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Estradiol 17-beta-dehydrogenase 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
EstroneIC50109.0 [1], 218.0 [2], 330.0 [3], 600.0 [4], 810.0 [5]
EstroneKi3.0 [1], 9500.0 [2]
6-(3-Hydroxyphenyl)-2-naphtholIC50116.0 [1], 229.0 [2]
O5'-[9-(3,17B-Dihydroxy-1,3,5(10)-estratrien-16B-YL)-nonanoyl]adenosineIC508.0 [1], 52.0 [2]
O5'-[9-(3,17B-Dihydroxy-1,3,5(10)-estratrien-16B-YL)-nonanoyl]adenosineKi3.0 [1]
6-(3-Hydroxyphenyl)-1-phenyl-2-naphtholIC5020.0 [1], 281.0 [2]
3-{[(9beta,14beta,16alpha,17alpha)-3,17-Dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamideIC5027.0 [1], 44.0 [2]
6-(4-Hydroxyphenyl)-1-naphtholIC502425.0 [1]
3,3'-Thiene-2,5-diyldiphenolIC50173.0 [1]
3-[5-(4-Hydroxyphenyl)-1,3-oxazol-2-yl]phenolIC50310.0 [1], 380.0 [2]
(3-Hydroxyphenyl)(5-(3-hydroxyphenyl)thiophen-2-yl)methanoneIC5022.0 [1], 69.0 [2]
5-(2-Fluoro-3-methoxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamideIC504452.0 [1]
3-(4-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylbenzamideIC503801.0 [1], 9099.0 [2]
5-(3-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylthiophene-2-carboxamideIC505449.0 [1]
CID 60196493IC506728.0 [1], 7593.0 [2]
N-(3-Methoxyphenyl)-N-methyl-5-(3-methylphenyl)thiophene-2-carboxamideIC506752.0 [1], 7616.0 [2]
(2,6-Difluoro-3-hydroxyphenyl)-[5-(4-hydroxyphenyl)thiophen-2-yl]methanoneIC503.0 [1], 3.1 [2], 7.9 [3]
[5-(4-Hydroxy-3-methylphenyl)-2-thienyl](3-hydroxyphenyl)-methanoneIC508.0 [1], 27.0 [2]
3-[[(8R,9S,13S,14S,16R,17S)-3-(2-Bromoethyl)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]methyl]benzamideIC5068.0 [1], 97.0 [2]
(6-Hydroxy-1,3-benzothiazol-2-yl)-(3-hydroxy-4-methylphenyl)methanoneIC5027.0 [1], 258.0 [2]
(4-Fluoro-3-hydroxyphenyl)-(6-hydroxy-1,3-benzothiazol-2-yl)methanoneIC5011.0 [1], 13.0 [2]
3-Cyano-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5021.0 [1], 30.0 [2], 402.0 [3]
6-(3-Hydroxyphenyl)-1-(6-methoxypyridin-3-yl)naphthalen-2-olIC5033.0 [1], 670.0 [2], 840.0 [3]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]methanesulfonamideIC5015.0 [1], 23.0 [2], 71.0 [3]
3-Chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamideIC503341.0 [1], 10000.0 [2]
2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamideIC5052.0 [1], 10000.0 [2]
3-(4-Fluorophenyl)-5-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazoleIC502.2 [1], 1000.0 [2]
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenolIC508.0 [1]
5-(3-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylthiophene-2-carboxamideIC5010000.0 [1], 100000.0 [2]
2-[(8R,9S,13S,14S)-3-Hydroxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-16-yl]-N-(pyridin-3-ylmethyl)acetamideIC5037.0 [1]
2-[(8R,9S,13S,14S,16R)-2-Ethyl-3-hydroxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-16-yl]-N-(pyridin-3-ylmethyl)acetamideIC5027.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 11-[(8R,9S,13S,14S,16R,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]undecanoateIC50310.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 10-[(8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]decanoateIC50140.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 8-[(8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]octanoateIC5093.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 7-[(8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]heptanoateIC50430.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 11-[(8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]undecanoateIC50120.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 12-[(8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]dodecanoateIC501000.0 [1]
[5-(2,4-Difluorophenyl)thiophen-2-yl]-(2,4,5-trifluoro-3-hydroxyphenyl)methanoneIC507.0 [1], 7.2 [2]
[5-(2,4-Difluorophenyl)thiophen-2-yl]-(3-hydroxy-2-methylphenyl)methanoneIC503400.0 [1], 3427.0 [2]
[6-(4-Hydroxy-3-methylphenyl)pyridin-2-yl]-(3-hydroxyphenyl)methanoneIC5019646.0 [1], 19650.0 [2]
3-[4-(3-Hydroxyphenyl)phenyl]phenolIC50173.0 [1]
4-[2-(3-Hydroxyphenyl)-1,3-thiazol-5-yl]phenolIC5050.0 [1]
3-(5-Phenylthiophen-2-yl)phenolIC50342.0 [1]
3-[5-(4-Hydroxyphenyl)-2-thienyl]phenolIC5069.0 [1]
3-[4-(4-Hydroxyphenyl)-2-thienyl]phenolIC5077.0 [1]
3-[4-(4-Hydroxyphenyl)phenyl]phenolIC50471.0 [1]
(13S,16Z)-3-Hydroxy-16-(hydroxymethylidene)-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-oneIC50110.0 [1]
(9S)-9-Methyl-6,7-diazapentacyclo[10.8.0.02,9.04,8.013,18]icosa-4(8),5,13(18),14,16-pentaen-16-olIC50180.0 [1]
(4-Fluoro-3-hydroxyphenyl)(5-(4-hydroxyphenyl)thiophen-2-yl)methanoneIC5021.0 [1]
4-(3-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylbenzamideIC50100000.0 [1]
4-(3-Hydroxyphenyl)-N-[(3-hydroxyphenyl)methyl]-N-methylbenzamideIC5013009.0 [1]
(4-Fluoro-3-hydroxyphenyl)-[4-(4-hydroxy-3-methylphenyl)phenyl]methanoneIC50289.0 [1], 290.0 [2]
[5-(4-Hydroxy-3-methylphenyl)pyridin-2-yl]-(3-hydroxyphenyl)methanoneIC505480.0 [1], 5482.0 [2]
(4-Fluoro-3-hydroxyphenyl)-[5-(4-hydroxy-3-methylphenyl)pyridin-2-yl]methanoneIC501270.0 [1], 1272.0 [2]
CID 60196908IC504821.0 [1]
CID 60196910IC5018663.0 [1]
16-OximinoestroneIC501100.0 [1]
3-[[(8R,9S,13S,14S,16R,17S)-3-(Bromomethyl)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]methyl]benzamideIC50430.0 [1]
6-(3-Hydroxyphenyl)-1-(pyridin-4-yl)-2-naphtholIC5039.0 [1], 64.0 [2]
(2,5-Dihydroxyphenyl)-(6-hydroxy-1,3-benzothiazol-2-yl)methanoneIC5078.0 [1], 365.0 [2]
[2-(4-Hydroxy-3-methylphenyl)-1,3-thiazol-5-yl](3-hydroxyphenyl)methanoneIC5035.0 [1], 107.0 [2]
[3-Chloro-4-[5-(2,6-difluoro-3-hydroxybenzoyl)thiophen-2-yl]phenyl] sulfamateIC5010.2 [1], 60.9 [2]
[2-Chloro-4-[5-(2,6-difluoro-3-hydroxybenzoyl)thiophen-2-yl]phenyl] sulfamateIC501.1 [1], 22.2 [2]
[4-[5-(2,6-Difluoro-3-hydroxybenzoyl)thiophen-2-yl]-3-fluorophenyl] sulfamateIC5012.2 [1], 42.1 [2]
[4-[5-(2,6-Difluoro-3-hydroxybenzoyl)thiophen-2-yl]-2-fluorophenyl] sulfamateIC502.5 [1], 20.0 [2]
6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphtholIC5026.0 [1], 165.0 [2]
1,6-Bis(3-hydroxyphenyl)-2-naphtholIC5036.0 [1], 115.0 [2]
2-Cyano-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5014.0 [1], 157.0 [2]
N-[4-[[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]sulfamoyl]phenyl]acetamideIC5012.0 [1], 240.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]-4-nitrobenzenesulfonamideIC5049.0 [1], 753.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]thiophene-2-sulfonamideIC5028.0 [1], 316.0 [2]
4-Bromo-2,5-difluoro-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5046.0 [1], 646.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]-3-nitrobenzenesulfonamideIC5020.0 [1], 396.0 [2]
(3-Hydroxyphenyl)(5-(4-hydroxyphenyl)thiophen-2-yl)methanoneIC5030.0 [1], 33.0 [2]
[5-(3-Fluoro-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)-methanoneIC5017.0 [1], 19.0 [2]
[5-(3-Chloro-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)-methanoneIC505.0 [1], 126.0 [2]
[5-(3-Ethyl-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)-methanoneIC5020.0 [1], 367.0 [2]
2,6-Difluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamideIC5013.0 [1], 37.0 [2]
2-Fluoro-5-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamideIC50112.0 [1], 152.0 [2]
3-Hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamideIC50243.0 [1], 245.0 [2]
2-Fluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamideIC5029.0 [1], 73.0 [2]
2-Fluoro-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5029.0 [1], 429.0 [2]
3-Fluoro-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5022.0 [1], 462.0 [2]
4-Fluoro-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5053.0 [1], 637.0 [2]
3-Hydroxy-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5014.0 [1], 701.0 [2]
4-Hydroxy-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5019.0 [1], 1009.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]-2-methylbenzenesulfonamideIC5031.0 [1], 525.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]-3-methylbenzenesulfonamideIC5033.0 [1], 440.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]-4-methylbenzenesulfonamideIC5035.0 [1], 633.0 [2]
2,2,2-Trifluoro-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]ethanesulfonamideIC5032.0 [1], 246.0 [2]
1-[1-(Benzenesulfonyl)indol-4-yl]-6-(3-hydroxyphenyl)naphthalen-2-olIC5032.0 [1], 1100.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]quinoline-6-sulfonamideIC5092.0 [1], 498.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5015.0 [1], 196.0 [2]
N-[3-[2-Hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]-2-nitrobenzenesulfonamideIC5017.0 [1], 462.0 [2]
4-Cyano-N-[3-[2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl]phenyl]benzenesulfonamideIC5025.0 [1], 555.0 [2]
GenisteinIC502210.0 [1]
ApigeninIC50710.0 [1]
KaempferolIC501050.0 [1]
NaringeninIC504960.0 [1]
EndosulfanIC5048250.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Estradiol 17-beta-dehydrogenase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/estradiol-17-beta-dehydrogenase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Estradiol 17-beta-dehydrogenase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/estradiol-17-beta-dehydrogenase-1-inhibitors-ic50-ki.
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