-[1-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyrrolo[2,3-b]pyridin-3-yl]acetic acidIC509.0 [1], 20.0 [2], 34.0 [3]
2-[8-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-6-yl]acetic acidIC501.4 [1], 13.0 [2]
2-[3-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyrrolo[3,2-b]pyridin-1-yl]acetic acidIC5014.0 [1], 15.0 [2], 20.0 [3]
2-[3-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]indazol-1-yl]acetic acidIC5019.0 [1], 47.0 [2]
2-[1-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]indol-3-yl]acetic acidIC5037.0 [1], 84.0 [2]
2-[3-[(E)-2-Cyano-3-(3,4-dihydro-2H-quinolin-1-yl)-3-oxoprop-1-enyl]indol-1-yl]acetic acidIC5010.0 [1], 14.0 [2], 54.0 [3], 160.0 [4]
2-(1-(3,4-Dichlorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidIC50112.0 [1], 354.0 [2], 629.0 [3]
2-(1-(3,4-Dichlorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acidKi52.0 [1]
2-[[(2As,8R,8aR)-3-(3-fluorobenzoyl)-2,2a,8,8a-tetrahydro-1H-cyclobuta[b]quinolin-8-yl]-cyclopropylcarbamoyl]oxyacetic acidIC500.8 [1], 1.1 [2], 13.0 [3]
2-[[(2As,8R,8aR)-3-(3-fluorobenzoyl)-2,2a,8,8a-tetrahydro-1H-cyclobuta[b]quinolin-8-yl]-cyclopropylcarbamoyl]oxyacetic acidKi4.1 [1]
4-[[(2As,8R,8aR)-3-(4-fluorobenzoyl)-2,2a,8,8a-tetrahydro-1H-cyclobuta[b]quinolin-8-yl]-cyclopropylamino]-4-oxobutanoic acidIC508.9 [1], 12.0 [2], 20.0 [3]
4-[[(2As,8R,8aR)-3-(4-fluorobenzoyl)-2,2a,8,8a-tetrahydro-1H-cyclobuta[b]quinolin-8-yl]-cyclopropylamino]-4-oxobutanoic acidKi7.3 [1]
2-[[(2As,8R,8aR)-3-(4-fluorobenzoyl)-2,2a,8,8a-tetrahydro-1H-cyclobuta[b]quinolin-8-yl]-cyclopropylcarbamoyl]oxyacetic acidIC501.4 [1], 2.0 [2], 3.6 [3]
Items per page: 1 - 10 of 97
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References

This online tool may be cited as follows

MLA

"Quest Database™ G protein-coupled receptor 44 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/g-protein-coupled-receptor-44-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ G protein-coupled receptor 44 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/g-protein-coupled-receptor-44-inhibitors-ic50-ki.
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