![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_3942941574d7691e66f7113d9a1c71fe.svg) | CID 68379135 | IC50 | 67.0 [1], 70.0 [2], 74.0 [3] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_35d0abdb263cef4220212d1d748172c5.svg) | GPR4 antagonist 1 | IC50 | 55.0 [1], 110.0 [2], 114.0 [3] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_5a1d53d3b8cd61995a829e80d56b2457.svg) | 4-[2,2-Dimethylpropyl-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]amino]pyrimidine-2-carbonitrile | IC50 | 1930.0 [1], 23000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_5fbf50d8fae3987931c878090c6d8ba4.svg) | 4-[2,2-Dimethylpropyl-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]amino]pyrimidine-2-carbonitrile | IC50 | 490.0 [1], 23000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_439297219bd8af3d22e6915ec4c25fbb.svg) | 4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-one | IC50 | 27.0 [1], 890.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_63035ee33b9ccc7bc35a16c67d7efad1.svg) | (2R)-3-[4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]propane-1,2-diol | IC50 | 21.0 [1], 67.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_cdbbd0786473bc4204a35a99ad57639e.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[3-(4-propan-2-ylpiperazin-1-yl)propyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 13.0 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_812ecb75d23c3a2872fdb01a2c1fdca4.svg) | 3-[(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-8-(piperidin-1-ylmethyl)-6,11-dihydro-5H-benzo[b][1]benzazepine | IC50 | 67.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_5a54230f7c81152d5654eb23dec49385.svg) | 3-[(2-Ethylbenzimidazol-1-yl)methyl]-6,11-dihydro-5H-benzo[b][1]benzazepine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_25090c54f11c06d3d2dc08d81c9a1fc0.svg) | 3-(Benzimidazol-1-ylmethyl)-6,11-dihydro-5H-benzo[b][1]benzazepine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_20371d04dc5d7c49856d120f1ba1d222.svg) | 3-[(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-10H-phenothiazine | IC50 | 910.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_ad5ed65f3e14f3fc900a7819ad5c7109.svg) | N-[4-(Dimethylamino)butyl]-4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]benzamide | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_9bab13b4b427e614da734ad4b005ba3a.svg) | 1-[2-[1-[4-[[2,2-Dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]phenyl]triazol-4-yl]ethyl]piperidin-4-ol | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_caa9db4820ec46e2a884669bca9cd423.svg) | 2-Chloro-N-(2,2-dimethylpropyl)-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 360.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_1dece0900fedf2aabe2f917a218c2ab8.svg) | N-(2,2-Dimethylpropyl)-2-methoxy-N-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_120142c3094f0ef58e324e649ae8ed05.svg) | 4-N-(2,2-Dimethylpropyl)-2-N,2-N-dimethyl-4-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidine-2,4-diamine | IC50 | 4800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_3e7dc3ebf4ea5519bc54df2e359ed2b7.svg) | 2-Chloro-N-(2,2-dimethylpropyl)-N-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_d8919817e8fc18c4247f52995401eb24.svg) | 6-Ethyl-2,4-dimethyl-7-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrrolo[2,3-d]pyrimidine | IC50 | 11600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_fff364c93d7dfcfd54b1186e5b6455eb.svg) | 5,7-Dimethyl-2-propan-2-yl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine | IC50 | 2440.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_edda6629938aa9475c85143d8e2405ea.svg) | N-(2,2-Dimethylpropyl)-2,6-dimethyl-N-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_135cf0ea8e5fd38a7a5a3f9a64af6b31.svg) | N-(2,2-Dimethylpropyl)-2-methyl-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_6b89405d3ec11f5a2fbf2f17a0c7742e.svg) | 2-Ethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine | IC50 | 9100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_92c53d5e592e5d554673f772f50e6bef.svg) | N-(2,2-Dimethylpropyl)-2,6-dimethyl-N-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 330.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_fce28f1c921ef8330aef3c30e46a9dca.svg) | 5-(Dimethylamino)-N-[4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]phenyl]pentanamide | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_f1b88ed6c08e95cb9583bfedc2f52561.svg) | N-(2,2-Dimethylpropyl)-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]-6-(trifluoromethyl)pyrimidin-4-amine | IC50 | 2970.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_0edc9dcb55e01b2a9f3eda96ed939de8.svg) | N-(2,2-Dimethylpropyl)-2-methoxy-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_751bd2e1214739ad6148f0d8d3b5ae1e.svg) | 5,7-Dimethyl-2-(2-methylpropyl)-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine | IC50 | 7310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_1a4049494e527555ba40fd8b0d02fc9f.svg) | N-(2,2-Dimethylpropyl)-2,6-dimethyl-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine | IC50 | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_020d8ee5634ac467f54698ec5eadd9ed.svg) | 4-[3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propyl]-1-propan-2-ylpiperidin-4-ol | IC50 | 63.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_30f4c8ce77deea3e68684eb83fc1ea14.svg) | 2-Ethyl-6,8-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[1,2-b]pyridazine | IC50 | 74.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_a8f5b6f616aba5f63bddfcfc72b20022.svg) | 3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1-piperidin-4-ylpropan-1-ol | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_512e851788fc6494c97f308ea1eda0c4.svg) | 2-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-5-piperazin-1-yl-1,3,4-oxadiazole | IC50 | 368.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_45685fa06fb83f826d56aeb9cdf1bbf3.svg) | 3-[(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-6,11-dihydro-5H-benzo[b][1]benzazepine | IC50 | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_a653b3cd637b39f712059f83559b5e2a.svg) | 4-[(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-N-phenylaniline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_7c7571fc569bc06bffbfb5776538fa66.svg) | 5,7-Dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]-2-propylimidazo[4,5-b]pyridine | IC50 | 760.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_20600ec70180a19c1647d809646837c5.svg) | 2,5,7-Trimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine | IC50 | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_9e2ca0ca2fa82c2f6d5fb52339d2b5e1.svg) | 1-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-one | IC50 | 73.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_d9b4231bc07c67ac8467692366529d33.svg) | 4-[3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propyl]piperidin-4-ol | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_8c56534ef1f53a9cf637b7899f5cd030.svg) | 3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1-piperazin-1-ylpropan-1-one | IC50 | 53.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_00f4a02c11643a32da9b9e935728555f.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 43.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_2c6ef610bdc95acde4ac174f9b2a2692.svg) | 3-[(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-8-[(4-methylpiperazin-1-yl)methyl]-6,11-dihydro-5H-benzo[b][1]benzazepine | IC50 | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_be54c273bcc85a5f8a32d59cb54d0ab6.svg) | 4-[5-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1,3,4-oxadiazol-2-yl]cyclohexan-1-amine | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_8c953e54eab776c766560140b2df4aad.svg) | [4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]-[(2S,3R)-3-hydroxypyrrolidin-2-yl]methanone | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_a07d72301983f5054d18f561dd095205.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[4-(piperazin-1-ylmethyl)triazol-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 38.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_8e4d9d02d011087eac7d4edea9b7ab54.svg) | 2-Ethyl-3-[[4-[(E)-3-[(3S)-3-(methoxymethyl)piperazin-1-yl]prop-1-enyl]phenyl]methyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine | IC50 | 33.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_21ddb3bb5ccf51696cd927b083aed2e2.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[(E)-3-piperazin-1-ylprop-1-enyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_262e35f455626db31679cf2f344d55e0.svg) | 2-Amino-1-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]ethanone | IC50 | 38.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_a9a1a31304d61e83bf6d6358fb90d465.svg) | (2S)-1-[4-[5-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1,3,4-oxadiazol-2-yl]piperidin-1-yl]-3-hydroxy-2-(methylamino)propan-1-one | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_10ba7a41cc1ae81237224e91432db2f3.svg) | Tert-butyl 4-[3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propanoyl]piperazine-1-carboxylate | IC50 | 54.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_6fde3d115d3e93ac25ceb6ea37350483.svg) | 1-[[1-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]pyrazol-4-yl]methyl]azetidin-3-ol | IC50 | 118.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_3e7197736b4f331b7f64e7c4c54ec8e3.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[4-(piperazin-1-ylmethyl)pyrazol-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 43.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_fb19cf5ad8a242729397f42dd720bfeb.svg) | Tert-butyl 4-[(E)-2-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]ethenyl]-4-hydroxypiperidine-1-carboxylate | IC50 | 45.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_61d32de8b3e2a87a2a43c504b8aa7a1e.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[(E)-3-[(3S)-3-methylpiperazin-1-yl]prop-1-enyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_b470bde6877d06d06b42ce26f3f78892.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-[(E)-3-[4-(1-methyltetrazol-5-yl)piperidin-1-yl]prop-1-enyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 33.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_b88d64f50141f33fb2aad85d6eceff07.svg) | Tert-butyl 4-[3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propyl]-4-hydroxypiperidine-1-carboxylate | IC50 | 47.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_469bbaf14e38ff564371348a21b0853c.svg) | 4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperidin-4-ol | IC50 | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_50f7d64fbde31d3d7e11cc6644971f1c.svg) | Tert-butyl N-[2-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]-4-hydroxypiperidin-1-yl]-2-oxoethyl]-N-methylcarbamate | IC50 | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_0d171693ce36bc138925d4f678096506.svg) | [(2S)-4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-yl]methanol | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_f839b3823ac8aac78dde01d338538cdb.svg) | 4-[[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenoxy]methyl]cyclohexan-1-amine | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_b1ac3657459bc26b1e33ebb26a56e8b8.svg) | Tert-butyl 4-[2-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenoxy]ethyl]piperazine-1-carboxylate | IC50 | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_75a9b40a5cb8e13dc7425949ce118ede.svg) | 1-[[1-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]pyrazol-4-yl]methyl]piperidin-4-amine | IC50 | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_8bd92b15164e7d5c699d34b41d35559b.svg) | Tert-butyl 3-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]-3-hydroxyazetidine-1-carboxylate | IC50 | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_c4b3188768286aedf83473eb5b9995cd.svg) | 4-[2-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenoxy]ethyl]piperidin-4-ol | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_6c88165318820bd900a4c9afbb9aeaa9.svg) | 2-Ethyl-3-[[4-[2-[(3R)-3-(methoxymethyl)piperazin-1-yl]ethoxy]phenyl]methyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_a3ee1cd0f314c83d37bb7a684f142567.svg) | 2-Ethyl-5,7-dimethyl-3-[[4-(piperidin-4-ylmethoxy)phenyl]methyl]pyrazolo[1,5-a]pyrimidine | IC50 | 22.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_4d8a33c61d8f18047da6389a00fd498a.svg) | (2S)-1-[4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]-3-hydroxy-2-(methylamino)propan-1-one | IC50 | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_afbd46a033cb7dfb30ae79896a184d1a.svg) | [4-[[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenoxy]methyl]piperidin-1-yl]-[(2S,3R)-3-hydroxypyrrolidin-2-yl]methanone | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_81fd411b804ac874e54e290c106693d3.svg) | (2S,4S)-4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]-2-methylpiperidin-4-ol | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_1e2b948d3f4eee9644468b89a39f36dc.svg) | (2R)-3-[4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]-4-hydroxypiperidin-1-yl]propane-1,2-diol | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_10224f3d0c3025d66246a87697fec43d.svg) | Tert-butyl 4-[[1-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]triazol-4-yl]methyl]-4-hydroxypiperidine-1-carboxylate | IC50 | 77.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_ecf89f56482159317827eea5ec65705b.svg) | 1-[[1-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]pyrazol-4-yl]methyl]azetidin-3-amine | IC50 | 21.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_87acdec8606066593d9ff575a3cf8a19.svg) | (2S,3R)-N-[4-[[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenoxy]methyl]cyclohexyl]-3-hydroxypyrrolidine-2-carboxamide | IC50 | 54.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_ac10583f02a9211b7b756524d01c8d31.svg) | 1-[(2S)-4-[(E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]-1-methylpiperazin-2-yl]-N,N-dimethylmethanamine | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_121c6d746cb3eb6e024d9680107972d9.svg) | (2R)-1-[Tert-butyl(dimethyl)silyl]oxy-3-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]propan-2-ol | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/g-protein-coupled-receptor-4_9ee6d950d7b05a7fdba8ecf133d95f42.svg) | (E)-3-[4-[(2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1-(4-methylpiperazin-1-yl)prop-2-en-1-one | IC50 | 81.0 [1] |