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Eukaryotic translation initation factor Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
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Standard Values (in nM)
▲
▼
2-MethylguanosineIC50400000.0 [1]
7-Methylguanosine triphosphateKi28.0 [1]
6-Mercapto-7-methylguanosineIC50400000.0 [1]
(2e)-2-{2-[4-(3,4-Dichlorophenyl)-1,3-Thiazol-2-Yl]hydrazinylidene}-3-(2-Nitrophenyl)propanoic AcidIC5043500.0 [1]
N(7)-Methylguanosine 5'-phosphateIC5014000.0 [1]
[4-[7-[2-(4-Chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-1H-purin-8-yl]phenyl]phosphonic acidIC5095.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-7-benzyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC5015500.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[(3-chlorophenyl)methyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC5056800.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[(2-chlorophenyl)methyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC5054500.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[(4-chlorophenyl)methyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC5010000.0 [1]
9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,7-dimethylpurin-9-ium-6-oneIC50400000.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-chlorophenoxy)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC5059.0 [1]
[(2R,3S,4R,5S)-5-[2-Amino-5-[2-(4-chlorophenoxy)ethyl]-4-oxo-3H-pyrrolo[3,2-d]pyrimidin-7-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC506580.0 [1]
2'-Deoxyguanosine 5'-(tetrasodium triphosphate)IC50400000.0 [1]
[(2R,3S,4R,5S)-5-[2-Amino-5-[2-(4-bromophenoxy)ethyl]-4-oxo-3H-pyrrolo[3,2-d]pyrimidin-7-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC503600.0 [1]
7-[2-(4-Chlorophenoxy)ethyl]-8-(4-diethoxyphosphorylphenyl)-2-(methylamino)-1H-purin-6-oneIC50300000.0 [1]
[4-[7-[2-(4-Chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-1H-purin-8-yl]phenyl]-ethoxyphosphinic acidIC501350.0 [1]
[4-[7-[2-(4-Chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-1H-purin-8-yl]phenyl]methylphosphonic acidIC50160.0 [1]
[[4-[7-[2-(4-Chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-1H-purin-8-yl]phenyl]-difluoromethyl]phosphonic acidIC5016.0 [1]
4-[7-[2-(4-Chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-1H-purin-8-yl]benzoic acidIC503140.0 [1]
2-Amino-9-[(2R,3R,4R,5R)-5-(hydroxymethyl)-3,4-di(propan-2-yloxy)oxolan-2-yl]-1H-purin-6-oneIC50400000.0 [1]
Sodium;[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino]phosphinateIC50400000.0 [1]
Sodium;[(2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxido-oxophosphanium;bromideIC50200000.0 [1]
Sodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxido-oxophosphaniumIC50130000.0 [1]
Sodium;[(2R,3R,4R,5R)-5-(2-amino-7-ethyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-oxido-oxophosphaniumIC5045000.0 [1]
Sodium;[(2R,3R,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-oxido-oxophosphaniumIC5055000.0 [1]
Tetrasodium;[[[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate;bromideIC505000.0 [1]
Disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-7-prop-2-enyl-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;bromideIC50220000.0 [1]
7-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(dimethylamino)-3H-pyrrolo[2,3-d]pyrimidin-4-oneIC50400000.0 [1]
2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-1H-purin-9-ium-6-one;bromideIC50400000.0 [1]
Disodium;[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;bromideIC5050000.0 [1]
Disodium;[(2R,3S,4R,5R)-5-(2-amino-7-ethyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;bromideIC50100000.0 [1]
Disodium;[(2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;bromideIC50220000.0 [1]
9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-[(4-methylphenyl)sulfanylamino]-1H-purin-6-oneIC50400000.0 [1]
[(2R,3R,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-hydroxy-oxophosphanium;N,N-diethylethanamineIC50180000.0 [1]
(2Z)-2-[(7,8-Dichloro-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5027000.0 [1]
(2Z)-2-[(6,7-Dichloro-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5015500.0 [1]
(2Z)-2-[(7,8-Dichloro-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5034000.0 [1]
(2Z)-2-[(7,8-Dimethoxy-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5045000.0 [1]
(2Z)-2-[(6,7-Dichloro-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5043500.0 [1]
(2E)-2-[(6,7-Dichloro-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5025000.0 [1]
(2E)-2-[(6,7-Dichloro-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5032000.0 [1]
(2E)-2-[(7,8-Dichloro-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5021500.0 [1]
(2E)-2-[(7,8-Dichloro-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5018500.0 [1]
(2Z)-2-[(7,8-Dichloro-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5014000.0 [1]
(2E)-2-[(6,7-Dichloro-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5028000.0 [1]
(2Z)-2-[(6,7-Dichloro-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5011500.0 [1]
(2E)-2-[(7,8-Dimethoxy-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5010500.0 [1]
(2E)-2-[(7,8-Dimethoxy-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5010500.0 [1]
(2E)-2-[(7,8-Dichloro-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5015500.0 [1]
(2Z)-2-[(7,8-Dichloro-5-oxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5030000.0 [1]
(2E)-2-[(7,8-Dichloro-5-oxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5030500.0 [1]
(2Z)-2-[(6,7-Dichloro-5-oxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5032500.0 [1]
(2E)-2-[(7,8-Dichloro-5,5-dioxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5049000.0 [1]
(2Z)-2-[(7,8-Dichloro-5,5-dioxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5049000.0 [1]
(2E)-2-[(6,7-Dimethoxy-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5016500.0 [1]
(2Z)-2-[(7,8-Dimethoxy-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5051500.0 [1]
(2Z)-2-[(6,7-Dimethoxy-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5055500.0 [1]
(2Z)-2-[(6,7-Dichloro-5,5-dioxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5039000.0 [1]
(2E)-2-[(6,7-Dichloro-5,5-dioxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5040500.0 [1]
(2E)-2-[(6,7-Dichloro-5-oxo-4H-thiochromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acidIC5048500.0 [1]
2-[5-[Amino(hydroxy)methyl]-2-chlorophenyl]-5-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]benzoic acidIC503500.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-bromophenoxy)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC5041.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-chlorophenyl)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC5049300.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[3-(4-chlorophenyl)propyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC505350.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-6-oxo-7-(2-phenoxyethyl)-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC5043000.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-fluorophenoxy)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC501590.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-cyanophenoxy)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC50125.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-6-oxo-7-[2-[4-(trifluoromethyl)phenoxy]ethyl]-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC502570.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-chloro-3-fluorophenoxy)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC5056.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-chloroanilino)-2-oxoethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC5085400.0 [1]
[(2R,3S,4R,5R)-5-[2-Amino-7-[(5-chloro-1-benzofuran-2-yl)methyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateIC50117.0 [1]
[(3Ar,4R,6R,6aR)-4-[2-amino-7-[2-(4-chlorophenoxy)ethyl]-6-oxo-1H-purin-9-ium-9-yl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl dihydrogen phosphateIC5051.0 [1]
2-[[[(2R,3R,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]amino]acetic acidIC50400000.0 [1]
[(2R,3R,4R,5R)-5-(2-Amino-7-benzyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-oxido-oxophosphaniumIC5085000.0 [1]
[[(2R,3S,5R)-5-(2-Amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC504000.0 [1]
2-[[[(2R,3R,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]amino]-3-(1H-indol-3-yl)propanoic acidIC50400000.0 [1]
3-[[[(2R,3R,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]amino]propanoic acidIC50400000.0 [1]
[(2R,3R,4R,5R)-5-[2-Amino-7-(cyclodecapentaenylmethyl)-6-oxo-1H-purin-9-ium-9-yl]-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-oxido-oxophosphaniumIC5070000.0 [1]
2-[[[(2R,3R,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]amino]-3-oxo-3-phenylpropanoic acidIC50400000.0 [1]
2-Amino-7-ethyl-9-[(2R,3R,4R,5R)-5-(hydroxymethyl)-3,4-di(propan-2-yloxy)oxolan-2-yl]-1H-purin-9-ium-6-oneIC50400000.0 [1]
2-Amino-9-[(2R,3R,4R,5R)-5-(hydroxymethyl)-3,4-di(propan-2-yloxy)oxolan-2-yl]-7-methyl-1H-purin-9-ium-6-oneIC50400000.0 [1]
2-Amino-7-benzyl-9-[(2R,3R,4R,5R)-5-(hydroxymethyl)-3,4-di(propan-2-yloxy)oxolan-2-yl]-1H-purin-9-ium-6-oneIC50400000.0 [1]
[1-[[(2R,3S,4R,5R)-5-(2-Amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]triazol-4-yl]phosphonic acidKi382000.0 [1]
4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acidIC50500.0 [1]
5-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-[2-(dimethylamino)ethylcarbamoyl]phenyl]benzoic acidIC5080000.0 [1]
5-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-[3-(diethylamino)propylcarbamoyl]phenyl]benzoic acidIC5080000.0 [1]
2-[4-[(1-Acetylpiperidin-4-yl)carbamoyl]phenyl]-5-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]benzoic acidIC5010000.0 [1]
5-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-[(2-methylpyrazol-3-yl)methylcarbamoyl]phenyl]benzoic acidIC507800.0 [1]
5-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-(4-methylpiperazine-1-carbonyl)phenyl]benzoic acidIC5080000.0 [1]
4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-phenethylcarbamoyl-biphenyl-2-carboxylic acidIC502900.0 [1]
4'-Benzylcarbamoyl-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acidIC502300.0 [1]
2-(2-Carbamoylpyridin-3-yl)-5-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]benzoic acidIC501300.0 [1]
5-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-(1-phenylethylcarbamoyl)phenyl]benzoic acidIC50970.0 [1]
2'-Carbamoyl-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acidIC5015000.0 [1]
5-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2-(2-ethoxy-pyrimidin-5-yl)-benzoic acidIC503600.0 [1]
5-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2-(2-methoxy-pyrimidin-5-yl)-benzoic acidIC5014000.0 [1]
5-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2-(6-methoxy-pyridin-2-yl)-benzoic acidIC509700.0 [1]
5-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2-(2-hydroxy-pyrimidin-5-yl)-benzoic acidIC501200.0 [1]
5-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2-(2-methoxy-pyridin-3-yl)-benzoic acidIC5015000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Eukaryotic translation initation factor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/eukaryotic-translation-initation-factor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Eukaryotic translation initation factor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/eukaryotic-translation-initation-factor-inhibitors-ic50-ki.
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