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Fibroblast growth factor receptor 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Azd4547IC50103.0 [1]
N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC5014.0 [1]
InfigratinibIC500.82 [1], 60.0 [2], 62.0 [3], 64.0 [4], 71.0 [5]
2-Formyl-N-[5-(trifluoromethyl)pyridin-2-yl]quinoline-8-carboxamideIC5057.0 [1]
(1S,2S,3R,4R)-3-[[5-Cyano-2-[4-[4-(dimethylamino)piperidin-1-yl]-2-(2-methylpropoxy)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamideIC506.9 [1]
N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-(prop-2-enoylamino)benzamideIC500.8 [1], 1.5 [2], 3.6 [3], 443.0 [4]
6-Chloro-N-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-3-nitropyridin-2-amineIC5021.0 [1], 32.0 [2], 53.0 [3], 10000.0 [4]
Nvp-tae 684IC5016.0 [1], 20.0 [2], 1920.0 [3]
N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamideIC50189.0 [1], 261.0 [2], 261.3 [3]
N-(5-Cyano-4-methoxypyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC506.3 [1], 72.0 [2]
N-[5-Cyano-4-(2-methoxyethoxy)pyridin-2-yl]-2-formyl-5,6,7,8-tetrahydropyrido[2,3-b]azepine-9-carboxamideIC50175.0 [1], 741.0 [2]
N-(5-Chloropyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5021.0 [1], 916.0 [2]
N-[5-Cyano-4-[2-(dimethylamino)ethoxy]pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5010.6 [1], 11.0 [2], 588.0 [3]
N-(5-Cyanopyrimidin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5045.0 [1], 131.0 [2]
N-(5-Cyanopyridin-2-yl)-2-formyl-5,6,7,8-tetrahydropyrido[2,3-b]azepine-9-carboxamideIC50660.0 [1], 3000.0 [2]
6-Formyl-N-[5-(trifluoromethyl)pyridin-2-yl]-2,3-dihydropyrido[3,2-b][1,4]oxazine-4-carboxamideIC5042.0 [1], 531.0 [2]
N-(5-Cyano-4-morpholin-4-ylpyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5027.0 [1], 224.0 [2]
N-[5-Cyano-4-(4-hydroxy-4-methylpiperidin-1-yl)pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC501.2 [1], 24.0 [2]
N-[5-Cyano-4-(2-methoxyethoxy)pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC501.3 [1], 18.0 [2]
N-(5-Cyano-4-propan-2-yloxypyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC500.7 [1], 29.0 [2]
N-(5-Cyanopyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5015.8 [1], 16.0 [2], 108.0 [3]
7-Formyl-N-(6-methoxypyrimidin-4-yl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC50140.0 [1], 3000.0 [2]
N-(5-Cyano-4-propan-2-yloxypyridin-2-yl)-6-formyl-2,3-dihydropyrrolo[2,3-b]pyridine-1-carboxamideIC501.1 [1], 55.0 [2]
N-[5-Cyano-4-(oxan-4-yl)pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5017.0 [1], 150.0 [2]
B-Cell ImmunosuppressantIC5010000.0 [1]
8-[[5-(Trifluoromethyl)pyridin-2-yl]carbamoyl]quinoline-2-carboxylic acidIC5010000.0 [1]
2-(Hydroxymethyl)-N-[5-(trifluoromethyl)pyridin-2-yl]quinoline-8-carboxamideIC5010000.0 [1]
2-Formyl-N-[4-(trifluoromethyl)phenyl]quinoline-8-carboxamideIC5010000.0 [1]
Debio-1347IC50290.0 [1]
H3B-6527IC500.2 [1], 1.0 [2]
N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC504.0 [1], 11.1 [2]
7-Formyl-N-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5013.0 [1], 13.3 [2]
7-Formyl-N-pyridin-2-yl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC50300.0 [1]
N-(5-Cyanopyrazin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5033.0 [1]
2-[4-[6-Chloro-2-[4-(4-methylpiperazin-1-yl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamideIC5020.0 [1], 130.0 [2]
3-[5-Cyano-4-(2-methoxyethylamino)pyridin-2-yl]-1-(6-formylpyridin-2-yl)-1-methylureaIC506.5 [1], 41.0 [2]
3-[5-Cyano-4-(2-methoxyethylamino)pyridin-2-yl]-1-(6-formylpyridin-2-yl)-1-(2-methoxyethyl)ureaIC507.4 [1], 91.0 [2]
N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC5023.0 [1], 2800.0 [2]
7-Formyl-N-(5-methyl-1H-pyrazol-3-yl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamideIC50790.0 [1], 3000.0 [2]
N-(5-Cyano-4-propan-2-yloxypyridin-2-yl)-6-formylpyrrolo[2,3-b]pyridine-1-carboxamideIC503.2 [1], 750.0 [2]
Infigratinib phosphateIC5060.0 [1], 168.0 [2]
4-N-(3,5-Dimethoxyphenyl)-4-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-1-N-propan-2-ylcyclohexane-1,4-diamineIC506.76 [1], 25.12 [2]
StaurosporineIC50148.3 [1]
AcrylamideIC50938.0 [1]
NintedanibIC50610.0 [1]
Nintedanib esylateIC50610.0 [1]
PonatinibIC507.1 [1]
CeritinibIC50950.0 [1]
DoramapimodIC507000.0 [1]
Nvp-aew541IC505000.0 [1]
ErdafitinibIC506.61 [1]
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamideIC50500.0 [1]
CID 59604787IC5010000.0 [1]
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC50560.0 [1]
CID 118295624IC5019.3 [1]
CID 44814409IC5010000.0 [1]
RoblitinibIC501.9 [1]
6H-Purin-6-one, 2-amino-1,7-dihydro-8-phenyl-IC5020000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC502800.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
N-[4-[[3-(3,5-Dimethoxyphenyl)-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamideIC5032.0 [1]
6-[2-[(E)-2-[4-(Morpholin-4-ylmethyl)phenyl]ethenyl]pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-oneIC5010000.0 [1]
CID 46864270IC5034.0 [1]
Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylateIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
N-(3-Imidazo[1,2-b]pyridazin-6-yloxyphenyl)-3-(trifluoromethyl)benzamideIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[3-[[4-[(2,2-Difluoro-3-oxo-4H-1,4-benzoxazin-6-yl)amino]-5-fluoropyrimidin-2-yl]amino]phenoxy]-N-methylacetamideKi217.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
1-[3-[8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5050000.0 [1]
4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrileIC505900.0 [1]
6-[(2r)-2-(3-Fluorophenyl)pyrrolidin-1-Yl]-3-(Pyridin-2-Yl)imidazo[1,2-B]pyridazineIC509200.0 [1]
2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acidIC505300.0 [1]
1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC504400.0 [1]
N-[(3R,4S)-4-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]oxolan-3-yl]prop-2-enamideIC5013.0 [1]
N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC503.0 [1]
N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-5-(4-ethylpiperazin-1-yl)-3-methylphenyl]prop-2-enamideIC504.0 [1]
N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]phenyl]prop-2-enamideIC508.0 [1]
4-Chloro-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(5-morpholin-4-ylpyridin-3-yl)ethynyl]benzamideIC505.5 [1]
7-(1,3,4,6,7,8,9,9a-Octahydropyrido[1,2-a]pyrazin-2-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amineIC5052.7 [1]
Clk1-IN-1IC5010000.0 [1]
[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-(3-methylphenyl)methanoneIC504100.0 [1]
5-[5-Amino-4-(1H-indole-2-carbonyl)pyrazol-1-yl]-1,3-dihydrobenzimidazol-2-oneIC5050000.0 [1]
[5-Amino-1-(2-chlorophenyl)pyrazol-4-yl]-(1H-indol-2-yl)methanoneIC503100.0 [1]
[5-Amino-1-(1H-indol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanoneIC50110.0 [1]
[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-quinolin-6-ylmethanoneIC50740.0 [1]
[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-(1H-indol-2-yl)methanoneIC50200.0 [1]
[5-Amino-1-(2-methyl-1H-indol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanoneIC5085.0 [1]
[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]methanoneIC50160.0 [1]
[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-(1-benzofuran-2-yl)methanoneIC50730.0 [1]
N-[2-[[5-[(3,5-Dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC50188.0 [1]
N-[3-Chloro-2-[[5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]phenyl]prop-2-enamideIC503.8 [1]
N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-(trifluoromethyl)phenyl]prop-2-enamideIC5024.9 [1]
N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methoxyphenyl]prop-2-enamideIC504.8 [1]
N-[3,5-Dichloro-2-[[5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]phenyl]prop-2-enamideIC508.5 [1]
N-[3-Chloro-2-[[5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-5-fluorophenyl]prop-2-enamideIC502.6 [1]
N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-fluorophenyl]prop-2-enamideIC505.3 [1]
N-[2-[[5-[1-(2,6-Dichloro-3,5-dimethoxyphenyl)ethoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC5010000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Fibroblast growth factor receptor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Fibroblast growth factor receptor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-4-inhibitors-ic50-ki.
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