Eukaryotic translation initiation factor 2-alpha kinase 4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-[2-[4-[5-[(1-Ethylpyrazol-3-yl)amino]triazolo[4,5-d]pyrimidin-1-yl]phenyl]propan-2-yloxy]ethanol	IC50	300.0 [1]
	1-(4-Ethoxyphenyl)-N-[1-(3-piperidin-4-ylpropyl)pyrazol-3-yl]triazolo[4,5-d]pyrimidin-5-amine	IC50	300.0 [1]
	4-[3-[[1-(4-Chloro-3-fluorophenyl)triazolo[4,5-d]pyrimidin-5-yl]amino]pyrazol-1-yl]cyclohexan-1-ol	IC50	300.0 [1]
	1-(1H-Indazol-6-yl)-N-[1-(oxan-4-yl)pyrazol-3-yl]triazolo[4,5-d]pyrimidin-5-amine	IC50	300.0 [1]
	CID 53469059	IC50	3388.0 [1]
	LY-3009120	IC50	450.0 [1]
	4-[2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	7300.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	2-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone	IC50	3900.0 [1]
	N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-methyl-3-oxo-2,5-diphenylpyrazole-4-carboxamide	IC50	290.0 [1]
	4-[2-Amino-4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	42.0 [1]
	1-Methyl-4-[4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-2,5-diphenylpyrazol-3-one	IC50	5.0 [1]
	4-[4-Amino-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	12.0 [1]
	4-[4-Chloro-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	10.0 [1]
	4-[2-Amino-3-[5-fluoro-2-(methylamino)quinazolin-7-yl]oxy-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	36.0 [1]
	4-[2-Amino-3-[5-chloro-2-(methylamino)quinazolin-7-yl]oxy-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	42.0 [1]
	4-[2-Amino-4-methyl-3-(2-methylquinazolin-7-yl)oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	240.0 [1]
	4-[2-Amino-4-methyl-3-(2-methyl-1,3-benzothiazol-5-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	10000.0 [1]
	4-[2-Amino-4-methyl-3-(2-methyl-1,3-benzothiazol-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	1400.0 [1]
	4-[2-Amino-3-(2-amino-1,3-benzothiazol-6-yl)-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	100.0 [1]
	4-[2-Amino-3-[2-(fluoromethyl)-1,3-benzothiazol-6-yl]-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	310.0 [1]
	4-[2-Amino-3-[2-(difluoromethyl)-1,3-benzothiazol-6-yl]-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	610.0 [1]
	4-[2-Amino-4-methyl-3-[2-(trifluoromethyl)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	50000.0 [1]
	2-[5-(4-Amino-2,7-dimethylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone	IC50	50000.0 [1]
	1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-[6-(trifluoromethyl)pyridin-2-yl]ethanone	IC50	776.0 [1]
	2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamide	IC50	10000.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	2500.0 [1]
	2-Amino-N-[4-Methoxy-3-(Trifluoromethyl)phenyl]-4-Methyl-3-[2-(Methylamino)quinazolin-6-Yl]benzamide	IC50	420.0 [1]
	4-[2-Amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one	IC50	97.0 [1]
	4-[4-[[3-(4-Chloro-3-fluorophenyl)triazolo[4,5-d]pyrimidin-5-yl]amino]pyrazol-1-yl]cyclohexan-1-ol	IC50	300.0 [1]
	3-Hydroxy-6-[[8-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]amino]-3-propan-2-yl-1H-indol-2-one	IC50	300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 31 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Eukaryotic translation initiation factor 2-alpha kinase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/eukaryotic-translation-initiation-factor-2-alpha-kinase-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Eukaryotic translation initiation factor 2-alpha kinase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/eukaryotic-translation-initiation-factor-2-alpha-kinase-4-inhibitors-ic50-ki.
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