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FK506 binding protein 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-Succinyl-ala-ala-pro-phe-p-nitroanilideIC50540000.0 [1], 850000.0 [2]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC509370.0 [1], 10500.0 [2]
Cyclosporin AIC5016.0 [1]
CycloheximideKi24200.0 [1]
AscomycinIC508000.0 [1]
(S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylateIC50100000.0 [1]
BiricodarIC507370.0 [1]
TimcodarIC50100000.0 [1]
Suc-Ala-Gly-Pro-Phe-pNAIC501450000.0 [1]
SAFit1Ki50000.0 [1]
(S)-1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carboxylic acid 3-pyridin-3-yl-propyl esterIC50150000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[(2S)-2-Cyclohexyl-2-phenylacetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidKi500000.0 [1]
(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]acetyl]-N-[(2S,3S)-3-methyl-1-oxo-1-(2-phenylethylamino)pentan-2-yl]pyrrolidine-2-carboxamideIC50325000.0 [1]
(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]acetyl]-N-[(2S,3S)-1-(2,2-diphenylethylamino)-3-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamideIC50365000.0 [1]
Methyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[(2R)-2-Cyclohexylpent-4-enoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidKi500000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[(2R)-2-Cyclohexylpropanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidKi1000000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[(2S)-2-Cyclohexyl-2-(3,5-dimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidKi50000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[(2S)-2-Cyclohexyl-2-(3-methoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidKi100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(2-Cyclohexylacetyl)piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidKi9700.0 [1]
(1S,5S,6R)-10-(3,5-Dichlorophenyl)sulfonyl-5-(methoxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-oneKi18.9 [1]
[(1R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateIC501070.0 [1]
(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-5-aminopentanoyl]amino]propanoyl]amino]acetyl]-N-[(2R,3R)-1-[[(2R)-1-amino-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamideIC5010000000.0 [1]
1-[3-[[(2S)-2-Acetamidopropanoyl]amino]-2-oxopropanoyl]-N-[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamideIC50215000.0 [1]
4-[[(2S)-1-[[Ethoxy-[2-[[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]phosphoryl]methylamino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acidIC505400000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1S,2R)-2-ethyl-1-hydroxycyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC504200.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1R,2S)-2-ethyl-1-hydroxycyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC503500.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1S,2S)-1-hydroxy-2-(hydroxymethyl)cyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC506200.0 [1]
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateIC50100000.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateIC502800.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylateIC505550.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5011600.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1S,2R)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC502440.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1R,2S)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC502880.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1S,2S)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC502200.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1R,2R)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC502640.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(4-pyrimidin-2-ylphenyl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3-Chlorophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5032800.0 [1]
2-[3-[(1R)-1-[(2S)-1-(1,3-Benzothiazol-6-ylsulfonyl)piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5032500.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(furan-3-ylsulfonyl)piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(1-Benzothiophen-2-ylsulfonyl)piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3-Cyanophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5069900.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3-nitrophenyl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3-Aminophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3-fluorophenyl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5084500.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3-Bromophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5015690.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3,5-Dichlorophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5014300.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3,4-Dichlorophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3,4-dimethoxyphenyl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3-Chloro-4-methoxyphenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5040300.0 [1]
2-[3-[(1R)-1-[(2S)-1-[3,5-Bis(trifluoromethyl)phenyl]sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[3-Bromo-5-(trifluoromethyl)phenyl]sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-[3,5-Bis(methoxycarbonyl)phenyl]sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3,5-Dichloro-4-hydroxyphenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5020300.0 [1]
2-[3-[(1R)-1-[(2S)-1-(3,5-Dichloro-4-methoxyphenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5017700.0 [1]
2-[3-[(1R)-1-[(2S)-1-(4-Acetamido-3,5-dichlorophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC5020500.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[(7-nitro-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5043900.0 [1]
2-[3-[(1R)-1-[(2S)-1-[(7-Amino-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[(2-methyl-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5026500.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[(2-oxo-3H-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5066500.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[(2-oxo-1,3-dihydroindol-5-yl)sulfonyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-(3,5-dichlorophenyl)sulfonylpiperidine-2-carboxylateIC50100000.0 [1]
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-(1,3-benzothiazol-6-ylsulfonyl)piperidine-2-carboxylateIC50100000.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(3,5-dichlorophenyl)sulfonylpiperidine-2-carboxylateIC5050000.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(1,3-benzothiazol-6-ylsulfonyl)piperidine-2-carboxylateIC5050000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5041600.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(3,5-dichloro-4-hydroxyphenyl)sulfonylpiperidine-2-carboxylateIC50710.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(3,5-dichloro-4-methoxyphenyl)sulfonylpiperidine-2-carboxylateIC5050000.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-[(2-oxo-3H-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carboxylateIC503410.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-(4-acetamido-3,5-dichlorophenyl)sulfonylpiperidine-2-carboxylateIC508300.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)-3,6-dihydro-2H-pyridine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC5049200.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(3R)-4-(3,3-dimethyl-2-oxopentanoyl)thiomorpholine-3-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-1-[[(2S)-1-(3,5-Dichloro-4-hydroxyphenyl)sulfonylpiperidine-2-carbonyl]amino]-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[[(2S)-1-[(2-oxo-3H-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carbonyl]amino]propyl]phenoxy]acetic acidIC50100000.0 [1]
1,7-Dipyridin-3-ylheptan-4-yl (2S)-1-(3,5-dichloro-4-hydroxyphenyl)sulfonylpiperidine-2-carboxylateIC5015130.0 [1]
2-[3-[3-(3,4-Dimethoxyphenyl)-1-[[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]amino]propyl]phenoxy]acetic acidIC50100000.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-[2-[(1S,2R)-2-ethyl-1-hydroxycyclohexyl]-2-oxoacetyl]piperidine-2-carboxylateIC503720.0 [1]
2-(3,4-Dimethoxyphenyl)ethyl (2S)-1-[2-[(1S,2R)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carboxylateIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-[2-[(1S,2S)-2-ethyl-1-hydroxycyclohexyl]-2-oxoacetyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC509770.0 [1]
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-[2-[(1S,2R)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carboxylateIC5011700.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(2-methylpyrimidin-4-yl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-pyrimidin-4-ylsulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acidIC50100000.0 [1]
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-[2-[(1S,2R)-2-ethyl-1-hydroxycyclohexyl]-2-oxoacetyl]piperidine-2-carboxylateIC50100000.0 [1]
[(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-[2-[(1S,2R)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carboxylateIC50890.0 [1]
(2S)-1-[(2R)-2-[[(2S)-2-Acetamidopropanoyl]amino]propanoyl]-N-[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamideIC50640000.0 [1]
4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosane-2,3,7,20-tetroneKi290000.0 [1]
18-(2-Cyclohexylethyl)-4,4-dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosane-2,3,7,20-tetroneKi190000.0 [1]
(8E,10Z)-4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosa-8,10-diene-2,3,7,20-tetroneKi340000.0 [1]
4,4-Dimethyl-6,23-dioxa-1-azabicyclo[23.4.0]nonacosane-2,3,7,24-tetroneKi11000000.0 [1]
4,4-Dimethyl-6,11-dioxa-1-azabicyclo[11.4.0]heptadecane-2,3,7,12-tetroneKi2900000.0 [1]
(8E,10E)-4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosa-8,10-diene-2,3,7,20-tetroneKi840000.0 [1]
(3R)-N-[(2S)-1-(Benzylamino)-3-methyl-1-oxopentan-2-yl]-1-[2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-(3-methylbutanoylamino)propanoyl]amino]propanoyl]amino]acetyl]pyrrolidine-3-carboxamideIC5028000.0 [1]
(21S)-1Aza-4,4-dimethyl-6,19-dioxa-2,3,7,20-tetraoxobicyclo[19.4.0] pentacosaneKi100000.0 [1]
(19S)-4,4-Dimethyl-6,17-dioxa-1-azabicyclo[17.4.0]tricosane-2,3,7,18-tetroneKi30000.0 [1]
4,4-Dimethyl-6,17-dioxa-1-azabicyclo[17.4.0]tricosane-2,3,7,18-tetroneKi90000.0 [1]
Items per page: 1 - 10 of 96
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References

This online tool may be cited as follows

MLA

"Quest Database™ FK506 binding protein 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/fk506-binding-protein-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ FK506 binding protein 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/fk506-binding-protein-4-inhibitors-ic50-ki.
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