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Flap endonuclease 1 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
3-Hydroxyquinazoline-2,4(1H,3H)-dioneIC500.08 [1], 300.0 [2]
3-Hydroxy-1H-thieno[2,3-d]pyrimidine-2,4-dioneIC500.03 [1], 9.0 [2]
3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dioneIC500.01 [1], 3.0 [2]
3-Hydroxy-7-(4-methylphenyl)furo[3,2-d]pyrimidine-2,4(1H,3H)-dioneIC500.08 [1], 57.0 [2]
1-Benzyl-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dioneIC500.23 [1], 680.0 [2]
2,4-Dioxo-4-phenylbutanoic acidIC5024900.0 [1]
5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acidIC5016400.0 [1]
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acidIC5010400.0 [1]
N-(4-Fluorobenzyl)-5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxamideIC502100.0 [1]
N-HydroxynaphthalimideIC50300.0 [1]
6-Chloro-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dioneIC50700.0 [1]
5-Hydroxy-1-methyl-6-oxo-2-(2-thienyl)pyrimidine-4-carboxylic acidIC5088900.0 [1]
3-Hydroxy-6-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dioneIC500.15 [1]
5,6-Dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamideIC5023300.0 [1]
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl esterIC5010100.0 [1]
3-Hydroxy-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dioneIC500.01 [1]
2(1H)-Pyridinone, 5-(4-fluorophenyl)-3-hydroxy-IC50100000.0 [1]
5,6-Dibutyl-3-hydroxy-1H-thieno[2,3-d]pyrimidine-2,4-dioneIC500.01 [1]
1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dioneIC500.01 [1]
4-(2-Fluorophenyl)-2,4-dioxobutyric acidIC5014500.0 [1]
2,4-Dioxo-4-(4-phenoxyphenyl)butanoic acidIC501750.0 [1]
4-(Furan-2-yl)-2,4-dioxobutanoic acidIC5064200.0 [1]
(1,1'-BIPHENYL)-4-BUTANOIC ACID, alpha,gamma-DIOXO-IC503500.0 [1]
2-Anilino-N-[2-(3,4-dihydroxyphenyl)ethyl]acetamideIC50100000.0 [1]
4-(2-Chloro-phenyl)-2,4-dioxo-butyric acidIC503510.0 [1]
3-Hydroxy-1-(7-methoxy-benzo[1,3]dioxol-5-ylmethyl)-5-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dioneIC500.02 [1]
3-Hydroxy-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dioneIC500.04 [1]
1-(3-Bromo-benzyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dioneIC500.07 [1]
3-Hydroxy-5-methyl-1-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dioneIC500.03 [1]
7-Biphenyl-4-yl-3-hydroxy-1H-furo[3,2-d]pyrimidine-2,4-dioneIC500.02 [1]
3-Hydroxybenzofuro[3,2-d]pyrimidine-2,4(1H,3H)-dioneIC500.28 [1]
CID 11608580IC500.04 [1]
N-[3-[3-[(3-Hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]phenyl]acetamideIC500.0 [1]
7-Tert-Butyl-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dioneIC500.14 [1]
4-[3-[(3-Hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]benzamideIC500.0 [1]
7-(Benzenesulfonyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dioneIC500.01 [1]
3-Hydroxy-7-(3-methoxy-phenyl)-1H-furo[3,2-d]pyrimidine-2,4-dioneIC500.03 [1]
2-Anilino-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
2-Anilino-N-(3,4-dihydroxyphenyl)acetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-3-phenylpropanamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenoxyacetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylacetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylpropanamideIC50100000.0 [1]
2-(4-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
2-(2-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-1-phenylcyclohexane-1-carboxamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]cyclopentanecarboxamideIC50100000.0 [1]
2-Cyclohexyl-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-(4-morpholin-4-ylphenyl)acetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-1-[(4-fluorophenyl)methyl]piperidine-4-carboxamideIC50100000.0 [1]
2-(2,4-Dichlorophenyl)-1-(6,7-dihydroxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanoneIC50100000.0 [1]
2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]-N-methylacetamideIC50100000.0 [1]
N-[(2-Chloro-3,4-dihydroxyphenyl)methyl]-2-(2,4-dichlorophenyl)acetamideIC50100000.0 [1]
2-(2,4-Dichlorophenyl)-N-[(2-fluoro-4,5-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
1-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]methanesulfonamideIC50100000.0 [1]
N-[(2,4-Dichlorophenyl)methyl]-2-(3,4-dihydroxyphenyl)acetamideIC50100000.0 [1]
1-(4-Chlorophenyl)-3-[(3,4-dihydroxyphenyl)methyl]ureaIC50100000.0 [1]
1-[(4-Chlorophenyl)methyl]-3-[(3,4-dihydroxyphenyl)methyl]imidazolidin-2-oneIC50100000.0 [1]
4-[[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzene-1,2-diolIC50100000.0 [1]
3-Hydroxy-5-(3-pyrazol-1-ylphenyl)-1H-pyridin-2-oneIC50100000.0 [1]
5-(3-Chloro-4-fluorophenyl)-3-hydroxy-1H-pyridin-2-oneIC50100000.0 [1]
N-[4-(5-Hydroxy-6-oxo-1H-pyridin-3-yl)phenyl]acetamideIC50100000.0 [1]
3-Hydroxy-5-(1-methylindazol-6-yl)-1H-pyridin-2-oneIC50100000.0 [1]
7-Anilino-3-hydroxy-1H-quinazoline-2,4-dioneIC50230.0 [1]
3-Hydroxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dioneIC501100.0 [1]
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-8-yl)acetamideIC5038.0 [1]
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-6-yl)acetamideIC502000.0 [1]
3-Hydroxy-6-phenyl-1H-pyrimidine-2,4-dioneIC50630.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]benzamideIC50100000.0 [1]
N-[(E)-(2,5-Dibromo-3,4-dihydroxyphenyl)methylideneamino]-2-(3-methylanilino)acetamideIC50100000.0 [1]
Methyl 5,6-dihydroxy-2-phenylpyrimidine-4-carboxylateIC5053400.0 [1]
2-Anilino-N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]acetamideIC50100000.0 [1]
2-Methylene-3-(4-phenoxybenzoyl)propionic acidIC50100000.0 [1]
4-[3-[(4-Chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]benzene-1,2-diolIC50100000.0 [1]
5-Hydroxy-N-methyl-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC5012000.0 [1]
5-Hydroxy-6-oxo-N-propyl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC504200.0 [1]
5-Hydroxy-N-(2-hydroxyethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC504000.0 [1]
5-Hydroxy-4-(pyrrolidine-1-carbonyl)-2-thiophen-2-yl-1H-pyrimidin-6-oneIC5013700.0 [1]
N-Butan-2-yl-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC501300.0 [1]
5-Hydroxy-N-(3-methylbutyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC503500.0 [1]
N-(2-Acetamidoethyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC505000.0 [1]
N-(4-Fluorophenyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC5010500.0 [1]
5-Hydroxy-6-oxo-N-pyridin-3-yl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC508600.0 [1]
5-Hydroxy-N-(2-morpholin-4-ylethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC504100.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-[4-(morpholin-4-ylmethyl)phenyl]-6-oxo-1H-pyrimidine-4-carboxamideIC5038100.0 [1]
2-[4-[(Dimethylamino)methyl]phenyl]-5-hydroxy-N-(3-methylbutyl)-6-oxo-1H-pyrimidine-4-carboxamideIC5071300.0 [1]
5-Hydroxy-N-(3-methylbutyl)-6-oxo-2-piperidin-2-yl-1H-pyrimidine-4-carboxamideIC50100000.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-3-yl)-6-oxo-1H-pyrimidine-4-carboxamideIC50100000.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-4-yl)-6-oxo-1H-pyrimidine-4-carboxamideIC50100000.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-2-yl)-6-oxo-1H-pyrimidine-4-carboxamideIC50100000.0 [1]
2,4-Dioxo-4-(thiophen-2-yl)butanoic acidIC5010100.0 [1]
4-(2,4-Dichloro-phenyl)-2,4-dioxo-butyric acidIC505530.0 [1]
3-Hydroxy-1-methylquinazoline-2,4(1H,3H)-dioneIC502100.0 [1]
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-7-yl)acetamideIC502100.0 [1]
4-(4-Chlorophenyl)-2,4-dioxobutanoic acidIC5019300.0 [1]
5-Chloro-3-hydroxyquinazoline-2,4(1H,3H)-dioneIC500.01 [1]
4-[3-[(3-Hydroxy-7-methyl-2,4-dioxothieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]benzamideIC501.08 [1]
3-Hydroxy-7-phenylfuro[3,2-d]pyrimidine-2,4(1H,3H)-dioneIC500.14 [1]
3-Hydroxy-7-(4-methoxyphenyl)-1H-furo[3,2-d]pyrimidine-2,4-dioneIC500.03 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Flap endonuclease 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/flap-endonuclease-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Flap endonuclease 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/flap-endonuclease-1-inhibitors-ic50-ki.
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