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Estrogen-related receptor alpha Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Xct790IC50270.0 [1], 370.0 [2]
4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrileIC5040.0 [1], 600.0 [2]
EstradiolIC503.6 [1], 6.0 [2]
1-Cyclohexyl-N-{[1-(4-Methylphenyl)-1h-Indol-3-Yl]methyl}methanamineIC50190.0 [1]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzoic Acid Methyl EsterIC50470.0 [1], 10000.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-2-trifluoromethylbenzonitrileIC50470.0 [1], 10000.0 [2]
Methyl 4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]-2-(trifluoromethyl)benzoateIC5057.0 [1], 10000.0 [2]
Methyl 4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]-3-(trifluoromethyl)benzoateIC5016.0 [1], 1500.0 [2]
Methyl 2-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]-5-(trifluoromethyl)benzoateIC5070.0 [1], 9300.0 [2]
2-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-5-trifluoromethylbenzonitrileIC50240.0 [1], 4500.0 [2]
5-[4-(2-Chloro-4-trifluoromethylphenoxy)-3-methoxybenzylidene]thiazolidine-2,4-dioneIC50165.0 [1], 2300.0 [2]
Methyl 4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]naphthalene-1-carboxylateIC5013.0 [1], 90.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-naphthalene-1-carbonitrileIC5062.0 [1], 2300.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-bromobenzonitrileIC50720.0 [1], 6300.0 [2]
5-[4-(2-Bromo-4-trifluoromethylphenoxy)-3-methoxybenzylidene]thiazolidine-2,4-dioneIC50140.0 [1], 2700.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-chlorobenzonitrileIC50540.0 [1], 10000.0 [2]
(6Z)-6-[[4-[2-(2,6-Dimethylphenoxy)ethoxy]-3-methoxyphenyl]methylidene]-2-ethyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-oneIC501400.0 [1], 2300.0 [2]
5-[3-Methoxy-4-(2-nitro-4-trifluoromethylphenoxy)benzylidene]-thiazolidine-2,4-dioneIC50270.0 [1], 3600.0 [2]
5-[3-Methoxy-4-(2-nitrophenoxy)benzylidene]thiazolidine-2,4-dioneIC50290.0 [1], 10000.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrileIC501100.0 [1], 10000.0 [2]
5-[3-Methoxy-4-(4-nitro-3-trifluoromethylphenoxy)benzylidene]-thiazolidine-2,4-dioneIC50280.0 [1], 5000.0 [2]
Methyl 3-chloro-4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]benzoateIC5047.0 [1], 5900.0 [2]
Methyl 3-bromo-4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]benzoateIC5080.0 [1], 3400.0 [2]
(5Z)-5-[[4-[2,4-Bis(trifluoromethyl)phenoxy]-3-methoxyphenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC5036.0 [1], 10000.0 [2]
5-[4-(2-Trifluoromethylphenoxy)-3-methoxybenzylidene]-thiazolidine-2,4-dioneIC5068.0 [1], 700.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-2-methylbenzonitrileIC50890.0 [1], 10000.0 [2]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-phthalonitrileIC50220.0 [1], 6900.0 [2]
TamoxifenIC50200.0 [1]
GenisteinIC5010.0 [1]
KaempferolIC509640.0 [1]
FulvestrantIC502.0 [1]
4-[(1S,7S,7Ar)-1-ethyl-7-hydroxy-3-oxo-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-yl]-2-chloro-3-methylbenzonitrileKi10000.0 [1]
1-[[2,5-Diethoxy-4-(methanesulfonamido)phenyl]methyl]-3-phenylureaIC5021080.0 [1]
2-(4-Hydroxyphenyl)-4-vinylquinolin-6-olIC5060.0 [1]
4-Cyano-2-(4-hydroxyphenyl)quinolin-6-olIC5028.0 [1]
4-Ethyl-2-(4-hydroxyphenyl)quinolin-6-olIC5052.0 [1]
4-Bromo-2-(4-hydroxyphenyl)quinolin-6-olIC504.3 [1]
4-Chloro-2-(4-hydroxyphenyl)quinolin-6-olIC504.6 [1]
4-Ethynyl-2-(4-hydroxyphenyl)quinolin-6-olIC5075.0 [1]
Methyl 2-butoxy-5-[[2,5-diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]benzoateIC503430.0 [1]
5-[[2,5-Diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-ethoxy-N-phenylbenzamideIC503720.0 [1]
5-[[2,5-Diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-ethoxy-N-(4-methylphenyl)benzamideIC503040.0 [1]
5-[[2,5-Diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-ethoxy-N-(3-methoxyphenyl)benzamideIC504230.0 [1]
(E)-3-[4-[[2,4-Bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-(1,3,4-thiadiazol-2-yl)prop-2-enamideIC50750.0 [1]
(E)-2-Cyano-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]-N-(1,3,4-thiadiazol-2-yl)prop-2-enamideIC501400.0 [1]
(E)-2-Cyano-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]-N-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)prop-2-enamideIC502600.0 [1]
(E)-N-(5-Tert-butyl-1,3,4-thiadiazol-2-yl)-2-cyano-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]prop-2-enamideIC501700.0 [1]
(E)-2-Cyano-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamideIC501500.0 [1]
(E)-2-Cyano-N-[5-[4-(dimethylamino)phenyl]-1,3,4-thiadiazol-2-yl]-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]prop-2-enamideIC502000.0 [1]
(E)-2-Cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-[4-[[4-fluoro-2-(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]prop-2-enamideIC501500.0 [1]
(E)-2-Cyano-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]-N-(5-ethyl-1,3,4-oxadiazol-2-yl)prop-2-enamideIC503300.0 [1]
(E)-2-Cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-[3-methoxy-4-[[2-(trifluoromethoxy)phenyl]methoxy]phenyl]prop-2-enamideIC501800.0 [1]
(E)-3-[4-[(2-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)prop-2-enamideIC502200.0 [1]
(E)-3-[4-[[2,4-Bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-(5-phenyl-1,3,4-thiadiazol-2-yl)prop-2-enamideIC50500.0 [1]
(E)-2-Cyano-3-[4-[2-(2,6-dimethylphenoxy)ethoxy]-3-methoxyphenyl]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)prop-2-enamideIC502000.0 [1]
(E)-3-[4-[[2,4-Bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-2-cyanoprop-2-enamideIC5010000.0 [1]
(E)-2-Cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-[3-methoxy-4-(naphthalen-1-ylmethoxy)phenyl]prop-2-enamideIC501800.0 [1]
(E)-2-Cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-[4-[[5-fluoro-2-(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]prop-2-enamideIC501700.0 [1]
(E)-3-[4-[[2,4-Bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)prop-2-enamideIC50540.0 [1]
4-[(Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol;hydrochlorideIC5010000.0 [1]
7-(3-Chlorophenyl)-6H-chromeno[4,3-b]quinoline-3,9-diolIC50144.0 [1]
3-(3,9-Dihydroxy-6H-chromeno[4,3-b]quinolin-7-yl)benzonitrileIC50150.0 [1]
4-(3,9-Dihydroxy-6H-chromeno[4,3-b]quinolin-7-yl)benzonitrileIC5065.0 [1]
7-Vinyl-6H-chromeno[4,3-b]quinoline-3,9-diolIC5022.0 [1]
7-(3-Methoxyphenyl)-6H-chromeno[4,3-b]quinoline-3,9-diolIC5086.0 [1]
3,9-DIHYDROXY-7-[4-(TRIFLUOROMETHYL)PHENYL]-6H-CHROMENO[4,3-b]QUINOLINEIC50319.0 [1]
7-Ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diolIC5052.0 [1]
7-(4-Chlorophenyl)-6H-chromeno[4,3-b]quinoline-3,9-diolIC50160.0 [1]
7-Ethyl-6H-chromeno[4,3-b]quinoline-3,9-diolIC5046.0 [1]
7-Chloro-6H-chromeno[4,3-b]quinoline-3,9-diolIC503.3 [1]
7-(4-Methoxyphenyl)-6H-chromeno[4,3-b]quinoline-3,9-diolIC5094.0 [1]
3,9-Dihydroxy-6H-chromeno[4,3-b]quinoline-7-carbonitrileIC506.1 [1]
7-Bromo-6H-chromeno[4,3-b]quinoline-3,9-diolIC503.6 [1]
N-[5-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]pentyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamideIC5080.0 [1]
N-[[4-[[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]methyl]phenyl]methyl]-3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)propanamideIC50170.0 [1]
1-[3-[[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]methyl]pyrrolidin-1-yl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propan-1-oneIC50770.0 [1]
1-[4-[[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]methyl]piperidin-1-yl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propan-1-oneIC50210.0 [1]
N-[2-[2-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]ethoxy]ethyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamideIC50280.0 [1]
N-[3-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]propyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamideIC50490.0 [1]
N-[2-[2-[2-[2-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamideIC50570.0 [1]
N-[4-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]butyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamideIC50170.0 [1]
1-[6-[(2R)-4-[1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-methylthieno[2,3-c]pyrazole-5-carbonyl]-2-methylpiperazin-1-yl]pyridin-3-yl]ethanoneIC5022.0 [1]
N-[2-[2-[2-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]ethoxy]ethoxy]ethyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamideIC50390.0 [1]
N-[2-[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]ethyl]-3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)propanamideIC50650.0 [1]
1-[2-[[3-[[5-[(3R)-4-(5-Acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]methyl]morpholin-4-yl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propan-1-oneIC501000.0 [1]
N-Benzyl-5-[[2,5-diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-ethoxybenzamideIC503810.0 [1]
Methyl 5-[[2,5-diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-phenylmethoxybenzoateIC504060.0 [1]
5-[[2,5-Diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-ethoxy-N-[(4-methoxyphenyl)methyl]benzamideIC501900.0 [1]
5-[[2,5-Diethoxy-4-(methanesulfonamido)phenyl]methylcarbamoylamino]-2-ethoxy-N-propan-2-ylbenzamideIC503480.0 [1]
(5Z)-5-[[1-[[4-Chloro-2-(trifluoromethyl)phenyl]methyl]indazol-5-yl]methylidene]-3-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-1,3-thiazolidine-2,4-dioneIC5045.0 [1]
(Cyclohexylmethyl)[(1-phenyl-1H-indol-3-yl)methyl]amineIC50700.0 [1]
6-(3,5-Dimethyl-1,2-oxazol-4-yl)-2,2,4,4-tetramethyl-1,7,8,9-tetrahydrocyclopenta[h]quinolin-3-oneKi2300.0 [1]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)phenoxy]-2-trifluoromethylbenzonitrileIC50720.0 [1]
4-[4-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methylphenoxy]-2-(trifluoromethyl)benzonitrileIC50800.0 [1]
4-[4-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-ethoxyphenoxy]-2-(trifluoromethyl)benzonitrileIC50350.0 [1]
4-[4-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]-3-methoxyphenoxy]-2-(trifluoromethyl)benzonitrileIC50730.0 [1]
4-[4-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]-2,6-dimethoxyphenoxy]-2-(trifluoromethyl)benzonitrileIC501800.0 [1]
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)naphthalen-1-yloxy]-2-trifluoromethylbenzonitrileIC502600.0 [1]
2-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-5-nitrobenzonitrileIC501000.0 [1]
2-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-benzonitrileIC502400.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Estrogen-related receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/estrogen-related-receptor-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Estrogen-related receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/estrogen-related-receptor-alpha-inhibitors-ic50-ki.
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