Folylpoly-gamma-glutamate synthetase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	5-Amino-2-[[4-[(2-amino-5-chloro-4-oxo-3H-quinazolin-6-yl)methylamino]benzoyl]amino]pentanoic acid	Ki	8.3 [1], 8300.0 [2]
	5-Amino-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanoic acid	Ki	5900.0 [1]
	5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanoic acid	IC50	210.0 [1]
	5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanoic acid	Ki	64.0 [1]
	2-((4-(((2,4-Diaminopteridin-6-yl)methyl)methylamino)phenyl)carbonylamino)-4-sulfobutanoic acid	Ki	188000.0 [1], 198000.0 [2]
	2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl]amino}benzoyl)amino]-4-sulfobutanoic acid	Ki	45000.0 [1], 59000.0 [2]
	Methotrexate	IC50	3200.0 [1]
	5-Amino-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanoic acid	IC50	33000.0 [1]
	Admpo	Ki	4000.0 [1]
	2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-4-methylidenepentanedioic acid	IC50	200000.0 [1]
	2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propyl]-hydroxy-phosphinoyloxy}-pentanedioic acid	IC50	5700.0 [1]
	3-[1-(Carboxymethyl)imidazol-4-yl]-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]propanoic acid	IC50	200000.0 [1]
	(2S)-2-[[(3S)-3-Carboxy-3-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]propyl]-hydroxyphosphoryl]oxypentanedioic acid	IC50	120.0 [1]
	2-[[3-Carboxy-3-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]propyl]-hydroxyphosphoryl]oxypentanedioic acid	IC50	20.0 [1]
	5-Amino-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-4,4-difluoropentanoic acid	IC50	300000.0 [1]
	2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hydroxy-phosphinoyloxy}-pentanedioic acid	IC50	8600.0 [1]
	(2S)-5-Amino-2-[6-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanoic acid	Ki	200.0 [1]
	(2S)-5-Amino-2-[6-[(2-amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanoic acid	Ki	110000.0 [1]
	2-[[4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid	IC50	200000.0 [1]
	5-Amino-2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid	Ki	6000.0 [1]
	5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanoic acid	Ki	200.0 [1]
	(2S)-5-Amino-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-oxopentanoic acid	Ki	10000.0 [1]
	5-Amino-2-[[4-[[2-amino-4-oxo-5-(trifluoromethyl)-3H-quinazolin-6-yl]methylamino]benzoyl]amino]pentanoic acid	Ki	8.8 [1]
	5-Amino-2-[[4-[[(2-amino-5-chloro-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanoic acid	Ki	500.0 [1]
	5-Amino-2-[[4-[[(2-amino-5-fluoro-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanoic acid	Ki	900.0 [1]
	5-Amino-2-[[4-[[(5-fluoro-2-methyl-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanoic acid	Ki	150.0 [1]
	5-Amino-2-[[4-[[[2-amino-4-oxo-5-(trifluoromethyl)-3H-quinazolin-6-yl]amino]methyl]benzoyl]amino]pentanoic acid	Ki	11.0 [1]
	5-Amino-2-[[4-[(4-oxo-3H-quinazolin-6-yl)methoxy]benzoyl]amino]pentanoic acid	Ki	1200.0 [1]
	5-Amino-2-[[4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methoxy]benzoyl]amino]pentanoic acid	Ki	5900.0 [1]
	5-Amino-2-[[4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methylsulfanyl]benzoyl]amino]pentanoic acid	Ki	2800.0 [1]
	5-Amino-2-[[4-[(4-oxo-3H-quinazolin-6-yl)methylsulfanyl]benzoyl]amino]pentanoic acid	Ki	420.0 [1]
	(S)-5-Amino-2-[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoylamino]valeric acid	Ki	300.0 [1]
	5-Amino-2-[[4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoyl]amino]pentanoic acid	Ki	1.7 [1]
	2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-3-hydroxypentanedioic acid	IC50	200000.0 [1]
	2-[[4-[2-(2,4-Diaminopteridin-6-yl)ethyl]benzoyl]amino]-3-hydroxypentanedioic acid	IC50	50000.0 [1]
	2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]-4-methylidenepentanedioic acid	IC50	118000.0 [1]
	2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-4-phosphonooxybutanoic acid	Ki	1900.0 [1]
	2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid	IC50	200000.0 [1]
	2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-3-sulfopropanoic acid	Ki	136000.0 [1]
	2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-3-sulfopropanoic acid	Ki	43000.0 [1]
	2-((4-(((2,4-Diaminopteridin-6-yl)methyl)methylamino)phenyl)carbonylamino)-4-phosphonobutanoic acid	Ki	185000.0 [1]
	2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid	IC50	200000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 42 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Folylpoly-gamma-glutamate synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/folylpoly-gamma-glutamate-synthetase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Folylpoly-gamma-glutamate synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/folylpoly-gamma-glutamate-synthetase-inhibitors-ic50-ki.
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