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Eukaryotic translation initiation factor 2-alpha kinase 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC506.0 [1], 84.0 [2], 770.0 [3], 50000.0 [4]
4-[2-Amino-4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC503.0 [1], 12.0 [2], 17.0 [3], 480.0 [4], 550.0 [5]
4-[2-Amino-4-methyl-3-(2-methyl-1,3-benzothiazol-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC504.0 [1], 20.0 [2], 320.0 [3], 520.0 [4], 50000.0 [5]
4-[2-Amino-3-(2-amino-1,3-benzothiazol-6-yl)-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC5011.0 [1], 41.0 [2], 44.0 [3], 1100.0 [4], 1200.0 [5]
4-[2-Amino-3-[2-(fluoromethyl)-1,3-benzothiazol-6-yl]-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC506.0 [1], 53.0 [2], 65.0 [3], 2100.0 [4], 3700.0 [5]
4-[2-Amino-3-[2-(difluoromethyl)-1,3-benzothiazol-6-yl]-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC5011.0 [1], 79.0 [2], 86.0 [3], 1900.0 [4], 4800.0 [5]
4-[2-Amino-4-methyl-3-[2-(trifluoromethyl)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC5053.0 [1], 88.0 [2], 3000.0 [3], 50000.0 [4]
4-[2-Amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC509.0 [1], 50.0 [2], 82.0 [3], 760.0 [4], 1300.0 [5]
CID 53469448IC500.4 [1], 30.0 [2]
2-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanoneIC501.0 [1], 6.0 [2], 20.0 [3], 50000.0 [4]
1-Methyl-4-[4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-2,5-diphenylpyrazol-3-oneIC501.0 [1], 110.0 [2], 140.0 [3], 480.0 [4]
4-[4-Amino-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC503.0 [1], 45.0 [2], 240.0 [3], 320.0 [4]
4-[4-Chloro-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC505.0 [1], 120.0 [2], 140.0 [3], 1000.0 [4]
4-[2-Amino-3-[5-fluoro-2-(methylamino)quinazolin-7-yl]oxy-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC504.0 [1], 30.0 [2], 400.0 [3], 520.0 [4]
4-[2-Amino-3-[5-chloro-2-(methylamino)quinazolin-7-yl]oxy-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC506.0 [1], 59.0 [2], 650.0 [3], 1100.0 [4]
4-[2-Amino-4-methyl-3-(2-methylquinazolin-7-yl)oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC505.0 [1], 35.0 [2], 2300.0 [3], 6000.0 [4]
2-[5-(4-Amino-2,7-dimethylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanoneIC502.0 [1], 12.0 [2], 89.0 [3], 50000.0 [4]
2-Amino-N-[4-Methoxy-3-(Trifluoromethyl)phenyl]-4-Methyl-3-[2-(Methylamino)quinazolin-6-Yl]benzamideIC5041.0 [1], 65.0 [2], 640.0 [3], 1200.0 [4]
CID 53469059IC500.8 [1], 30.0 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-(1-methylpyrazol-3-yl)ethanoneIC50251.19 [1], 7943.28 [2]
2-(1-Benzofuran-3-yl)-1-[5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]ethanoneIC5010.0 [1], 31622.78 [2]
2-(2,5-Difluorophenyl)-1-[5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]ethanoneIC500.4 [1], 50.12 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-indol-1-ylethanoneIC506.31 [1], 316.23 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-(7-fluoro-2-methyl-1H-indol-3-yl)ethanoneIC501.58 [1], 39.81 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-(1H-indol-3-yl)ethanoneIC505.01 [1], 501.19 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-(6-fluoro-2-methyl-1H-indol-3-yl)ethanoneIC500.63 [1], 25.12 [2]
4-[2-Amino-4-methyl-3-(2-methyl-1,3-benzothiazol-5-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-oneIC50240.0 [1], 10000.0 [2]
1-[5-(4-Aminothieno[3,2-C]pyridin-3-Yl)-2,3-Dihydro-1h-Indol-1-Yl]-2-PhenylethanoneIC5011.7 [1], 300.0 [2]
1-[5-[4-Amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]-2,3-dihydroindol-1-yl]-2-phenylethanoneIC501.3 [1], 30.0 [2]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(2,5-difluorophenyl)ethanoneIC500.4 [1], 30.0 [2]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(3,5-dimethylpyrazol-1-yl)ethanoneIC501.9 [1], 100.0 [2]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanoneIC502.5 [1], 100.0 [2]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-[6-(trifluoromethyl)pyridin-2-yl]ethanoneIC500.5 [1], 30.0 [2]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(3,5-dimethylpyrazol-1-yl)ethanoneIC502.7 [1], 30.0 [2]
5-{1-[(3-Chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC500.2 [1], 30.0 [2]
3-[1-(Phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7-(3-pyridinyl)thieno[3,2-c]pyridin-4-amineIC503.2 [1], 100.0 [2]
5-{1-[(4-Fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC501.5 [1], 100.0 [2]
Perk-IN-2IC500.2 [1], 30.0 [2]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[6-(trifluoromethyl)pyridin-2-yl]ethanoneIC500.5 [1], 30.0 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-(2-methyl-1H-indol-3-yl)ethanoneIC500.79 [1], 19.95 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-4-fluoro-2,3-dihydroindol-1-yl]-2-(2-methyl-1H-indol-3-yl)ethanoneIC501.0 [1], 12.59 [2]
1-[5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,3-dihydroindol-1-yl]-2-(6-fluoro-2-methylindol-1-yl)ethanoneIC503.16 [1], 79.43 [2]
EntrectinibIC5010000.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
CID 118295624IC50792.0 [1]
GSK PERK InhibitorIC500.3 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
(E)-Ethyl 3-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-ylamino)furo[2,3-c]pyridine-2-carboxylateIC5030.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-methyl-3-oxo-2,5-diphenylpyrazole-4-carboxamideIC504.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-methyl-3-oxo-2-phenyl-5-pyridin-4-ylpyrazole-4-carboxamideIC5042.0 [1]
5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamideIC5010.0 [1]
5-(2-(Pyrimidin-2-yl)furo[2,3-c]pyridin-3-ylamino)isoindolin-1-one oximeIC5018.0 [1]
5-[2,4-Dihydroxy-6-[4-(propan-2-ylamino)phenoxy]phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamideIC5010.0 [1]
5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-[1-(1,4-dioxaspiro[4.5]decan-8-yl)piperidin-4-yl]-1,2-oxazole-3-carboxamideIC5010.0 [1]
3-[(5-Hydroxynaphthalen-2-Yl)amino]-N-(Pyrimidin-4-Yl)furo[2,3-C]pyridine-2-CarboxamideIC5037.9 [1]
6-(2-(Pyrimidin-2-yl)furo[2,3-c]pyridin-3-ylamino)naphthalen-1-olIC504.1 [1]
5-(2-(Pyrimidin-2-yl)furo[2,3-c]pyridin-3-ylamino)-2,3-dihydro-1h-inden-1-oneIC50820.0 [1]
Ethyl 3-(5-aminonaphthalen-2-ylamino)furo[2,3-c]pyridine-2-carboxylateIC509100.0 [1]
Ethyl 3-(6-fluoro-5-hydroxynaphthalen-2-ylamino)furo[2,3-c]pyridine-2-carboxylateIC50142.0 [1]
Ethyl 3-(5-hydroxynaphthalen-2-ylamino)furo[2,3-c]pyridine-2-carboxylateIC5054.0 [1]
3-[(5-Hydroxynaphthalen-2-yl)amino]-N-propan-2-ylfuro[2,3-c]pyridine-2-carboxamideIC5086.7 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(methylamino)-2-oxo-1-phenylpyridine-3-carboxamideIC501000.0 [1]
8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
8-[(1-Benzoylpiperidin-4-yl)amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
N,1-Dimethyl-8-[[1-(1-methylsulfonylpiperidine-4-carbonyl)piperidin-4-yl]amino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
2-Chloro-5-{[2-(Pyrimidin-2-Yl)furo[2,3-C]pyridin-3-Yl]amino}phenolIC5031.0 [1]
2-{[2-Amino-5-(1,3-Benzodioxol-5-Ylmethyl)[1,2,4]triazolo[1,5-C]quinazolin-8-Yl]amino}ethanolIC5010000.0 [1]
N-(1,4-Dihydroindeno[1,2-c]pyrazol-6-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC501100.0 [1]
N-(7-Chloro-1H-indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC50250.0 [1]
5-(1,3-Benzodioxol-5-ylmethyl)-[1,2,4]triazolo[1,5-c]quinazoline-2,8-diamineIC5010000.0 [1]
5-(1,3-Benzodioxol-5-Ylmethyl)-10-Fluoro[1,2,4]triazolo[1,5-C]quinazolin-2-AmineIC5010000.0 [1]
5-(1,3-Benzodioxol-5-ylmethyl)-10-fluoro-8-(4-methylpiperazin-1-yl)-[1,2,4]triazolo[1,5-c]quinazolin-2-amineIC5010000.0 [1]
Ethyl 3-(1-oxo-2,3-dihydro-1h-inden-5-ylamino)furo[2,3-c]pyridine-2-carboxylateIC506800.0 [1]
N-(7-Chloro-3-ethyl-2H-indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC50140.0 [1]
3-[[1-(Hydroxyamino)-3H-isoindol-5-yl]amino]-N-propan-2-ylfuro[2,3-c]pyridine-2-carboxamideIC501300.0 [1]
N-(7-Methyl-1H-indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC50840.0 [1]
N-[3-(3-Aminopropyl)-7-chloro-2H-indazol-4-yl]-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC501300.0 [1]
3-(1,4-Dihydroindeno[1,2-c]pyrazol-6-ylamino)-N-propan-2-ylfuro[2,3-c]pyridine-2-carboxamideIC507800.0 [1]
N-(7-Chloro-6-methyl-1H-indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC50300.0 [1]
N-[(E)-2-(Dimethylamino)ethenyl]-3-[(5-hydroxynaphthalen-2-yl)amino]furo[2,3-c]pyridine-2-carboxamideIC50102.0 [1]
N-(1H-Indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC502500.0 [1]
N-(6-Chloro-1H-indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC501600.0 [1]
3-[(7-Chloro-1H-indazol-4-yl)amino]-N-propan-2-ylfuro[2,3-c]pyridine-2-carboxamideIC504200.0 [1]
3-(7-Chloro-4-(2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-ylamino)-1H-indazol-3-yl)propan-1-olIC50350.0 [1]
3-(4-Chloro-3-hydroxyanilino)-N-propan-2-ylfuro[2,3-c]pyridine-2-carboxamideIC50823.0 [1]
N-(7-Fluoro-1H-indazol-4-yl)-2-pyrimidin-2-ylfuro[2,3-c]pyridin-3-amineIC503500.0 [1]
3-(1,4-Dihydroindeno[1,2-c]pyrazol-6-ylamino)-N-[(E)-2-(methylamino)ethenyl]furo[2,3-c]pyridine-2-carboxamideIC504600.0 [1]
Ethyl 3-(quinolin-3-ylamino)furo[2,3-c]pyridine-2-carboxylateIC505000.0 [1]
Ethyl 3-(4-chloro-3-hydroxyphenylamino)furo[2,3-c]pyridine-2-carboxylateIC50442.0 [1]
6-(2-(5-((4-Methylpiperazin-1-yl)methyl)pyrimidin-2-yl)furo[2,3-c]pyridin-3-ylamino)naphthalen-1-olIC5016.0 [1]
3-(4-Chloro-3-hydroxyanilino)-N-pyrimidin-2-ylfuro[2,3-c]pyridine-2-carboxamideIC50556.0 [1]
1-[5-(4-Amino-1-methylpyrazolo[3,4-d]pyrimidin-3-yl)-2,3-dihydroindol-1-yl]-2-(2,5-difluorophenyl)ethanoneIC505.4 [1]
3-[1-(Phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7-(4-piperidinyl)thieno[3,2-c]pyridin-4-amineIC501.9 [1]
5-{1-[(2,5-Difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}thieno[2,3-d]pyrimidin-4-amineIC500.6 [1]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(3-fluorophenyl)ethanoneIC500.2 [1]
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(2-chlorophenyl)ethanoneIC500.9 [1]
3-{1-[(2,5-Difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}thieno[3,2-c]pyridin-4-amineIC502.5 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Eukaryotic translation initiation factor 2-alpha kinase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 3 Jul. 2024, https://www.aatbio.com/data-sets/eukaryotic-translation-initiation-factor-2-alpha-kinase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, July 3). Quest Database™ Eukaryotic translation initiation factor 2-alpha kinase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/eukaryotic-translation-initiation-factor-2-alpha-kinase-3-inhibitors-ic50-ki.
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