Estradiol 17-beta-dehydrogenase 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-(3-Hydroxyphenyl)-2-naphthol	IC50	5641.0 [1]
	CID 60196493	IC50	58.0 [1], 68.0 [2], 119.0 [3]
	N-(3-Methoxyphenyl)-N-methyl-5-(3-methylphenyl)thiophene-2-carboxamide	IC50	58.0 [1], 68.0 [2], 73.0 [3]
	6-(4-Hydroxyphenyl)-1-naphthol	IC50	302.0 [1]
	3,3'-Thiene-2,5-diyldiphenol	IC50	745.0 [1]
	5-(2-Fluoro-3-methoxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	61.0 [1]
	3-(4-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylbenzamide	IC50	482.0 [1], 639.0 [2]
	5-(3-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	394.0 [1]
	Quercetin	IC50	1540.0 [1]
	Genistein	IC50	16500.0 [1]
	Apigenin	IC50	20000.0 [1]
	Kaempferol	IC50	360.0 [1]
	Naringenin	IC50	14400.0 [1]
	Biochanin A	IC50	9900.0 [1]
	7-Hydroxyflavone	IC50	20000.0 [1]
	2-(2-Bromo-4,6-dimethylphenoxy)-N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]acetamide	IC50	4100.0 [1], 23000.0 [2]
	6-(3-Hydroxyphenyl)-1-phenyl-2-naphthol	IC50	540.0 [1]
	(3-Hydroxyphenyl)(5-(3-hydroxyphenyl)thiophen-2-yl)methanone	IC50	109.0 [1]
	5-(3-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	370.0 [1], 371.0 [2]
	[5-(2,4-Difluorophenyl)thiophen-2-yl]-(2,4,5-trifluoro-3-hydroxyphenyl)methanone	IC50	1.4 [1]
	[5-(2,4-Difluorophenyl)thiophen-2-yl]-(3-hydroxy-2-methylphenyl)methanone	IC50	299.0 [1], 300.0 [2]
	[6-(4-Hydroxy-3-methylphenyl)pyridin-2-yl]-(3-hydroxyphenyl)methanone	IC50	260.0 [1], 263.0 [2]
	(2,6-Difluoro-3-hydroxyphenyl)-[5-(4-hydroxyphenyl)thiophen-2-yl]methanone	IC50	71.0 [1], 71.3 [2]
	3-[4-(3-Hydroxyphenyl)phenyl]phenol	IC50	2259.0 [1]
	4-[2-(3-Hydroxyphenyl)-1,3-thiazol-5-yl]phenol	IC50	4000.0 [1], 4004.0 [2]
	3-(5-Phenylthiophen-2-yl)phenol	IC50	2337.0 [1]
	3-[5-(4-Hydroxyphenyl)-2-thienyl]phenol	IC50	1950.0 [1], 1953.0 [2]
	3-[4-(4-Hydroxyphenyl)-2-thienyl]phenol	IC50	1270.0 [1], 1271.0 [2]
	3-[4-(4-Hydroxyphenyl)phenyl]phenol	IC50	4509.0 [1]
	4-Chloro-N-(3-hydroxyphenyl)-2,5-dimethylbenzenesulfonamide	IC50	1000.0 [1]
	3-[4,5-Bis(3-hydroxyphenyl)thiophen-2-yl]phenol	IC50	188.0 [1]
	3-[5-(3-Hydroxyphenyl)-4-methylthiophen-2-yl]phenol	IC50	856.0 [1]
	[5-(4-Hydroxy-3-methylphenyl)-2-thienyl](3-hydroxyphenyl)-methanone	IC50	382.0 [1]
	6-[4-Hydroxy-3-(trifluoromethyl)phenyl]naphthalen-1-ol	IC50	19.0 [1], 31.0 [2]
	4-(3-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylbenzamide	IC50	494.0 [1]
	4-(3-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylbenzamide	IC50	594.0 [1]
	(4-Fluoro-3-hydroxyphenyl)-[4-(4-hydroxy-3-methylphenyl)phenyl]methanone	IC50	34.0 [1], 40.0 [2]
	[5-(4-Hydroxy-3-methylphenyl)pyridin-2-yl]-(3-hydroxyphenyl)methanone	IC50	260.0 [1]
	(4-Fluoro-3-hydroxyphenyl)-[5-(4-hydroxy-3-methylphenyl)pyridin-2-yl]methanone	IC50	100.0 [1], 101.0 [2]
	(4S,5S)-5-[(S)-Hydroxy-(5-pyridin-3-ylthiophen-2-yl)methyl]-1-methyl-4-phenylpyrrolidin-2-one	IC50	50.0 [1]
	CID 60165269	IC50	62.0 [1], 105.0 [2]
	CID 60196908	IC50	621.0 [1]
	CID 60196910	IC50	296.0 [1]
	N-(3-Chloro-4-hydroxyphenyl)-4-fluorobenzenesulfonamide	IC50	3000.0 [1], 10000.0 [2]
	(4R,5R)-4-(2-Fluorophenyl)-5-[(S)-[5-(4-fluorophenyl)thiophen-2-yl]-hydroxymethyl]-1-methylpyrrolidin-2-one	IC50	60.0 [1], 220.0 [2]
	(4R,5R)-5-[(S)-[5-(Benzenesulfonyl)thiophen-2-yl]-hydroxymethyl]-1-methyl-4-phenylpyrrolidin-2-one	IC50	60.0 [1], 480.0 [2]
	(4R,5R)-4-(2-Fluorophenyl)-5-[(S)-hydroxy-(5-pyridin-3-ylthiophen-2-yl)methyl]-1-methylpyrrolidin-2-one	IC50	30.0 [1]
	6-(3-Hydroxyphenyl)-1-(pyridin-4-yl)-2-naphthol	IC50	583.0 [1], 3340.0 [2]
	2-Hydroxyphenyl 4-tert-butylbenzenesulfonate	IC50	240000.0 [1], 520000.0 [2]
	N-(2,1,3-Benzothiadiazol-4-yl)-2-[(4-hydroxypyrimidin-2-yl)sulfanyl]acetamide	IC50	1100.0 [1], 1500.0 [2]
	6-(3-Hydroxyphenyl)-1-(6-methoxypyridin-3-yl)naphthalen-2-ol	IC50	500.0 [1], 530.0 [2]
	N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]methanesulfonamide	IC50	403.0 [1], 540.0 [2]
	6-(2-Fluoro-4-hydroxyphenyl)naphthalen-1-ol	IC50	132.0 [1], 1227.0 [2]
	6-[4-Hydroxy-2-(trifluoromethyl)phenyl]naphthalen-1-ol	IC50	156.0 [1], 171.0 [2]
	(4R,5R)-5-((S)-Hydroxy(5-(pyridin-3-yl)thiophen-2-yl)methyl)-1-methyl-4-phenylpyrrolidin-2-one	IC50	50.0 [1], 90.0 [2]
	(4R,5R)-5-((S)-(5-(4-Fluorophenyl)thiophen-2-yl)(hydroxy)methyl)-1-methyl-4-phenylpyrrolidin-2-one	IC50	100.0 [1], 120.0 [2]
	Curcumin	IC50	1730.0 [1]
	Nordihydroguaiaretic acid	IC50	380.0 [1]
	Rosmarinic acid	IC50	3720.0 [1]
	Isoliquiritigenin	IC50	360.0 [1]
	Butein	IC50	7300.0 [1]
	Jaceosidin	IC50	9300.0 [1]
	(-)-Dihydroguaiaretic acid	IC50	940.0 [1]
	2'-Hydroxygenistein	IC50	2030.0 [1]
	3-Chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide	IC50	96.0 [1]
	Acetoxolone	IC50	3780.0 [1]
	2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide	IC50	284.0 [1]
	3-(1-Adamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine	IC50	3300.0 [1]
	N-Benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide	IC50	3420.0 [1]
	Ethyl vanillate	IC50	1280.0 [1]
	(8R,9S,13S,14S,17S)-3-Hydroxy-13-methylspiro[7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17,6'-oxane]-2'-one	IC50	34.0 [1]
	2-(3-Chloro-4-hydroxyphenyl)-N-phenethylacetamide	IC50	1570.0 [1]
	2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol	IC50	940.0 [1]
	3,3'-(1,2,4,5-Tetrazine-3,6-diyl)diphenol	IC50	5102.0 [1]
	3-[5-(4-Hydroxyphenyl)-1,3-oxazol-2-yl]phenol	IC50	17500.0 [1]
	Lupinalbin A	IC50	1520.0 [1]
	4-Tert-butyl-N-(2-hydroxyphenyl)benzenesulfonamide	IC50	1230.0 [1]
	4-Tert-butyl-N-(2-hydroxy-4-methylphenyl)benzenesulfonamide	IC50	4400.0 [1]
	(4-Fluoranyl-3-Oxidanyl-Phenyl)-[6-(2-Fluoranyl-3-Oxidanyl-Phenyl)pyridin-2-Yl]methanone	Ki	450.0 [1]
	3-(2-Naphthyl)phenol	IC50	4007.0 [1]
	(4-Fluoranyl-3-Oxidanyl-Phenyl)-[6-(3-Methyl-4-Oxidanyl-Phenyl)pyridin-2-Yl]methanone	IC50	757.0 [1]
	3-[5-(3-Hydroxyphenyl)-1,2,4-thiadiazol-3-yl]phenol	IC50	602.0 [1]
	3-[4-(4-Hydroxyphenyl)-1H-1,2,3-triazol-1-yl]phenol	IC50	7280.0 [1]
	(4-Fluoro-3-hydroxyphenyl)(5-(4-hydroxyphenyl)thiophen-2-yl)methanone	IC50	69.0 [1]
	(6-Hydroxy-1,3-benzothiazol-2-yl)-(3-hydroxy-4-methylphenyl)methanone	IC50	4003.0 [1]
	(4-Fluoro-3-hydroxyphenyl)-(6-hydroxy-1,3-benzothiazol-2-yl)methanone	IC50	121.0 [1]
	3-(3-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylbenzamide	IC50	482.0 [1]
	5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	496.0 [1]
	5-(2-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	149.0 [1]
	N-[(3-Hydroxyphenyl)methyl]-N-methyl-5-phenylthiophene-2-carboxamide	IC50	186.0 [1]
	CID 56934183	IC50	222.0 [1]
	5-(4-Cyanophenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	790.0 [1]
	5-(3-Fluorophenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamide	IC50	326.0 [1]
	3-Cyano-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamide	IC50	607.0 [1]
	3-[4-[5-(3-Hydroxyphenyl)-2-methyl-1,2,4-triazol-3-yl]phenyl]phenol	IC50	1400.0 [1]
	5-[3-(Dimethylamino)phenyl]-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide	IC50	169.0 [1]
	5-(2-Fluoro-3-methoxyphenyl)-N-methyl-N-(3-methylphenyl)thiophene-2-carboxamide	IC50	62.0 [1]
	N,3-Bis(3-methoxyphenyl)-N-methylbenzamide	IC50	517.0 [1]
	3-Hydroxy-N-[4-(3-hydroxyphenyl)phenyl]-N-methylbenzenesulfonamide	IC50	511.0 [1]
	(4R,5R)-5-[(S)-[5-(4-Chlorophenyl)thiophen-2-yl]-hydroxymethyl]-1-methyl-4-phenylpyrrolidin-2-one	IC50	1280.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Estradiol 17-beta-dehydrogenase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/estradiol-17-beta-dehydrogenase-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Estradiol 17-beta-dehydrogenase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/estradiol-17-beta-dehydrogenase-2-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan