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Estradiol 17-beta-dehydrogenase 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
AndrostenedioneIC50489.0 [1], 650.0 [2], 758.0 [3]
EtiocholanoloneIC50182.0 [1], 330.0 [2]
(3R,8R,9S,10S,13S,14S)-3-Benzyl-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5057.0 [1], 98.0 [2]
(3R,5S,8R,9S,10S,13S,14S)-3-[[(2R,5S)-2,5-Dimethyl-4-[2-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]methyl]-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC506.0 [1], 85.0 [2]
TC Hsd 21IC506.0 [1], 14.0 [2]
(3R,8R,9S,10S,13S,14S)-3-Hydroxy-10,13-dimethyl-3-(2-phenylethyl)-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5099.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Hexyl-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50100.0 [1]
(3R,8R,9S,10S,13S,14S)-3-(2-Cyclohexylethyl)-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5060.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Hydroxy-10,13-dimethyl-3-octyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50147.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Cyclohexyl-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5097.0 [1]
(3S,8R,9S,10S,13S,14S)-3-(Cyclohexylmethyl)-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5087.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Hydroxy-10,13-dimethyl-3-propyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5067.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Butan-2-yl-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5073.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Hydroxy-10,13-dimethyl-3-phenyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5081.0 [1]
(5Z)-5-[(3-Bromo-4-hydroxyphenyl)methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-oxazolidin-4-oneIC5013.0 [1]
(5Z)-5-[(3-Bromo-4-hydroxyphenyl)methylidene]-3-(4-methoxyphenyl)-1,3-oxazolidine-2,4-dioneIC5023.0 [1]
1-[9-(Benzylamino)-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC504.0 [1], 8.0 [2]
Methyl 2-(5-acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)benzoateIC500.02 [1], 0.5 [2]
1-(11,12-Dihydro-6H-benzo[c][1,6]benzodiazocin-5-yl)ethanoneIC504740.0 [1], 10000.0 [2]
1-(6,11-Dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC50320.0 [1], 400.0 [2]
N-(5-Acetyl-11,12-dihydro-6H-benzo[c][1]benzazocin-9-yl)benzamideIC50160.0 [1], 260.0 [2]
N-[3-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)phenyl]methanesulfonamideIC50140.0 [1], 190.0 [2]
1-[8-[3-(Aminomethyl)phenyl]-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC50180.0 [1], 290.0 [2]
Methyl 3-(5-acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)benzoateIC501.4 [1], 2.0 [2]
1-[2-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)phenyl]ethanoneIC500.02 [1], 0.5 [2]
N-[2-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)phenyl]methanesulfonamideIC502.0 [1], 9.0 [2]
1-(3-Methyl-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC50870.0 [1], 1000.0 [2]
1-[(11Z)-2-Chloro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC50240.0 [1], 500.0 [2]
1-(2-Chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC5070.0 [1], 630.0 [2]
1-[2-Chloro-8-(2-methoxyphenyl)-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC502.0 [1], 5.0 [2]
1-(3,4-Dichloro-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC50760.0 [1], 1300.0 [2]
1-(3-Methoxy-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC502060.0 [1], 10000.0 [2]
1-(8-Phenyl-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC500.02 [1], 4.0 [2]
1-(2-Chloro-8-phenyl-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC504.0 [1], 18.0 [2]
1-(11,12-Dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC5090.0 [1], 220.0 [2]
1-[2-Chloro-8-[2-(hydroxymethyl)phenyl]-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC500.9 [1], 2.0 [2]
1-[8-[2-(Aminomethyl)phenyl]-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC50182.0 [1], 239.0 [2]
2-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)-N-methylbenzamideIC5025.0 [1]
Methyl 2-(5-acetyl-2-bromo-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)benzoateIC500.7 [1], 1.0 [2]
1-(3-Chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC5050.0 [1], 130.0 [2]
1-(8-Bromo-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC509.0 [1], 32.0 [2]
1-[2-Chloro-8-(3-methoxyphenyl)-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC508.0 [1], 53.0 [2]
1-[2-Chloro-8-(4-methoxyphenyl)-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl]ethanoneIC503.0 [1], 48.0 [2]
1-(3-Fluoro-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC5090.0 [1], 290.0 [2]
1-(3-Bromo-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC50120.0 [1], 250.0 [2]
1-(2,3-Dichloro-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC5010.0 [1], 130.0 [2]
1-(9-Bromo-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC507.0 [1], 36.0 [2]
9-Bromo-11,12-dihydro-6H-benzo[c][1]benzazocine-5-carboxamideIC50280.0 [1], 930.0 [2]
9-Bromo-5-ethyl-11,12-dihydro-6H-benzo[c][1]benzazocineIC501000.0 [1], 2200.0 [2]
(9-Bromo-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)-cyclopropylmethanoneIC50320.0 [1], 1750.0 [2]
1-(9-Amino-11,12-dihydro-6H-benzo[c][1]benzazocin-5-yl)ethanoneIC50490.0 [1]
2-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)benzonitrileIC505.0 [1], 62.0 [2]
3-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)benzonitrileIC503.0 [1], 15.0 [2]
1-(3-Chloro-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC50100.0 [1], 160.0 [2]
1-(2-Chloro-6,11-dihydrobenzo[c][1,6]benzothiazocin-12-yl)ethanoneIC5030.0 [1], 170.0 [2]
5-Acetyl-11,12-dihydro-6H-benzo[c][1]benzazocine-9-carboxamideIC501000.0 [1], 2980.0 [2]
4-(5-Acetyl-2-chloro-11,12-dihydro-6H-benzo[c][1]benzazocin-8-yl)benzonitrileIC503.0 [1], 19.0 [2]
BaicaleinIC50185920.0 [1]
4-MethylumbelliferoneIC501000.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC5067300.0 [1]
4'-HydroxyacetophenoneIC501708920.0 [1]
7-HydroxyflavoneIC5066980.0 [1]
ParoxypropioneIC50150560.0 [1]
7-Hydroxy-4-(trifluoromethyl)coumarinIC50190.0 [1]
3-Chloro-7-hydroxy-4-methyl-2H-chromen-2-oneIC50100.0 [1]
7-Hydroxy-4-phenylcoumarinIC501000.0 [1]
2,6-Bis(3,4,5-trimethoxybenzylidene)cyclohexanoneIC50100.0 [1]
1,5-Bis(4-dimethylaminophenyl)-1,4-pentadien-3-oneIC502400.0 [1]
{(3s)-1-[5-(Cyclohexylcarbamoyl)-6-(Propylsulfanyl)pyridin-2-Yl]piperidin-3-Yl}acetic AcidIC5030000.0 [1]
1-Pentanone, 1-(4-hydroxyphenyl)-IC5060520.0 [1]
7-Hydroxy-3-methyl-2H-chromen-2-oneIC501000.0 [1]
3-Benzyl-7-hydroxy-4-methyl-2H-chromen-2-oneIC50200.0 [1]
3-Cyano-7-hydroxy-4-methylcoumarinIC501000.0 [1]
7-Hydroxy-3,4-dimethyl-2H-chromen-2-oneIC50210.0 [1]
2-(2-Bromo-4,6-dimethylphenoxy)-N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]acetamideIC501600.0 [1]
1-(4-Hydroxyphenyl)nonan-1-oneIC502860.0 [1]
3-Fluoro-7-hydroxy-4-methyl-2H-chromen-2-oneIC501000.0 [1]
7-Hydroxy-4-propyl-2H-chromen-2-oneIC5059.0 [1]
4-Ethyl-7-hydroxycoumarinIC50100.0 [1]
7-Hydroxy-4-(phenylthiomethyl)-2H-chromen-2-oneIC5093.0 [1]
5-[(3-Bromo-4-hydroxyphenyl)methyl]-3-(4-methoxyphenyl)-1,3-thiazol-2-oneIC50570.0 [1]
4'-HydroxybutyrophenoneIC5089510.0 [1]
1-Octanone, 1-(4-hydroxyphenyl)-IC506520.0 [1]
N-(3-Chloro-4-hydroxyphenyl)-4-fluorobenzenesulfonamideIC503900.0 [1]
(3R,8R,9S,10S,13S,14S)-3-(2-Cyclohexylethyl)-3-methoxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50354.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Tert-butyl-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50142.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Benzyl-3-methoxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50154.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Butyl-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50116.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Methoxy-10,13-dimethyl-3-(2-phenylethyl)-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC5073.0 [1]
(3R,8R,9S,10S,13S,14S)-3-Benzyl-3-ethoxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50352.0 [1]
(3R,5S,8R,9S,10S,13S,14S)-3-[[(2R,5S)-4-[5-(Dimethylamino)naphthalen-1-yl]sulfonyl-2,5-dimethylpiperazin-1-yl]methyl]-3-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-oneIC50262.0 [1]
1,5-Bis(3-bromophenyl)-1,4-pentadiene-3-oneIC502700.0 [1]
2-Hydroxyphenyl 4-tert-butylbenzenesulfonateIC508500.0 [1]
7-Hydroxy-4-((1-methyl-1H-imidazol-2-ylthio)methyl)-2H-chromen-2-oneIC5091.0 [1]
(5Z)-5-(3-Bromo-4-hydroxybenzylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-oneIC50120.0 [1]
3-Benzyl-7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-oneIC5030.0 [1]
7-Hydroxy-3-((pyridin-2-ylthio)methyl)-4-(trifluoromethyl)-2H-chromen-2-oneIC50320.0 [1]
7-Hydroxy-4-((4-nitropyridin-2-ylthio)methyl)-2H-chromen-2-oneIC5088.0 [1]
7-Hydroxy-4-((6-methylpyridin-2-ylthio)methyl)-2H-chromen-2-oneIC501.5 [1]
7-Hydroxy-4-((5-(trifluoromethyl)pyridin-2-ylthio)methyl)-2H-chromen-2-oneIC50230.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Estradiol 17-beta-dehydrogenase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/estradiol-17-beta-dehydrogenase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Estradiol 17-beta-dehydrogenase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/estradiol-17-beta-dehydrogenase-3-inhibitors-ic50-ki.
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