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Equilibrative nucleoside transporter 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
4-NitrobenzylthioinosineIC500.3 [1], 8.51 [2]
4-NitrobenzylthioinosineKi0.43 [1], 0.71 [2]
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolIC501698.24 [1]
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolKi19.95 [1], 53.0 [2]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(5-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolIC503019.95 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(5-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolKi250.0 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(8-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolIC503630.78 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(8-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolKi300.0 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(6-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolIC50181.97 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(6-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolKi15.0 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(7-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolIC505.5 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(7-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diolKi0.45 [1]
DipyridamoleKi8.18 [1], 8.79 [2]
NbtgrIC5021.38 [1]
NbtgrKi1.1 [1]
6-S-((4-Chlorophenyl)methyl)-6-thioinosineKi14.23 [1], 14.79 [2]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-methylphenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolIC506309.57 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-methylphenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi67.61 [1]
(2R,3R,4S,5R)-2-[6-[(2-Chlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi99.49 [1], 117.49 [2]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(m-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diolIC5012022.64 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(m-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diolKi16.22 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(p-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diolIC50457.09 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(p-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diolKi15.14 [1]
(2R,3R,4S,5R)-2-[6-[(4-Bromophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi9.98 [1], 11.48 [2]
(2R,3R,4S,5R)-2-[6-[(4-Fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi9.02 [1], 9.12 [2]
(2R,3R,4S,5R)-2-[6-[(2-Fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi19.87 [1], 23.99 [2]
9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purineKi135.0 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(4-iodophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi3.8 [1], 3.88 [2]
(2R,3R,4S,5R)-2-[6-(3,4-Dihydro-1H-isoquinolin-2-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501819.7 [1]
(2R,3R,4S,5R)-2-[6-(3,4-Dihydro-1H-isoquinolin-2-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi150.0 [1]
(2R,3R,4S,5R)-2-[6-[(3-Fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi11.21 [1], 12.88 [2]
(2R,3R,4S,5R)-2-[6-[(3-Chlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi15.96 [1], 18.2 [2]
(2R,3R,4S,5R)-2-[6-[(2-Bromophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi134.23 [1], 151.36 [2]
(2R,3R,4S,5R)-2-[6-[(3-Bromophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi20.54 [1], 20.89 [2]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-iodophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi16.13 [1], 19.5 [2]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(3-iodophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi13.79 [1], 13.8 [2]
(1R,13R,14S,15R)-7-(7-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolIC50331.13 [1]
(1R,13R,14S,15R)-7-(7-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolKi18.89 [1]
(1R,13R,14S,15R)-7-(8-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolIC501737800.83 [1]
(1R,13R,14S,15R)-7-(8-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolKi1000.0 [1]
(1R,13R,14S,15R)-7-(5-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolIC507413102.41 [1]
(1R,13R,14S,15R)-7-(5-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolKi1000.0 [1]
(1R,13R,14S,15R)-7-(6-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolIC50245470.89 [1]
(1R,13R,14S,15R)-7-(6-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diolKi1000.0 [1]
AdenosineIC5017000.0 [1]
UridineIC5052000.0 [1]
PhlorizinKi1000000.0 [1]
N6-CyclopentyladenosineKi1100.0 [1]
DilazepIC5017.5 [1]
LidoflazineKi279.9 [1]
5-IodotubercidinIC50229086.77 [1]
6-Methylmercaptopurine ribosideIC50229086.77 [1]
N6-BenzyladenosineIC5010715.19 [1]
Kinetin ribosideIC5036307.81 [1]
TecadenosonIC5012000.0 [1]
N6-PhenyladenosineIC5032359.37 [1]
S-(2-Hydroxy-5-nitrobenzyl)-6-thioguanosineIC502.75 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(propan-2-ylamino)purin-9-yl]oxolane-3,4-diolIC50257039.58 [1]
2-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diolIC5077624.71 [1]
7H-Pyrrolo[2,3-d]pyrimidine-4-thiol, 7-beta-D-ribofuranosyl-IC50389045.14 [1]
N-[(4-Aminophenyl)methyl]adenosineIC504168.69 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[[3-(trifluoromethyl)phenyl]methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi19.05 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(3-nitrophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi1.78 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi7.08 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(4-methoxyphenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diolKi34.67 [1]
(2R,3R,4S,5R)-2-[6-[(4-Tert-butylphenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi10000.0 [1]
Methyl 4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]sulfanylmethyl]benzoateKi46.77 [1]
4-[[9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]sulfanylmethyl]benzonitrileKi4.57 [1]
(2R,3R,4S,5R)-2-[6-[(2,4-Dichlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi4.37 [1]
(2R,3R,4S,5R)-2-[6-[(2-Chloro-6-fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi87.1 [1]
(2R,3R,4S,5R)-2-[6-[(3,4-Dichlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi12.59 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(4-methoxypyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diolIC50338844.16 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(pentylamino)purin-9-yl]oxolane-3,4-diolIC5013489.63 [1]
9h-Purin-2-amine, 9-propyl-6-[(2-pyridinylmethyl)thio]-IC5091201.08 [1]
9-Butyl-6-(pyridin-2-ylmethylsulfanyl)purin-2-amineIC5052480.75 [1]
2-Hydroxymethyl-5-[6-(2,4,6-trimethyl-benzylsulfanyl)-purin-9-yl]-tetrahydro-furan-3,4-diolKi1905.46 [1]
(2R,3R,4S,5R)-2-(2-Amino-6-methylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolIC50204173.79 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(4-piperidin-1-ylpyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diolIC50194984.46 [1]
(2R,3R,4S,5R)-2-(5-Bromo-4-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diolIC50114815.36 [1]
(2R,3R,4S,5R)-2-[6-(Cyclopentylamino)-8-(propylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolKi97.0 [1]
6-[(4-Nitrophenyl)methylsulfanyl]-9-[[2-[4-(trifluoromethyl)phenyl]phenyl]methyl]purineKi39.0 [1]
2-[6-(4-Nitro-benzylsulfanyl)-purin-9-ylmethyl]-phenolKi39.0 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(3-methoxyphenyl)methylamino]purin-9-yl]oxolane-3,4-diolIC50114815.36 [1]
2-{[6-(2-Hydroxyethoxy)-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl]oxy}ethan-1-olKi325.2 [1]
(2R,3R,4S,5R)-2-[2-Amino-6-(3-methyl-5-nitroimidazol-4-yl)sulfanylpurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC50575439.94 [1]
(2R,3R,4S,5R)-2-(4-Benzylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diolIC505248.07 [1]
CID 25195323Ki1000000.0 [1]
N-(3-Methylbutyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50234422.88 [1]
(2R,3R,4S,5R)-2-[2-Amino-6-(pyridin-2-ylmethylsulfanyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5034673.69 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-phenylmethoxypurin-9-yl)oxolane-3,4-diolIC502089.3 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(thiophen-2-ylmethylamino)purin-9-yl]oxolane-3,4-diolIC5017782.79 [1]
3-[4-[3-(3,4,5-Trimethoxybenzoyl)oxypropyl]piperazin-1-yl]propyl 3,4,5-trimethoxybenzoateIC5066.1 [1]
6-EthylthioinosineIC5057543.99 [1]
2-N,2-N,6-N,6-N-Tetrakis(2-methoxyethyl)-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diamineKi91.6 [1]
9-(2,5-Difluoro-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purineKi1637.0 [1]
9-(2,4-Difluoro-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purineKi4877.0 [1]
6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purineKi2200.0 [1]
2-[6-(4-Nitro-benzylsulfanyl)-purin-9-ylmethyl]-phenylamineKi124.0 [1]
9-(2-Methoxy-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purineKi110.0 [1]
9-(3-Methoxy-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purineKi264.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Equilibrative nucleoside transporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/equilibrative-nucleoside-transporter-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Equilibrative nucleoside transporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/equilibrative-nucleoside-transporter-1-inhibitors-ic50-ki.
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