![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_86a175a32a0307c3d948d8bce5128a5a.svg) | 5-Amino-2-[[4-[(2-amino-5-chloro-4-oxo-3H-quinazolin-6-yl)methylamino]benzoyl]amino]pentanoic acid | Ki | 8.3 [1], 8300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_946caf5aa3708e8be91eb2b628d2108a.svg) | 5-Amino-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanoic acid | Ki | 5900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_7d8249507827309b78c20523a6b18906.svg) | 5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanoic acid | IC50 | 210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_7d8249507827309b78c20523a6b18906.svg) | 5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanoic acid | Ki | 64.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_0ea192e1d7a5d69d9062f5720997fccb.svg) | 2-((4-(((2,4-Diaminopteridin-6-yl)methyl)methylamino)phenyl)carbonylamino)-4-sulfobutanoic acid | Ki | 188000.0 [1], 198000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_383da709fff0a040bbb7d29583f7d5e4.svg) | 2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl]amino}benzoyl)amino]-4-sulfobutanoic acid | Ki | 45000.0 [1], 59000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_1cc257bab28d3e85f276bcae9f111347.svg) | Methotrexate | IC50 | 3200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_b9b93c51997fc7ea00d9a8a0dc6501d6.svg) | 5-Amino-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanoic acid | IC50 | 33000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_ef2607c94cce30216e1f9be0501cce5b.svg) | Admpo | Ki | 4000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_4909fd5cc159fff9ea4ac1b98f2614f8.svg) | 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-4-methylidenepentanedioic acid | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_8fe7ebfd681cff6844fd975989c7b64b.svg) | 2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propyl]-hydroxy-phosphinoyloxy}-pentanedioic acid | IC50 | 5700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_0ea7a6850fdd76d9a0276ed427be32a9.svg) | 3-[1-(Carboxymethyl)imidazol-4-yl]-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]propanoic acid | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_9f823d6d8342e1073d866cafb2331fa2.svg) | (2S)-2-[[(3S)-3-Carboxy-3-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]propyl]-hydroxyphosphoryl]oxypentanedioic acid | IC50 | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_10e3c54a4e89f502e5f9036945b10ec4.svg) | 2-[[3-Carboxy-3-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]propyl]-hydroxyphosphoryl]oxypentanedioic acid | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_ffa4c41b17dbf388508ef38904063dcb.svg) | 5-Amino-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-4,4-difluoropentanoic acid | IC50 | 300000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_3345c05b3c15ab0c4cf7b2d5b7363742.svg) | 2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hydroxy-phosphinoyloxy}-pentanedioic acid | IC50 | 8600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_e48958b3d7a22ca1b7bbfdb1caf94999.svg) | (2S)-5-Amino-2-[6-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanoic acid | Ki | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_9300ce9e006d258833d6b64000810ee8.svg) | (2S)-5-Amino-2-[6-[(2-amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanoic acid | Ki | 110000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_c622e2709b81771b152fcdd80142a604.svg) | 2-[[4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_651ac5cf237a18e7fdf99a61c595f6e1.svg) | 5-Amino-2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | Ki | 6000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_43ed84bbc2ca9f6e18ed292caf86cf66.svg) | 5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanoic acid | Ki | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_bf779a6b2f50b84ce18ed0fe96a7eecf.svg) | (2S)-5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-oxopentanoic acid | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_0a36fd72a0b7e8a347f0cea7b380dcb7.svg) | 5-Amino-2-[[4-[[2-amino-4-oxo-5-(trifluoromethyl)-3H-quinazolin-6-yl]methylamino]benzoyl]amino]pentanoic acid | Ki | 8.8 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_b2fd354f4a8f8bc9e0d934fb199c9fe7.svg) | 5-Amino-2-[[4-[[(2-amino-5-chloro-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanoic acid | Ki | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_af7cea50e16358b177649f74dd4da8ee.svg) | 5-Amino-2-[[4-[[(2-amino-5-fluoro-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanoic acid | Ki | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_aac13ca1d6bc45f5c46b04807efe7490.svg) | 5-Amino-2-[[4-[[(5-fluoro-2-methyl-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanoic acid | Ki | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_a51700d0a6412d23eef88fd1d19f0675.svg) | 5-Amino-2-[[4-[[[2-amino-4-oxo-5-(trifluoromethyl)-3H-quinazolin-6-yl]amino]methyl]benzoyl]amino]pentanoic acid | Ki | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_1ace0af00ddc2c99decd54fa09832937.svg) | 5-Amino-2-[[4-[(4-oxo-3H-quinazolin-6-yl)methoxy]benzoyl]amino]pentanoic acid | Ki | 1200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_b204d7d29dc6fe5644424d2b17c7deba.svg) | 5-Amino-2-[[4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methoxy]benzoyl]amino]pentanoic acid | Ki | 5900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_91d8d44198e1f3c4fcd0a9dd2635d733.svg) | 5-Amino-2-[[4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methylsulfanyl]benzoyl]amino]pentanoic acid | Ki | 2800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_9823c603a330c768731b71b2d91d504e.svg) | 5-Amino-2-[[4-[(4-oxo-3H-quinazolin-6-yl)methylsulfanyl]benzoyl]amino]pentanoic acid | Ki | 420.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_00c974e65f2d62021372d8fb25444aa5.svg) | (S)-5-Amino-2-[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoylamino]valeric acid | Ki | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_4436907ecb0e950869acf4d678d03f9b.svg) | 5-Amino-2-[[4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoyl]amino]pentanoic acid | Ki | 1.7 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_56ca915bc183b8e82fc26420b8ec4f75.svg) | 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-3-hydroxypentanedioic acid | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_4652c32c083c4bdedf1111416ad63300.svg) | 2-[[4-[2-(2,4-Diaminopteridin-6-yl)ethyl]benzoyl]amino]-3-hydroxypentanedioic acid | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_1f0249518571ab215c76f81a7408ca63.svg) | 2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]-4-methylidenepentanedioic acid | IC50 | 118000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_c3521f4c671a5ac560ca9b83ea493f56.svg) | 2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-4-phosphonooxybutanoic acid | Ki | 1900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_19a53f1668573b5c0e831f232a923b16.svg) | 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_817be6241f74b3f16d8ef922247756a2.svg) | 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-3-sulfopropanoic acid | Ki | 136000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_ce74d6f4ad70f4677e3c24ba6569dd70.svg) | 2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-3-sulfopropanoic acid | Ki | 43000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_63f45ab25470850c426262f0a1de15e9.svg) | 2-((4-(((2,4-Diaminopteridin-6-yl)methyl)methylamino)phenyl)carbonylamino)-4-phosphonobutanoic acid | Ki | 185000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/folylpoly-gamma-glutamate-synthetase_f806992d892d203e8cb28534eb49a88d.svg) | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid | IC50 | 200000.0 [1] |