Farnesyl diphosphate synthase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Risedronic acid	IC50	11.0 [1]
	Risedronic acid	Ki	0.36 [1], 16.0 [2], 82.2 [3]
	Zoledronic acid	IC50	4.1 [1]
	Zoledronic acid	Ki	0.07 [1], 85.9 [2]
	[1-Hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid)	IC50	78.0 [1], 363.0 [2], 2930.0 [3], 5370.32 [4], 5400.0 [5]
	[1-Hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid)	Ki	78.0 [1], 362.6 [2], 510.0 [3]
	(1-Hydroxyheptane-1,1-Diyl)bis(Phosphonic Acid)	IC50	660.0 [1], 1940.0 [2], 2370.0 [3], 5888.44 [4], 5900.0 [5]
	(1-Hydroxyheptane-1,1-Diyl)bis(Phosphonic Acid)	Ki	240.0 [1], 400.0 [2], 560.0 [3]
	Alendronic acid	IC50	50.0 [1], 950.0 [2], 954.99 [3]
	Alendronic acid	Ki	44.2 [1], 91.0 [2], 393.1 [3]
	Pamidronic acid	IC50	200.0 [1], 1862.09 [2], 1900.0 [3]
	Pamidronic acid	Ki	55.9 [1], 180.0 [2], 331.4 [3]
	2-[(Bis-phosphono-methyl)-amino]-pyridinium	IC50	85.0 [1], 208.93 [2], 210.0 [3]
	2-[(Bis-phosphono-methyl)-amino]-pyridinium	Ki	2.3 [1], 20.0 [2], 29.1 [3]
	1-(Carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid	IC50	920.0 [1]
	Ibandronic Acid	IC50	20.0 [1], 478.63 [2], 480.0 [3]
	Ibandronic Acid	Ki	3.6 [1], 46.0 [2], 195.0 [3]
	(1-Hydroxyoctane-1,1-diyl)diphosphonic acid	IC50	3570.0 [1], 9360.0 [2], 19952.62 [3], 20000.0 [4]
	(1-Hydroxyoctane-1,1-diyl)diphosphonic acid	Ki	980.0 [1], 1900.0 [2]
	Cimadronate	IC50	158.49 [1], 160.0 [2]
	Cimadronate	Ki	10.0 [1], 16.0 [2], 62.4 [3]
	Neridronic acid	IC50	4570.88 [1], 4600.0 [2]
	Neridronic acid	Ki	63.5 [1], 415.7 [2], 440.0 [3]
	2-Hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid	IC50	200000.0 [1], 253500.0 [2], 1000000.0 [3]
	2-Hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid	Ki	61000.0 [1], 97500.0 [2]
	(1-Hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid	IC50	16595.87 [1], 17000.0 [2]
	(1-Hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid	Ki	302.6 [1], 367.9 [2], 1600.0 [3]
	{[(3-Methylpyridin-2-Yl)amino]methanediyl}bis(Phosphonic Acid)	IC50	110.0 [1], 112.2 [2]
	{[(3-Methylpyridin-2-Yl)amino]methanediyl}bis(Phosphonic Acid)	Ki	1.09 [1], 11.0 [2], 12.1 [3]
	[1-Phosphono-2-(pyridin-2-ylamino)ethyl]phosphonic acid	IC50	169.82 [1], 170.0 [2]
	[1-Phosphono-2-(pyridin-2-ylamino)ethyl]phosphonic acid	Ki	2.3 [1], 16.0 [2], 36.9 [3]
	(1-Hydroxy-2-(pyridin-2-yl)ethylidene)bis(phosphonic acid)	IC50	140.0 [1], 141.25 [2]
	(1-Hydroxy-2-(pyridin-2-yl)ethylidene)bis(phosphonic acid)	Ki	0.74 [1], 14.0 [2], 59.3 [3]
	(5-Amino-1-hydroxy-1-phosphono-pentyl)phosphonic Acid	IC50	4365.16 [1], 4400.0 [2]
	(5-Amino-1-hydroxy-1-phosphono-pentyl)phosphonic Acid	Ki	48.2 [1], 194.1 [2], 420.0 [3]
	(1-Phosphono-hexyl)-phosphonic acid	IC50	5670.0 [1], 9549.93 [2], 9600.0 [3]
	(1-Phosphono-hexyl)-phosphonic acid	Ki	470.0 [1], 920.0 [2]
	Incadronic acid	IC50	30.0 [1], 229.09 [2], 230.0 [3]
	Incadronic acid	Ki	22.0 [1]
	1,1-Diphosphono-2-(1H-imidazole-4-yl)ethanol	IC50	1.1 [1], 309.03 [2], 330.0 [3]
	1,1-Diphosphono-2-(1H-imidazole-4-yl)ethanol	Ki	30.0 [1]
	Deoxy Risedronic Acid	IC50	33.0 [1], 34.2 [2]
	Deoxy Risedronic Acid	Ki	7.4 [1], 34.76 [2]
	{1-Hydroxy-3-[methyl(4-phenylbutyl)amino]propane-1,1-diyl}bis(phosphonic acid)	IC50	1.05 [1], 489.78 [2], 490.0 [3]
	{1-Hydroxy-3-[methyl(4-phenylbutyl)amino]propane-1,1-diyl}bis(phosphonic acid)	Ki	46.0 [1]
	[1-Hydroxy-3-(methyl-phenethyl-amino)-1-phosphono-propyl]-phosphonic acid	IC50	3.92 [1], 309.03 [2], 310.0 [3]
	[1-Hydroxy-3-(methyl-phenethyl-amino)-1-phosphono-propyl]-phosphonic acid	Ki	30.0 [1]
	{1-Hydroxy-3-[methyl-(3-phenyl-propyl)-amino]-1-phosphono-propyl}-phosphonic acid	IC50	2.59 [1], 489.78 [2], 500.0 [3]
	{1-Hydroxy-3-[methyl-(3-phenyl-propyl)-amino]-1-phosphono-propyl}-phosphonic acid	Ki	47.0 [1]
	(Bis-phosphono-methyl)-(4-methyl-thiazol-2-yl)-ammonium	IC50	346.74 [1], 1862.09 [2], 1900.0 [3]
	(Bis-phosphono-methyl)-(4-methyl-thiazol-2-yl)-ammonium	Ki	180.0 [1]
	[1-Hydroxy-3-(3-phenoxy-propylamino)-1-phosphono-propyl]-phosphonic acid	IC50	3.25 [1], 446.68 [2], 450.0 [3]
	[1-Hydroxy-3-(3-phenoxy-propylamino)-1-phosphono-propyl]-phosphonic acid	Ki	43.0 [1]
	[1-Hydroxy-3-(4-phenyl-butylamino)-1-phosphono-propyl]-phosphonic acid	IC50	2.69 [1], 250.0 [2], 251.19 [3]
	[1-Hydroxy-3-(4-phenyl-butylamino)-1-phosphono-propyl]-phosphonic acid	Ki	24.0 [1]
	[({5-[4-(Cyclopropyloxy)phenyl]pyridin-3-YL}amino)methanediyl]bis(phosphonic acid)	IC50	16.0 [1], 18.0 [2]
	({[6-(4-Methylphenyl)thieno[2,3-D]pyrimidin-4-Yl]amino}methanediyl)bis(Phosphonic Acid)	IC50	22.0 [1], 390.0 [2]
	(1-Hydroxy-1-phosphonodecyl)phosphonic acid	IC50	2344.23 [1], 2400.0 [2]
	(1-Hydroxy-1-phosphonodecyl)phosphonic acid	Ki	230.0 [1]
	[(5-Chloro-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid	IC50	239.88 [1], 240.0 [2]
	[(5-Chloro-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid	Ki	23.0 [1]
	1-Hydroxy-2-(4-aminophenyl)ethane-1,1-diphosphonic acid	IC50	43000.0 [1], 43651.58 [2]
	1-Hydroxy-2-(4-aminophenyl)ethane-1,1-diphosphonic acid	Ki	4200.0 [1]
	(1-Hydroxy-2-(pyridin-4-yl)ethylidene)bis(phosphonic acid)	IC50	1300.0 [1], 1348.96 [2]
	(1-Hydroxy-2-(pyridin-4-yl)ethylidene)bis(phosphonic acid)	Ki	130.0 [1]
	Phosphonic acid, (1-hydroxybutylidene)di-	IC50	42830.0 [1], 100000.0 [2]
	Phosphonic acid, (1-hydroxybutylidene)di-	Ki	5040.0 [1]
	2-[(Bis-phosphono-methyl)-amino]-4-methyl-pyridinium	IC50	180.0 [1], 181.97 [2]
	2-[(Bis-phosphono-methyl)-amino]-4-methyl-pyridinium	Ki	17.0 [1]
	Lauryl alcohol diphosphonic acid	IC50	7762.47 [1], 7800.0 [2]
	Lauryl alcohol diphosphonic acid	Ki	740.0 [1]
	(3-Amino-1-hydroxy-1-phosphono-butyl)-phosphonic acid	IC50	1000.0 [1], 1047.13 [2]
	(3-Amino-1-hydroxy-1-phosphono-butyl)-phosphonic acid	Ki	100.0 [1]
	(1-Hydroxy-1-phosphono-hexyl)-phosphonic acid	IC50	1940.0 [1], 3120.0 [2]
	(1-Hydroxy-1-phosphono-hexyl)-phosphonic acid	Ki	400.0 [1]
	[[(6-Methylpyridin-2-yl)amino]-phosphonomethyl]phosphonic acid	IC50	1288.25 [1], 1300.0 [2]
	[[(6-Methylpyridin-2-yl)amino]-phosphonomethyl]phosphonic acid	Ki	120.0 [1]
	Azepan-1-ylmethylenediphosphonic acid	IC50	510.0 [1], 512.86 [2]
	Azepan-1-ylmethylenediphosphonic acid	Ki	49.0 [1]
	1,1-Diphosphono-1-undecanol	IC50	3388.44 [1], 3400.0 [2]
	1,1-Diphosphono-1-undecanol	Ki	330.0 [1]
	[(Isoquinolin-1-ylamino)-phosphono-methyl]-phosphonic acid	IC50	426.58 [1], 430.0 [2]
	[(Isoquinolin-1-ylamino)-phosphono-methyl]-phosphonic acid	Ki	41.0 [1]
	N-Nonyl-aminomethylene-bisphosphonate	IC50	891.25 [1], 900.0 [2]
	N-Nonyl-aminomethylene-bisphosphonate	Ki	86.0 [1]
	3-[(Diphosphonomethyl)amino]pyridine	IC50	158.49 [1], 160.0 [2]
	3-[(Diphosphonomethyl)amino]pyridine	Ki	15.0 [1]
	Piperidin-1-ylmethylenediphosphonic acid	IC50	3200.0 [1], 3235.94 [2]
	Piperidin-1-ylmethylenediphosphonic acid	Ki	300.0 [1]
	[(Propylamino)methanediyl]bis(phosphonic acid)	IC50	1659.59 [1], 1700.0 [2]
	[(Propylamino)methanediyl]bis(phosphonic acid)	Ki	160.0 [1]
	[(3-Methylbutylamino)-phosphonomethyl]phosphonic acid	IC50	489.78 [1], 490.0 [2]
	[(3-Methylbutylamino)-phosphonomethyl]phosphonic acid	Ki	47.0 [1]
	[(Butylamino)methanediyl]bis(phosphonic acid)	IC50	208.93 [1], 210.0 [2]
	[(Butylamino)methanediyl]bis(phosphonic acid)	Ki	20.0 [1]
	[(2-Methylbutylamino)-phosphonomethyl]phosphonic acid	IC50	360.0 [1], 363.08 [2]
	[(2-Methylbutylamino)-phosphonomethyl]phosphonic acid	Ki	34.0 [1]
	(1-Hydroxynonane-1,1-Diyl)bis(Phosphonic Acid)	IC50	4540.0 [1], 8450.0 [2]
	(1-Hydroxynonane-1,1-Diyl)bis(Phosphonic Acid)	Ki	590.0 [1]
	[[(5-Bromo-2-pyridyl)amino]-phosphono-methyl]phosphonic acid	IC50	1400.0 [1], 1412.54 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Farnesyl diphosphate synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/farnesyl-diphosphate-synthase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Farnesyl diphosphate synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/farnesyl-diphosphate-synthase-inhibitors-ic50-ki.
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