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Fibroblast growth factor receptor 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
Azd4547IC500.9 [1]
3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinoneIC502800.0 [1]
NintedanibIC5060.0 [1]
SemaxanibIC507080.0 [1]
OrantinibIC503000.0 [1]
4-N-(3,5-Dimethoxyphenyl)-4-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-1-N-propan-2-ylcyclohexane-1,4-diamineIC5013.18 [1]
PD173074IC5019.0 [1], 21.5 [2], 28.0 [3], 30.0 [4]
VandetanibIC502310.0 [1], 3600.0 [2], 6000.0 [3], 10000.0 [4]
PonatinibIC500.7 [1], 1.2 [2], 2.2 [3]
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC50110.0 [1], 130.0 [2], 140.0 [3]
3-Substituted indolin-2-one 16gIC501200.0 [1], 1400.0 [2], 1500.0 [3], 17900.0 [4]
SunitinibIC50170.0 [1], 1064.0 [2], 2900.0 [3]
BrivanibIC5028.0 [1], 148.0 [2]
InfigratinibIC500.8 [1], 1.0 [2]
ErdafitinibIC501.86 [1], 83.18 [2], 10000.0 [3]
Unii-NA856793UTIC5048.0 [1], 60.0 [2], 600.0 [3]
Debio-1347IC509.3 [1]
N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC50239.9 [1], 2700.0 [2], 3200.0 [3]
2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 38IC5030.0 [1], 460.0 [2]
1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5010000.0 [1]
N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamideIC503.6 [1], 3.65 [2], 9.2 [3]
CID 91827382IC502.9 [1], 6.2 [2]
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acidIC502290.0 [1], 10000.0 [2], 50000.0 [3]
3-[5-[(Z)-[6-(3,5-Dimethoxyphenyl)-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]propanoic acidIC50400.0 [1], 520.0 [2], 18200.0 [3]
4-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamineIC502.0 [1], 15.85 [2], 60.0 [3]
1,6-Naphthyridine deriv. 20IC5012.0 [1], 31.0 [2]
7-(1,3,4,6,7,8,9,9a-Octahydropyrido[1,2-a]pyrazin-2-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amineIC500.2 [1], 0.5 [2], 1.0 [3]
4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC5014.5 [1], 18.0 [2], 391.2 [3]
Infigratinib phosphateIC500.9 [1], 2.9 [2], 4.6 [3]
2-[3-Methoxy-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-5-(trideuteriomethoxy)anilino]ethanolIC502.63 [1], 257.04 [2], 3019.95 [3]
N'-(3,5-Dimethoxyphenyl)-N-propan-2-yl-N'-[3-[1-(trideuteriomethyl)pyrazol-4-yl]quinoxalin-6-yl]ethane-1,2-diamineIC500.87 [1], 29.51 [2], 10000.0 [3]
N'-[3-Methoxy-5-(trideuteriomethoxy)phenyl]-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamineIC500.91 [1], 23.99 [2], 10000.0 [3]
N'-[3-Fluoro-5-(trideuteriomethoxy)phenyl]-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamineIC5013.18 [1], 588.84 [2], 10000.0 [3]
N'-[3,5-Bis(trideuteriomethoxy)phenyl]-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-(2,2,2-trifluoroethyl)propane-1,3-diamineIC5013.18 [1], 85.11 [2], 10000.0 [3]
3-[N-[3-(1-Methylpyrazol-4-yl)quinoxalin-6-yl]-3,5-bis(trideuteriomethoxy)anilino]propan-1-olIC501.62 [1], 57.54 [2], 10000.0 [3]
N-[3,5-Bis(trideuteriomethoxy)phenyl]-3-(1-propan-2-ylpyrazol-4-yl)-N-(3-pyridin-4-ylprop-2-ynyl)quinoxalin-6-amineIC506.17 [1], 15.85 [2], 6025.6 [3]
N-[3,5-Bis(trideuteriomethoxy)phenyl]-1,1,2,2,3,3-hexadeuterio-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamineIC5010.0 [1], 194.98 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-(1-propan-2-ylpyrazol-4-yl)quinoxalin-6-yl]-N-(2,2,2-trifluoroethyl)propane-1,3-diamine;hydrochlorideIC5010.23 [1], 208.93 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-(1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine;hydrochlorideIC502.4 [1], 1659.59 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-N-[3-(2,5-dimethylimidazol-1-yl)propyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC5010.0 [1], 588.84 [2], 10000.0 [3]
2-[4-[7-[3,5-Dimethoxy-N-[2-(methylamino)ethyl]anilino]quinoxalin-2-yl]pyrazol-1-yl]-N-methylacetamide;hydrochlorideIC501.74 [1], 1621.81 [2], 10000.0 [3]
N-[(2-Aminophenyl)methyl]-N'-(3,5-dimethoxycyclohexa-2,4-dien-1-yl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamineIC5010.0 [1], 123.03 [2], 10000.0 [3]
3-[4-[3-[4-[7-[N-(Cyclopropylmethyl)-3,5-dimethoxyanilino]quinoxalin-2-yl]pyrazol-1-yl]propyl]piperazin-1-yl]propan-1-ol;hydrochlorideIC504.79 [1], 691.83 [2], 5623.41 [3]
2-[4-[7-[3,5-Dimethoxy-N-[2-(propan-2-ylamino)ethyl]anilino]quinoxalin-2-yl]pyrazol-1-yl]-N-methylacetamide;hydrochlorideIC502.34 [1], 21.88 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-(oxolan-2-ylmethyl)ethane-1,2-diamine;hydrochlorideIC504.9 [1], 54.95 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N-methyl-N'-[3-(1-propan-2-ylpyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine;hydrochlorideIC502.04 [1], 85.11 [2], 10000.0 [3]
N'-(3,4-Difluoro-5-methoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-(2,2,2-trifluoroethyl)propane-1,3-diamine;hydrochlorideIC50257.04 [1], 10000.0 [2]
(2S)-1-(3,5-Dimethoxy-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]anilino)-3-(propan-2-ylamino)propan-2-ol;hydrochlorideIC501.91 [1], 20.89 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(3-piperidin-1-ylpropyl)quinoxalin-6-amine;hydrochlorideIC500.55 [1], 67.61 [2], 10000.0 [3]
1,1,2,2,3,3-Hexadeuterio-3-[N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-3,5-bis(trideuteriomethoxy)anilino]propan-1-olIC503.98 [1], 67.61 [2], 10000.0 [3]
N-[(5-Chlorothiophen-2-yl)methyl]-N-(3,5-dimethoxyphenyl)-3-[1-(2-piperazin-1-ylethyl)pyrazol-4-yl]quinoxalin-6-amine;hydrochlorideIC504.07 [1], 1584.89 [2], 2754.23 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-[3-[(2S)-2-methylpyrrolidin-1-yl]propyl]quinoxalin-6-amine;hydrochlorideIC500.59 [1], 7.59 [2], 10000.0 [3]
N'-[2-(3,5-Dimethoxy-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]anilino)ethyl]-N'-propan-2-ylpropane-1,3-diamine;hydrochlorideIC503.24 [1], 58.88 [2], 6606.93 [3]
N-(3,5-Dimethoxyphenyl)-N-[3-(2-methylpiperidin-1-yl)propyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC501.15 [1], 58.88 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-N-[3-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]propyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC502.04 [1], 4.9 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-N-[2-(2,4-dimethylimidazol-1-yl)ethyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC50100.0 [1], 1479.11 [2], 10000.0 [3]
N-(2-Chloro-3,5-dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(3-pyrrolidin-1-ylpropyl)quinoxalin-6-amine;hydrochlorideIC501.82 [1], 16.22 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-ylethyl)quinoxalin-6-amine;hydrochlorideIC503.71 [1], 186.21 [2], 10000.0 [3]
N'-[3-[1-(3-Aminopropyl)pyrazol-4-yl]quinoxalin-6-yl]-N'-(3,5-dimethoxyphenyl)-N-(2,2,2-trifluoroethyl)propane-1,3-diamine;hydrochlorideIC503.55 [1], 602.56 [2], 9120.11 [3]
2-[4-[7-[N-(Cyclopropylmethyl)-3-(2-hydroxyethoxy)-5-methoxyanilino]quinoxalin-2-yl]pyrazol-1-yl]ethanol;hydrochlorideIC5011.48 [1], 794.33 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N-propan-2-yl-N'-[3-(1-propan-2-ylpyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine;hydrochlorideIC501.74 [1], 6.76 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-N-[(3-methoxypiperidin-3-yl)methyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amineIC507.24 [1], 446.68 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylpropane-1,3-diamine;hydrochlorideIC501.32 [1], 34.67 [2], 10000.0 [3]
N-(Cyclopropylmethyl)-3-(1-methylpyrazol-4-yl)-N-[3-(trifluoromethoxy)phenyl]quinoxalin-6-amine;hydrochlorideIC507943.28 [1], 10000.0 [2]
N'-(3,5-Dimethoxyphenyl)-N-propan-2-yl-N'-[3-(1,3,5-trimethylpyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine;hydrochlorideIC508.13 [1], 173.78 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(2-pyrazol-1-ylethyl)quinoxalin-6-amine;hydrochlorideIC501.58 [1], 416.87 [2], 10000.0 [3]
N'-(3-Methoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine;hydrochlorideIC506.03 [1], 107.15 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N-methyl-N'-[3-[1-(oxan-4-ylmethyl)pyrazol-4-yl]quinoxalin-6-yl]ethane-1,2-diamine;hydrochlorideIC505.62 [1], 34.67 [2], 10000.0 [3]
1-N-(3,5-Dimethoxyphenyl)-3-methyl-1-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-2-N-propan-2-ylbutane-1,2-diamine;hydrochlorideIC5036.31 [1], 1096.48 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-(5-ethyl-1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine;hydrochlorideIC501.78 [1], 69.18 [2], 6760.83 [3]
N'-[3-[1-(3-Aminopropyl)pyrazol-4-yl]quinoxalin-6-yl]-N'-(3,5-dimethoxyphenyl)-N-propan-2-ylethane-1,2-diamine;2,2,2-trifluoroacetic acidIC500.78 [1], 60.26 [2], 10000.0 [3]
2-[(2S)-1-[3-(3,5-Dimethoxy-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]anilino)propyl]pyrrolidin-2-yl]acetonitrile;hydrochlorideIC502.04 [1], 10.23 [2], 10000.0 [3]
N-(3-Fluoro-5-methoxyphenyl)-3-(1H-pyrazol-4-yl)-N-(3-pyrrolidin-1-ylpropyl)quinoxalin-6-amine;hydrochlorideIC501.26 [1], 218.78 [2], 10000.0 [3]
N-[3-(3,6-Dihydro-2H-pyridin-1-yl)propyl]-N-(3,5-dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC501.74 [1], 9.33 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-N-[3-[3-(methylamino)pyrrolidin-1-yl]propyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC501.41 [1], 323.59 [2], 10000.0 [3]
(2R)-1-(3,5-Dimethoxy-N-[3-(1-propan-2-ylpyrazol-4-yl)quinoxalin-6-yl]anilino)-3-methoxypropan-2-ol;hydrochlorideIC502.57 [1], 69.18 [2], 10000.0 [3]
N-(Cyclopropylmethyl)-N-(3,5-dimethoxyphenyl)-3-[1-(3-morpholin-4-ylpropyl)pyrazol-4-yl]quinoxalin-6-amine;hydrochlorideIC502.95 [1], 1778.28 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(3-morpholin-4-ylpropyl)quinoxalin-6-amine;hydrochlorideIC502.69 [1], 43.65 [2], 10000.0 [3]
2-(N-[3-[1-(3-Aminopropyl)pyrazol-4-yl]quinoxalin-6-yl]-3,5-dimethoxyanilino)ethanol;hydrochlorideIC500.98 [1], 630.96 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(piperidin-4-ylmethyl)quinoxalin-6-amine;hydrochlorideIC502.69 [1], 123.03 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-[1-(oxan-4-ylmethyl)pyrazol-4-yl]quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine;hydrochlorideIC501.51 [1], 9.55 [2], 10000.0 [3]
N-(Cyclopropylmethyl)-N-(3,5-dimethoxyphenyl)-3-[1-(2-piperidin-4-ylethyl)pyrazol-4-yl]quinoxalin-6-amine;hydrochlorideIC501.26 [1], 1318.26 [2], 5623.41 [3]
N-[3-(3,3-Difluoropyrrolidin-1-yl)propyl]-N-(3,5-dimethoxyphenyl)-3-[1-(oxan-4-ylmethyl)pyrazol-4-yl]quinoxalin-6-amine;hydrochlorideIC505.75 [1], 537.03 [2], 10000.0 [3]
2-[(3,5-Dimethoxycyclohexa-2,4-dien-1-yl)-[3-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]quinoxalin-6-yl]amino]ethanolIC5064.57 [1], 2570.4 [2], 10000.0 [3]
N-[3-(3,3-Difluoropyrrolidin-1-yl)propyl]-N-(3,5-dimethoxyphenyl)-3-(1H-pyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC507.94 [1], 870.96 [2], 10000.0 [3]
(2R)-1-(N-[3-[1-(3-Aminopropyl)pyrazol-4-yl]quinoxalin-6-yl]-3,5-dimethoxyanilino)-3-methoxypropan-2-ol;hydrochlorideIC502.09 [1], 194.98 [2], 10000.0 [3]
N'-(3,5-Dimethoxyphenyl)-N'-[3-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine;hydrochlorideIC501.41 [1], 52.48 [2], 4265.8 [3]
N-[3-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(cyclopropylmethyl)-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC50794.33 [1], 10000.0 [2]
N-(2-Chloro-5-methoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(3-pyrrolidin-1-ylpropyl)quinoxalin-6-amine;hydrochlorideIC5042.66 [1], 10000.0 [2]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-(3-pyrrolidin-1-ylpropyl)quinoxalin-6-amine;hydrochlorideIC500.76 [1], 10.72 [2], 10000.0 [3]
N-(Cyclopropylmethyl)-N-(3-methoxy-5-propan-2-yloxyphenyl)-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC50524.81 [1], 10000.0 [2]
2-[4-[7-[3,5-Dimethoxy-N-(3-pyrrolidin-1-ylpropyl)anilino]quinoxalin-2-yl]pyrazol-1-yl]ethanol;hydrochlorideIC501.07 [1], 11.75 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-N-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl]-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC508.51 [1], 616.6 [2], 10000.0 [3]
N-(3,5-Dimethoxy-2-methylphenyl)-3-(1-methylpyrazol-4-yl)-N-(3-pyrrolidin-1-ylpropyl)quinoxalin-6-amine;hydrochlorideIC502.19 [1], 16.6 [2], 10000.0 [3]
N-[2-[(1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-2-yl]ethyl]-N-(3,5-dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)quinoxalin-6-amine;hydrochlorideIC502.69 [1], 134.9 [2], 10000.0 [3]
1-N-(3,5-Dimethoxyphenyl)-1-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-2-N-propan-2-ylpropane-1,2-diamine;hydrochlorideIC501.51 [1], 37.15 [2], 10000.0 [3]
(2R)-1-(3,5-Dimethoxy-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]anilino)-3-(propan-2-ylamino)propan-2-ol;hydrochlorideIC502.51 [1], 50.12 [2], 10000.0 [3]
N-(3,5-Dimethoxyphenyl)-3-(1-methylpyrazol-4-yl)-N-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]quinoxalin-6-amine;hydrochlorideIC501.55 [1], 33.11 [2], 10000.0 [3]
3-(3,5-Dimethoxy-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]anilino)propanoic acid;hydrochlorideIC506.46 [1], 4466.84 [2], 10000.0 [3]
2-(2-Chloro-5-methoxy-N-[3-(1H-pyrazol-4-yl)quinoxalin-6-yl]anilino)ethanol;hydrochlorideIC5010.47 [1], 2089.3 [2], 10000.0 [3]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Fibroblast growth factor receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Fibroblast growth factor receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-1-inhibitors-ic50-ki.
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