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Eukaryotic initiation factor 4A-III Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
4-Chloro-7-fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidIC50360.0 [1], 970.0 [2]
4-Chloro-7-fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidKi430.0 [1]
Eif4A3-IN-2IC50110.0 [1], 200.0 [2]
HippuristanolIC5040000.0 [1]
6-Methyl-1H-indole-2-carboxylic acidIC50100000.0 [1]
6-Chloro-1H-indole-2-carboxylic acidIC50100000.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC502200.0 [1]
(4-Bromophenyl)-[(2R)-4-(6-bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]methanoneIC5060000.0 [1]
6-Benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50100000.0 [1]
(3S,3'R,5'S)-5-Fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC50100000.0 [1]
(3S,3'R,5'S)-1'-(1-Benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC50100000.0 [1]
6-Benzyl-3-(3-phenylmethoxyphenyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50100000.0 [1]
3-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidIC5020000.0 [1]
(3-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)-1-[(2-phenyl-1,3-oxazol-5-yl)methyl]piperazin-2-oneIC50100000.0 [1]
(2-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1-phenylpyrazole-3-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
7-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidIC506900.0 [1]
(4-Bromophenyl)-[4-(6-bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]methanoneIC50420.0 [1]
[4-(5-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanoneIC50830.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(5-phenyl-1,3-oxazole-2-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
(4-Bromophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC50660.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)-1,4-diazepan-1-yl]methanoneIC50100000.0 [1]
Eif4A3-IN-1IC50260.0 [1]
(3R,3'S,5'R)-1'-(1-Benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC50100000.0 [1]
[4-(4-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanoneIC508900.0 [1]
3-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrileIC50600.0 [1]
7-Chloro-6-propan-2-yl-1H-indole-2-carboxylic acidIC50100000.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1H-indole-3-carbonyl)piperazin-1-yl]methanoneIC502300.0 [1]
[2-(4-Chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]-phenylmethanoneIC5011000.0 [1]
(4-Bromophenyl)-[2-(4-chlorophenyl)-4-(6-methoxypyrazolo[1,5-a]pyridine-3-carbonyl)piperazin-1-yl]methanoneIC50920.0 [1]
4-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidIC505000.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1-phenylpyrazole-4-carbonyl)piperazin-1-yl]methanoneIC502400.0 [1]
(4-Chlorophenyl)-[2-cyclohexyl-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
6-Benzyl-3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50100000.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(pyrazolo[1,5-a]pyridine-3-carbonyl)piperazin-1-yl]methanoneIC501100.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-[(2-phenyl-1,3-oxazol-5-yl)methyl]piperazin-1-yl]methanoneIC50100000.0 [1]
(4-Chlorophenyl)-[2-(3-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
6-Propan-2-yl-1H-indole-2-carboxamideIC50100000.0 [1]
2-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrileIC502100.0 [1]
5-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidIC5030000.0 [1]
2-[5-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]pyridine-4-carbonitrileIC50390.0 [1]
4-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrileIC508400.0 [1]
[4-(6-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanoneIC50720.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(5-methyl-1-phenylpyrazole-4-carbonyl)piperazin-1-yl]methanoneIC501600.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-4-carbonyl)piperazin-1-yl]methanoneIC5069000.0 [1]
(4-Chlorophenyl)-[2-(2-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanoneIC50100000.0 [1]
3-[5-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrileIC50360.0 [1]
6-Propan-2-yl-2-(2H-tetrazol-5-yl)-1H-indoleIC5030000.0 [1]
4-Chloro-6-propan-2-yl-1H-indole-2-carboxylic acidIC501900.0 [1]
[4-(7-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanoneIC501900.0 [1]
(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1H-indazole-3-carbonyl)piperazin-1-yl]methanoneIC5062000.0 [1]
[3-(4-Chlorophenyl)-4-[(4-chlorophenyl)methyl]piperazin-1-yl]-(2-phenyl-1,3-oxazol-5-yl)methanoneIC50100000.0 [1]
(3R,3'S,5'R)-5-Fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC50100000.0 [1]
6-Benzyl-3-[3-(pyridin-3-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50100000.0 [1]
3-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]pyrazolo[1,5-a]pyridine-6-carbonitrileIC509000.0 [1]
3-[4-[(3R)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methylpyrazol-1-yl]benzonitrileIC50100000.0 [1]
3-[4-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methylpyrazol-1-yl]benzonitrileIC50580.0 [1]
5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-phenyl-3-[3-(trifluoromethyl)phenyl]pyridin-2-oneIC50140.0 [1]
4-[(3S)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2H-isoquinolin-1-oneIC50290.0 [1]
5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(3-chlorophenyl)-1H-pyridin-2-oneIC50290.0 [1]
[(2S)-4-(6-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(5-bromopyridin-2-yl)methanoneIC50280.0 [1]
5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(4-chlorophenyl)-1H-pyridin-2-oneIC501100.0 [1]
3-[5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-methyl-2-oxopyridin-3-yl]benzonitrileIC50100.0 [1]
5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-[3-(trifluoromethyl)phenyl]-1H-pyridin-2-oneIC50700.0 [1]
5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-phenyl-1H-pyridin-2-oneIC50410.0 [1]
5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-methyl-3-[3-(trifluoromethyl)phenyl]pyridin-2-oneIC50750.0 [1]
5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(2-chlorophenyl)-1H-pyridin-2-oneIC50420.0 [1]
3-[5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2-oxo-1H-pyridin-3-yl]benzonitrileIC5050.0 [1]
(4-Bromophenyl)-[(2S)-2-(4-chlorophenyl)-4-(isoquinoline-4-carbonyl)piperazin-1-yl]methanoneIC501600.0 [1]
3-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2-oxo-1H-pyridin-3-yl]benzonitrileIC50190.0 [1]
5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(3-methylsulfonylphenyl)-1H-pyridin-2-oneIC50490.0 [1]
(4-Bromophenyl)-[(2S)-2-(4-chlorophenyl)-4-(quinoline-4-carbonyl)piperazin-1-yl]methanoneIC502700.0 [1]
4-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2H-isoquinolin-1-oneIC501300.0 [1]
6-Isopropyl-1H-indole-2-carboxylic acidIC5027000.0 [1]
6-Ethyl-1H-indole-2-carboxylic AcidIC50100000.0 [1]
7-Isopropyl-1H-indole-2-carboxylic acidIC50100000.0 [1]
Methyl 6-isopropyl-1H-indole-2-carboxylateIC50100000.0 [1]
5-Isopropyl-1H-indole-2-carboxylic acidIC50100000.0 [1]
3-[5-[(Z)-(2-Cyclohexyl-5-imino-7-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-ylidene)methyl]furan-2-yl]benzoic acidIC5032000.0 [1]
1-Methyl-6-(1-methylethyl)-1H-indole-2-carboxylic AcidIC50100000.0 [1]
Items per page: 1 - 10 of 81
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References

This online tool may be cited as follows

MLA

"Quest Database™ Eukaryotic initiation factor 4A-III Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/eukaryotic-initiation-factor-4a-iii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Eukaryotic initiation factor 4A-III Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/eukaryotic-initiation-factor-4a-iii-inhibitors-ic50-ki.
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